Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State

FGF-21 as a novel metabolic regulator

Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125

Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action

Frederich, R. C., Hamann, A., Anderson, S., Löllmann, B., Lowell, B. B., & Flier, J. S. (1995) · Nature Medicine · doi:10.1038/nm1295-1311 · Cited by 1,660

Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.003 · Cited by 1,504

Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

Xu, J., Lloyd, D. J., Hale, C., Stanislaus, S., Chen, M., Sivits, G., Vonderfecht, S., Hecht, R., Li, Y.-S., Lindberg, R. A., et al. (2009) · Diabetes · doi:10.2337/db08-0392 · Cited by 1,151

Fibroblast Growth Factor 21 Corrects Obesity in Mice

Coskun, T., Bina, H. A., Schneider, M. A., Dunbar, J. D., Hu, C. C., Chen, Y., Moller, D. E., & Kharitonenkov, A. (2008) · Endocrinology · doi:10.1210/en.2008-0816 · Cited by 1,031

Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans

Zhang, X., Yeung, D. C. Y., Karpisek, M., Stejskal, D., Zhou, Z.-G., Liu, F., Wong, R. L. C., Chow, W.-S., Tso, A. W. K., Lam, K. S. L., et al. (2008) · Diabetes · doi:10.2337/db07-1476 · Cited by 908

Tissue-specific Expression of βKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21

Kurosu, H., Choi, M., Ogawa, Y., Dickson, A. S., Goetz, R., Eliseenkova, A. V., Mohammadi, M., Rosenblatt, K. P., Kliewer, S. A., & Kuro-o, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704165200 · Cited by 748

The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21

Kharitonenkov, A., Wroblewski, V. J., Koester, A., Chen, Y.-F., Clutinger, C. K., Tigno, X. T., Hansen, B. C., Shanafelt, A. B., & Etgen, G. J. (2007) · Endocrinology · doi:10.1210/en.2006-1168 · Cited by 738

The role of SOCS-3 in leptin signaling and leptin resistance

Bjørbæk, C., El-Haschimi, K., Frantz, J. D., & Flier, J. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.30059 · Cited by 639

The relationship between Fibroblast Growth Factor-21 and characteristic parameters related to energy balance in dairy cows

Xu, C., Xu, Q., Chen, Y., Yang, W., Xia, C., Yu, H., Zhu, K., Shen, T., & Zhang, Z. (2015) · BMC Veterinary Research · doi:10.1186/s12917-015-0585-4 · Cited by 20

Comparison of Beneficial Metabolic Effects of Liraglutide and Semaglutide in Male C57BL/6J Mice

Liu, D., Gu, J., Shao, W., Pang, J., Qian, X., & Jin, T. (2021) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2021.08.012 · Cited by 21

Tetrahydrocurcumin protects against nonalcoholic fatty liver disease by improving lipid metabolism and redox homeostasis

Gao, F., Chen, M., Yu, J., Xu, L., Yu, L., Jiang, H., & Gu, Z. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.104957 · Cited by 21

Fibroblast Growth Factor 19 and Fibroblast Growth Factor 21 Regulation in Obese Diabetics, and Non-Alcoholic Fatty Liver Disease after Gastric Bypass

Guo, J., Chen, H.-H., Lee, W., Chen, S., Lee, S., & Chen, C. (2022) · Nutrients · doi:10.3390/nu14030645 · Cited by 21

Acute endurance exercise lowers serum fibroblast growth factor 21 levels in Japanese men

Taniguchi, H., Tanisawa, K., Sun, X., & Higuchi, M. (2016) · Clinical Endocrinology · doi:10.1111/cen.13162 · Cited by 20

Fibroblast growth factor 21 reverses suppression of adiponectin expression via inhibiting endoplasmic reticulum stress in adipose tissue of obese mice

Guo, Q., Xu, L., Liu, J., Li, H., Sun, H., Wu, S., & Zhou, B. (2016) · Experimental Biology and Medicine · doi:10.1177/1535370216677354 · Cited by 20

Metabolic Factors Determining the Susceptibility to Weight Gain: Current Evidence

Hollstein, T., & Piaggi, P. (2020) · Current Obesity Reports · doi:10.1007/s13679-020-00371-4 · Cited by 24

Fibroblast Growth Factor-21 to Adiponectin Ratio: A Potential Biomarker to Monitor Liver Fat in Children With Obesity

Tas, E., Bai, S., Ou, X., Mercer, K. E., Lin, H., Mansfield, K., Buchmann, R. F., Diaz, E. C., Oden, J. D., Børsheim, E., et al. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00654 · Cited by 20

