The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet–Induced Insulin Resistance
Open accessAbstract
OBJECTIVE: Tissue inflammation is a key factor underlying insulin resistance in established obesity. Several models of immuno-compromised mice are protected from obesity-induced insulin resistance. However, it is unanswered whether inflammation triggers systemic insulin resistance or vice versa in obesity. The purpose of this study was to assess these questions. RESEARCH DESIGN AND METHODS: We fed a high-fat diet (HFD) to wild-type mice and three different immuno-compromised mouse models (lymphocyte-deficient Rag1 knockout, macrophage-depleted, and hematopoietic cell-specific Jun NH2-terminal kinase–deficient mice) and measured the time course of changes in macrophage content, inflammatory markers, and lipid accumulation in adipose tissue, liver, and skeletal muscle along with systemic insulin sensitivity. RESULTS: In wild-type mice, body weight and adipose tissue mass, as well as insulin resistance, were clearly increased by 3 days of HFD. Concurrently, in the short-term HFD period inflammation was selectively elevated in adipose tissue. Interestingly, however, all three immuno-compromised mouse models were not protected from insulin resistance induced by the short-term HFD. On the other hand, lipid content was markedly increased in liver and skeletal muscle at day 3 of HFD. CONCLUSIONS: These data suggest that the initial stage of HFD-induced insulin resistance is independent of inflammation, whereas the more chronic state of insulin resistance in established obesity is largely mediated by macrophage-induced proinflammatory actions. The early-onset insulin resistance during HFD feeding is more likely related to acute tissue lipid overload.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Lee et al. demonstrated a mild proinflammatory response in the epididymal adipose depot of mice fed a HFD for three days (16), and the proinflammatory polarization of macrophages was of particular importance in this response.”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [16]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690
Oh, D. Y., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W., Li, P., Lu, W. J., Watkins, S. M., & Olefsky, J. M. (2010) · Cell · doi:10.1016/j.cell.2010.07.041 · Cited by 2,428
Self-citationNishimura, S., Manabe, I., Nagasaki, M., Eto, K., Yamashita, H., Ohsugi, M., Otsu, M., Hara, K., Ueki, K., Sugiura, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.1964 · Cited by 2,230
Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., Lee, J., Goldfine, A. B., Benoist, C., Shoelson, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2002 · Cited by 2,145
Mechanism of free fatty acid-induced insulin resistance in humans.
Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., & Shulman, G. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118742 · Cited by 1,539
Normalization of obesity-associated insulin resistance through immunotherapy
Winer, S., Chan, Y., Paltser, G., Truong, D., Tsui, H., Bahrami, J., Dorfman, R., Wang, Y., Zielenski, J., Mastronardi, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2001 · Cited by 1,370
Holland, W. L., Brozinick, J. T., Wang, L.-P., Hawkins, E. D., Sargent, K. M., Liu, Y., Narra, K., Hoehn, K. L., Knotts, T. A., Siesky, A., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.01.002 · Cited by 1,232
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–300 of 564
Germoush, M. O., Elgebaly, H. A., Hassan, S. M., Kamel, E. M., Bin-Jumah, M. N., & Mahmoud, A. M. (2019) · Antioxidants · doi:10.3390/antiox9010022 · Cited by 46
