The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet–Induced Insulin Resistance
Open accessAbstract
OBJECTIVE: Tissue inflammation is a key factor underlying insulin resistance in established obesity. Several models of immuno-compromised mice are protected from obesity-induced insulin resistance. However, it is unanswered whether inflammation triggers systemic insulin resistance or vice versa in obesity. The purpose of this study was to assess these questions. RESEARCH DESIGN AND METHODS: We fed a high-fat diet (HFD) to wild-type mice and three different immuno-compromised mouse models (lymphocyte-deficient Rag1 knockout, macrophage-depleted, and hematopoietic cell-specific Jun NH2-terminal kinase–deficient mice) and measured the time course of changes in macrophage content, inflammatory markers, and lipid accumulation in adipose tissue, liver, and skeletal muscle along with systemic insulin sensitivity. RESULTS: In wild-type mice, body weight and adipose tissue mass, as well as insulin resistance, were clearly increased by 3 days of HFD. Concurrently, in the short-term HFD period inflammation was selectively elevated in adipose tissue. Interestingly, however, all three immuno-compromised mouse models were not protected from insulin resistance induced by the short-term HFD. On the other hand, lipid content was markedly increased in liver and skeletal muscle at day 3 of HFD. CONCLUSIONS: These data suggest that the initial stage of HFD-induced insulin resistance is independent of inflammation, whereas the more chronic state of insulin resistance in established obesity is largely mediated by macrophage-induced proinflammatory actions. The early-onset insulin resistance during HFD feeding is more likely related to acute tissue lipid overload.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Lee et al. demonstrated a mild proinflammatory response in the epididymal adipose depot of mice fed a HFD for three days (16), and the proinflammatory polarization of macrophages was of particular importance in this response.”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [16]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690
Oh, D. Y., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W., Li, P., Lu, W. J., Watkins, S. M., & Olefsky, J. M. (2010) · Cell · doi:10.1016/j.cell.2010.07.041 · Cited by 2,428
Self-citationNishimura, S., Manabe, I., Nagasaki, M., Eto, K., Yamashita, H., Ohsugi, M., Otsu, M., Hara, K., Ueki, K., Sugiura, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.1964 · Cited by 2,230
Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., Lee, J., Goldfine, A. B., Benoist, C., Shoelson, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2002 · Cited by 2,145
Mechanism of free fatty acid-induced insulin resistance in humans.
Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., & Shulman, G. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118742 · Cited by 1,539
Normalization of obesity-associated insulin resistance through immunotherapy
Winer, S., Chan, Y., Paltser, G., Truong, D., Tsui, H., Bahrami, J., Dorfman, R., Wang, Y., Zielenski, J., Mastronardi, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2001 · Cited by 1,370
Holland, W. L., Brozinick, J. T., Wang, L.-P., Hawkins, E. D., Sargent, K. M., Liu, Y., Narra, K., Hoehn, K. L., Knotts, T. A., Siesky, A., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.01.002 · Cited by 1,232