Current understanding and controversies on the clinical implications of fibroblast growth factor 21

Badakhshi, Y., & Jin, T. (2020) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2020.1864278 · Cited by 20

Free Fatty Acids Impair FGF21 Action in HepG2 Cells

Asrih, M., Montessuit, C., Philippé, J., & Jornayvaz, F. R. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000438540 · Cited by 20

FGF21/adiponectin ratio predicts deterioration in glycemia: a 4.6-year prospective study in China

Liu, D., Wu, L., Gao, Q., Long, X., Hou, X., Qian, L., Ni, J., Fang, Q., Li, H., & Jia, W. (2021) · Cardiovascular Diabetology · doi:10.1186/s12933-021-01351-1 · Cited by 19

Fibroblast growth factor 21 (FGF21) is increased in MDD and interacts with body mass index (BMI) to affect depression trajectory

Mason, B. L., Minhajuddin, A., Czysz, A. H., Jha, M. K., Gadad, B. S., Mayes, T. L., & Trivedi, M. H. (2022) · Translational Psychiatry · doi:10.1038/s41398-021-01679-y · Cited by 20

Leukemia inhibitory factor protects against liver steatosis in nonalcoholic fatty liver disease patients and obese mice

Yuan, Y., Li, K., Teng, F., Wang, W., Zhou, B., Zhou, X., Lin, J., Ye, X., Deng, Y., Liu, W., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101946 · Cited by 18

Meal sugar-protein balance determines postprandial FGF21 response in humans

Ramne, S., Duizer, L., Nielsen, M. S., Jørgensen, N. R., Svenningsen, J. S., Grarup, N., Sjödin, A. M., Raben, A., & Gillum, M. P. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00241.2023 · Cited by 20

Ameliorative role of bioactive phytoconstituents targeting obesity associated NAFLD by modulation of inflammation and lipogenesis pathways: a comprehensive review

Barbhuiya, P. A., Sen, S., & Pathak, M. P. (2023) · Phytochemistry Reviews · doi:10.1007/s11101-023-09912-w · Cited by 20

Basal and postprandial change in serum fibroblast growth factor-21 concentration in type 1 diabetic mellitus and in healthy controls

Zibar, K., Blaslov, K., Bulum, T., Čuča, J. K., & Duvnjak, L. S. (2014) · Endocrine · doi:10.1007/s12020-014-0413-9 · Cited by 19

Epicardial fat, body mass index, and triglyceride are independent contributors of serum fibroblast growth factor 21 level in obese premenopausal women

Akyıldız, Z. İ., Polat, S., Yürekli, B. Ş., Kocabaş, G. Ü., Tülüce, K., Tülüce, S. Y., Kocabaş, U., Bozkaya, G., Yüksel, A., & Nazlı, C. (2014) · Journal of Endocrinological Investigation · doi:10.1007/s40618-014-0185-3 · Cited by 19

Receptor Antibodies as Novel Therapeutics for Diabetes

Ussar, S., Vienberg, S. G., & Kahn, C. R. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3003447 · Cited by 19

Insulin sensitizes FGF21 in glucose and lipid metabolisms via activating common AKT pathway

Yu, D., Ye, X., Wu, Q., Li, S., Yang, Y., He, J., Liu, Y., Zhang, X., Yuan, Q., Liu, M., et al. (2015) · Endocrine · doi:10.1007/s12020-015-0801-9 · Cited by 19

FGF-21: promising biomarker for detecting ketosis in dairy cows

Xu, C., Xu, Q., Chen, Y., Yang, W., Xia, C., Yu, H., Zhu, K., Shen, T., & Zhang, Z. (2016) · Veterinary Research Communications · doi:10.1007/s11259-015-9650-5 · Cited by 19

Serum concentrations of fibroblast growth factor 21 are elevated in patients with congenital or acquired lipodystrophy

Miehle, K., Ebert, T., Kralisch, S., Hoffmann, A., Kratzsch, J., Schlögl, H., Stümvoll, M., & Faßhauer, M. (2016) · Cytokine · doi:10.1016/j.cyto.2016.04.015 · Cited by 19

Fibroblast Growth Factor 21 Promotes C2C12 Cells Myogenic Differentiation by Enhancing Cell Cycle Exit

Liu, X., Wang, Y., Zhao, S., & Li, X. (2017) · BioMed Research International · doi:10.1155/2017/1648715 · Cited by 19

Effect of Weight Loss by Low-Calorie Diet on Cardiovascular Health in Type 2 Diabetes: An Interventional Cohort Study

