Redox control of inflammation in macrophages
Open accessAbstract
Macrophages are present throughout the human body, constitute important immune effector cells, and have variable roles in a great number of pathological, but also physiological, settings. It is apparent that macrophages need to adjust their activation profile toward a steadily changing environment that requires altering their phenotype, a process known as macrophage polarization. Formation of reactive oxygen species (ROS), derived from NADPH-oxidases, mitochondria, or NO-producing enzymes, are not necessarily toxic, but rather compose a network signaling system, known as redox regulation. Formation of redox signals in classically versus alternatively activated macrophages, their action and interaction at the level of key targets, and the resulting physiology still are insufficiently understood. We review the identity, source, and biological activities of ROS produced during macrophage activation, and discuss how they shape the key transcriptional responses evoked by hypoxia-inducible transcription factors, nuclear-erythroid 2-p45-related factor 2 (Nrf2), and peroxisome proliferator-activated receptor-γ. We summarize the mechanisms how redox signals add to the process of macrophage polarization and reprogramming, how this is controlled by the interaction of macrophages with their environment, and addresses the outcome of the polarization process in health and disease. Future studies need to tackle the option whether we can use the knowledge of redox biology in macrophages to shape their mediator profile in pathophysiology, to accelerate healing in injured tissue, to fight the invading pathogens, or to eliminate settings of altered self in tumors.
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In macrophages, ROS regulates cell death, proliferation, motility and phagocytic ability, and it is linked to an M1-like polarisation that helps defend the body against bacteria and other pathogens.
“In macrophages, ROS regulates cell death, proliferation, motility and phagocytic ability, and it is linked to an M1-like polarisation, which help to defend the body against bacteria and other pathogens [117, 118].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [117]
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3 retracted
Xie, Z., Zhang, J., Wu, J., Viollet, B., & Zou, M. (2008) · Diabetes · doi:10.2337/db08-0610 · Cited by 163 · see citing works
RetractedMalhotra, D., Thimmulappa, R. K., Mercado, N., Ito, K., Kombairaju, P., Kumar, S., Ma, J., Feller-Kopman, D. J., Wise, R. A., Barnes, P. J., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45144 · Cited by 135 · see citing works
RetractedGaredew, A., Henderson, S. O., & Moncada, S. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.27 · Cited by 124 · see citing works
RetractedExploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144 · see citing works
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189 · see citing works
A role for mitochondria in nlrp3 inflammasome activation
Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602 · see citing works
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528 · see citing works
Protective and pathogenic functions of macrophage subsets
Murray, P. J., & Wynn, T. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3073 · Cited by 5,269 · see citing works
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190 · see citing works
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175 · see citing works
Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients
Locatelli, F., Fishbane, S. N., Block, G. A., & Macdougall, I. C. (2017) · American Journal of Nephrology · doi:10.1159/000455166 · Cited by 4,834 · see citing works
Cytokine-mediated regulation of CXCR4 expression in human neutrophils
Nagase, H., Miyamasu, M., Yamaguchi, M., Imanishi, M., Tsuno, N. H., Matsushima, K., Yamamoto, K., Morita, Y., & Hirai, K. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.4.711 · Cited by 4,713 · see citing works
AMPK: a nutrient and energy sensor that maintains energy homeostasis
Hardie, D. G., Ross, F. A., & Hawley, S. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3311 · Cited by 4,602 · see citing works
Autophagy and Viruses: Adversaries or Allies?
Dong, X., & Levine, B. (2013) · Journal of Innate Immunity · doi:10.1159/000346388 · Cited by 4,441 · see citing works
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026 · see citing works
Coordinated regulation of myeloid cells by tumours
Gabrilovich, D. I., Ostrand-Rosenberg, S., & Bronte, V. (2012) · Nature Reviews Immunology · doi:10.1038/nri3175 · Cited by 3,544 · see citing works
Crosstalk of reactive oxygen species and NF-κB signaling
Morgan, M. J., & Liu, Z.-G. (2011) · Cell Research · doi:10.1038/cr.2010.178 · Cited by 3,505 · see citing works
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,366 · see citing works
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300 · see citing works
M-1/M-2 Macrophages and the Th1/Th2 Paradigm
Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6166 · Cited by 3,287 · see citing works
Yang, Y., Li, S., Yang, Q., Shi, Y., Zheng, M., Liu, Y., Chen, F., Song, G., Xu, H., Wan, T., et al. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000358696 · Cited by 3,262 · see citing works
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.
Kaelin, W. G., & Ratcliffe, P. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.04.009 · Cited by 3,251 · cited 3× · see citing works
“Mechanistically, both HIF-1a and HIF-2a are continuously hydroxylated at proline residues by PHDs, whose activity is regulated by oxygen availability, thus serving as oxygen sensors [reviewed in (138)].”
BackgroundDevelopment of Monocytes, Macrophages, and Dendritic Cells
Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., & Ley, K. (2010) · Science · doi:10.1126/science.1178331 · Cited by 3,049 · see citing works
Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049 · see citing works
PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
Jiang, C., Ting, A. T., & Seed, B. (1998) · Nature · doi:10.1038/34184 · Cited by 2,899 · see citing works
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
Qian, B.-Z., Li, J., Zhang, H., Kitamura, T., Zhang, J., Campion, L. R., Kaiser, E. A., Snyder, L. A., & Pollard, J. W. (2011) · Nature · doi:10.1038/nature10138 · Cited by 2,874 · see citing works
DAMPs, PAMPs and alarmins: all we need to know about danger
Bianchi, M. E. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0306164 · Cited by 2,794 · see citing works
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
Zhou, R., Tardivel, A., Thorens, B., Choi, I., & Tschopp, J. (2010) · Nature Immunology · doi:10.1038/ni.1831 · Cited by 2,708 · see citing works
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578 · see citing works
Resolution of inflammation: the beginning programs the end
Serhan, C. N., & Savill, J. (2005) · Nature Immunology · doi:10.1038/ni1276 · Cited by 2,552 · see citing works
Nomenclature of monocytes and dendritic cells in blood
Ziegler‐Heitbrock, L., Ancuța, P., Crowe, S. M., Dalod, M., Grau, V., Hart, D. N. J., Leenen, P. J. M., Liu, Y.-J., MacPherson, G. G., Randolph, G. J., et al. (2010) · Blood · doi:10.1182/blood-2010-02-258558 · Cited by 2,436 · see citing works
Integrating cell-signalling pathways with NF-κB and IKK function
Perkins, N. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2083 · Cited by 2,350 · see citing works
Transcriptional regulation of macrophage polarization: enabling diversity with identity
Lawrence, T., & Natoli, G. (2011) · Nature Reviews Immunology · doi:10.1038/nri3088 · Cited by 2,284 · see citing works
Inflammasomes in health and disease
Strowig, T., Henao-Mejia, J., Elinav, E., & Flavell, R. (2012) · Nature · doi:10.1038/nature10759 · Cited by 2,230 · see citing works
Macrophage-specific PPARγ controls alternative activation and improves insulin resistance
Odegaard, J. I., Ricardo-Gonzalez, R. R., Goforth, M. H., Morel, C. R., Subramanian, V., Mukundan, L., Eagle, A. R., Vats, D., Brombacher, F., Ferrante, A. W., et al. (2007) · Nature · doi:10.1038/nature05894 · Cited by 2,107 · cited 1× · see citing works
“Mice with a functional deletion of PPARc in the myeloid lineage failed to generate a woundhealing macrophage phenotype (215).”