Flagged first, then by citations
Cited by
Sorted by citations
Items 501–564 of 564
The Effects of Interleukin-10 on Skeletal Muscle Insulin Resistance and Myogenesis
Dağdeviren, S. (2016) · eScholarship@UMassChan · doi:10.13028/m2qp42 · Cited by 1
Meal Timing & Its Effects on the Pathogenesis of Metabolic Syndrome
Wayne, M. J. (2015)
Pisi, P. C. B. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2017.tde-06062017-163504
Chan, K. L. (2017) · TSpace (University of Toronto)
Brown, A. (2017) · UTAS Research Repository · doi:10.25959/23238647
The Role of Pik3r1 in the Regulation of Adipose Tissue Insulin Sensitivity
Clayton, Z. S. (2018) · Scholars' Bank (University of Oregon)
The Role of Physical Activity and Exercise in Acute Metabolic Perturbations to the Liver
Peppler, W. T. (2018) · The Atrium (University of Guelph)
Models of gestational diabetes and offspring outcomes in mice
Talton, O. O. (2017) · doi:10.32469/10355/63758
Chronic consumption of a high-fat diet: investigation of negative consequences
Vigil, D. W. (2018) · Purdue e-Pubs (Purdue University System) · doi:10.7912/c2/1007
Kim, K. (2019) · The Asian Journal of Kinesiology · doi:10.15758/ajk.2019.21.1.37
The Rag1-/- Mouse: Establishing Links between Obesity and Prostate Cancer
Maugham, M. (2019) · Queensland University of Technology · doi:10.5204/thesis.eprints.126971
Darr, J., Lassi, M., Tomar, A., Gerlini, R., Scheid, F., de Angelis, M. H., Witting, M. A., & Teperino, R. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/670398
WITHDRAWN: Ceramide and Sphingosine 1-Phosphate in adipose dysfunction
Fang, Z., Pyne, S., & Pyne, N. J. (2019) · Progress in Lipid Research · doi:10.1016/j.plipres.2019.100991
Grice, B. A. (2019) · IUScholarWorks (Indiana University) · doi:10.7912/c2/2030
Pakhomova, A. V., Pershina, О. V., Nebolsin, V. E., Ermakova, N. N., Krupin, V. A., Sandrikina, L. A., Pan, E. S., Widera, D., Дыгай, А. М., & Skurikhin, Е. G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.562358
Effects of Exercise on Factors Regulating Adipose Tissue Expandability
Ludzki, A. C. (2020) · Deep Blue (University of Michigan)
Clarke, J. R., Silva, N. M. L. E., Figueiredo, C. P., Frozza, R. L., Ledo, J. H., Beckman, D., Katashima, C. K., Razolli, D. S., Carvalho, B. M., Frazão, R., et al. (2015) · Americanae (AECID Library) · doi:10.15252/emmm.201404183/abstract
CONDIÇÕES HIGIÊNICO-SANITÁRIAS DE CANTINAS ESCOLARES NO BRASIL: REVISÃO SISTEMÁTICA
Brasil, C. C. B., & Pereira, L. S. (2021) · doi:10.22533/at.ed.0512120087
Cox, A. R., Masschelin, P. M., Saha, P., Felix, J. B., Sharp, R., Lian, Z., Xia, Y., Chernis, N., Bader, D. A., Kim, K. H., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.11.459899
Wang, O., Han, L., Lin, H.-S., Tian, M., Zhang, S., Duan, B., Chung, S., Zhang, C., Lian, X., Wang, Y., et al. (2021) · bioRxiv · doi:10.1101/2021.10.11.463939
Immune Cells in Adipose Tissue: Key Players in Metabolic Disorders
Volat, F., & Bouloumié, A. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8069-3_11
Chiang, J. Y. L. (2017) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.727333300.793538896
Parathyroid hormone related peptide levels may be related to obesity: a novel target for treatment?Preprint
ozturk, G., & Ersavaş, C. (2022) · Research Square · doi:10.21203/rs.3.rs-1973581/v1
Diet, Inflammation and Cardiovascular Disorders
Kesavan, M., & Manjunathachar, H. (2022) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815050837122010006