Melhem, S., Steven, S., Taylor, R., & Al-Mrabeh, A. H. (2021) · Nutrients · doi:10.3390/nu13051465 · Cited by 19

Diabetes Mellitus: New Challenges and Innovative Therapies

Sena, C. M., Bento, C. F., Pereira, P., Marquês, F., & Seiça, R. M. F. (2013) · Advances in predictive, preventive and personalised medicine · doi:10.1007/978-94-007-5971-8_3 · Cited by 20

Fibroblast growth factor 21: update on genetics and molecular biology

Barros, D. R., & Hegele, R. A. (2024) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000960 · Cited by 18

Fibroblast growth factor 21, fibroblast growth factor receptor 1, and β-Klotho expression in bovine growth hormone transgenic and growth hormone receptor knockout mice

Brooks, N. E., Hjortebjerg, R., Henry, B. E., List, E. O., Kopchick, J. J., & Berryman, D. E. (2016) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2016.08.003 · Cited by 18

Mechanisms underlying the metabolic beneficial effect of curcumin intervention: Beyond anti-inflammation and anti-oxidative stress

Jin, T. (2018) · Obesity Medicine · doi:10.1016/j.obmed.2018.11.002 · Cited by 19

Dose–response relationship between serum fibroblast growth factor 21 and liver fat content in non-alcoholic fatty liver disease

Xiao, F., Shi, X., Huang, P., Zeng, X., Wang, L., Zeng, J., Liu, C., Yan, B., Song, H., Xu, Y., et al. (2020) · Diabetes & Metabolism · doi:10.1016/j.diabet.2020.101221 · Cited by 18

FGF21 at physiological concentrations regulates vascular endothelial cell function through multiple pathways

Yang, N., Zhang, Y., Huang, Y., Yan, J., Qian, Z., Li, H., Luo, P., Yang, Z. L., Luo, M., Wei, X., et al. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166558 · Cited by 18

Nicotinamide riboside ameliorates high-fructose-induced lipid metabolism disorder in mice via improving FGF21 resistance in the liver and white adipose tissue

Zhao, H. J., Tian, Y., Zuo, Y., Zhang, X., Gao, Y., Wang, P., Sun, L., Zhang, H., & Liang, H. (2022) · Food & Function · doi:10.1039/d2fo01934e · Cited by 21

Characteristic and fate determination of adipose precursors during adipose tissue remodeling

Ye, J., Gao, C. D., Liang, Y., Hou, Z., Shi, Y., & Wang, Y. (2023) · Cell Regeneration · doi:10.1186/s13619-023-00157-8 · Cited by 19

The role of Klotho and sirtuins in sleep-related cardiovascular diseases: a review study

Rostamzadeh, F., Joukar, S., & Yeganeh‐Hajahmadi, M. (2024) · npj Aging · doi:10.1038/s41514-024-00165-1 · Cited by 18

Dietary restriction in obese children and its relation with eating behavior, fibroblast growth factor 21 and leptin: a prospective clinical intervention study

Ibarra‐Reynoso, L. D. R., Pisarchyk, L., Pérez-Luque, E. L., Garay‐Sevilla, M. E., & Malacara, J. M. (2015) · Nutrition & Metabolism · doi:10.1186/s12986-015-0027-0 · Cited by 18

Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21

Pol, C. J., Pollak, N. M., Jurczak, M. J., Zacharia, E. M., Karagiannides, I., Kyriazis, I. D., Ntziachristos, P., Scerbo, D. A., Brown, B. R., Aifantis, I., et al. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.04.010 · Cited by 18

Therapeutic Effects of Fibroblast Growth Factor-21 on Diabetic Nephropathy and the Possible Mechanism in Type 1 Diabetes Mellitus Mice

Weng, W., Ge, T., Wang, Y., He, L., Liu, T., Wang, W., Zheng, Z., Yu, L., Zhang, C., & Lu, X. (2020) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2019.0089 · Cited by 18

PPARα agonist and metformin co-treatment ameliorates NASH in mice induced by a choline-deficient, amino acid-defined diet with 45% fat

Okishio, S., Yamaguchi, K., Ishiba, H., Tochiki, N., Yano, K., Takahashi, A., Kataoka, S., Okuda, K., Seko, Y., Liu, Y., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-75805-z · Cited by 19

The Orphan Nuclear Receptor ERRγ Regulates Hepatic CB1 Receptor-Mediated Fibroblast Growth Factor 21 Gene Expression