Elsayed, R. H., Kamel, E. M., Mahmoud, A. M., El‐Bassuony, A. A., Bin-Jumah, M. N., Lamsabhi, A. M., & Ahmed, S. A. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111202 · Cited by 47
Brunner, J. S., Vogel, A., Lercher, A., Caldera, M., Korosec, A., Pühringer, M., Hofmann, M., Hajto, A., Kieler, M., Garrido, L. Q., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00311-5 · Cited by 45
Jeelani, I., Moon, J.-S., da Cunha, F. F., Nasamran, C. A., Jeon, S., Zhang, X., Bandyopadhyay, G. K., Dobaczewska, K., Mikulski, Z., Hosseini, M., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adi0284 · Cited by 50
Self-citationLi, D., Zhang, T., Lu, J., Peng, C. Y., & Lin, L. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1768044 · Cited by 45
Filho, R. I., Ochioni, A. C., Esteves, A. M., Leandro, J. G. B., Demaria, T. M., Sola‐Penna, M., & Zancan, P. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03929-9 · Cited by 41
Targeting hepatic kisspeptin receptor ameliorates nonalcoholic fatty liver disease in a mouse model
Guzman, S., Dragan, M., Kwon, H., Oliveira, V. D., Rao, S., Bhatt, V., Kalemba, K. M., Shah, A., Rustgi, V. K., Wang, H., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci145889 · Cited by 43
Abe, T., Hirasaka, K., Kagawa, S., Kohno, S., Ochi, A., Utsunomiya, K., Sakai, A., Ohno, A., Teshima-Kondo, S., Okumura, Y., et al. (2013) · Diabetes · doi:10.2337/db12-0677 · Cited by 41
Benencia, F., Harshman, S. G., Duran‐Ortiz, S., Lubbers, E. R., List, E. O., Householder, L. A., Alnaeeli, M., Liang, X., Welch, L. R., Kopchick, J. J., et al. (2014) · Endocrinology · doi:10.1210/en.2014-1794 · Cited by 40
Inflammatory and Oxidative Stress Markers in Skeletal Muscle of Obese Subjects
Catalán, V., Frühbeck, G., & Gómez‐Ambrosi, J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812504-5.00008-8 · Cited by 44
STAT1 Dissociates Adipose Tissue Inflammation From Insulin Sensitivity in Obesity
Admin, A., Cox, A. R., Chernis, N., Bader, D., Saha, P. K., Masschelin, P. M., Felix, J. B., Sharp, R., 连泽勤, Putluri, V., et al. (2020) · Diabetes · doi:10.2337/db20-0384 · Cited by 42
Park, J., Huh, J. Y., Oh, J., Kim, J. I., Han, S. M., Shin, K. C., Jeon, Y. G., Choe, S. S., Park, J., & Kim, J. B. (2019) · Genes & Development · doi:10.1101/gad.329557.119 · Cited by 41
Self-citationMunkonda, M. N., Lapointe, M., Miegueu, P., Roy, C., Gauvreau, D., Richard, D., & Cianflone, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046883 · Cited by 38
Liu, W., Zhai, X., Li, H., & Ji, L. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.11.025 · Cited by 40
Frendo‐Cumbo, S., MacPherson, R. E. K., & Wright, D. C. (2016) · Physiological Reports · doi:10.14814/phy2.12877 · Cited by 40
The role of dietary fat in obesity-induced insulin resistance
Lackey, D. E., Lazaro, R. G., Li, P., Johnson, A., Hernandez, A. M., Weber, N., Vorobyova, I., Tsukomoto, H., & Osborn, O. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00323.2016 · Cited by 43
Self-citationJung, T. W., Kim, H., El‐Aty, A. M. A., & Jeong, J. H. (2017) · Scientific Reports · doi:10.1038/s41598-017-01603-9 · Cited by 40
Acute high-fat feeding leads to disruptions in glucose homeostasis and worsens stroke outcome
Haley, M., Krishnan, S., Burrows, D., de Hoog, L., Thakrar, J., Schießl, I., Allan, S. M., & Lawrence, C. B. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17744718 · Cited by 42
Zhu, M. J., Kang, Y., Xue, Y., Liang, X., García, M. P. G., Rodgers, D. B., Kagel, D. R., & Du, . (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.10.012 · Cited by 38
Neuronal modulation of brown adipose activity through perturbation of white adipocyte lipogenesis