Mucinski, J. M. (2022) · MOspace Institutional Repository (University of Missouri) · doi:10.32469/10355/93980
Liu, Y., Liu, J., Chen, Y., Luo, Y., Huang, C., Liu, Y., Yang, T., & Wang, X. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4582894
Shetty, S., Duesman, S. J., Patel, S., Huyhn, P., Shroff, S., Das, A., Chowhan, D., Sebra, R., Beaumont, K. G., McAlpine, C. S., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.17.567534
Metabesity: pathogenetic bases and predictive capabilities. A review
Orazov, M. R., Radzinsky, V. E., Khamoshina, M. B., Dolgov, E. D., Александровна, М. И., Artemenko, Y. S., & Андреевна, Р. В. (2023) · GYNECOLOGY · doi:10.26442/20795696.2023.4.202520
Tufan, Ö., Parlak, T. M., & Dik, B. (2024) · Journal of Advances in VetBio Science and Techniques · doi:10.31797/vetbio.1476384
Li, J., Mei, Q., Yang, C., Zhu, N., & Li, G. (2024) · Briefings in Bioinformatics · doi:10.1093/bib/bbaf050 · Cited by 1
Ernst, I. V. S., Lehtonen, L., Nilsson, S. M., Nielsen, F. L., Marcher, A.-B., Mandrup, S., & Madsen, J. G. S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.01.646568
Jeelani, I., da Cunha, F. F., Rohm, T. V., Nasamran, C. A., Moon, J.-S., Wang, L., Prakash, S., Issac, R., Murphy, C., Glass, C. K., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.20.670151
Self-citationO’Connell, F. P., Hajnal, A. S., Lorenzo, P. M. D., & Czaja, K. (2025) · Nutrients · doi:10.3390/nu17213445
Guo, Y., Zheng, X., Jiao, J.-R., Wu, H., & An, Y. (2025) · Human Mutation · doi:10.1155/humu/4623346
Complex Roles of Macrophages in Lipid Metabolism and Metabolic Disease: A Dissertation
Negrin, K. A. (2014) · eScholarship@UMassChan · doi:10.13028/m24p4s
Ukichi, R., Takahashi, Y., Ibukuro, M., Sugimura, Y. K., Matoba, K., Nishimura, R., & Kato, F. (2026) · The Journal of Physiological Sciences · doi:10.1016/j.jphyss.2026.100058
Developmental origins of immunometabolic health
Alharithi, Y. J., Smith, G., & Maloyan, A. (2026) · Immunometabolism · doi:10.1097/in9.0000000000000075
Immunomodulatory effect of capsaicinoids on metainflammation in Wistar rats with nutritional obesity
Ēn, T., Riger, N. A., Мустафина, О. К., Николаевич, Т. А., Aksenov, I. V., & Tutelyan, V. A. (2026) · Obesity and metabolism · doi:10.14341/omet13140
Hepatic HuR modulates glucose metabolism through the C/EBPβ/PCK1 pathway
Lachiondo‐Ortega, S., González‐Recio, I., Bravo, M., Gonzalez-Rellan, M. J., Sanz-Parra, A., Porteiro, B., Goikoetxea‐Usandizaga, N., Rejano-Gordillo, C. M., Zapata-Pavas, L. E., Peña-Sanfélix, P., et al. (2026) · Molecular Metabolism · doi:10.1016/j.molmet.2026.102354
Rôle de la mPGES-1 dans le développement de l'inflammation chronique de bas seuil et de l'obésité
Clément, P. (2018) · theses.fr (ABES) · doi:10.70675/03fb1889z1609z4461z931dze2b1aebfa2b6
Akar, E. A. (2022) · theses.fr (ABES) · doi:10.70675/a7b15e3fz84e7z4915z9447zc112181e06e4
IRF5 and the metabolic adaptations of adipose tissue macrophages upon metabolic stress
Orliaguet, L. (2022) · theses.fr (ABES) · doi:10.70675/145b35eazd61az4b32zacc7z422afeae6061
Lipid rewiring by adipose tissue macrophages during diet-induced inflammation and insulin resistance
Dahik, V. D. (2023) · theses.fr (ABES) · doi:10.70675/8f4f001ez6ebez4d7az934bz039a1f4d4116
Alzubi, A., Lucchesi, A., Burns, J. L., Cho, C. Y., Ma, D. W. L., Robinson, L. E., & Monk, J. M. (2026) · Marine Drugs · doi:10.3390/md24050166