BackgroundFat and Beyond: The Diverse Biology of PPARγ
Tontonoz, P., & Spiegelman, B. M. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061307.091829 · Cited by 2,085 · see citing works
HIF-1α is essential for myeloid cell-mediated inflammation
Cramer, T., Yamanishi, Y., Clausen, B. E., Förster, I., Pawlinski, R., Mackman, N., Haase, V. H., Jaenisch, R., Corr, M., Nizet, V., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00154-5 · Cited by 2,046 · see citing works
Stein, M., Keshav, S., Harris, N., & Gordon, S. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.1.287 · Cited by 1,960 · see citing works
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
Chandel, N. S., Maltepe, E., Goldwasser, E., Mathieu, C. E., Simon, M. C., & Schumacker, P. T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11715 · Cited by 1,926 · see citing works
Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling
Wen, H., Gris, D., Lei, Y. L., Jha, S., Zhang, L., Huang, M. T.-H., Brickey, W. J., & Ting, J. P. ‐. (2011) · Nature Immunology · doi:10.1038/ni.2022 · Cited by 1,811 · see citing works
Stuehr, D. J., & Nathan, C. F. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.5.1543 · Cited by 1,744 · see citing works
Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb
Jiang, J., & Struhl, G. (1998) · Nature · doi:10.1038/35154 · Cited by 1,735 · see citing works
Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes
Dalton, D. K., Pitts-Meek, S., Keshav, S., Figari, I. S., Bradley, A., & Stewart, T. A. (1993) · Science · doi:10.1126/science.8456300 · Cited by 1,733 · see citing works
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
Keith, B., Johnson, R. S., & Simon, M. C. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3183 · Cited by 1,693 · see citing works
NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α
Rius, J., Guma, M., Schachtrup, C., Akassoglou, K., Zinkernagel, A. S., Nizet, V., Johnson, R. S., Haddad, G. G., & Karin, M. (2008) · Nature · doi:10.1038/nature06905 · Cited by 1,614 · see citing works
A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish
Niethammer, P., Grabher, C., Look, A. T., & Mitchison, T. J. (2009) · Nature · doi:10.1038/nature08119 · Cited by 1,541 · see citing works
NF-κB activation by reactive oxygen species: Fifteen years later
Gloire, G., Legrand-Poels, S., & Piette, J. G. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.04.011 · Cited by 1,540 · see citing works
Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite
Hibbs, J. B., Taintor, R. R., & Vavrin, Z. (1987) · Science · doi:10.1126/science.2432665 · Cited by 1,527 · see citing works
Stewart, C. R., Stuart, L. M., Wilkinson, K., van Gils, J. M., Deng, J., Halle, A., Rayner, K. J., Boyer, L., Zhong, R., Frazier, W. A., et al. (2010) · Nature Immunology · doi:10.1038/ni.1836 · Cited by 1,513 · see citing works
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
Pétrilli, V, Papin, S., Dostert, C., Mayor, A., Martinon, F., & Tschopp, J. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402195 · Cited by 1,445 · see citing works
Jenkins, S., Ruckerl, D., Cook, P., Jones, L., Finkelman, F., van Rooijen, N., MacDonald, A., & Allen, J. (2011) · Science · doi:10.1126/science.1204351 · Cited by 1,427 · see citing works
Shi, C.-S., Shenderov, K., Huang, N.-N., Kabat, J., Abu-Asab, M., Fitzgerald, K. A., Sher, A., & Kehrl, J. H. (2012) · Nature Immunology · doi:10.1038/ni.2215 · Cited by 1,367 · see citing works
A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis
Chawla, A., Boisvert, W. A., Lee, C.-H., Laffitte, B. A., Barak, Y., Joseph, S. B., Liao, D., Nagy, L., Edwards, P. A., Curtiss, L. K., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00164-2 · Cited by 1,347 · see citing works
Gene-specific control of inflammation by TLR-induced chromatin modifications
Foster, S. L., Hargreaves, D. C., & Medzhitov, R. (2007) · Nature · doi:10.1038/nature05836 · Cited by 1,344 · see citing works
Oxidative stress: From basic research to clinical application
Sies, H. (1991) · The American Journal of Medicine · doi:10.1016/0002-9343(91)90281-2 · Cited by 1,332 · see citing works
Masters, S. L., Dunne, A., Subramanian, S. L., Hull, R. L., Tannahill, G. M., Sharp, F. A., Becker, C., Franchi, L., Yoshihara, E., Chen, Z., et al. (2010) · Nature Immunology · doi:10.1038/ni.1935 · Cited by 1,330 · cited 1× · see citing works
“However, this pathway was questioned by experiments in TXNIP-deficient macrophages (185).”
MethodBouhlel, M. A., Derudas, B., Rigamonti, E., Dièvart, R., Brozek, J., Haulon, S., Zawadzki, C., Jude, B., Torpier, G., Marx, N., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.010 · Cited by 1,325 · see citing works
Talks, K. L., Turley, H., Gatter, K. C., Maxwell, P. H., Pugh, C. W., Ratcliffe, P. J., & Harris, A. L. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64554-3 · Cited by 1,312 · see citing works
Stamler (2001) · doi:10.1016/s0092-8674(01)00495-0 · Cited by 1,261 · see citing works
Differential Roles of Macrophages in Diverse Phases of Skin Repair
Lucas, T., Waisman, A., Ranjan, R., Roes, J., Krieg, T., Müller, W., Roers, A., & Eming, S. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903356 · Cited by 1,205 · cited 1× · see citing works
“Accordingly, macrophage depletion shortly after introducing skin wounds in mice resulted in delayed re-epithelization and angiogenesis, as well as prolonged inflammation (177).”
BackgroundTrophic macrophages in development and disease
Pollard, J. W. (2009) · Nature Reviews Immunology · doi:10.1038/nri2528 · Cited by 1,178 · see citing works
Corzo, C. A., Condamine, T., Lu, L., Cotter, M. J., Youn, J.-I., Cheng, P., Cho, H.-I., Celis, E., Quiceno, D. G., Padhya, T., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100587 · Cited by 1,173 · see citing works
van Furth, R., Cohn, Z. A., Jg, H., Humphrey, J., Spector, W. G., & Langevoort, H. L. (1972) · PubMed Central · Cited by 1,133 · see citing works
Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
McKercher, S. R., Torbett, B. E., Anderson, K. L., Henkel, G. W., Vestal, D. J., Baribault, H., Klemsz, M., Feeney, A. J., Wu, G. E., Paige, C. J., et al. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00949.x · Cited by 1,130 · see citing works
Stuehr, D. J., & Marletta, M. A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.22.7738 · Cited by 1,126 · see citing works
Galli, S. J., Borregaard, N., & Wynn, T. A. (2011) · Nature Immunology · doi:10.1038/ni.2109 · Cited by 1,055 · see citing works
A Clonogenic Bone Marrow Progenitor Specific for Macrophages and Dendritic Cells
Fogg, D. K., Sibon, C., Miled, C., Jung, S., Aucouturier, P., Littman, D. R., Cumano, A., & Geissmann, F. (2005) · Science · doi:10.1126/science.1117729 · Cited by 1,050 · see citing works
Rodríguez-Prados, J.-C., Través, P. G., Cuenca, J., Rico, D., Aragonés, J., Martín-Sanz, P., Cascante, M., & Boscá, L. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901698 · Cited by 1,022 · see citing works
Wang, Y., Szretter, K. J., Vermi, W., Gilfillan, S., Rossini, C., Cella, M., Barrow, A. D., Diamond, M. S., & Colonna, M. (2012) · Nature Immunology · doi:10.1038/ni.2360 · Cited by 1,011 · see citing works
The chemical biology of nitric oxide: Implications in cellular signaling
Thomas, D. D., Ridnour, L. A., Isenberg, J. S., Flores-Santana, W., Switzer, C. H., Donzelli, S., Hussain, P., Vecoli, C., Paolocci, N., Ambs, S., et al. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.03.020 · Cited by 975 · see citing works
Mori, K., Lee, H. T., Rapoport, D., Drexler, I. R., Foster, K., Yang, J., Schmidt-Ott, K. M., Chen, X., Li, J. Y., Weiss, S., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23056 · Cited by 954 · see citing works
Weidemann, A., & Johnson, R. S. (2008) · Cell Death & Differentiation · doi:10.1038/cdd.2008.12 · Cited by 941 · see citing works
Emerging roles of PPARS in inflammation and immunity
Daynes, R. A., & Jones, D. C. (2002) · Nature reviews. Immunology · doi:10.1038/nri912 · Cited by 922 · see citing works
Reactive Oxygen Species: A Breath of Life or Death?