Guilherme, A., Pedersen, D. J., Henriques, F. D. S., Bedard, A. H., Henchey, E., Kelly, M., Morgan, D. A., Rahmouni, K., & Czech, M. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.06.014 · Cited by 40
Reidy, P. T., Mahmassani, Z. S., McKenzie, A. I., Petrocelli, J. J., Summers, S. A., & Drummond, M. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041514 · Cited by 43
Domingo‐Espín, J., Lindahl, M., Nilsson, O., Cushman, S. W., Stenkula, K. G., & Lagerstedt, J. O. (2016) · Diabetes · doi:10.2337/db15-1493 · Cited by 38
Regenerative Medicine and Immunomodulatory Therapy: Insights From the Kidney, Heart, Brain, and Lung
Pino, C. J., Westover, A. J., Johnston, K. A., Buffington, D. A., & Humes, H. D. (2018) · Kidney International Reports · doi:10.1016/j.ekir.2017.12.012 · Cited by 38
CD4+ T cells in obesity and obesity-associated diseases
Zhao, Y., Lin, L., Li, J., Xiao, Z., Chen, B., Wan, L., Li, M., Wu, X., Cho, C. H., & Shen, J. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.08.013 · Cited by 38
Obese Adipose Tissue Secretion Induces Inflammation in Preadipocytes: Role of Toll-Like Receptor-4
Renovato‐Martins, M., Moreira-Nunes, C., Atella, G. C., Barja‐Fidalgo, C., & Moraes, J. A. (2020) · Nutrients · doi:10.3390/nu12092828 · Cited by 40
Recent advances in JAK inhibitors for the treatment of metabolic syndrome
Collotta, D., Franchina, M. P., Carlucci, V., & Collino, M. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1245535 · Cited by 43
MicroRNA regulated macrophage activation in obesity
Li, C., Qu, L., Farragher, C., Vella, A. T., & Zhou, B. (2019) · Journal of Translational Internal Medicine · doi:10.2478/jtim-2019-0011 · Cited by 38
Monocyte Trafficking and Polarization Contribute to Sex Differences in Meta-Inflammation
Varghese, M., Clemente, J., Lerner, A., Abrishami, S., Islam, M., Subbaiah, P., & Singer, K. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.826320 · Cited by 37
Bazzano, M. V., Torelli, C., Pustovrh, M. C., Paz, D. A., & Elia, E. M. (2015) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2015.08.004 · Cited by 38
Diet‐induced obesity causes metabolic impairment independent of alterations in gut barrier integrity
Kleß, C., Müller, V. M., Schüppel, V. L., Lichtenegger, M., Rychlik, M., Daniel, H., Klingenspor, M., & Haller, D. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400840 · Cited by 36
Trajcevski, K., O'Neill, H., Wang, D. C., Thomas, M. M., Al‐Sajee, D., Steinberg, G., Ceddia, R., & Hawke, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071747 · Cited by 39
Duggan, B. M., Foley, K. P., Henriksbo, B. D., Cavallari, J. F., Tamrakar, A. K., & Schertzer, J. D. (2017) · Scientific Reports · doi:10.1038/s41598-017-01822-0 · Cited by 36
Dalbram, E., Basse, A. L., Zierath, J. R., & Treebak, J. T. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00737.2018 · Cited by 37
Tff3, as a Novel Peptide, Regulates Hepatic Glucose Metabolism
Xue, Y., Shen, L., Cui, Y., Zhang, H., Chen, Q., Cui, A., Fang, F., & Chang, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075240 · Cited by 37
C-Peptide and its Correlation to Parameters of Insulin Resistance in the Metabolic Syndrome
Banu, S., Jabir, N. R., Manjunath, C. N., Shakil, S., & Kamal, M. A. (2011) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152711799219271 · Cited by 36
Ying, W., Kanameni, S., Chang, C.-A., Nair, V., Safe, S. H., Bazer, F. W., & Zhou, B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098835 · Cited by 35
Endogenous catalase delays high-fat diet-induced liver injury in mice
Piao, L., Choi, J., Kwon, G., & Ha, H. (2017) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2017.21.3.317 · Cited by 35