Jung, Y. S., Lee, J.-M., Kim, D., Lee, Y. S., Kim, K.-S., Kim, Y., Kim, J., Lee, M., Lee, I., Kim, S. H., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159425 · Cited by 18

NLRP3 inhibition by VTX3232 tempers inflammation resulting in reduced body weight, hyperglycemia, and hepatic steatosis in obese male mice

Bultinck, J., Yuan, S., Cantuti‐Castelvetri, L., Brosens, L., Bracke, D., Collins, J., Goethals, J., Christianson, C. A., Nuss, J. M., & Ogilvie, K. M. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102282 · Cited by 18

Metabolic remodeling induced by mitokines in heart failure

Duan, J., Chen, Z., Wu, Y., Zhu, B., Yang, L., & Yang, C. (2019) · Aging · doi:10.18632/aging.102247 · Cited by 17

SIRT7 Deficiency Protects against Aging-Associated Glucose Intolerance and Extends Lifespan in Male Mice

Mizumoto, T., Yoshizawa, T., Sato, Y., Ito, T., Tsuyama, T., Satoh, A., Araki, S., Tsujita, K., Tamura, M., Oike, Y., et al. (2022) · Cells · doi:10.3390/cells11223609 · Cited by 18

Weighing in on the role of brown adipose tissue for treatment of obesity

Prapaharan, B., Lea, M. B. S., & Beaudry, J. L. (2024) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.3389/jpps.2024.13157 · Cited by 19

Adipocytokines, gut hormones and growth factors in anorexia nervosa

Kowalska, I., Karczewska‐Kupczewska, M., & Strączkowski, M. (2011) · Clinica Chimica Acta · doi:10.1016/j.cca.2011.06.007 · Cited by 18

Fibroblast Growth Factor 21 Is Not Required for the Reductions in Circulating Insulin-Like Growth Factor-1 or Global Cell Proliferation Rates in Response to Moderate Calorie Restriction in Adult Mice

Thompson, A. C. S., Bruss, M. D., Nag, N., Kharitonenkov, A., Adams, A. C., & Hellerstein, M. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111418 · Cited by 17

Vildagliptin and caloric restriction for cardioprotection in pre-diabetic rats

Tanajak, P., Pintana, H., Siri‐Angkul, N., Khamseekaew, J., Apaijai, N., Chattipakorn, S. C., & Chattipakorn, N. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0406 · Cited by 17

Mediterranean Tomato‐Based Sofrito Sauce Improves Fibroblast Growth Factor 21 (FGF21) Signaling in White Adipose Tissue of Obese ZUCKER Rats

Sandoval, V., Rodríguez‐Rodríguez, R., Martínez‐Garza, Ú., Rosell‐Cardona, C., Lamuela-Raventós, R. M., Marrero, P. F., Haro, D., & Relat, J. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700606 · Cited by 17

Effects of EPA and lipoic acid supplementation on circulating FGF21 and the fatty acid profile in overweight/obese women following a hypocaloric diet

Escoté, X., Félix‐Soriano, E., Gayoso, L., Huerta, A. E., Alvarado, M. A., Ansorena, D., Astiasarán, I., Martínez, J. A., & Moreno-Aliaga, M. J. (2018) · Food & Function · doi:10.1039/c8fo00355f · Cited by 17

Postprandial dynamics and response of fibroblast growth factor 21 in older adults

Herpich, C., Haß, U., Kochlik, B., Franz, K., Laeger, T., Klaus, S., Bosy‐Westphal, A., & Norman, K. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.04.037 · Cited by 17

Serum FGF21 levels are altered by various factors including lifestyle behaviors in male subjects

Nakanishi, K., Ishibashi, C., Ide, S., Yamamoto, R., Nishida, M., Nagatomo, I., Moriyama, T., & Yamauchi‐Takihara, K. (2021) · Scientific Reports · doi:10.1038/s41598-021-02075-8 · Cited by 17

Expression profile and overexpression outcome indicate a role for βKlotho in skeletal muscle fibro/adipogenesis

Phelps, M., Stuelsatz, P., & Yablonka‐Reuveni, Z. (2016) · FEBS Journal · doi:10.1111/febs.13682 · Cited by 17

Oral administration of a new HRI activator as a new strategy to improve high‐fat‐diet‐induced glucose intolerance, hepatic steatosis, and hypertriglyceridaemia through FGF21

Zarei, M., Pujol, E., Quesada‐López, T., Villarroya, F., Barroso, E., Vázquez, S., Pizarro‐Delgado, J., Palomer, X., & Vázquez‐Carrera, M. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14678 · Cited by 17