Fruehauf, J. P., & Meyskens, F. L. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2082 · Cited by 908 · see citing works
Transcriptional Regulation of Metabolism
Desvergne, B., Michalik, L., & Wahli, W. (2006) · Physiological Reviews · doi:10.1152/physrev.00025.2005 · Cited by 889 · see citing works
Biochemical and functional characterization of three activated macrophage populations
Edwards, J. P., Zhang, X., Frauwirth, K. A., & Mosser, D. M. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0406249 · Cited by 863 · see citing works
Li, A. C., Brown, K. K., Silvestre, M., Willson, T. M., Palinski, W., & Glass, C. K. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10370 · Cited by 833 · see citing works
Clements, C. M., McNally, R. S., Conti, B. J., Mak, T. W., & Ting, J. P.-Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607260103 · Cited by 818 · see citing works
THE IMMUNOLOGICAL BASIS OF ACQUIRED CELLULAR RESISTANCE
Mackaness, G. B. (1964) · The Journal of Experimental Medicine · doi:10.1084/jem.120.1.105 · Cited by 806 · see citing works
Sağ, D., Carling, D., Stout, R. D., & Suttles, J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.12.8633 · Cited by 798 · see citing works
Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation
Harris, J., Hartman, M., Roche, C., Zeng, S. G., O'Shea, A., Sharp, F. A., Lambe, E. M., Creagh, E. M., Golenbock, D. T., Tschopp, J., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.202911 · Cited by 794 · see citing works
Cummins, E. P., Berra, E., Comerford, K. M., Ginouves, A., Fitzgerald, K. T., Seeballuck, F., Godson, C., Nielsen, J. E., Moynagh, P., Pouyssegur, J., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602235103 · Cited by 788 · see citing works
Cruz, C. M., Rinna, A., Forman, H. J., Ventura, A. L. M., Persechini, P. M., & Ojcius, D. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608083200 · Cited by 786 · see citing works
SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization
Finley, L. W. S., Carracedo, A., Lee, J., Souza, A., Egia, A., Zhang, J., Teruya-Feldstein, J., Moreira, P. I., Cardoso, S. M., Clish, C. B., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.02.014 · Cited by 782 · see citing works
Deciphering the transcriptional network of the dendritic cell lineage
Miller, J. C., Brown, B. D., Shay, T., Gautier, E. L., Jojic, V., Cohain, A. T., Pandey, G. S., Leboeuf, M., Elpek, K. G., Helft, J., et al. (2012) · Nature Immunology · doi:10.1038/ni.2370 · Cited by 779 · see citing works
Nitric oxide and redox mechanisms in the immune response
Wink, D. A., Hines, H. B., Cheng, R. Y. S., Switzer, C. H., Flores-Santana, W., Vitek, M. P., Ridnour, L. A., & Colton, C. A. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.1010550 · Cited by 765 · see citing works
A role for uncoupling protein‐2 as a regulator of mitochondrial hydrogen peroxide generation
Nègre‐Salvayre, A., Hirtz, C., Carrera, G., Cazenave, R., Troly, M., Salvayre, R., Pénicaud, L., & Casteilla, L. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.10.9271366 · Cited by 757 · see citing works
Regulation of hypoxia-inducible factor-1α by NF-κB
van Uden, P., Kenneth, N. S., & Rocha, S. (2008) · Biochemical Journal · doi:10.1042/bj20080476 · Cited by 729 · see citing works
High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq
Schödel, J., Oikonomopoulos, S., Ragoussis, J., Pugh, C. W., Ratcliffe, P. J., & Mole, D. R. (2011) · Blood · doi:10.1182/blood-2010-10-314427 · Cited by 724 · see citing works
Ricote, M., Huang, J. T., Lluis Fajas, A., Li, A. I., Welch, J. S., Najïb, J., Witztum, J. L., Auwerx, J. H., Palinski, W., & Glass, C. K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7614 · Cited by 721 · see citing works
Invertebrate immune systems – not homogeneous, not simple, not well understood
Loker, E. S., Adema, C. M., Zhang, S., & Kepler, T. B. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.0117.x · Cited by 718 · see citing works
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
Alexander, A., Cai, S.-L., Kim, J., Nanez, A., Sahin, M., MacLean, K. H., Inoki, K., Guan, K.-L., Shen, J., Person, M. D., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913860107 · Cited by 717 · see citing works
Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1α
Hagen, T., Taylor, C. T., Lam, F., & Moncada, S. (2003) · Science · doi:10.1126/science.1088805 · Cited by 704 · see citing works
HIF-1α expression regulates the bactericidal capacity of phagocytes
Peyssonnaux, C., Datta, V., Cramer, T., Doedens, A. L., Theodorakis, E. A., Gallo, R. L., Hurtado‐Ziola, N., Nizet, V., & Johnson, R. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23865 · Cited by 702 · see citing works
Arginase: an emerging key player in the mammalian immune system
Munder, M. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00291.x · Cited by 701 · see citing works
Two physically, functionally, and developmentally distinct peritoneal macrophage subsets
Ghosn, E. E. B., Cassado, A. A., Govoni, G. R., Fukuhara, T., Yang, Y., Monack, D. M., Bortoluci, K. R., Almeida, S. R., Herzenberg, L. A., & Herzenberg, L. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0915000107 · Cited by 689 · see citing works
A Cell-Surface Receptor for Lipocalin 24p3 Selectively Mediates Apoptosis and Iron Uptake
Devireddy, L. R., Gazin, C., Zhu, X., & Green, M. R. (2005) · Cell · doi:10.1016/j.cell.2005.10.027 · Cited by 672 · see citing works
Role of NRF2 in Protection Against Hyperoxic Lung Injury in Mice
Cho, H., Jedlicka, A., Reddy, S. P., Kensler, T. W., Yamamoto, M. P., Zhang, L.-Y., & Kleeberger, S. R. (2002) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.26.2.4501 · Cited by 660 · see citing works
Doedens, A. L., Stockmann, C., Rubinstein, M. P., Liao, D., Zhang, N., DeNardo, D. G., Coussens, L. M., Karin, M., Goldrath, A. W., & Johnson, R. S. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1439 · Cited by 652 · see citing works
Macrophage Autophagy Plays a Protective Role in Advanced Atherosclerosis
Liao, X., Sluimer, J. C., Wang, Y., Subramanian, M., Brown, K., Pattison, J. S., Robbins, J., Martinez, J., & Tabas, I. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.022 · Cited by 627 · see citing works
Kazama, H., Ricci, J.-E., Herndon, J. M., Hoppe, G., Green, D. R., & Ferguson, T. A. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.013 · Cited by 627 · see citing works
Reactive Oxygen Species Activate the HIF-1α Promoter Via a Functional NFκB Site
Bonello, S., Zähringer, C., BelAiba, R. S., Djordjevic, T., Hess, J., Michiels, C., Kietzmann, T., & Görlach, A. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000258979.92828.bc · Cited by 626 · see citing works
Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase
Schröder, K., Zhang, M., Benkhoff, S., Mieth, A., Pliquett, R., Kosowski, J., Kruse, C., Luedike, P., Michaelis, U. R., Weissmann, N., et al. (2012) · Circulation Research · doi:10.1161/circresaha.112.267054 · Cited by 622 · see citing works
Takeda, N., O'Dea, E. L., Doedens, A. L., Kim, J., Weidemann, A., Stockmann, C., Asagiri, M., Simon, M. C., Hoffmann, A., & Johnson, R. S. (2010) · Genes & Development · doi:10.1101/gad.1881410 · Cited by 621 · see citing works
Bauernfeind, F., Bartok, E., Rieger, A., Franchi, L., Núñez, G., & Hornung, V. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100613 · Cited by 617 · see citing works
Autophagy Links Inflammasomes to Atherosclerotic Progression
Razani, B., Feng, C., Coleman, T., Emanuel, R., Wen, H., Hwang, S., Ting, J. P., Virgin, H. W., Kastan, M. B., & Semenkovich, C. F. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.02.011 · Cited by 601 · see citing works
Li, G., Mongillo, M., Chin, K., Harding, H. P., Ron, D., Marks, A. R., & Tabas, I. A. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200904060 · Cited by 597 · see citing works
A signalling role for 4‐hydroxy‐2‐nonenal in regulation of mitochondrial uncoupling
Echtay, K. S., Esteves, T. C., Pakay, J. L., Jekabsons, M. B., Lambert, A. J., Portero‐Otín, M., Pamplona, R., Vidal‐Puig, A. J., Wang, S., Roebuck, S. J., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg412 · Cited by 597 · see citing works
JunD Reduces Tumor Angiogenesis by Protecting Cells from Oxidative Stress
Gerald, D., Berra, E., Frapart, Y. M., Chan, D. A., Giaccia, A. J., Mansuy, D., Pouysségur, J., Yaniv, M., & Mechta-Grigoriou, F. (2004) · Cell · doi:10.1016/j.cell.2004.08.025 · Cited by 588 · see citing works
Apétoh, L., Ghiringhelli, F., Tesnière, A., Criollo, A., Ortiz, C., Lidereau, R., Mariette, C., Chaput, N., Mira, J. P., Delaloge, S., et al. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00573.x · Cited by 575 · see citing works
Stearns-Kurosawa, D. J., Osuchowski, M. F., Valentine, C., Kurosawa, S., & Remick, D. G. (2011) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130327 · Cited by 573 · see citing works
PPARs and molecular mechanisms of transrepression
Ricote, M., & Glass, C. K. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2007.02.013 · Cited by 567 · see citing works
Decoding Cell Death Signals in Inflammation and Immunity
Zitvogel, L., Kepp, O., & Kroemer, G. (2010) · Cell · doi:10.1016/j.cell.2010.02.015 · Cited by 558 · see citing works
The updated biology of hypoxia-inducible factor
Greer, S. N., Metcalf, J. L., Wang, Y., & Ohh, M. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.125 · Cited by 545 · see citing works
Redox signaling in macrophages.
