Carbohydrate Metabolism in Non-Insulin-Dependent Diabetes Mellitus

Dinneen, Sean; Gerich, John; Rizza, Robert

doi:10.1056/nejm199209033271007

Cited by 279Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and ManagementDiabetes Management and Research

Carbohydrate Metabolism in Non-Insulin-Dependent Diabetes Mellitus

Dinneen, Sean, Gerich, John, Rizza, Robert·1992·New England Journal of Medicine

DOI 10.1056/nejm199209033271007

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Abstract

DIABETES mellitus is characterized by both fasting hyperglycemia and exaggerated postprandial increases in the plasma glucose level. Understanding the causes of these abnormalities is important for the rational use of current treatments and for developing more effective therapy. In this seminar, we review the physiology of normal carbohydrate metabolism and the pathophysiology of abnormalities in diabetes mellitus.Normal Physiology: Postabsorptive StateThe term "postabsorptive state" refers to the period 6 to 12 hours after a meal during which the transition from the postprandial to the fasting state occurs. At this time plasma glucose levels are at a nearly steady state; . . .

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The rise in plasma glucose concentration stimulates insulin secretion, which results in suppression of glucose release and stimulation of glucose uptake.
“The rise in plasma glucose concentration stimulates insulin secretion, which results in suppression of glucose release and stimulation of glucose uptake (12,31).”
From Impaired basal glucose effectiveness but unaltered fasting glucose release and gluconeogenesis during short-term hypercortisolemia in healthy subjects (2004) · cites this paper as [12]

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Authors: Dinneen, S., Gerich, J., & Rizza, R.
Affiliations: From the Department of Medicine, Mayo Clinic, Rochester, Minn. (S.D., R.R.), and the Department of Biochemistry, Whittier Institute for Diabetes and Endocrinology, La Jolla, Calif. (J.G.). Address reprint requests to Dr. Rizza at the Endocrine Research Unit, Rm. 5–164, W. Joseph Bldg., Mayo Clinic, Rochester, MN 55905.
Mayo Clinic (US)
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1992-09-03
Volume: 327
Issue: 10
Pages: 707-713
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm199209033271007
OpenAlex: W2074366941
Cited by: 279
References: 59
Citations by year: 2025: 3 · 2023: 1 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 9 · 2018: 6 · 2017: 7 · 2016: 6 · 2015: 13 · 2014: 12 · 2013: 6 · 2012: 14
FWCI: 2.28
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK-20411, DK 29953)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: carbohydrate metabolism, type 2 diabetes, fasting hyperglycemia, postprandial hyperglycemia, postabsorptive state, plasma glucose regulation, diabetes pathophysiology
MeSH terms: Diabetes Mellitus, Type 2, Humans, Carbohydrate Metabolism

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Carbohydrate Metabolism in Non-Insulin-Dependent Diabetes Mellitus

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