Whey protein isolate inhibits hepatic FGF21 production, which precedes weight gain, hyperinsulinemia and hyperglycemia in mice fed a high-fat diet

Nonogaki, K., & Kaji, T. (2020) · Scientific Reports · doi:10.1038/s41598-020-72975-8 · Cited by 16

Preclinical evidence construction for epigallocatechin-3-gallate against non-alcoholic fatty liver disease: a meta-analysis and machine learning study

Zhang, Y., Li, J., Wang, Z., Chen, J., Zhao, M., Guo, C. X., Wang, T., Li, R., Zhang, H., Ma, X., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156651 · Cited by 16

Serum irisin levels in polycystic ovary syndrome after ovarian drilling

Foda, A. A., Foda, E. A., & El-Said, Z. H. (2019) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2019.02.019 · Cited by 16

Chronic docosahexaenoic acid supplementation improves metabolic plasticity in subcutaneous adipose tissue of aged obese female mice

Félix‐Soriano, E., Sáinź, N., Fernández‐Galilea, M., Gil‐Iturbe, E., Celay, J., Martinez-Climent, J. A., & Moreno-Aliaga, M. J. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109153 · Cited by 18

Periconceptional biomarkers for maternal obesity: a systematic review

Hojeij, B., Rousian, M., Sinclair, K. D., Dinnyés, A., Steegers‐Theunissen, R. P. M., & Schoenmakers, S. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09762-5 · Cited by 17

The Single Nucleotide Polymorphism rs499765 Is Associated with Fibroblast Growth Factor 21 and Nonalcoholic Fatty Liver Disease in a Chinese Population with Normal Glucose Tolerance

Jiang, S., Zhang, R., Li, H., Fang, Q., Jiang, F., Hou, X., Hu, C., & Jia, W. (2014) · Lifestyle Genomics · doi:10.1159/000367943 · Cited by 16

Serum Fibroblast Growth Factor 21 and New-Onset Metabolic Syndrome: KoGES-ARIRANG Study

Choi, J. R., Kim, J., Park, I. H., Huh, J. H., Kim, K. W., Cha, S., Park, K., Sohn, J. H., Park, J. T., & Koh, S. B. (2018) · Yonsei Medical Journal · doi:10.3349/ymj.2018.59.2.287 · Cited by 16

Identification and characterization of adipose surface epitopes

Onogi, Y., Khalil, A., & Ussar, S. (2020) · Biochemical Journal · doi:10.1042/bcj20190462 · Cited by 16

The Effect of FGF21 and Its Genetic Variants on Food and Drug Cravings, Adipokines and Metabolic Traits

Epperlein, S., Gebhardt, C., Rohde, K., Chakaroun, R., Patt, M., Schamarek, I., Kralisch, S., Heiker, J. T., Scholz, M. R., Stümvoll, M., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9040345 · Cited by 16

Interventional effect of dietary fiber on blood glucose and pregnancy outcomes in patients with gestational diabetes mellitus

ZHANG, Z., Li, J., Hu, T., Xu, C., Ni, X. I. E., & Chen, D. (2021) · Journal of Zhejiang University (Medical Sciences) · doi:10.3724/zdxbyxb-2021-0115 · Cited by 16

Obesity induces resistance to central action of BMP8B through a mechanism involving the BBSome

Rial‐Pensado, E., Freire-Agulleiro, Ó., García, M. R., Guo, D., Contreras, C., Seoane‐Collazo, P., Tovar, S. A., Nogueiras, R., Diéguez, C., Rahmouni, K., et al. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101465 · Cited by 15

Secreted EMC10 is upregulated in human obesity and its neutralizing antibody prevents diet-induced obesity in mice

Wang, X., Li, Y., Qiang, G., Wang, K., Dai, J., McCann, M. A., Munoz, M. D., Gil, V., Yu, Y., Li, S., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34259-9 · Cited by 15

An Exome-Chip Association Analysis in Chinese Subjects Reveals a Functional Missense Variant of GCKR That Regulates FGF21 Levels

Cheung, C. Y. Y., Tang, C. S.-M., Xu, A., Lee, C., Au, K., Xu, L., Fong, C. H.-Y., Kwok, K. H. M., Chow, W.-S., Woo, Y. C., et al. (2017) · Diabetes · doi:10.2337/db16-1384 · Cited by 16

Baseline Circulating FGF21 Concentrations and Increase after Fenofibrate Treatment Predict More Rapid Glycemic Progression in Type 2 Diabetes: Results from the FIELD Study

