Cited by 90Adipokines, Inflammation, and Metabolic DiseasesImmune cells in cancerLiver physiology and pathology

Liver innate immune cells and insulin resistance: the multiple facets of Kupffer cells

Jager, J., Aparicio‐Vergara, M., Aouadi, M.·2016·Journal of Internal Medicine

Abstract

Obesity, which affects 600 million adults worldwide, is a major risk factor for type 2 diabetes (T2D) and insulin resistance. Current therapies for these metabolic disorders include weight management by lifestyle intervention or bariatric surgery and pharmacological treatment with the aim of regulating blood glucose. Probably because of their short‐term effectiveness, these therapies have not been able to stop the rapidly rising prevalence of T2D over the past decades, highlighting an urgent need to develop new therapeutic strategies. The role of immune cells, such as macrophages, in insulin resistance has been extensively studied. Major advances have been made to elucidate the role of adipose tissue macrophages in these pathogeneses. Recently, anti‐inflammatory drugs have been suggested as an alternative treatment for T2D, and clinical trials of these agents are currently ongoing. In addition, results of previous clinical trials using antibodies against inflammatory cytokines, which showed modest effects, are now being rigorously re‐evaluated. However, it is still unclear how liver macrophages [termed Kupffer cells (KCs)], which constitute the major source of macrophages in the body, contribute to the development of insulin resistance. In this review, we will discuss the present understanding of the role of liver immune cells in the development of insulin resistance. We will particularly focus on KCs, which could represent an attractive target for the treatment of metabolic diseases.

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Crossref · 10.1111/joim.12483

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Authors
Jager, J., Aparicio‐Vergara, M., & Aouadi, M.
Affiliations
  • Karolinska University Hospital (SE)
  • Department of Medicine KI/AZ Integrated CardioMetabolic Center Karolinska Institutet at Karolinska University Hospital Huddinge C2‐84, S‐141 86 Stockholm Sweden
Corresponding author
Aouadi, M.
Venue
Journal of Internal Medicine
Publisher
Wiley
Published
2016-02-11
Volume
280
Issue
2
Pages
209-220
ISSN
  • 0954-6820 (ISSN-L)
  • 1365-2796
OpenAlex
W2262478237
Cited by
90
References
108
Citations by year
2026: 7 · 2025: 6 · 2024: 2 · 2023: 11 · 2022: 7 · 2021: 6 · 2020: 20 · 2019: 9 · 2018: 6 · 2017: 9 · 2016: 7
FWCI
1.40
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Center
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords
Kupffer cells, insulin resistance, type 2 diabetes, obesity, hepatic macrophages, anti-inflammatory therapy, metabolic disease treatment
MeSH terms
Animals, Diabetes Mellitus, Type 2, Hepatitis, Humans, Insulin Resistance, Kupffer Cells, Liver, Obesity, Hepatocytes

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