Forman, H., & Torres, M. (2001) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(01)00010-3 · Cited by 539 · see citing works
Uncoupling proteins and the control of mitochondrial reactive oxygen species production
Mailloux, R. J., & Harper, M. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.022 · Cited by 534 · see citing works
Nitric oxide and the regulation of gene expression
Bogdan, C. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01900-0 · Cited by 534 · see citing works
Chang, M.-K., Binder, C. J., Torzewski, M., & Witztum, J. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192399699 · Cited by 517 · see citing works
Update on Mechanism and Catalytic Regulation in the NO Synthases
Stuehr, D. J., Santolini, J., Wang, Z., Wei, C., & Adak, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r400017200 · Cited by 516 · see citing works
Physiological Significance of Reactive Cysteine Residues of Keap1 in Determining Nrf2 Activity
Yamamoto, T., Suzuki, T., Kobayashi, A., Wakabayashi, J., Maher, J. M., Motohashi, H., & Yamamoto, M. P. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01704-07 · Cited by 515 · see citing works
Regulation of Nox and Duox enzymatic activity and expression.
Lambeth, J., Kawahara, T., & Diebold, B. (2007) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2007.03.028 · Cited by 509 · see citing works
EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages
Lancaster, J. R., & Hibbs, J. B. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.3.1223 · Cited by 507 · see citing works
Rahman, I., Marwick, J., & Kirkham, P. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.05.042 · Cited by 507 · see citing works
Macrophages as APC and the Dendritic Cell Myth
Hume, D. A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.9.5829 · Cited by 504 · see citing works
Kukidome, D., Nishikawa, T., Sonoda, K., Imoto, K., Fujisawa, K., Yano, M., Motoshima, H., Taguchi, T., Matsumura, T., & Araki, E. (2006) · Diabetes · doi:10.2337/diabetes.55.01.06.db05-0943 · Cited by 504 · see citing works
Scortegagna, M., Ding, K., Oktay, Y., Gaur, A., Thurmond, F., Yan, L.-J., Marck, B. T., Matsumoto, A. M., Shelton, J. M., Richardson, J. A., et al. (2003) · Nature Genetics · doi:10.1038/ng1266 · Cited by 496 · see citing works
IDO Activates Regulatory T Cells and Blocks Their Conversion into Th17-Like T Cells
Baban, B., Chandler, P., Sharma, M. D., Pihkala, J. P. S., Koni, P. A., Munn, D. H., & Mellor, A. L. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900986 · Cited by 494 · see citing works
Peyssonnaux, C., Cejudo-Martin, P., Doedens, A., Zinkernagel, A. S., Johnson, R. S., & Nizet, V. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.12.7516 · Cited by 480 · see citing works
Free radicals and phagocytic cells
Rosen, G. M., Pou, S., Ramos, C. L., Cohen, M. S., & Britigan, B. E. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.2.7540156 · Cited by 478 · see citing works
Seimon, T. A., Nadolski, M. J., Liao, X., Magallon, J., Nguyen, M. T., Feric, N. T., Koschinsky, M. L., Harkewicz, R., Witztum, J. L., Tsimikas, S., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.09.010 · Cited by 478 · see citing works
Identification of Activating Transcription Factor 4 (ATF4) as an Nrf2-interacting Protein
He, C. H., Gong, P., Hu, B., Stewart, D., Choi, M. E., Choi, A. M. K., & Alam, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101198200 · Cited by 473 · see citing works
Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans
Chou, M.-Y., Fogelstrand, L., Hartvigsen, K., Hansen, L. F., Woelkers, D., Shaw, P. X., Choi, J., Perkmann, T., Bäckhed, F., Miller, Y. I., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36800 · Cited by 468 · see citing works
Imtiyaz, H. Z., Williams, E. P., Hickey, M. M., Patel, S. A., Durham, A. C., Yuan, L.-J., Hammond, R., Gimotty, P. A., Keith, B., & Simon, M. C. (2010) · Journal of Clinical Investigation · doi:10.1172/jci39506 · Cited by 461 · see citing works
Desreumaux, P., Dubuquoy, L., Nutten, S., Peuchmaur, M. M., Englaro, W., Schoonjans, K., Dérijard, B., Desvergne, B., Wahli, W., Chambon, P., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.7.827 · Cited by 458 · see citing works
Chang, M.-K., Bergmark, C., Laurila, A., Hörkkö, S., Han, K., Friedman, P., Dennis, E. A., & Witztum, J. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.11.6353 · Cited by 456 · see citing works
A role for the NLRP3 inflammasome in metabolic diseases—did Warburg miss inflammation?
Wen, H., Ting, J. P. ‐., & O'Neill, L. A. J. (2012) · Nature Immunology · doi:10.1038/ni.2228 · Cited by 455 · see citing works
The LDL modification hypothesis of atherogenesis: an update
Steinberg, D. H. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800087-jlr200 · Cited by 452 · see citing works
Hanna, R. N., Shaked, I., Hubbeling, H., Punt, J. A., Wu, R., Herrley, E., Zaugg, C., Pei, H., Geissmann, F., Ley, K. F., et al. (2011) · Circulation Research · doi:10.1161/circresaha.111.253377 · Cited by 449 · see citing works
Exposure to hydrogen peroxide induces oxidation and activation of AMP-activated protein kinase
Zmijewski, J. W., Banerjee, S., Bae, H., Friggeri, A., Lazarowski, E. R., & Abraham, E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.143685 · Cited by 441 · see citing works
Regulation of HIF-1α Stability through S-Nitrosylation
Li, F., Sonveaux, P., Rabbani, Z. N., Liu, S., Yan, B., Huang, Q., Vujašković, Ž., Dewhirst, M. W., & Li, C. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.02.024 · Cited by 439 · see citing works
Differential regulation of iron homeostasis during human macrophage polarized activation
Recalcati, S., Locati, M., Marini, A., Santambrogio, P., Zaninotto, F., De Pizzol, M., Zammataro, L., Girelli, D., & Cairo, G. (2010) · European Journal of Immunology · doi:10.1002/eji.200939889 · Cited by 438 · see citing works
Itoh, K., Igarashi, K., Hayashi, N., Nishizawa, M., & Yamamoto, M. P. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.8.4184 · Cited by 438 · see citing works
Pédruzzi, E., Guichard, C., Ollivier, V., Driss, F., Fay, M., Prunet, C., Marie, J., Pouzet, C., Samadi, M. H., Elbim, C., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.24.10703-10717.2004 · Cited by 435 · see citing works
Greenberg, M. E., Sun, M., Zhang, R., Febbraio, M., Silverstein, R., & Hazen, S. L. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060370 · Cited by 430 · see citing works
Mitochondrial nitric oxide synthase
Ghafourifar, P., & Cadenas, E. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.02.005 · Cited by 429 · see citing works
Villeneuve, N. F., Lau, A., & Zhang, D. D. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3211 · Cited by 423 · see citing works
Bae, Y. S., Lee, J. H., Choi, S. H., Kim, S. A., Almazan, F., Witztum, J. L., & Miller, Y. I. (2008) · Circulation Research · doi:10.1161/circresaha.108.181040 · Cited by 423 · see citing works
Timmins, J. M., Özcan, L., Seimon, T. A., Li, G., Malagelada, C., Backs, J., Backs, T., Bassel‐Duby, R., Olson, E. N., Anderson, M. E., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38857 · Cited by 422 · see citing works
Metchnikoff and the phagocytosis theory
Tauber, A. I. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1244 · Cited by 413 · see citing works
Sun, Z., Chin, Y. E., & Zhang, D. D. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01639-08 · Cited by 413 · see citing works
Yang, Z., Kahn, B. B., Shi, H., & Xue, B. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.123620 · Cited by 413 · see citing works
Paul Ehrlich (1854-1915) and His Contributions to the Foundation and Birth of Translational Medicine