Ong, K. L., O'Connell, R. L., Januszewski, A. S., Jenkins, A. J., Xu, A., SULLIVAN, D. R., Barter, P. J., Scott, R. S., Taskinen, M., Waldman, B., et al. (2017) · Clinical Chemistry · doi:10.1373/clinchem.2016.270876 · Cited by 16

Circulating level of fibroblast growth factor 21 is independently associated with the risks of unstable angina pectoris

Cheng, J., Su, X., Qiao, L., Zhai, C., & Chen, W. (2018) · Bioscience Reports · doi:10.1042/bsr20181099 · Cited by 16

Short-term exposure to an obesogenic diet during adolescence elicits anxiety-related behavior and neuroinflammation: modulatory effects of exogenous neuregulin-1

Vega-Torres, J. D., Ontiveros‐Ángel, P., Terrones, E., Stuffle, E. C., Solak, S., Tyner, E., Oropeza, M., Peña, I. D., Obenaus, A., Ford, B. D., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01788-2 · Cited by 18

Fibroblast growth factor 21

Trusz, G. J. (2024) · Differentiation · doi:10.1016/j.diff.2024.100793 · Cited by 15

Fibroblast Activation Protein is a GH Target: A Prospective Study of Patients with Acromegaly Before and After Treatment

Arlien-Søborg, M. C., Grøndahl, C., Bæk, A., Dal, J., Madsen, M. A., Høgild, M. L., Pedersen, S. B., Bjerre, M., & Jørgensen, J. O. L. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz033 · Cited by 15

CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms

Satoh, A., Han, S., Araki, M., Nakagawa, Y., Ohno, H., Mizunoe, Y., Kumagai, K., Murayama, Y., Osaki, Y., IWASAKI, H. O., et al. (2020) · iScience · doi:10.1016/j.isci.2020.100930 · Cited by 15

Circulating Fibroblast Growth Factor-21 Levels in Rheumatoid Arthritis: Associations With Disease Characteristics, Body Composition, and Physical Functioning

Gould, P. W., Zemel, B. S., Taratuta, E., & Baker, J. F. (2020) · The Journal of Rheumatology · doi:10.3899/jrheum.200673 · Cited by 15

Altered adipokines in obese adolescents: a cross-sectional and longitudinal analysis across the spectrum of glycemia

Wolf, R. M., Jaffe, A. E., Rodriguez, S., Lei, X., Sarver, D. C., Straub, A. T., Wong, G. W., & Magge, S. N. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00626.2020 · Cited by 16

Growth differentiation factor-15 prevents glucotoxicity and connexin-36 downregulation in pancreatic beta-cells

Asrih, M., Dusaulcy, R., Gosmain, Y., Philippé, J., Somm, E., Jornayvaz, F. R., Kang, B. E., Jo, Y., Choi, M. J., Yi, H., et al. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111503 · Cited by 15

Maternal Fibroblast Growth Factor 21 Levels Decrease during Early Pregnancy in Normotensive Pregnant Women but Are Higher in Preeclamptic Women—A Longitudinal Study

Buell‐Acosta, J. D., Garcés, M. F., Baños, A. J. P., Ángel‐Müller, E., Páez, M. C., Eslava-Schmalbach, J. H., Escobar-Córdoba, F., Caminos-Cepeda, S. A., Lacunza, E., Castano, J. P., et al. (2022) · Cells · doi:10.3390/cells11142251 · Cited by 15

Serum fibroblast growth factor 21 in overweight and obese Thai children and adolescents: its relation to glucose metabolism and its change after glucose loading

Korwutthikulrangsri, M., Mahachoklertwattana, P., Chanprasertyothin, S., Pongratanakul, S., & Poomthavorn, P. (2015) · Clinical Endocrinology · doi:10.1111/cen.12808 · Cited by 15

Photoperiodic regulation of FGF21 production in the Siberian hamster

Samms, R. J., Fowler, M. J., Cooper, S., Emmerson, P. J., Coşkun, T., Adams, A. C., Kharitonenkov, A., Tsintzas, K., & Ebling, F. J. P. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.03.013 · Cited by 15

Associations between FGF21, osteonectin and bone turnover markers in type 2 diabetic patients with albuminuria

Xu, L., Niu, M., Yu, W., Xia, W., Gong, F., & Wang, O. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.11.012 · Cited by 16

Hepatic, adipocyte, enteric and pancreatic hormones: response to dietary macronutrient composition and relationship with metabolism