McGregor, R. A., Kwon, E.-Y., Shin, S.-K., Jung, U. J., Kim, E., Park, J. H. Y., Yu, R., Yun, J. W., & Choi, M.-S. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.52 · Cited by 37
Subramanian, S., Turner, M. S., Ding, Y., Goodspeed, L., Wang, S., Buckner, J. H., O’Brien, K. D., Getz, G. S., Reardon, C. A., & Chait, A. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m041020 · Cited by 34
Gladding, J. M., Abbott, K. N., Antoniadis, C. P., Stuart, A., & Begg, D. P. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00752 · Cited by 33
ANT2 drives proinflammatory macrophage activation in obesity
Moon, J.-S., da Cunha, F. F., Huh, J. Y., Andreyev, A. Y., Lee, J., Mahata, S. K., Reis, F. C. G., Nasamran, C. A., & Lee, Y. S. (2021) · JCI Insight · doi:10.1172/jci.insight.147033 · Cited by 36
Self-citationCox, A. R., Masschelin, P. M., Saha, P., Felix, J. B., Sharp, R., Lian, Z., Xia, Y., Chernis, N., Bader, D. A., Kim, K. H., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2022.09.019 · Cited by 33
Alruhaimi, R. S., Mostafa‐Hedeab, G., Abduh, M. S., Bin‐Ammar, A., Hassanein, E. H. M., Kamel, E. M., & Mahmoud, A. M. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1204641 · Cited by 33
Danneskiold‐Samsøe, N. B., Andersen, D., Radulescu, I. D., Normann‐Hansen, A., Brejnrod, A., Kragh, M., Madsen, T. L., Nielsen, C., Josefsen, K. E., Fretté, X. C., et al. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600528 · Cited by 38
Reduced α-MSH Underlies Hypothalamic ER-Stress-Induced Hepatic Gluconeogenesis
Schneeberger, M., Gómez-Valadés, A. G., Altirriba, J., Sebastián, D., Ramírez, S., García, A., Esteban, Y., Drougard, A., Ferrés‐Coy, A., Bortolozzi, A. A., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.06.041 · Cited by 34
Damage-Fitness Model: the missing piece in integrative stress models
Wada, H. (2019) · Stress · doi:10.1080/10253890.2019.1614556 · Cited by 33
Demaria, T. M., Crepaldi, L. D., Costa-Bartuli, E., Branco, J. R., Zancan, P., & Sola‐Penna, M. (2023) · Scientific Reports · doi:10.1038/s41598-023-30254-2 · Cited by 32
Lee, J., An, H. S., Shin, H. J., Jang, H. M., Im, C. O., Jeong, Y., Eum, K., Yoon, S., Lee, S. J., Jeong, E. A., et al. (2024) · Nutrients · doi:10.3390/nu16010159 · Cited by 36
Li, S., Zeng, X., Zhou, X., Wang, H., Jo, E., Robinson, S. R., Xu, A., & Ye, J. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.08.021 · Cited by 32
Nucleotides released from palmitate-activated murine macrophages attract neutrophils
Tam, T. H., Chan, K. L., Boroumand, P., Liu, Z., Brozinick, J. T., Bui, H. H., Roth, K. D. W., Wakefield, B., Peñuela, S., Bilan, P. J., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010868 · Cited by 32
Haar, L., Ren, X., Liu, Y., Koch, S. E., Goines, J., Tranter, M., Engevik, M. A., Nieman, M. L., Rubinstein, J., & Jones, W. K. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00271.2014 · Cited by 31
Global Transcriptome Analysis of Brown Adipose Tissue of Diet-Induced Obese Mice
Cao, J., Zhu, Q., Liu, L., Glazier, B., Hinkel, B. C., Liang, C., & Shi, H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041095 · Cited by 34
Teslow, E. A., Mitrea, C., Bao, B., Mohammad, R. M., Polin, L., Dyson, G. E., Purrington, K. S., & Bollig-Fischer, A. B. (2019) · Molecular Oncology · doi:10.1002/1878-0261.12444 · Cited by 31
Intermittent fasting improves metabolic flexibility in short-term high-fat diet-fed mice
Dedual, M. A., Wueest, S., Borsigova, M., & Konrad, D. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00187.2019 · Cited by 33
de Santana, A. A., Santamarina, A. B., Souza, G., Mennitti, L. V., Okuda, M. H., Venâncio, D. P., Seelaender, M. C. L., do Nascimento, C. O., Ribeiro, E., Lira, F. S., et al. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.03.001 · Cited by 31