Valent, P., Groner, B., Schumacher, U., Superti‐Furga, G., Busslinger, M., Královics, R., Zielinski, C. C., Penninger, J. M., Kerjaschki, D., Stingl, G., et al. (2016) · Journal of Innate Immunity · doi:10.1159/000443526 · Cited by 410 · see citing works
The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis
Cummins, E. P., Seeballuck, F., Keely, S. J., Mangan, N. E., Callanan, J. J., Fallon, P. G., & Taylor, C. T. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.10.012 · Cited by 407 · see citing works
Park, Y. M., Febbraio, M., & Silverstein, R. L. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35535 · Cited by 407 · see citing works
Takeda, K., Ho, V. C., Takeda, H., Duan, L.-J., Nagy, A., & Fong, G.-H. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00425-06 · Cited by 401 · see citing works
Mechanisms of the Antioxidant Effects of Nitric Oxide
Wink, D. A., Miranda, K. M., Espey, M. G., Pluta, R. M., Hewett, S. J., Colton, C. A., Vitek, M. P., Feelisch, M., & Grisham, M. B. (2001) · Antioxidants and Redox Signaling · doi:10.1089/152308601300185179 · Cited by 400 · see citing works
Life history of eNOS: partners and pathways
DUDZINSKI, D., & MICHEL, T. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.03.023 · Cited by 400 · see citing works
Role of Nrf2 in the Regulation of CD36 and Stress Protein Expression in Murine Macrophages
Ishii, T., Itoh, K., Ruiz, E., Leake, D. S., Unoki‐Kubota, H., Yamamoto, M. P., & Mann, G. E. (2004) · Circulation Research · doi:10.1161/01.res.0000119171.44657.45 · Cited by 400 · see citing works
Regulation by S-Nitrosylation of Protein Post-translational Modification
Hess, D. T., & Stamler, J. S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.r111.285742 · Cited by 385 · see citing works
Mungai, P. T., Waypa, G. B., Jairaman, A., Prakriya, M., Dokic, D., Ball, M. K., & Schumacker, P. T. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05124-11 · Cited by 385 · see citing works
Collins, A. R., Meehan, W. P., Kintscher, U., Jackson, S. M., Wakino, S., Noh, G. J., Palinski, W., Hsueh, W. A., & Law, R. E. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.3.365 · Cited by 384 · see citing works
Gray, M. J., Zhang, J., Ellis, L. M., Semenza, G. L., Evans, D. B., Watowich, S. S., & Gallick, G. E. (2005) · Oncogene · doi:10.1038/sj.onc.1208513 · Cited by 372 · see citing works
Dendritic Cell and Macrophage Heterogeneity In Vivo
Hashimoto, D., Miller, J. C., & Mérad, M. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.007 · Cited by 366 · see citing works
Cowland, J. B., Sørensen, O. E., Sehested, M., & Borregaard, N. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.12.6630 · Cited by 354 · see citing works
Molecular mechanisms of late apoptotic/necrotic cell clearance
Poon, I. K. H., Hulett, M. D., & Parish, C. R. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.195 · Cited by 353 · see citing works
(2003) · PubMed · Cited by 350 · see citing works
Anemia of inflammation: the cytokine-hepcidin link
Andrews, N. C. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21441 · Cited by 350 · see citing works
Sussan, T. E., Rangasamy, T., Blake, D. J., Malhotra, D., El-Haddad, H., Bedja, D., Yates, M. S., Kombairaju, P., Yamamoto, M., Liby, K. T., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804333106 · Cited by 346 · see citing works
Galić, S., Fullerton, M. D., Schertzer, J. D., Sikkema, S. R., Marcinko, K., Walkley, C. R., Izon, D. J., Honeyman, J. E., Chen, Z., van Denderen, B. J., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58577 · Cited by 344 · see citing works
Targeting and Regulation of Reactive Oxygen Species Generation by Nox Family NADPH Oxidases
Leto, T. L., Morand, S. C., Hurt, D. E., & Ueyama, T. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2637 · Cited by 343 · see citing works
Harvey, C. J., Thimmulappa, R. K., Sethi, S., Kong, X., Yarmus, L. B., Brown, R. H., Feller-Kopman, D. J., Wise, R. A., & Biswal, S. S. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002042 · Cited by 343 · see citing works
IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors
Kerkar, S. P., Goldszmid, R. S., Muranski, P. J., Chinnasamy, D., Yu, Z., Reger, R. N., Leonardi, A. J., Morgan, R. A., Wang, E., Marincola, F. M., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58814 · Cited by 342 · see citing works
ER stress activates the NLRP3 inflammasome via an UPR-independent pathway
Menu, P., Mayor, A., Zhou, R., Tardivel, A., Ichijo, H., Mori, K., & Tschopp, J. (2012) · Cell Death and Disease · doi:10.1038/cddis.2011.132 · Cited by 321 · see citing works
Fang, H.-Y., Hughes, R., Murdoch, C., Coffelt, S. B., Biswas, S. K., Harris, A. L., Johnson, R. S., Imityaz, H. Z., Simon, M. C., Fredlund, E., et al. (2009) · Blood · doi:10.1182/blood-2008-12-195941 · Cited by 319 · see citing works
Free Radicals, Mitochondria, and Oxidized Lipids
Gutiérrez, J., Ballinger, S. W., Darley-Usmar, V. M., & Landar, A. L. (2006) · Circulation Research · doi:10.1161/01.res.0000248212.86638.e9 · Cited by 319 · see citing works
Three pathways to mature macrophages in the early mouse yolk sac
Bertrand, J. Y., Jalil, A., Klaine, M., Jung, S., Cumano, A., & Godin, I. (2005) · Blood · doi:10.1182/blood-2005-02-0461 · Cited by 315 · see citing works
What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology
Hill, B. G., Dranka, B. P., Bailey, S. M., Lancaster, J. R., & Darley-Usmar, V. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.101618 · Cited by 310 · see citing works
Kobayashi, Y. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0310149 · Cited by 306 · see citing works
Li, G., Scull, C. M., Özcan, L., & Tabas, I. A. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201006121 · Cited by 306 · see citing works
Polarization dictates iron handling by inflammatory and alternatively activated macrophages
Corna, G., Campana, L., Pignatti, E., Castiglioni, A., Tagliafico, E., Bosurgi, L., Campanella, A., Brunelli, S., Manfredi, A. A., Apostoli, P., et al. (2010) · Haematologica · doi:10.3324/haematol.2010.023879 · Cited by 304 · see citing works
The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency
Bigley, V., Haniffa, M. A., Doulatov, S. R., Wang, X., Dickinson, R. E., McGovern, N. N., Jardine, L., Pagan, S., Dimmick, I., Chua, I. C., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101459 · Cited by 304 · see citing works
Superoxide dismutase 1 regulates caspase-1 and endotoxic shock
Meissner, F., Molawi, K., & Zychlinsky, A. (2008) · Nature Immunology · doi:10.1038/ni.1633 · Cited by 302 · see citing works
Freigang, S., Ampenberger, F., Spohn, G., Heer, S., Shamshiev, A. T., Kisielow, J., Hersberger, M., Yamamoto, M., Bachmann, M. F., & Kopf, M. (2011) · European Journal of Immunology · doi:10.1002/eji.201041316 · Cited by 300 · see citing works
Judkins, C. P., Diep, H., Broughton, B. R. S., Mast, A. E., Hooker, E. U., Miller, A. A., Selemidis, S., Dusting, G. J., Sobey, C. G., & Drummond, G. R. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00799.2009 · Cited by 299 · see citing works
Wang, S., Zhang, M., Liang, B., Xu, J., Xie, Z., Liu, C., Viollet, B., Yan, D., & Zou, M.-H. (2010) · Circulation Research · doi:10.1161/circresaha.109.212530 · Cited by 296 · see citing works
Identification of Common Transcriptional Regulatory Elements in Interleukin-17 Target Genes
Shen, F., Hu, Z., Goswami, J., & Gaffen, S. L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604597200 · Cited by 294 · see citing works
Kaufmann, S. H. E. (2008) · Nature Immunology · doi:10.1038/ni0708-705 · Cited by 293 · see citing works
Molecular mechanism in tolerance to lipopolysaccharide.