Hron, B. M., Ebbeling, C. B., Feldman, H. A., & Ludwig, D. S. (2017) · Nutrition & Metabolism · doi:10.1186/s12986-017-0198-y · Cited by 15

Reciprocal Effects of Antiretroviral Drugs Used To Treat HIV Infection on the Fibroblast Growth Factor 21/β-Klotho System

Moure, R., Domingo, P., Villarroya, J., Gasa, L., Gallego-Escuredo, J. M., Quesada‐López, T., Morón‐Ros, S., Maroto, A. F., Mateo, G. M., Domingo, J. C., et al. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00029-18 · Cited by 15

Soluble Fgl2 restricts autoimmune hepatitis progression via suppressing Tc17 and conventional CD8+ T cell function

Ai, G., Yan, W., Yu, H., Xiao, F., Xi, D., Ma, K., Huang, J., Luo, X., Wan, X., & Ning, Q. (2018) · The Journal of Gene Medicine · doi:10.1002/jgm.3023 · Cited by 15

Predictors of weight loss in patients with obesity treated with a Very Low-Calorie Ketogenic Diet

Ernesti, I., Baratta, F., Watanabe, M., Risi, R., Camajani, E., Persichetti, A., Tuccinardi, D., Mariani, S., Lubrano, C., Genco, A., et al. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1058364 · Cited by 19

Short‐term semaglutide treatment improves FGF21 responsiveness in primary hepatocytes isolated from high fat diet challenged mice

Feng, J. N., Shao, W., & Jin, T. (2023) · Physiological Reports · doi:10.14814/phy2.15620 · Cited by 13

The association of circulating fibroblast growth factor 21 levels with incident heart failure: The Multi-Ethnic Study of Atherosclerosis

Tucker, W., McClelland, R. L., Allison, M., Szklo, M., Rye, K., & Ong, K. L. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155535 · Cited by 14

FGF21 Depletion Attenuates Colitis through Intestinal Epithelial IL-22-STAT3 Activation in Mice

Liu, L., Li, F., Shao, T., Zhang, L., Lee, J., Dryden, G. W., McClain, C. J., Zhao, C., & Feng, W. (2023) · Nutrients · doi:10.3390/nu15092086 · Cited by 14

The effects of exercise on FGF21 in adults: a systematic review and meta-analysis

Liu, C., Yan, X., Zong, Y., He, Y., Yang, G., Xiao, Y., & Wang, S. (2024) · PeerJ · doi:10.7717/peerj.17615 · Cited by 14

Weight-loss maintenance is accompanied by interconnected alterations in circulating FGF21-adiponectin-leptin and bioactive sphingolipids

Fiorenza, M., Checa, A., Sandsdal, R. M., Jensen, S. B. K., Juhl, C. R., Noer, M. H., Bogh, N. P., Lundgren, J. R., Janus, C., Stallknecht, B. M., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101629 · Cited by 14

Oleuropein mitigates non‐alcoholic fatty liver disease (NAFLD) and modulates liver metabolites in high‐fat diet‐induced obese mice via activating PPARα

Zhou, W., & Du, Z. (2024) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.13691 · Cited by 14

Nuclear factor E2-related factor 2 knockdown enhances glucose uptake and alters glucose metabolism in AML12 hepatocytes

Yuan, X., Huang, H., Huang, Y., Wang, J., Yan, J., Ding, L., Zhang, C., & Zhang, L. (2017) · Experimental Biology and Medicine · doi:10.1177/1535370217694435 · Cited by 14

Molecular role of peptides/proteins in subfertility of polycystic ovarian syndrome

Çelik, Ö., Aydın, S., Çelik, N., Uğur, K., Yavuzkır, Ş., Hatırnaz, Ş., Yardım, M., & Celik, S. (2019) · Cellular and Molecular Biology · doi:10.14715/cmb/2019.65.3.5 · Cited by 14

Thermogenesis and Related Metabolic Targets in Anti-Diabetic Therapy

Arch, J. R. S. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-17214-4_10 · Cited by 14

Relationship of fibroblast growth factor 21 with kidney function and albuminuria: multi-ethnic study of atherosclerosis

Anuwatmatee, S., Allison, M., Shlipak, M. G., McClelland, R. L., Kramer, H., Tang, S., Hou, L., Rye, K., & Ong, K. L. (2018) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfy120 · Cited by 14

Performance of the CONTOUR® TS Blood Glucose Monitoring System

Frank, J., Wallace, J. F., Pardo, S. A., & Parkes, J. L. (2011) · Journal of Diabetes Science and Technology · doi:10.1177/193229681100500128 · Cited by 14