Chronic fractalkine administration improves glucose tolerance and pancreatic endocrine function
Riopel, M., Seo, J. B., Bandyopadhyay, G. K., Li, P., Wollam, J., Chung, H., Jung, S., Murphy, A. N., Wilson, M. E., de Jong, R., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci94330 · Cited by 31
Self-citationLee, J. H., Zhang, Y., Zhao, Z., Ye, X., Zhang, X., Wang, H., & Ye, J. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.3 · Cited by 30
Clayton, Z. S., & McCurdy, C. E. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00364.2017 · Cited by 30
Bader, J. E., Enos, R. T., Velázquez, K. T., Carson, M. S., Sougiannis, A. T., McGuinness, O. P., Robinson, C. M., & Murphy, E. A. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00438.2018 · Cited by 31
Isocaloric intake of a high‐fat diet promotes insulin resistance and inflammation in Wistar rats
Jacob, P., Fujii, T. M. D. M., Yamada, M., Borges, M. C., Pantaleão, L. C., Borelli, P., Fock, R. A., & Rogero, M. M. (2012) · Cell Biochemistry and Function · doi:10.1002/cbf.2894 · Cited by 30
Tyrosine kinase inhibitors as novel drugs for the treatment of diabetes
Prada, P. O., & Saad, M. J. A. (2013) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2013.802768 · Cited by 31
Endothelial metabolic control of insulin sensitivity through resident macrophages
Zhang, J., Sjøberg, K. A., Gong, S., Wang, T., Li, F., Kuo, A., Durot, S., Majcher, A., Ardicoglu, R., Desgeorges, T., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.08.008 · Cited by 30
The Role of TLRs in Obesity and Its Related Metabolic Disorders
Campos-Bayardo, T. I., Román-Rojas, D., García-Sánchez, A., Cardona-Muñóz, E. G., Sánchez-Lozano, D. I., Totsuka-Sutto, S. E., Gómez-Hermosillo, L. F., Casillas-Moreno, J., Sierra, J. A., Pazarín–Villaseñor, L., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26052229 · Cited by 36
Liver-derived metabolites as signaling molecules in fatty liver disease
Keles, U., Ow, J. R., Kuentzel, K. B., Zhao, L. N., & Kaldis, P. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04658-8 · Cited by 32
Knockout of STAT3 in skeletal muscle does not prevent high-fat diet-induced insulin resistance
White, A. T., LaBarge, S. A., McCurdy, C. E., & Schenk, S. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.05.001 · Cited by 28
Bashir, S., Ali, S., & Khan, F. (2015) · Immunological Investigations · doi:10.3109/08820139.2015.1025960 · Cited by 28
Jensen, B. A. H., Nielsen, T. S., Fritzen, A. M., Holm, J. B., Fjære, E., Serup, A. K., Borkowski, K., Risis, S., Pærregaard, S. I., Larsen, I., et al. (2016) · Metabolism · doi:10.1016/j.metabol.2016.09.002 · Cited by 28
De-silencing Grb10 contributes to acute ER stress-induced steatosis in mouse liver
Luo, L., Jiang, W., Liu, H., Bu, J., Tang, P., Du, C., Xu, Z., Luo, H., Liu, B., Xiao, B., et al. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0018 · Cited by 30
Chia oil induces browning of white adipose tissue in high-fat diet-induced obese mice
de Souza, T., da Silva, S. V., Fonte‐Faria, T., Nascimento-Silva, V., Barja‐Fidalgo, C., & Citelli, M. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110772 · Cited by 29
Sieckmann, K., Winnerling, N., Huebecker, M., Leyendecker, P., Ribeiro, D. J. S., Gnad, T., Pfeifer, A., Wachten, D., & Hansen, J. N. (2022) · Molecular Biology of the Cell · doi:10.1091/mbc.e21-11-0592 · Cited by 28
Abduh, M. S., Alzoghaibi, M. A., Alzoghaibi, A. M., Bin‐Ammar, A., Alotaibi, M., Kamel, E. M., & Mahmoud, A. M. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121612 · Cited by 29
Lee, Y. S., Riopel, M., Cabrales, P., & Bandyopadhyay, G. K. (2019) · Science Advances · doi:10.1126/sciadv.aaw4176 · Cited by 30
