Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State

FGF-21 as a novel metabolic regulator

Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125

Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action

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Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.003 · Cited by 1,504

Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

Xu, J., Lloyd, D. J., Hale, C., Stanislaus, S., Chen, M., Sivits, G., Vonderfecht, S., Hecht, R., Li, Y.-S., Lindberg, R. A., et al. (2009) · Diabetes · doi:10.2337/db08-0392 · Cited by 1,151

Fibroblast Growth Factor 21 Corrects Obesity in Mice

Coskun, T., Bina, H. A., Schneider, M. A., Dunbar, J. D., Hu, C. C., Chen, Y., Moller, D. E., & Kharitonenkov, A. (2008) · Endocrinology · doi:10.1210/en.2008-0816 · Cited by 1,031

Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans

Zhang, X., Yeung, D. C. Y., Karpisek, M., Stejskal, D., Zhou, Z.-G., Liu, F., Wong, R. L. C., Chow, W.-S., Tso, A. W. K., Lam, K. S. L., et al. (2008) · Diabetes · doi:10.2337/db07-1476 · Cited by 908

Tissue-specific Expression of βKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21

Kurosu, H., Choi, M., Ogawa, Y., Dickson, A. S., Goetz, R., Eliseenkova, A. V., Mohammadi, M., Rosenblatt, K. P., Kliewer, S. A., & Kuro-o, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704165200 · Cited by 748

The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21

Kharitonenkov, A., Wroblewski, V. J., Koester, A., Chen, Y.-F., Clutinger, C. K., Tigno, X. T., Hansen, B. C., Shanafelt, A. B., & Etgen, G. J. (2007) · Endocrinology · doi:10.1210/en.2006-1168 · Cited by 738

The role of SOCS-3 in leptin signaling and leptin resistance

Bjørbæk, C., El-Haschimi, K., Frantz, J. D., & Flier, J. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.30059 · Cited by 639

Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease

Zarei, M., Barroso, E., Palomer, X., Dai, J., Rada, P., Quesada‐López, T., Escolá‐Gil, J. C., Cedó, L., Zali, M. R., Molaei, M., et al. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.12.008 · Cited by 123

Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress

Yang, C., Lu, W., Lin, T., You, P., Ye, M., Huang, Y., Jiang, X., Wang, C., Wang, F., Lee, M., et al. (2013) · BMC Gastroenterology · doi:10.1186/1471-230x-13-67 · Cited by 117

Fibroblast growth factors in cardiovascular disease: The emerging role of FGF21

Domouzoglou, E. M., Naka, K. Κ., Vlahos, A. P., Papafaklis, M. I., Michalis, L. K., Tsatsoulis, A., & Maratos–Flier, E. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00527.2015 · Cited by 115

Skeletal muscle adiponectin induction in obesity and exercise

Martínez-Huenchullán, S., Tam, C. S., Ban, L. A., Ehrenfeld-Slater, P., McLennan, S. V., & Twigg, S. M. (2019) · Metabolism · doi:10.1016/j.metabol.2019.154008 · Cited by 119

FGF21 Revolutions: Recent Advances Illuminating FGF21 Biology and Medicinal Properties

Kharitonenkov, A., & DiMarchi, R. D. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.09.007 · Cited by 114

MECHANISMS IN ENDOCRINOLOGY: Biological role, clinical significance, and therapeutic possibilities of the recently discovered metabolic hormone fibroblastic growth factor 21

Iglesias, P., Selgas, R., Romero, S., & Díez, J. J. (2012) · European Journal of Endocrinology · doi:10.1530/eje-12-0357 · Cited by 113

Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas

Singhal, G., Fisher, F. M., Chee, M. J. S., Tan, T. G., Ouaamari, A. E., Adams, A. C., Najarían, R. M., Kulkarni, R., Benoist, C. O., Flier, J. S., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148252 · Cited by 112

Role of fibroblast growth factors in bone regeneration

Charoenlarp, P., Rajendran, A. K., & Iseki, S. (2017) · Inflammation and Regeneration · doi:10.1186/s41232-017-0043-8 · Cited by 118

The link between fibroblast growth factor 21 and sterol regulatory element binding protein 1c during lipogenesis in hepatocytes

