Endothelial NO/cGMP/VASP Signaling Attenuates Kupffer Cell Activation and Hepatic Insulin Resistance Induced by High-Fat Feeding

Tateya, Sanshiro; Rizzo, Norma O.; Handa, Priya; Cheng, Andrew M.; Morgan-Stevenson, Vicki; Daum, Guenter; Clowes, Alexander W.; Morton, Gregory J.; Schwartz, Michael W.; Kim, Francis

doi:10.2337/db11-0255

Endothelial NO/cGMP/VASP Signaling Attenuates Kupffer Cell Activation and Hepatic Insulin Resistance Induced by High-Fat Feeding

OBJECTIVE Proinflammatory activation of Kupffer cells is implicated in the effect of high-fat feeding to cause liver insulin resistance. We sought to determine whether reduced endothelial nitric oxide (NO) signaling contributes to the effect of high-fat feeding to increase hepatic inflammatory si…