Self-citationRole of innate immune cells in metabolism: from physiology to type 2 diabetes
Dalmas, É. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00736-5 · Cited by 28
Guo, F., Han, M., Lin, S., Ye, H., Chen, J., Zhu, H., & Lin, W. (2021) · Journal of Food Science · doi:10.1111/1750-3841.15818 · Cited by 27
Kawanishi, N., Takagi, K., Lee, H., Nakano, D., Okuno, T., Yokomizo, T., & Machida, S. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00371.2017 · Cited by 26
Wilkins, J., Ghosh, P., Vivar, J. C., Chakraborty, B., & Ghosh, S. (2018) · BMC Obesity · doi:10.1186/s40608-018-0196-2 · Cited by 28
Sui, B., Liu, J., Zheng, C., Dang, L., Ji, C., Cao, Y., Zhang, K., Liu, L., Dang, M., Zhang, L., et al. (2022) · International Journal of Oral Science · doi:10.1038/s41368-022-00193-1 · Cited by 28
Kumar, S. P. S., Shen, M., Spicer, E. G., Goudjo-Ako, A. J., Stumph, J. D., Zhang, J., & Shi, H. (2014) · Endocrine Journal · doi:10.1507/endocrj.ej13-0455 · Cited by 26
Intact glucose uptake despite deteriorating signaling in adipocytes with high-fat feeding
Hansson, B., Wasserström, S., Morén, B., Periwal, V., Vikman, P. J., Cushman, S. W., Göransson, O., Storm, P., & Stenkula, K. G. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-17-0195 · Cited by 25
Kim, D. M., Lee, J. H., Pan, Q., Han, H. W., Shen, Z., Eshghjoo, S., Wu, C., Yang, W., Noh, J. Y., Threadgill, D. W., et al. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101852 · Cited by 28
Babuta, M., Nagesh, P. T., Datta, A. A., Remotti, V., Zhuang, Y., Mehta, J., Lami, F., Wang, Y., & Szabó, G. (2024) · Cells · doi:10.3390/cells13110960 · Cited by 27
Adipose tissue insulin sensitivity and macrophage recruitment
McCurdy, C. E., & Klemm, D. J. (2013) · Adipocyte · doi:10.4161/adip.24645 · Cited by 25
Memetimin, H., Li, D., Tan, K., Zhou, C., Liang, Y., Wu, Y., & Wang, S. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00273.2018 · Cited by 24
Effects of high‐fat diet‐induced adipokines and cytokines on colorectal cancer development
Zhang, J., Guo, S., Li, J., Bao, W., Zhang, P., Huang, Y., Ling, P., Wang, Y., & Zhao, Q. S. (2019) · FEBS Open Bio · doi:10.1002/2211-5463.12751 · Cited by 25
Fang, X., Xia, T., Xu, F., Wu, H., Ma, Z., Zhao, X., & Gu, X. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146511 · Cited by 23
Interferon regulatory factor 7 mediates obesity-associated MCP-1 transcription
Kuroda, M., Nishiguchi, M., Naho, U., Ishikawa, E., Yasuyo, K., Okamoto, S., Sasaki, W., Miyatake, Y., Sebe, M., Masumoto, S., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0233390 · Cited by 25
Blaszczak, A. M., Krishna, S. G., Hart, P. A., Bradley, D. P., Hsueh, W. A., Lara, L. F., Hussan, H., Hinton, A. M., Conwell, D. L., & Cruz‐Monserrate, Z. (2020) · Pancreatology · doi:10.1016/j.pan.2020.08.011 · Cited by 25
Chen, C., Ren, Y.-M., Zhu, J., Chen, J., Feng, Z., Zhang, T., Ye, Y., & Lin, L. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00797-z · Cited by 24
Orliaguet, L., Ejlalmanesh, T., Humbert, A., Ballaire, R., Diedisheim, M., Julla, J., Chokr, D., Cuenco, J., Michieletto, J., Charbit, J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32813-z · Cited by 25
miR155 deficiency aggravates high-fat diet-induced adipose tissue fibrosis in male mice
Velázquez, K. T., Enos, R. T., Carson, M. S., Cranford, T. L., Bader, J. E., Sougiannis, A. T., Pritchett, C., Fan, D., Carson, J. A., & Murphy, E. A. (2017) · Physiological Reports · doi:10.14814/phy2.13412 · Cited by 24
Thermoneutral housing does not influence fat mass or glucose homeostasis in C57BL/6 mice
