Updated survey of the steroid-converting enzymes in human adipose tissues
Abstract
Over the past decade, adipose tissues have been increasingly known for their endocrine properties, that is, their ability to secrete a number of adipocytokines that may exert local and/or systemic effects. In addition, adipose tissues have long been recognized as significant sites for steroid hormone transformation and action. We hereby provide an updated survey of the many steroid-converting enzymes that may be detected in human adipose tissues, their activities and potential roles. In addition to the now well-established role of aromatase and 11β-hydroxysteroid dehydrogenase (HSD) type 1, many enzymes have been reported in adipocyte cell lines, isolated mature cells and/or preadipocytes. These include 11β-HSD type 2, 17β-HSDs, 3β-HSD, 5α-reductases, sulfatases and glucuronosyltransferases. Some of these enzymes are postulated to bear relevance for adipose tissue physiology and perhaps for the pathophysiology of obesity. This elaborate set of steroid-converting enzymes in the cell types of adipose tissue deserves further scientific attention. Our work on 20α-HSD (AKR1C1), 3α-HSD type 3 (AKR1C2) and 17β-HSD type 5 (AKR1C3) allowed us to clarify the relevance of these enzymes for some aspects of adipose tissue function. For example, down-regulation of AKR1C2 expression in preadipocytes seems to potentiate the inhibitory action of dihydrotestosterone on adipogenesis in this model. Many additional studies are warranted to assess the impact of intra-adipose steroid hormone conversions on adipose tissue functions and chronic conditions such as obesity, diabetes and cancer.
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Adipose tissue expresses isoforms of all enzymes required for the activation of androgens from circulating precursors as well as their subsequent inactivation.
“Adipose tissue expresses isoforms of all enzymes required for the activation of androgens from circulating precursors (STS, HSD3B1, reductive 17βHSDs, namely HSD17B1, HSR17B3 and AKR1C3 with involvement in androgen activation, and SRD5A1) as well as their subsequent inactivation (reductive 3αHSDs (mainly AKR1C2), UGT2B15 and UGT2B17) (Blouin et al., 2009b, O'Reilly et al., 2014a, Tchernof et al.,”
From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Tchernof et al., 2015
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- Authors
- Tchernof, A., Mansour, M. F., Pelletier, M., Boulet, M.-M., Nadeau, M., & Luu-The, V.
- Affiliations
- Centre hospitalier universitaire de Québec (CA)
- Institut universitaire de cardiologie et de pneumologie de Québec (CA)
- Corresponding author
- Tchernof, André
- Venue
- The Journal of Steroid Biochemistry and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 147
- Pages
- 56-69
- ISSN
- 0960-0760 (ISSN-L)
- OpenAlex
- W2037733825
- Cited by
- 73
- References
- 243
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 8 · 2023: 9 · 2022: 9 · 2021: 9 · 2020: 2 · 2019: 6 · 2018: 5 · 2017: 6 · 2016: 4 · 2015: 8
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Corpus Université Laval (Université Laval) (submittedVersion)
- Funders
- Canadian Institutes of Health Research Operating (MOP-53195, MOP-102642, MOP-130313, MOP-77698)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- human adipose tissue, adipose tissue endocrine function, aromatase, 11β-hydroxysteroid dehydrogenase type 1, 11β-hydroxysteroid dehydrogenase type 2, 17β-hydroxysteroid dehydrogenase, 3β-hydroxysteroid dehydrogenase, 5α-reductase, sulfatase, glucuronosyltransferase, 20α-hydroxysteroid dehydrogenase, 3α-hydroxysteroid dehydrogenase, 17β-hydroxysteroid dehydrogenase type 5, preadipocytes, adipogenesis, dihydrotestosterone, obesity, steroid hormone metabolism
- MeSH terms
- Adipose Tissue, Animals, Humans, Hydroxysteroid Dehydrogenases, Obesity, Steroids, Body Fat Distribution
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