Zhang, Y., Lei, T., Huang, J., Wang, S. B., Zhou, L., Yang, Z., & Chen, X. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.05.003 · Cited by 110

Exenatide decreases hepatic fibroblast growth factor 21 resistance in non-alcoholic fatty liver disease in a mouse model of obesity and in a randomised controlled trial

Samson, S. L., Sathyanarayana, P., Jogi, M., Gonzalez, E. V., Gutierrez, A., Krishnamurthy, R., Muthupillai, R., Chan, L., & Bajaj, M. (2011) · Diabetologia · doi:10.1007/s00125-011-2317-z · Cited by 110

Fundamentals of FGF19 & FGF21 Action In Vitro and In Vivo

Adams, A. C., Coskun, T., Irizarry Rovira, A. R., Schneider, M. A., Raches, D. W., Micanovic, R., Bina, H. A., Dunbar, J. D., & Kharitonenkov, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038438 · Cited by 109

High Glucose Represses β-Klotho Expression and Impairs Fibroblast Growth Factor 21 Action in Mouse Pancreatic Islets

So, W. Y., Cheng, Q., Chen, L., Evans‐Molina, C., Xu, A., Lam, K. S. L., & Leung, P. S. (2013) · Diabetes · doi:10.2337/db13-0645 · Cited by 112

Increased Adiposity, Dysregulated Glucose Metabolism and Systemic Inflammation in Galectin-3 KO Mice

Pang, J., Rhodes, D., Pini, M., Akasheh, R. T., Castellanos, K. J., Cabay, R. J., Cooper, D., Perretti, M., & Fantuzzi, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057915 · Cited by 104

Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis

Markan, K. R., & Potthoff, M. J. (2016) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2015.09.021 · Cited by 103

Glucocorticoids Regulate the Metabolic Hormone FGF21 in a Feed-Forward Loop

Patel, R., Bookout, A. L., Magomedova, L., Owen, B. M., Consiglio, G. P., Shimizu, M., Zhang, Y., Mangelsdorf, D. J., Kliewer, S. A., & Cummins, C. L. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1259 · Cited by 102

Distinct Changes in Serum Fibroblast Growth Factor 21 Levels in Different Subtypes of Diabetes

Xiao, Y., Xu, A., Law, L. S., Chen, C., Li, H., Li, X., Yang, L., Liu, S., Zhou, Z., & Lam, K. S. L. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1930 · Cited by 102

Low-carbohydrate ketogenic diets, glucose homeostasis, and nonalcoholic fatty liver disease

Schugar, R. C., & Crawford, P. A. (2012) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3283547157 · Cited by 107

Fish Oil Supplements Lower Serum Lipids and Glucose in Correlation with a Reduction in Plasma Fibroblast Growth Factor 21 and Prostaglandin E2 in Nonalcoholic Fatty Liver Disease Associated with Hyperlipidemia: A Randomized Clinical Trial

Qin, Y., Zhou, Y. G., Chen, S., Zhao, X.-L., Ran, L., Zeng, X.-L., Wu, Y., Chen, J., Kang, C., Shu, F., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133496 · Cited by 104

Endurance Exercise Reduces Hepatic Fat Content and Serum Fibroblast Growth Factor 21 Levels in Elderly Men

Taniguchi, H., Tanisawa, K., Sun, X., Kubo, T., & Higuchi, M. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3308 · Cited by 104

Role of PAI-1 in hepatic steatosis and dyslipidemia

Levine, J. A., Oleaga, C., Eren, M., Amaral, A. P., Shang, M., Lux, E., Khan, S. S., Shah, S. J., Omura, Y., Pamir, N., et al. (2021) · Scientific Reports · doi:10.1038/s41598-020-79948-x · Cited by 105

Plasma Fibroblast Growth Factor 21 Is Associated With Severity of Nonalcoholic Steatohepatitis in Patients With Obesity and Type 2 Diabetes

Barb, D., Bril, F., Kalavalapalli, S., & Cusi, K. J. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-02414 · Cited by 100

Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity

Salminen, A., Kaarniranta, K., & Kauppinen, A. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.08.009 · Cited by 100

The role of FGF21 and its analogs on liver associated diseases

Falamarzi, K., Malekpour, M., Tafti, M. F., Azarpira, N., Behboodi, M., & Zarei, M. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.967375 · Cited by 94