Ziegler‐Heitbrock, H. W. L. (1995) · PubMed · Cited by 290 · see citing works
Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis
Takeda, Y., Costa, S., Delamarre, E., Roncal, C., de Oliveira, R. L., Squadrito, M. L., Finisguerra, V., Deschoemaeker, S., Bruyére, F., Wenes, M., et al. (2011) · Nature · doi:10.1038/nature10507 · Cited by 287 · see citing works
Suzuki, M., Betsuyaku, T., Ito, Y., Nagai, K., Nasuhara, Y., Kaga, K., Kondo, S., & Nishimura, M. (2008) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0424oc · Cited by 286 · see citing works
Cockman, M. E., Lancaster, D. E., Stolze, I. P., Hewitson, K. S., McDonough, M. A., Coleman, M. L., Coles, C. H., Yu, X., Hay, R. T., Ley, S. C., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606877103 · Cited by 285 · see citing works
Autocrine formation of hepcidin induces iron retention in human monocytes
Theurl, I., Theurl, M., Seifert, M., Mair, S., Nairz, M., Rumpold, H., Zoller, H., Bellmann-Weiler, R., Niederegger, H., Talasz, H., et al. (2008) · Blood · doi:10.1182/blood-2007-05-090019 · Cited by 275 · see citing works
Induction of regulatory T cells by macrophages is dependent on production of reactive oxygen species
Kraaij, M. D., Savage, N. D. L., van der Kooij, S. W., Koekkoek, K. M., Wang, J., van den Berg, J. M., Ottenhoff, T. H. M., Kuijpers, T. W., Holmdahl, R., van Kooten, C., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012016107 · Cited by 253 · see citing works
A Comparison of Thiol Peroxidase Mechanisms
Flohé, L., Toppo, S., Cozza, G., & Ursini, F. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3397 · Cited by 250 · see citing works
Role of Oxidants in Lung Injury During Sepsis
Guo, R., & Ward, P. A. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1785 · Cited by 246 · see citing works
Takahashi, K., Yamamura, F., & Naito, M. (1989) · Journal of Leukocyte Biology · doi:10.1002/jlb.45.2.87 · Cited by 242 · see citing works
Protective Role of Uncoupling Protein 2 in Atherosclerosis
Blanc, J., Alves‐Guerra, M., Esposito, B., Rousset, S., Gourdy, P., Ricquier, D., Tedgui, A., Miroux, B., & Mallat, Z. (2003) · Circulation · doi:10.1161/01.cir.0000051722.66074.60 · Cited by 239 · see citing works
Filardy, A. A., Pires, D. R., Nunes, M. P., Takiya, C. M., Freire-de-Lima, C. G., Ribeiro-Gomes, F. L., & DosReis, G. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000017 · Cited by 237 · see citing works
Leishmania–macrophage interactions: Insights into the redox biology
Assche, T. V., Deschacht, M., da Luz, R. I., Maes, L. J. R. M., & Cos, P. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.011 · Cited by 236 · see citing works
12/15-Lipoxygenase Orchestrates the Clearance of Apoptotic Cells and Maintains Immunologic Tolerance
Uderhardt, S., i, M. H., Oskolkova, O., Aschermann, S., Bicker, W., Ipseiz, N., Sarter, K., Frey, B., Rothe, T., Voll, R. E., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.010 · Cited by 235 · see citing works
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Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181 · see citing works
Nitric oxide synthase in innate and adaptive immunity: an update
Bogdan, C. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.01.003 · Cited by 862 · see citing works
González, P., Lozano, P., Ros, G., & Solano, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119352 · Cited by 891 · see citing works
Macrophage activation and its role in repair and pathology after spinal cord injury
Gensel, J. C., & Zhang, B. (2015) · Brain Research · doi:10.1016/j.brainres.2014.12.045 · Cited by 774 · see citing works
Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease
Steven, S., Frenis, K., Oelze, M. W., Kalinovic, S., Kuntić, M., Jiménez, M. T. B., Vujačić-Mirski, K., Helmstädter, J., Kröller‐Schön, S., Münzel, T. F., et al. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7092151 · Cited by 729 · see citing works
Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death
Kapralov, A. A., Yang, Q., Dar, H. H., Tyurina, Y. Y., Anthonymuthu, T. S., Kim, R., Croix, C. M. S., Mikulska‐Ruminska, K., Liu, B., Shrivastava, I. H., et al. (2020) · Nature Chemical Biology · doi:10.1038/s41589-019-0462-8 · Cited by 657 · see citing works
Functions of ROS in Macrophages and Antimicrobial Immunity
Herb, M., & Schramm, M. (2021) · Antioxidants · doi:10.3390/antiox10020313 · Cited by 633 · see citing works
Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach
Cuadrado, A., Manda, G., Hassan, A., Alcaraz, M. J., Barbas, C., Daiber, A., Ghezzi, P., León, R., López, M. G., Oliva, B., et al. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014753 · Cited by 632 · see citing works
Mammalian lipoxygenases and their biological relevance
Kühn, H., Banthiya, S., & van Leyen, K. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.10.002 · Cited by 629 · see citing works
Reactive Oxygen Species in Macrophages: Sources and Targets
Canton, M., Sánchez‐Rodríguez, R., Spera, I., Venegas, F. C., Favia, M., Viola, A., & Castegna, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.734229 · Cited by 463 · see citing works
Genard, G. C., Lucas, S., & Michiels, C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00828 · Cited by 420 · see citing works
Macrophage polarization and meta-inflammation
Li, C., Xu, M. M., Wang, K., Adler, A. J., Vella, A. T., & Zhou, B. (2017) · Translational research · doi:10.1016/j.trsl.2017.10.004 · Cited by 369 · see citing works
Osteolysis around total knee arthroplasty: A review of pathogenetic mechanisms
Gallo, J., Goodman, S. B., Konttinen, Y. T., Wimmer, M. A., & Holinka, M. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.05.005 · Cited by 354 · see citing works
Oxidative Stress and Inflammation in Acute and Chronic Lung Injuries
Bezerra, F. S., Lanzetti, M., Nesi, R. T., Nagato, A. C., Silva, C. P. E., Kennedy-Feitosa, E., Melo, A. C., Cattani‐Cavalieri, I., Pôrto, L. C., & Valença, S. S. (2023) · Antioxidants · doi:10.3390/antiox12030548 · Cited by 353 · see citing works
Microglial/Macrophage Polarization Dynamics following Traumatic Brain Injury
Kumar, A., Alvarez-Croda, D.-M., Stoica, B. A., Faden, A. I., & Loane, D. J. (2016) · Journal of Neurotrauma · doi:10.1089/neu.2015.4268 · Cited by 339 · see citing works
Wang, L., & He, C.-Q. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.967193 · Cited by 352 · see citing works
Redox regulation in metabolic programming and inflammation
Griffiths, H. R., Gao, D., & Pararasa, C. (2017) · Redox Biology · doi:10.1016/j.redox.2017.01.023 · Cited by 284 · see citing works
Daiber, A., Lisa, F. D., Oelze, M. W., Kröller‐Schön, S., Steven, S., Schulz, E., & Münzel, T. F. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13403 · Cited by 271 · see citing works
Cancer cell and macrophage cross-talk in the tumor microenvironment
Dehne, N., Mora, J., Namgaladze, D., Weigert, A., & Brüne, B. (2017) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2017.04.007 · Cited by 265 · see citing works
Self-citationOxidative Stress in Pulmonary Fibrosis
Otoupalova, E., Smith, S., Cheng, G., & Thannickal, V. J. (2020) · Comprehensive physiology · doi:10.1002/cphy.c190017 · Cited by 309 · see citing works
Can Activation of NRF2 Be a Strategy against COVID-19?
