The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Serum Vaspin Concentrations in Human Obesity and Type 2 Diabetes
Open accessAbstract
OBJECTIVE— Vaspin was identified as an adipokine with insulin-sensitizing effects, which is predominantly secreted from visceral adipose tissue in a rat model of type 2 diabetes. We have recently shown that vaspin mRNA expression in adipose tissue is related to parameters of obesity and glucose metabolism. However, the regulation of vaspin serum concentrations in human obesity and type 2 diabetes is unknown. RESEARCH DESIGN AND METHODS— For the measurement of vaspin serum concentrations, we developed an enzyme-linked immunosorbent assay (ELISA). Using this ELISA, we assessed circulating vaspin in a cross-sectional study of 187 subjects with a wide range of obesity, body fat distribution, insulin sensitivity, and glucose tolerance and in 60 individuals with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), or type 2 diabetes before and after a 4-week physical training program. RESULTS— Vaspin serum concentrations were significantly higher in female compared with male subjects. There was no difference in circulating vaspin between individuals with NGT and type 2 diabetes. In the normal glucose-tolerant group, circulating vaspin significantly correlated with BMI and insulin sensitivity. Moreover, physical training for 4 weeks resulted in significantly increased circulating vaspin levels. CONCLUSIONS— We found a sexual dimorphism in circulating vaspin. Elevated vaspin serum concentrations are associated with obesity and impaired insulin sensitivity, whereas type 2 diabetes seems to abrogate the correlation between increased circulating vaspin, higher body weight, and decreased insulin sensitivity. Low circulating vaspin correlates with a high fitness level, whereas physical training in untrained individuals causes increased vaspin serum concentrations.
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Cites
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The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus* (2002) · Diabetes Care · doi:10.2337/diacare.25.2007.s5 · Cited by 10,338
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Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome
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Metabolic Implications of Body Fat Distribution
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Androgens Decrease Plasma Adiponectin, an Insulin-Sensitizing Adipocyte-Derived Protein
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“Sex differences with higher serum concentrations in female subjects have been demonstrated for the adipokines leptin (17,18) and adiponectin (19).”
BackgroundHida, K., Wada, J., Eguchi, J., Zhang, H., Baba, M., Seida, A., Hashimoto, I., Okada, T., Yasuhara, A., Nakatsuka, A., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504703102 · Cited by 719
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Cited by
Adipokines in health and disease
Fasshauer, M., & Blüher, M. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.04.014 · Cited by 1,050
Self-citationKlöting, N., Fasshauer, M., Dietrich, A., Kovacs, P., Schön, M. R., Kern, M., Stumvoll, M., & Blüher, M. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00586.2009 · Cited by 856
Self-citationGluteofemoral body fat as a determinant of metabolic health
Manolopoulos, K. N., Karpe, F., & Frayn, K. N. (2010) · International Journal of Obesity · doi:10.1038/ijo.2009.286 · Cited by 811
The impact of aging on adipose function and adipokine synthesis
Mancuso, P., & Bouchard, B. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00137 · Cited by 314
Systemic chemerin is related to inflammation rather than obesity in type 2 diabetes
Weigert, J., Neumeier, M., Wanninger, J., Filarsky, M., Bauer, S., Wiest, R., Farkas, S., Scherer, M. N., Schäffler, A., Aslanidis, C., et al. (2010) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2009.03664.x · Cited by 291
Metadata
- Authors
- Youn, B.-S., Klöting, N., Kratzsch, J., Lee, N., Park, J. W., Song, E.-S., Ruschke, K., Oberbach, A., Fasshauer, M., Stumvoll, M., & Blüher, M.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2008-02-01
- Volume
- 57
- Issue
- 2
- Pages
- 372-377
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2158288207
- Cited by
- 419
- References
- 28
- FWCI
- 12.14
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Youn, B.-S., Klöting, N., Kratzsch, J., Lee, N., Park, J. W., Song, E.-S., Ruschke, K., Oberbach, A., Fasshauer, M., Stumvoll, M., & Blüher, M. (2008). Serum Vaspin Concentrations in Human Obesity and Type 2 Diabetes. Diabetes. https://doi.org/10.2337/db07-1045
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