FGF19 and FGF21 for the Treatment of NASH—Two Sides of the Same Coin? Differential and Overlapping Effects of FGF19 and FGF21 From Mice to Human

Henriksson, E., & Andersen, B. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.601349 · Cited by 97

Fibroblast Growth Factor 21 (FGF21) Inhibits Chondrocyte Function and Growth Hormone Action Directly at the Growth Plate

Wu, S., Levenson, A. E., Kharitonenkov, A., & Luca, F. D. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.343707 · Cited by 94

Fibroblast growth factor 21 reflects liver fat accumulation and dysregulation of signalling pathways in the liver of C57BL/6J mice

Rusli, F., Deelen, J., Andriyani, E., Boekschoten, M. V., Lute, C., van den Akker, E. B., Müller, M. M., Beekman, M., & Steegenga, W. T. (2016) · Scientific Reports · doi:10.1038/srep30484 · Cited by 96

The Role of PPARγ in Cardiovascular Diseases

Kvandová, M., Majzúnová, M., & Dovinová, I. (2016) · Physiological Research · doi:10.33549/physiolres.933439 · Cited by 95

Fibroblast growth factor 21 is a metabolic regulator that plays a role in the adaptation to ketosis

Domouzoglou, E. M., & Maratos–Flier, E. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.001941 · Cited by 93

Targeting FGF21 for the Treatment of Nonalcoholic Steatohepatitis

Zarei, M., Pizarro‐Delgado, J., Barroso, E., Palomer, X., & Vázquez‐Carrera, M. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2019.12.005 · Cited by 92

Plasma FGF21 Is Elevated by the Intense Lipid Mobilization of Lactation

Schoenberg, K. M., Giesy, S. L., Harvatine, K. J., Waldron, M. R., Cheng, C., Kharitonenkov, A., & Boisclair, Y. R. (2011) · Endocrinology · doi:10.1210/en.2011-1425 · Cited by 90

Implication of Progranulin and C1q/TNF-Related Protein-3 (CTRP3) on Inflammation and Atherosclerosis in Subjects with or without Metabolic Syndrome

Yoo, H. J., Hwang, S. Y., Hong, H. C., Choi, H. Y., Yang, S. J., Choi, D. S., Baik, S. H., Blüher, M., Youn, B., & Choi, K. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055744 · Cited by 85

Fibroblast Growth Factor 21 and the Adaptive Response to Nutritional Challenges

Martínez‐Garza, Ú., Torres‐Oteros, D., Yarritu, A., Marrero, P. F., Haro, D., & Relat, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194692 · Cited by 88

High-fat diet induces mouse liver steatosis with a concomitant decline in energy metabolism: attenuation by eicosapentaenoic acid (EPA) or hydroxytyrosol (HT) supplementation and the additive effects upon EPA and HT co-administration

Echeverría, F., Valenzuela, R., Bustamante, A., Álvarez, D., Ortíz, M., Espinosa, A., Illesca, P., Gonzalez‐Mañán, D., & Videla, L. A. (2019) · Food & Function · doi:10.1039/c9fo01373c · Cited by 86

Leucine and isoleucine have similar effects on reducing lipid accumulation, improving insulin sensitivity and increasing the browning of WAT in high-fat diet-induced obese mice

Ma, Q., Zhou, X., Hu, L., Chen, J., Zhu, J., & Shan, A. (2020) · Food & Function · doi:10.1039/c9fo03084k · Cited by 86

Emerging Roles of Dyslipidemia and Hyperglycemia in Diabetic Retinopathy: Molecular Mechanisms and Clinical Perspectives

Rao, H., Jalali, J. A., Johnston, T. P., & Koulen, P. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.620045 · Cited by 89

Glucocorticoid Receptor β Induces Hepatic Steatosis by Augmenting Inflammation and Inhibition of the Peroxisome Proliferator-activated Receptor (PPAR) α

Marino, J. S., Stechschulte, L. A., Stec, D. E., Nestor‐Kalinoski, A. L., Coleman, S., & Hinds, T. D. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.752311 · Cited by 87

Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood

Yuan, X.-M., Tsujimoto, K., Hashimoto, K., Kawahori, K., Hanzawa, N., Hamaguchi, M., Seki, T., Nawa, M., Ehara, T., Kitamura, Y., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03038-w · Cited by 77