Nutrigenomics in personalized obesity treatment: A systematic review
Fernandes, F. B., Maia, A. R. D. S., Carvalho, B. B., Santana, L. D. A., Alves, M. S., Silva, A. B., & Duarte, A. P. (2026) · Clinical Nutrition Open Science · doi:10.1016/j.nutos.2026.100674
Adipocyte caspase-8 but not RIPK3 promotes adiposity
Chan, C. K., Aslam, R., Yang, F., Panesar, A., Hakem, A., Hakem, R., Gaisano, H. Y., Winer, D. A., & Luk, C. T. (2026) · Cell Death Discovery · doi:10.1038/s41420-026-03201-z
Urbonaite, G., Cepauskyte, P., Biliute, N. I., Laurinavičiūtė, G., Dabkevičienė, D., Samulenaite, S., & Neniškytė, U. (2026) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.67.10.20
Li, H., Lu, W., Liu, J., Luo, D., Wang, M., Dong, R., Chu, J., Chen, Q., Wang, H., Huang, J., et al. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158702
Self-citationLipopolysaccharide binding triggers insulin inactivation and HDL-dependent clearancePreprint
Lu, X., 陆仲夏, Meng, Q., Liu, L., Zhang, J., Han, F., Gong, Q., & Yu, W. (2026) · Research Square · doi:10.21203/rs.3.rs-10599076/v1
Single nucleus multiomics reveals an early inflammatory response to high-fat diet in mouse islets
Ernst, I., Lehtonen, L., Nielsen, F. L., Ebbesen, M. F., Nilsson, S. M., Marcher, A.-B., Mandrup, S., & Madsen, J. G. S. (2026) · Life Science Alliance · doi:10.26508/lsa.202603840
Yu, G., Lin, Q., Luo, K., Zhou, T., Deng, Q., Muhammad, T., Mikkelsen, D., Yao, H. L., & Wu, X. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.109996
Single-Cell Insights into Obesity: Cellular Mechanisms across Metabolic Organs
Tang, Y., & Lin, D. (2026) · Journal of Nutrition · doi:10.1016/j.tjnut.2026.101893
Mantell, B. S. (2011) · D-Scholarship@Pitt (University of Pittsburgh)
Metadata
- Authors
- Lee, Y. S., Li, P., Huh, J. Y., Hwang, I. J., Lu, M., Kim, J. I., Ham, M., Talukdar, S., Chen, A., Lu, W. J., Bandyopadhyay, G. K., Schwendener, R., Olefsky, J., & Kim, J. B.
- Affiliations
- Seoul National University (KR)
- University of California San Diego (US)
- Institute of Molecular Biology and Genetics, Seoul National University, Seoul, Korea
- University of Zurich (CH)
- Corresponding author
- Kim, Jae Bum
- ORCID
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2011-09-16
- Volume
- 60
- Issue
- 10
- Pages
- 2474-2483
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- PMC
- PMC3178297
- OpenAlex
- W2095717717
- Cited by
- 566
- References
- 28
- Citations by year
- 2026: 24 · 2025: 23 · 2024: 26 · 2023: 33 · 2022: 40 · 2021: 41 · 2020: 44 · 2019: 47 · 2018: 53 · 2017: 50 · 2016: 37 · 2015: 46 · 2014: 24 · 2013: 49 · 2012: 23
- FWCI
- 24.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Diabetes (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK063491, DK 074868, DK 033651, T32DK007494, R37DK033651, P01DK074868, R01DK033651, P30DK063491)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P50HD012303, U54HD012303)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- insulin resistance, high-fat diet, inflammation, obesity, macrophages, adipose tissue, Rag1 knockout mice, macrophage depletion, lipid accumulation, hepatic lipid accumulation, skeletal muscle lipid accumulation
- MeSH terms
- Adipose Tissue, Animals, Blood Glucose, Ceramides, Dietary Fats, Drug Administration Schedule, Epididymis, Glucose, Glucose Tolerance Test, Inflammation, Insulin Resistance, Liver, Male, Mice, Inbred C57BL, Muscle, Skeletal, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