Grape Polyphenols May Prevent High-Fat Diet–Induced Dampening of the Hypothalamic–Pituitary–Adrenal Axis in Male Mice

Mezhibovsky, E., Tveter, K. M., Villa-Rodríguez, J. A., Bacalia, K. M. A., Kshatriya, D., Desai, N., Cabales, A., Wu, Y., Sui, K., Duran, R. M., et al. (2023) · Journal of the Endocrine Society · doi:10.1210/jendso/bvad095 · Cited by 12

A long‐acting FGF21 attenuates metabolic dysfunction‐associated steatohepatitis‐related fibrosis by modulating NR4A1‐mediated Ly6C phenotypic switch in macrophages

Ji, Y. R., Duan, Y., Li, Y., Lu, Q., Liu, D., Yang, Y., Chang, R., Jing, T., Yao, W., Yin, J., et al. (2024) · British Journal of Pharmacology · doi:10.1111/bph.16378 · Cited by 14

Identification of State Markers in Anorexia Nervosa: Replication and Extension of Inflammation-Associated Biomarkers Using Multiplex Profiling

Breithaupt, L. E., Holsen, L. M., Ji, C., Hu, J., Petterway, F., Rosa‐Caldwell, M. E., Nilsson, I. A. K., Thomas, J. J., Williams, K. A., Boutin, R., et al. (2024) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2024.100332 · Cited by 16

Myokines as potential mediators of changes in glucose homeostasis and muscle mass after bariatric surgery

Orioli, L., & Thissen, J. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1554617 · Cited by 17

Ileal Transposition Surgery Decreases Fat Mass and Improves Glucose Metabolism in Diabetic GK Rats: Possible Involvement of FGF21

Yan, K., Chen, W., Zhu, H., Lin, G., Pan, H., Li, N., Wang, L., Yang, H., Liu, M., & Gong, F. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00191 · Cited by 13

Effects of Weight Loss on FGF-21 in Human Subjects: An Exploratory Study

Headland, M. L., Clifton, P. M., & Keogh, J. B. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16234877 · Cited by 13

Digenic Variants in the FGF21 Signaling Pathway Associated with Severe Insulin Resistance and Pseudoacromegaly

Stone, S., Wegner, D., Wambach, J., Cole, F. S., Urano, F., & Ornitz, D. M. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaa138 · Cited by 12

Pubertal FGF21 deficit is central in the metabolic pathophysiology of an ovine model of polycystic ovary syndrome

Siemienowicz, K. J., Furmanska, K., Filis, P., Talia, C., Thomas, J. L., Fowler, P., Rae, M. T., & Duncan, W. C. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111196 · Cited by 13

Browning of white adipocytes by gold nanocluster mediated electromagnetic induction heating hyperthermia

Xue, T., Xu, H., Du, Y., Ding, J., Su, Y., & Lin, Z. (2021) · Nanoscale · doi:10.1039/d1nr07263c · Cited by 13

Lack of Overt FGF21 Resistance in Two Mouse Models of Obesity and Insulin Resistance

Hale, C., Chen, M. M., Stanislaus, S., Chinookoswong, N., Hager, T., Wang, M., Véniant, M. M., & Xu, J. (2012) · Endocrinology · doi:10.1210/en.2010-1262 · Cited by 185

Fibroblast Growth Factor 21 Corrects Obesity in Mice

Coskun, T., Bina, H. A., Schneider, M. A., Dunbar, J. D., Hu, C. C., Chen, Y., Moller, D. E., & Kharitonenkov, A. (2008) · Endocrinology · doi:10.1210/en.2008-0816 · Cited by 1,031

Defining “FGF21 Resistance” during obesity: Controversy, criteria and unresolved questions

Markan, K. R. (2018) · F1000Research · doi:10.12688/f1000research.14117.1 · Cited by 55

1896-P: Adipocyte-Derived Fibroblast Growth Factor 21 (FGF21) Contributes to Circulating FGF21 Pools in Diet-Induced Obese Mice

Wang, S., Goodspeed, L., Ogimoto, K., & den Hartigh, L. J. (2020) · Diabetes · doi:10.2337/db20-1896-p

Serum fibroblast growth factor 21 in human obesity: regulation by insulin infusion and relationship with glucose and lipid oxidation

Strączkowski, M., Karczewska‐Kupczewska, M., Adamska, A., Otziomek, E., Kowalska, I., & Nikołajuk, A. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.10 · Cited by 25