Fibroblast Growth Factor 21 As an Emerging Therapeutic Target for Type 2 Diabetes Mellitus

So, W. Y., & Leung, P. S. (2016) · Medicinal Research Reviews · doi:10.1002/med.21390 · Cited by 85

Liver-derived fibroblast growth factor 21 mediates effects of glucagon-like peptide-1 in attenuating hepatic glucose output

Liu, J., Yang, K., Yang, J., Xiao, W., Le, Y., Yu, F., Gu, L., Lang, S., Tian, Q., Jin, T., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.02.037 · Cited by 85

FGF21 as an Endocrine Regulator in Lipid Metabolism: From Molecular Evolution to Physiology and Pathophysiology

Murata, Y., Konishi, M., & Itoh, N. (2011) · Journal of Nutrition and Metabolism · doi:10.1155/2011/981315 · Cited by 87

Serum FGF 21 concentration is associated with hypertriglyceridaemia, hyperinsulinaemia and pericardial fat accumulation, independently of obesity, but not with current coronary artery status

Lee, Y., Lim, S. K., Hong, E. S., Kim, J. H., Moon, M. K., Chun, E. J., Choi, S. I., Kim, Y., Park, Y. J., Park, K. S., et al. (2012) · Clinical Endocrinology · doi:10.1111/cen.12134 · Cited by 84

Diabetes mellitus: new challenges and innovative therapies

Sena, C. M., Bento, C. F., Pereira, P., & Seiça, R. M. F. (2010) · The EPMA Journal · doi:10.1007/s13167-010-0010-9 · Cited by 92

Plasma FGF21 levels in obese patients undergoing energy-restricted diets or bariatric surgery: a marker of metabolic stress?

Crujeiras, A. B., Gómez-Arbeláez, D., Zulet, M. Á., Carreira, M. C., Sajoux, I., de Luis, D. A., Castro, A. I., Baltar, J., de la Torre, I. B., Sueiro, A. M., et al. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.138 · Cited by 83

FGF19 and FGF21: In NASH we trust

Talukdar, S., & Kharitonenkov, A. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101152 · Cited by 82

Circulating FGF21 Levels in Human Health and Metabolic Disease

Keuper, M., Häring, H., & Staiger, H. (2019) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-0879-2968 · Cited by 83

Central Resistin/TLR4 Impairs Adiponectin Signaling, Contributing to Insulin and FGF21 Resistance

Benomar, Y., Amine, H., Crépin, D., Al Rifai, S., Riffault, L., Gertler, A., & Taouis, M. (2016) · Diabetes · doi:10.2337/db15-1029 · Cited by 76

Glucagon Stimulates Hepatic FGF21 Secretion through a PKA- and EPAC-Dependent Posttranscriptional Mechanism

Cyphert, H. A., Alonge, K. M., Ippagunta, S. M., & Hillgartner, F. B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094996 · Cited by 80

Serum levels of fibroblast growth factor‐21 are increased in chronic and acute renal dysfunction

Hindricks, J., Ebert, T., Bachmann, A., Kralisch, S., Lössner, U., Kratzsch, J., Stolzenburg, J., Dietel, A., Beige, J., Anders, M. S., et al. (2013) · Clinical Endocrinology · doi:10.1111/cen.12380 · Cited by 80

Fibroblast activation protein (FAP) as a novel metabolic target

Sanchez-Garrido, M. A., Habegger, K. M., Clemmensen, C., Holleman, C. L., Müller, T. D., Pérez–Tilve, D., Li, P., Agrawal, A., Finan, B., Drucker, D. J., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.07.003 · Cited by 79

Fibroblast growth factor 21 deficiency exacerbates chronic alcohol-induced hepatic steatosis and injury

Liu, Y., Zhao, C., Xiao, J., Liu, L., Zhang, M., Wang, C., Wu, G., Zheng, M.-H., Xu, L.-M., Chen, Y.-P., et al. (2016) · Scientific Reports · doi:10.1038/srep31026 · Cited by 78

Loss of fibroblast growth factor 21 action induces insulin resistance, pancreatic islet hyperplasia and dysfunction in mice

So, W. Y., Cheng, Q., Xu, A., Lam, K. S. L., & Leung, P. S. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.80 · Cited by 79