Cuadrado, A., Pajares, M., Benito, C., Jiménez-Villegas, J., Escoll, M., Fernández-Ginés, R., García‐Yagüe, Á. J., Lastra, D., Manda, G., Rojo, A. I., et al. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.07.003 · Cited by 239 · see citing works
Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15)
Ivanov, I., Kühn, H., & Heydeck, D. (2015) · Gene · doi:10.1016/j.gene.2015.07.073 · Cited by 223 · see citing works
Kumar, A., Barrett, J. P., Alvarez-Croda, D.-M., Stoica, B. A., Faden, A. I., & Loane, D. J. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.07.158 · Cited by 213 · see citing works
Redox Regulation of Inflammation: Old Elements, a New Story
Lei, Y., Wang, K., Deng, L., Chen, Y., Nice, E. C., & Huang, C. (2014) · Medicinal Research Reviews · doi:10.1002/med.21330 · Cited by 208 · see citing works
Wang, Y., Huang, Y., Xu, Y., Ruan, W., Wang, H., Zhang, Y., Saavedra, J. M., Zhang, L., Huang, Z., & Pang, T. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7003 · Cited by 203 · see citing works
Redox Control of Skeletal Muscle Regeneration
Moal, E. L., Pialoux, V., Juban, G., Groussard, C., Zouhal, H., Chazaud, B., & Mounier, R. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6782 · Cited by 197 · see citing works
Medical gas plasma-stimulated wound healing: Evidence and mechanisms
Bekeschus, S., von Woedtke, T., Emmert, S., & Schmidt, A. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102116 · Cited by 193 · see citing works
Daiber, A., & Chłopicki, S. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.02.026 · Cited by 169 · see citing works
Roles of reactive oxygen species in inflammation and cancer
Yu, Y., Liu, S., Yang, L., Song, P., Liu, Z., Liu, X., Yan, X., & Dong, Q. (2024) · MedComm · doi:10.1002/mco2.519 · Cited by 170 · see citing works
Namgaladze, D., & Brüne, B. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.09.002 · Cited by 162 · see citing works
Self-citationReactive Oxygen Species Bridge the Gap between Chronic Inflammation and Tumor Development
Yu, W., Tu, Y., Long, Z., Liu, J., Kong, D., Peng, J., Wu, H., Zheng, G., Zhao, J., Chen, Y., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2606928 · Cited by 161 · see citing works
Wenzel, P., Kossmann, S., Münzel, T. F., & Daiber, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.01.027 · Cited by 158 · see citing works
Yu, W., Wang, X., Zhao, J., Liu, R., Liu, J., Wang, Z., Peng, J., Wu, H., Zhang, X., Long, Z., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101761 · Cited by 158 · see citing works
Santa, F. D., Vitiello, L., Torcinaro, A., & Ferraro, E. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7420 · Cited by 154 · see citing works
Metabolic Regulation of Adipose Tissue Macrophage Function in Obesity and Diabetes
Appari, M., Channon, K. M., & McNeill, E. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7060 · Cited by 148 · see citing works
Cárdeno, A., Aparicio‐Soto, M., la Paz, S. M., Bermúdez, B., Muriana, F. J. G., & Alarcón‐de‐la‐Lastra, C. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.03.009 · Cited by 141 · see citing works
Tauzin, S., Starnes, T. W., Barros-Becker, F., Lam, P., & Anna Huttenlocher, A. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201408090 · Cited by 137 · see citing works
Zhang, Q., Wei, J., Liu, Z., Huang, X., Sun, M., Lai, W., Chen, Z., Wu, J., Chen, Y., Guo, X., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102367 · Cited by 135 · see citing works
Monocyte differentiation and macrophage polarization
Orekhov, A. N., Orekhova, V. A., Nikiforov, N. G., Myasoedova, V. A., Grechko, A. V., Romanenko, E. B., Zhang, D., & Chistiakov, D. A. (2019) · Vessel Plus · doi:10.20517/2574-1209.2019.04 · Cited by 137 · see citing works
Redox regulation of NF ‐κB p50 and M1 polarization in microglia
Taetzsch, T., Levesque, S., McGraw, C., Brookins, S., Luqa, R., Bonini, M. G., Mason, R. P., Oh, U., & Block, M. L. (2014) · Glia · doi:10.1002/glia.22762 · Cited by 134 · see citing works
The Muscle Stem Cell Niche in Health and Disease
Mashinchian, O., Pisconti, A., Moal, E. L., & Bentzinger, C. F. (2017) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2017.08.003 · Cited by 127 · see citing works
Sphingosine-1-Phosphate and Macrophage Biology—How the Sphinx Tames the Big Eater
Weigert, A., Olesch, C., & Brüne, B. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01706 · Cited by 127 · see citing works
Self-citationFarruggia, C., Kim, M., Bae, M., Lee, Y., Pham, T. X., Yang, Y. J., Han, M. J., Park, Y., & Lee, J. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.09.005 · Cited by 129 · see citing works
Daiber, A., Kröller‐Schön, S., Oelze, M. W., Hahad, O., Li, H., Schulz, R., Steven, S., & Münzel, T. F. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101506 · Cited by 130 · see citing works
Spermidine Protects against Oxidative Stress in Inflammation Models Using Macrophages and Zebrafish
Jeong, J., Cha, H., Han, M. H., Hwang, S. J., Lee, D.-S., Yoo, J. S., Choi, I., Kim, S., Kim, H., Kim, G., et al. (2017) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2016.272 · Cited by 125 · see citing works
Xu, W., Lu, H., Yuan, Y., Deng, Z., Zheng, L., & Li, H. (2022) · Foods · doi:10.3390/foods11162439 · Cited by 122 · see citing works
Enzymatic oxidative biodegradation of nanoparticles: Mechanisms, significance and applications
Vlasova, I. I., Kapralov, A. A., Michael, Z. P., Burkert, S. C., Shurin, M. R., Star, A., Shvedova, A. A., & Kagan, V. E. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.01.002 · Cited by 120 · see citing works
Herb, M., Gluschko, A., Wiegmann, K., Farid, A., Wolf, A., Utermöhlen, O., Krut, O., Krönke, M., & Schramm, M. (2019) · Science Signaling · doi:10.1126/scisignal.aar5926 · Cited by 119 · see citing works
Zhao, J.-L., Huang, F., He, F., Gao, C.-C., Liang, S.-Q., Ma, P., Dong, G.-Y., Han, H., & Qin, H.-Y. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2019 · Cited by 111 · see citing works
Mury, P., Chirico, E. N., Mura, M., Millon, A., Canet‐Soulas, E., & Pialoux, V. (2018) · Sports Medicine · doi:10.1007/s40279-018-0996-z · Cited by 112 · see citing works
Ondua, M., Njoya, E. M., Abdalla, M. A., & McGaw, L. J. (2018) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2018.12.030 · Cited by 113 · see citing works
Novais, F. O., Nguyen, B. T., Beiting, D. P., Carvalho, L. P., Glennie, N. D., Passos, S., Carvalho, E. M., & Scott, P. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu013 · Cited by 109 · see citing works
Role of Nrf2 in Synaptic Plasticity and Memory in Alzheimer’s Disease
Davies, D. A., Adlimoghaddam, A., & Albensi, B. C. (2021) · Cells · doi:10.3390/cells10081884 · Cited by 111 · see citing works
Kong, F., Lee, B. H., & Wei, K. (2019) · Molecules · doi:10.3390/molecules24020275 · Cited by 107 · see citing works
Bi, C., Wang, H., Wang, Y., Sun, J., Dong, J., Meng, X., & Li, J. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.03.044 · Cited by 105 · see citing works
Komatsu, W., Kishi, H., Yagasaki, K., & Ohhira, S. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.06.023 · Cited by 105 · see citing works
Ke, X., Chen, C., Song, Y., Cai, Q., Li, J., Tang, Y., Han, X., Qu, W., Chen, A., Wang, H., et al. (2019) · Oncology Letters · doi:10.3892/ol.2019.10956 · Cited by 104 · see citing works
Scott, T., Lewis, C., Zhu, M., Wang, C., Samuel, C. S., Drummond, G. R., & Kemp‐Harper, B. K. (2023) · Scientific Reports · doi:10.1038/s41598-023-46237-2 · Cited by 106 · see citing works
Xu, H., Hertzel, A. V., Steen, K. A., Wang, Q., Suttles, J., & Bernlohr, D. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.01122-14 · Cited by 103 · see citing works
Macrophage iron homeostasis and polarization in the context of cancer
Jung, M., Mertens, C., & Brüne, B. (2014) · Immunobiology · doi:10.1016/j.imbio.2014.09.011 · Cited by 103 · see citing works
Self-citationRole of Nrf2 and Autophagy in Acute Lung Injury
de la Vega, M. R., Dodson, M. B., Groß, C., Mansour, H. M., Lantz, R. C., Chapman, E., Wang, T., Black, S. M., Garcia, J. G. N., & Zhang, D. D. (2016) · Current Pharmacology Reports · doi:10.1007/s40495-016-0053-2 · Cited by 102 · see citing works
FABP4/aP2 Regulates Macrophage Redox Signaling and Inflammasome Activation via Control of UCP2
Steen, K. A., Xu, H., & Bernlohr, D. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00282-16 · Cited by 94 · see citing works
Zhang, B., Bailey, W. M., McVicar, A. L., & Gensel, J. C. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.07.029 · Cited by 95 · see citing works
Haber, M., Abdel Baki, S. G., Grin'kina, N. M., Irizarry, R., Ershova, A., Orsi, S., Grill, R. J., Dash, P., & Bergold, P. J. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.09.002 · Cited by 95 · see citing works
Barrett, J. P., Henry, R. J., Villapol, S., Stoica, B. A., Kumar, A., Burns, M. P., Faden, A. I., & Loane, D. J. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0843-4 · Cited by 91 · see citing works
