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Cited by 419

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Serum Vaspin Concentrations in Human Obesity and Type 2 Diabetes

Open access
Youn, Byung-Soo, Klöting, Nora, Kratzsch, Jürgen, Lee, Namseok, Park, Ji Woo, Song, Eun-Sun, Ruschke, Karen, Oberbach, Andreas, Fasshauer, Mathias, Stumvoll, Michael, Blüher, Matthias·2008·Diabetes
DOI 10.2337/db07-1045
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Abstract

OBJECTIVE— Vaspin was identified as an adipokine with insulin-sensitizing effects, which is predominantly secreted from visceral adipose tissue in a rat model of type 2 diabetes. We have recently shown that vaspin mRNA expression in adipose tissue is related to parameters of obesity and glucose metabolism. However, the regulation of vaspin serum concentrations in human obesity and type 2 diabetes is unknown. RESEARCH DESIGN AND METHODS— For the measurement of vaspin serum concentrations, we developed an enzyme-linked immunosorbent assay (ELISA). Using this ELISA, we assessed circulating vaspin in a cross-sectional study of 187 subjects with a wide range of obesity, body fat distribution, insulin sensitivity, and glucose tolerance and in 60 individuals with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), or type 2 diabetes before and after a 4-week physical training program. RESULTS— Vaspin serum concentrations were significantly higher in female compared with male subjects. There was no difference in circulating vaspin between individuals with NGT and type 2 diabetes. In the normal glucose-tolerant group, circulating vaspin significantly correlated with BMI and insulin sensitivity. Moreover, physical training for 4 weeks resulted in significantly increased circulating vaspin levels. CONCLUSIONS— We found a sexual dimorphism in circulating vaspin. Elevated vaspin serum concentrations are associated with obesity and impaired insulin sensitivity, whereas type 2 diabetes seems to abrogate the correlation between increased circulating vaspin, higher body weight, and decreased insulin sensitivity. Low circulating vaspin correlates with a high fitness level, whereas physical training in untrained individuals causes increased vaspin serum concentrations.

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Metadata

Authors
Youn, B.-S., Klöting, N., Kratzsch, J., Lee, N., Park, J. W., Song, E.-S., Ruschke, K., Oberbach, A., Fasshauer, M., Stumvoll, M., & Blüher, M.
Venue
Diabetes
Publisher
American Diabetes Association
Published
2008-02-01
Volume
57
Issue
2
Pages
372-377
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/db07-1045
OpenAlex
W2158288207
Cited by
419
References
28
FWCI
12.14
Type
journal article
Language
en
Open access
bronze

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