FGF21-Mediated Improvements in Glucose Clearance Require Uncoupling Protein 1

Kwon, M. M., O’Dwyer, S. M., Baker, R. K., Covey, S. D., & Kieffer, T. J. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.10.021 · Cited by 77

Disruption of the Cereblon Gene Enhances Hepatic AMPK Activity and Prevents High-Fat Diet–Induced Obesity and Insulin Resistance in Mice

Lee, K. M., Yang, S.-J., Kim, Y. D., Choi, Y. D., Nam, J. H., Choi, C. S., Choi, H.-S., & Park, C.-S. (2013) · Diabetes · doi:10.2337/db12-1030 · Cited by 77

Fibroblast Growth Factor 21 (FGF21) and Glucagon-Like Peptide 1 Contribute to Diabetes Resistance in Glucagon Receptor–Deficient Mice

Omar, B. A., Andersen, B., Hald, J., Raun, K., Nishimura, E., & Åhrén, B. (2013) · Diabetes · doi:10.2337/db13-0710 · Cited by 76

Inflammation Markers in Type 2 Diabetes and the Metabolic Syndrome in the Pediatric Population

Reinehr, T., & Roth, C. L. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1110-5 · Cited by 78

Pharmacological strategies for targeting BAT thermogenesis

Whittle, A. J., Relat, J., & Vidal‐Puig, A. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.04.004 · Cited by 82

Effects of sex hormone treatment on the metabolic syndrome in transgender individuals: focus on metabolic cytokines

Auer, M. K., Ebert, T., Pietzner, M., Defreyne, J., Fuss, J., Stalla, G. K., & T’Sjoen, G. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01559 · Cited by 75

Ketogenic Diet Impairs FGF21 Signaling and Promotes Differential Inflammatory Responses in the Liver and White Adipose Tissue

Asrih, M., Altirriba, J., Rohner‐Jeanrenaud, F., & Jornayvaz, F. R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126364 · Cited by 75

Serum fibroblast growth factor 21 levels are related to subclinical atherosclerosis in patients with type 2 diabetes

Xiao, Y., Liu, L., Xu, A., Zhou, P., Long, Z., Tu, Y., Chen, X., Tang, W., Huang, G., & Zhou, Z. (2015) · Cardiovascular Diabetology · doi:10.1186/s12933-015-0229-9 · Cited by 75

Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones

Adams, A. C., Coşkun, T., Cheng, C., O’Farrell, L. S., DuBois, S. L., & Kharitonenkov, A. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.05.005 · Cited by 75

The potential function and clinical application of FGF21 in metabolic diseases

Chen, Z., Yang, L., Liu, Y., Huang, P., Song, H., & Zheng, P. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1089214 · Cited by 73

Effects of fibroblast growth factor 21 on the heart

Tanajak, P., Chattipakorn, S. C., & Chattipakorn, N. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0289 · Cited by 72

Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice

Matsui, S., Sasaki, T., Kohno, D., Yaku, K., Inutsuka, A., Yokota-Hashimoto, H., Kikuchi, O., Suga, T., Kobayashi, M., Yamanaka, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07033-z · Cited by 72

The Potential Role of Fibroblast Growth Factor 21 in Lipid Metabolism and Hypertension

Huang, Z. P., Xu, A., & Cheung, B. M. Y. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0730-5 · Cited by 71

Hepatic FGF21 mediates sex differences in high-fat high-fructose diet-induced fatty liver

Chukijrungroat, N., Khamphaya, T., Weerachayaphorn, J., Songserm, T., & Saengsirisuwan, V. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00076.2017 · Cited by 72

Overexpression of β-Klotho in Adipose Tissue Sensitizes Male Mice to Endogenous FGF21 and Provides Protection From Diet-Induced Obesity

Samms, R. J., Cheng, C. C., Kharitonenkov, A., Gimeno, R. E., & Adams, A. C. (2016) · Endocrinology · doi:10.1210/en.2015-1722 · Cited by 76

Implication of hepatokines in metabolic disorders and cardiovascular diseases

Jung, T. W., Yoo, H. J., & Choi, K. M. (2016) · BBA Clinical · doi:10.1016/j.bbacli.2016.03.002 · Cited by 71