M2 Polarization of Monocytes-Macrophages Is a Hallmark of Indian Post Kala-Azar Dermal Leishmaniasis
Mukhopadhyay, D., Mukherjee, S., Roy, S., Dalton, J. E., Kundu, S., Sarkar, A., Das, N. K., Kaye, P. M., & Chatterjee, M. (2015) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0004145 · Cited by 91 · see citing works
Tu, Y., Liu, J., Kong, D., Guo, X., Li, J., Long, Z., Peng, J., Wang, Z., Wu, H., Liu, P., et al. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.03.014 · Cited by 89 · see citing works
Reactive Oxygen Species‐Scavenging Nanomedicines for the Treatment of Oxidative Stress Injuries
Yoshitomi, T., & Nagasaki, Y. (2014) · Advanced Healthcare Materials · doi:10.1002/adhm.201300576 · Cited by 88 · see citing works
Cuadrado, A. (2021) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-052220-103416 · Cited by 86 · see citing works
Gopallawa, I., Freund, J. R., & Lee, R. J. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03494-y · Cited by 85 · see citing works
He, C., Larson‐Casey, J. L., Gu, L., Ryan, A. J., Murthy, S., & Carter, A. B. (2015) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2015-0183oc · Cited by 84 · see citing works
Tkaczenko, H., & Kurhaluk, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031098 · Cited by 80 · see citing works
Shao, M., Jin, X., Chen, S., Yang, N., & Feng, G. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115904 · Cited by 82 · see citing works
Wang, X., Hausding, M., Weng, S., Kim, Y. O., Steven, S., Klein, T., Daiber, A., & Schuppan, D. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6953 · Cited by 79 · see citing works
Macrophages potentiate STAT3 signaling in skeletal muscles and regulate pancreatic cancer cachexia
Shukla, S. K., Markov, S. D., Attri, K. S., Vernucci, E., King, R. J., Dasgupta, A., Grandgenett, P. M., Hollingsworth, M. A., Singh, P. K., Yu, F., et al. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.04.017 · Cited by 77 · see citing works
Jeong, J.-W., Hwang, S. J., Han, M. H., Lee, D.-S., Yoo, J. S., Choi, I., Cha, H., Kim, S., Kim, H., Kim, G., et al. (2017) · Molecular & Cellular Toxicology · doi:10.1007/s13273-017-0045-2 · Cited by 76 · see citing works
Thymoquinone: A Promising Natural Compound with Potential Benefits for COVID-19 Prevention and Cure
Badary, O. A., Hamza, M. S., & Tikamdas, R. (2021) · Drug Design Development and Therapy · doi:10.2147/dddt.s308863 · Cited by 76 · see citing works
Hou, L., Gan, F., Zhou, X., Zhou, Y., Qian, G., Liu, Z., & Huang, K. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.02.009 · Cited by 76 · see citing works
Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD
Lewis, B. W., Ford, M. L., Rogers, L. K., & Britt, R. D. (2021) · Antioxidants · doi:10.3390/antiox10091335 · Cited by 75 · see citing works
Bhokisham, N., VanArsdale, E. S., Stephens, K., Hauk, P., Payne, G. F., & Bentley, W. E. (2020) · Nature Communications · doi:10.1038/s41467-020-16249-x · Cited by 74 · see citing works
Bi, Z., Cai, Y., Shi, X., Chen, J., Li, D., Zhang, P., & Liu, J. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.150631 · Cited by 72 · see citing works
Shibata, N., Carlin, A. F., Spann, N. J., Saijo, K., Morello, C. S., McDonald, J. G., Romanoski, C. E., Maurya, M. R., Kaikkonen, M. U., Lam, M. T. Y., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.519637 · Cited by 72 · see citing works
Yin, G. N., Choi, M. J., Kim, W. J., Kwon, M., Song, K., Park, J., Das, N. D., Kwon, K., Batbold, D., Oh, G. T., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1403471111 · Cited by 72 · see citing works
Coelho, I., Duarte, N., Barros, A., Macedo, M. P., & Penha-Gonçalves, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.616044 · Cited by 70 · see citing works
Manzoni, A. G., Passos, D. F., da Silva, J. L. G., Bernardes, V. M., Bremm, J. M., Jantsch, M. H., de Oliveira, J. S., Mann, T. R., de Andrade, C. M., & Leal, D. B. R. (2018) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2018.12.005 · Cited by 70 · see citing works
Wei, K.-H., Lin, I.-T., Chowdhury, K., Lim, K. L., Liu, K., Ko, T., Chang, Y., Yang, K., & Lai, S.-L. (2023) · eLife · doi:10.7554/elife.84679 · Cited by 68 · see citing works
Fanelli, G. N., Grassini, D., Ortenzi, V., Pasqualetti, F., Montemurro, N., Perrini, P., Naccarato, A. G., & Scatena, C. (2021) · Genes · doi:10.3390/genes12030445 · Cited by 69 · see citing works
Targeting ROS production through inhibition of NADPH oxidases
Reis, J., Gorgulla, C., Massari, M., Marchese, S., Valente, S., Noce, B., Basile, L., Törner, R., Cox, H., Viennet, T., et al. (2023) · Nature Chemical Biology · doi:10.1038/s41589-023-01457-5 · Cited by 69 · see citing works
Effect of micro- and nanoplastic particles on human macrophages
Adler, M. Y., Issoual, I., Rückert, M., Deloch, L., Meier, C., Tschernig, T., Alexiou, C., Pfister, F., Ramsperger, A. F. R. M., Laforsch, C., et al. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.134253 · Cited by 69 · see citing works
Apoptotic cells enhance sphingosine‐1‐phosphate receptor 1 dependent macrophage migration
Weichand, B., Weis, N., Weigert, A., Grossmann, N., Levkau, B., & Brüne, B. (2013) · European Journal of Immunology · doi:10.1002/eji.201343441 · Cited by 68 · see citing works
Self-citationJin, J., & Yu, G. (2022) · World Journal of Surgical Oncology · doi:10.1186/s12957-022-02706-y · Cited by 67 · see citing works
Redox Regulation of Inflammatory Processes Is Enzymatically Controlled
Lorenzen, I., Mullen, L., Bekeschus, S., & Hanschmann, E.-M. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8459402 · Cited by 68 · see citing works
Håversen, L., Sundelin, J. P., Mardinoğlu, A., Rutberg, M., Ståhlman, M., Wilhelmsson, U., Hultén, L. M., Pekny, M., Fogelstrand, P., Bentzon, J. F., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-34659-2 · Cited by 64 · see citing works
Liu, Q., Zhuang, Y., Song, X., Niu, Q., Sun, Q., Li, X., Li, N., Liu, B., Huang, F., & Qiu, Z. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-00535-x · Cited by 65 · see citing works
How the redox state regulates immunity
Mullen, L., Mengozzi, M., Hanschmann, E.-M., Alberts, B. M., & Ghezzi, P. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.12.022 · Cited by 65 · see citing works
Oxidative Stress in Pulmonary Fibrosis
Otoupalova, E., Smith, S., Cheng, G., & Thannickal, V. J. (2020) · Comprehensive physiology · doi:10.1002/j.2040-4603.2020.tb00120.x · Cited by 65 · see citing works
Activity of antibacterial, antiviral, anti-inflammatory in compounds andrographolide salt
Li, W., Xia, N., Chen, X., Li, Y., Hong, Y., Liu, Y., Wang, Z., & Liu, Y. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.06.053 · Cited by 64 · see citing works
Modulatory role of dietary polyunsaturated fatty acids in Nrf2-mediated redox homeostasis
Abrescia, P., Treppiccione, L., Rossi, M., & Bergamo, P. (2020) · Progress in Lipid Research · doi:10.1016/j.plipres.2020.101066 · Cited by 64 · see citing works
Xu, H., Hao, S., Gan, F., Wang, H., Xu, J., Liu, D., & Huang, K. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.05.016 · Cited by 62 · see citing works
Aparicio‐Soto, M., Sánchez‐Fidalgo, S., González‐Benjumea, A., Maya, I., Fernández‐Bolaños, J. G., & Alarcón‐de‐la‐Lastra, C. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf503357s · Cited by 61 · see citing works
- Authors
- Brüne, B., Dehne, N., Grossmann, N., Jung, M., Namgaladze, D., Schmid, T., von Knethen, A., & Weigert, A.
- Affiliations
- Goethe University Frankfurt (DE)
- Faculty of Medicine, Institute of Biochemistry I–Pathobiochemistry, Goethe-University Frankfurt, Frankfurt, Germany.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2013-08-20
- Volume
- 19
- Issue
- 6
- Pages
- 595-637
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- PMC
- PMC3718318
- OpenAlex
- W2013150924
- Cited by
- 377
- References
- 352
- Citations by year
- 2026: 22 · 2025: 19 · 2024: 29 · 2023: 39 · 2022: 18 · 2021: 35 · 2020: 37 · 2019: 29 · 2018: 36 · 2017: 32 · 2016: 30 · 2015: 18 · 2014: 25 · 2013: 8
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antioxidants and Redox Signaling (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (SFB 815, BR999)
- Deutsche Krebshilfe (109599)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- macrophages, redox signaling, reactive oxygen species, macrophage polarization, inflammation, NADPH oxidase, mitochondrial reactive oxygen species, nitric oxide, hypoxia-inducible factor, Nrf2, PPARγ, macrophage reprogramming, M1 macrophages, M2 macrophages, antitumor immunity
- MeSH terms
- Animals, Humans, Inflammation, Macrophage Activation, Macrophages, Oxidation-Reduction, Signal Transduction, Cell Hypoxia, Reactive Oxygen Species, Oxidative Stress, Inflammation Mediators, Reactive Nitrogen Species
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