The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Systemic chemerin is related to inflammation rather than obesity in type 2 diabetes
Abstract
Summary: Background The adipokine chemerin modulates the function of innate immune cells and may link obesity and inflammation, and therefore, a possible relation of chemerin to inflammatory proteins in obesity and type 2 diabetes (T2D) was analysed. As visceral fat contributes to systemic inflammation, chemerin was measured in portal venous (PVS), hepatic venous (HVS) and systemic venous (SVS) blood of patients with liver cirrhosis. Patients and methods Systemic chemerin was determined by ELISA in the serum of normal‐weight, overweight and T2D males, in the serum of T2D patients of both sexes, and in PVS, HVS and SVS of patients with liver cirrhosis. Results Circulating chemerin was similar in T2D and obese individuals but was significantly elevated in both cohorts compared to normal‐weight individuals. Chemerin positively correlated with leptin, resistin and C‐reactive protein (CRP). In T2D, chemerin was similar in male and female patients and increased in patients with elevated CRP. Chemerin was similar in PVS and SVS, indicating that visceral fat is not a major site of chemerin synthesis. Higher levels of chemerin in HVS demonstrate that chemerin is also released by the liver. Conclusions Visceral fat is not a major site of chemerin release, and elevated systemic levels of chemerin in obesity and T2D seem to be associated with inflammation rather than body mass index.
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Chemerin Is a Novel Adipokine Associated with Obesity and Metabolic Syndrome
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Cited by
Chemerin: at the crossroads of inflammation and obesity
Ernst, M. C., & Sinal, C. J. (2010) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2010.08.001 · Cited by 425
Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism
Bondue, B., Wittamer, V., & Parmentier, M. (2011) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2011.11.004 · Cited by 294
Towards an integrative approach to understanding the role of chemerin in human health and disease
Rourke, J. L., Dranse, H. J., & Sinal, C. J. (2013) · Obesity Reviews · doi:10.1111/obr.12009 · Cited by 281
Cytokines and abnormal glucose and lipid metabolism
Shi, J., Fan, J., Su, Q., & Yang, Z. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00703 · Cited by 282
Adipokine inflammation and insulin resistance: the role of glucose, lipids and endotoxin
Piya, M. K., McTernan, P. G., & Kumar, S. (2013) · Journal of Endocrinology · doi:10.1530/joe-12-0498 · Cited by 264
Metadata
- Authors
- Weigert, J., Neumeier, M., Wanninger, J., Filarsky, M., Bauer, S., Wiest, R., Farkas, S., Scherer, M. N., Schäffler, A., Aslanidis, C., Schölmerich, J., & Buechler, C.
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 2010-02-10
- Volume
- 72
- Issue
- 3
- Pages
- 342-348
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2010665664
- Cited by
- 291
- References
- 29
- FWCI
- 10.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- Weigert, J., Neumeier, M., Wanninger, J., Filarsky, M., Bauer, S., Wiest, R., Farkas, S., Scherer, M. N., Schäffler, A., Aslanidis, C., Schölmerich, J., & Buechler, C. (2010). Systemic chemerin is related to inflammation rather than obesity in type 2 diabetes. Clinical Endocrinology. https://doi.org/10.1111/j.1365-2265.2009.03664.x
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