Human FGF-21 Is a Substrate of Fibroblast Activation Protein

Coppage, A. L., Heard, K. R., DiMare, M. T., Liu, Y., Wu, W., Lai, J. H.-S., & Bachovchin, W. W. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151269 · Cited by 71

An Overview of FGF19 and FGF21: The Therapeutic Role in the Treatment of the Metabolic Disorders and Obesity

Babaknejad, N., Nayeri, H., Hemmati, R., Bahrami, S., & Esmaillzadeh, A. (2018) · Hormone and Metabolic Research · doi:10.1055/a-0623-2909 · Cited by 70

The Nuanced Metabolic Functions of Endogenous FGF21 Depend on the Nature of the Stimulus, Tissue Source, and Experimental Model

Spann, R. A., Morrison, C. D., & den Hartigh, L. J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.802541 · Cited by 76

Relationship of Serum Fibroblast Growth Factor 21 with Abnormal Glucose Metabolism and Insulin Resistance: The Baltimore Longitudinal Study of Aging

Semba, R. D., Sun, K., Egan, J. M., Crasto, C., Carlson, O. D., & Ferrucci, L. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2823 · Cited by 70

Fibroblast Growth Factor 21 Analogs for Treating Metabolic Disorders

Zhang, J., & Li, Y. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00168 · Cited by 70

The hepatokine FGF21 is crucial for peroxisome proliferator-activated receptor-α agonist-induced amelioration of metabolic disorders in obese mice

Goto, T., Hirata, M., Aoki, Y., Iwase, M., Takahashi, H., Kim, M., Li, Y., Jheng, H., Nomura, W., Takahashi, N., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.767590 · Cited by 72

Relationship Between 12 Adipocytokines and Distinct Components of the Metabolic Syndrome

Ebert, T., Gebhardt, C., Scholz, M. R., Wohland, T., Schleinitz, D., Faßhauer, M., Blüher, M., Stümvoll, M., Kovacs, P. L., & Tönjes, A. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-02085 · Cited by 70

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Metformin ameliorates experimental-obesity-associated autoimmune arthritis by inducing FGF21 expression and brown adipocyte differentiation

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FGF21 resistance is not mediated by downregulation of beta-klotho expression in white adipose tissue

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Potential roles of fibroblast growth factor 21 in the brain

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The FGF21 Receptor Signaling Complex

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Exerkines and cardiometabolic benefits of exercise: from bench to clinic

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Hepatic CREB3L3 Controls Whole-Body Energy Homeostasis and Improves Obesity and Diabetes

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The role of fibroblast growth factor 21 in atherosclerosis

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The central fibroblast growth factor receptor/beta klotho system: Comprehensive mapping in Mus musculus and comparisons to nonhuman primate and human samples using an automated in situ hybridization platform

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Fibroblast growth factor-21 serum concentrations are associated with metabolic and hepatic markers in humans

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Circulating Irisin and Glucose-Dependent Insulinotropic Peptide Are Associated With the Development of Polycystic Ovary Syndrome

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Cinnamaldehyde induces fat cell-autonomous thermogenesis and metabolic reprogramming

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Peripheral signalling involved in energy homeostasis control

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FGF21 as a mediator of adaptive responses to stress and metabolic benefits of anti-diabetic drugs

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Fatty liver and FGF21 physiology

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Biological and pharmacological functions of the FGF19- and FGF21-coreceptor beta klotho

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Metformin Stimulates FGF21 Expression in Primary Hepatocytes

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Cardiac actions of fibroblast growth factor 23

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Metabolic role of fibroblast growth factor 21 in liver, adipose and nervous system tissues

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Resistance training attenuates circulating FGF-21 and myostatin and improves insulin resistance in elderly men with and without type 2 diabetes mellitus: A randomised controlled clinical trial

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Skeletal muscle and MASLD: Mechanistic and clinical insights

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Lack of Overt FGF21 Resistance in Two Mouse Models of Obesity and Insulin Resistance

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Fibroblast Growth Factor 21 Corrects Obesity in Mice

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1896-P: Adipocyte-Derived Fibroblast Growth Factor 21 (FGF21) Contributes to Circulating FGF21 Pools in Diet-Induced Obese Mice

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Serum fibroblast growth factor 21 in human obesity: regulation by insulin infusion and relationship with glucose and lipid oxidation

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