Small, L., Gong, H., Yassmin, C., Cooney, G. J., & Brandon, A. E. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0279 · Cited by 24
Blaszczak, A. M., Jalilvand, A., Liu, J., Wright, V. P., Suzo, A. J., NEEDLEMAN, B. J., Noria, S. F., Lafuse, W. P., Hsueh, W. A., & Bradley, D. P. (2019) · Journal of Diabetes Research · doi:10.1155/2019/8124563 · Cited by 24
Adipocyte CD1d determines adipose inflammation and insulin resistance in obesity
Huh, J. Y., Park, Y. J., & Kim, J. B. (2018) · Adipocyte · doi:10.1080/21623945.2018.1440928 · Cited by 25
Self-citationHistorical perspective of matrix metalloproteases
Pulkoski-Gross, A. E. (2015) · Frontiers in Bioscience-Scholar · doi:10.2741/s429 · Cited by 24
Dietary carbohydrates modulate metabolic and β-cell adaptation to high-fat diet-induced obesity
Her, T. K., Lagakos, W., Brown, M., LeBrasseur, N. K., Rakshit, K., & Matveyenko, A. V. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00539.2019 · Cited by 24
Zhao, L., Fan, M., Zhao, L., Yun, H., Yang, Y., Wang, C., & Qin, D. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15872 · Cited by 22
Kim, Y. J., Kim, H. J., Lee, S. G., Kim, D. H., Jang, S., Go, H. S., Lee, W. J., & Seong, J. K. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155178 · Cited by 23
Multiple functions and regulatory network of miR-150 in B lymphocyte-related diseases
Hu, Y.-Z., Li, Q., Wang, P., Li, X., & Hu, Z. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1140813 · Cited by 23
A macrophage-collagen fragment axis mediates subcutaneous adipose tissue remodeling in mice
Vujičić, M., Broderick, I., Salmantabar, P., Perian, C., Nilsson, J., Sihlbom, C., & Asterholm, I. W. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2313185121 · Cited by 21
Funke, A., Schreurs, M., Aparicio-Vergara, M., Sheedfar, F., Gruben, N., Kloosterhuis, N., Shiri‐Sverdlov, R., Groen, A. K., van de Sluis, B., Hofker, M. H., et al. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.11.074 · Cited by 23
Metadata
- Authors
- Lee, Y. S., Li, P., Huh, J. Y., Hwang, I. J., Lu, M., Kim, J. I., Ham, M., Talukdar, S., Chen, A., Lu, W. J., Bandyopadhyay, G. K., Schwendener, R., Olefsky, J., & Kim, J. B.
- Affiliations
- Seoul National University (KR)
- University of California San Diego (US)
- Institute of Molecular Biology and Genetics, Seoul National University, Seoul, Korea
- University of Zurich (CH)
- Corresponding author
- Kim, Jae Bum
- ORCID
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2011-09-16
- Volume
- 60
- Issue
- 10
- Pages
- 2474-2483
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- PMC
- PMC3178297
- OpenAlex
- W2095717717
- Cited by
- 566
- References
- 28
- Citations by year
- 2026: 24 · 2025: 23 · 2024: 26 · 2023: 33 · 2022: 40 · 2021: 41 · 2020: 44 · 2019: 47 · 2018: 53 · 2017: 50 · 2016: 37 · 2015: 46 · 2014: 24 · 2013: 49 · 2012: 23
- FWCI
- 24.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Diabetes (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK063491, DK 074868, DK 033651, T32DK007494, R37DK033651, P01DK074868, R01DK033651, P30DK063491)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P50HD012303, U54HD012303)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- insulin resistance, high-fat diet, inflammation, obesity, macrophages, adipose tissue, Rag1 knockout mice, macrophage depletion, lipid accumulation, hepatic lipid accumulation, skeletal muscle lipid accumulation
- MeSH terms
- Adipose Tissue, Animals, Blood Glucose, Ceramides, Dietary Fats, Drug Administration Schedule, Epididymis, Glucose, Glucose Tolerance Test, Inflammation, Insulin Resistance, Liver, Male, Mice, Inbred C57BL, Muscle, Skeletal, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review