Kupffer cells in the liver

Exploring the full spectrum of macrophage activation

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Alternative activation of macrophages

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Monocyte and macrophage heterogeneity

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Obesity induces a phenotypic switch in adipose tissue macrophage polarization

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TLR4 links innate immunity and fatty acid-induced insulin resistance

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Complement

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The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

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Mechanisms of Hepatic Fibrogenesis

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Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection

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Transcriptional regulation of macrophage polarization: enabling diversity with identity

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Macrophage-specific PPARγ controls alternative activation and improves insulin resistance

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Human Fatty Liver Disease: Old Questions and New Insights

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IKK-β links inflammation to obesity-induced insulin resistance

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Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

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Liver regeneration: from myth to mechanism

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CCR2 modulates inflammatory and metabolic effects of high-fat feeding

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Local macrophage proliferation, rather than recruitment from the blood, is a signature of Th2 inflammation

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CCR2 modulates inflammatory and metabolic effects of high-fat feeding

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Macrophage-mediated inflammation in metabolic disease

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NODs: intracellular proteins involved in inflammation and apoptosis

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Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice

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The core gut microbiome, energy balance and obesity

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Cytokines in Alcoholic and Nonalcoholic Steatohepatitis

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Function of Nod‐like receptors in microbial recognition and host defense

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Antigen-presenting cell function in the tolerogenic liver environment

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Enteric dysbiosis associated with a mouse model of alcoholic liver disease

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Krüppel-like factor 4 regulates macrophage polarization

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Functional plasticity of macrophages: reversible adaptation to changing microenvironments

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Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

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Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice

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Toll‐like receptor‐4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non‐alcoholic steatohepatitis

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The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

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CRIg: A Macrophage Complement Receptor Required for Phagocytosis of Circulating Pathogens

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Inactivation of Kupffer cells prevents early alcohol-induced liver injury

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Complement: a unique innate immune sensor for danger signals

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Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients

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Increased tumor necrosis factor production by monocytes in alcoholic hepatitis

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Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess

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Epidemiology of Alcoholic Liver Disease

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Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance

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NADPH oxidase–derived free radicals are key oxidants in alcohol-induced liver disease

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Oxidants and antioxidants in alcohol-induced liver disease

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Scar-Associated Macrophages Are a Major Source of Hepatic Matrix Metalloproteinase-13 and Facilitate the Resolution of Murine Hepatic Fibrosis

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Ethanol, oxidative stress, and cytokine-induced liver cell injury

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Endotoxemia and gut barrier dysfunction in alcoholic liver disease†

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Kupffer cells in non-alcoholic fatty liver disease: The emerging view

Baffy, G. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.03.008 · Cited by 475 · see citing works

Plasma endotoxin concentrations in patients with alcoholic and non-alcoholic liver disease: reevaluation with an improved chromogenic assay

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Kupffer Cells Promote Hepatic Steatosis Via Interleukin-1β–Dependent Suppression of Peroxisome Proliferator-Activated Receptor α Activity

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CONSEQUENCES OF ALCOHOL CONSUMPTION ON HOST DEFENCE

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Alcohol as a Risk Factor for Global Burden of Disease

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The role of extracellular matrix in postinflammatory wound healing and fibrosis

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The critical role of toll‐like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88†

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Up-regulation of MicroRNA-155 in Macrophages Contributes to Increased Tumor Necrosis Factor α (TNFα) Production via Increased mRNA Half-life in Alcoholic Liver Disease

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II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin

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Intestinal Dysbiosis: A Possible Mechanism of Alcohol‐Induced Endotoxemia and Alcoholic Steatohepatitis in Rats

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Identifying Functional MicroRNAs in Macrophages with Polarized Phenotypes

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Protective Role of Kupffer Cells in Acetaminophen-Induced Hepatic Injury in Mice

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Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats

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Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species

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Mechanisms of drug-induced liver injury

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Toll-like receptors as targets in chronic liver diseases

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Limiting inflammatory responses during activation of innate immunity

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C-C Chemokine Receptor 2 (CCR2) Regulates the Hepatic Recruitment of Myeloid Cells That Promote Obesity-Induced Hepatic Steatosis

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Exacerbation of Alcoholic Liver Injury by Enteral Endotoxin in Rats

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Nucleotide-Binding Oligomerization Domain-2 Modulates Specific TLR Pathways for the Induction of Cytokine Release

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Alcohol, host defence and society

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Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice

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Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans

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Molecular Mechanism for Adiponectin-dependent M2 Macrophage Polarization

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Mechanisms of macrophage activation in obesity-induced insulin resistance

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The role of kupffer cell oxidant production in early ethanol-induced liver disease,

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Differential liver sensitization to Toll-like receptor pathways in mice with alcoholic fatty liver

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The hepatic extracellular matrix

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Nuclear factor high-mobility group box1 mediating the activation of toll-like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice

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Obesity, diabetes mellitus, and liver fibrosis

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Molecular Mechanisms of Liver Fibrogenesis – A Homage to the Role of Activated Fat-Storing Cells

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Recent Insights into the Role of the Innate Immune System in the Development of Alcoholic Liver Disease

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Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog

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Endocannabinoids in liver disease

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The C3a Anaphylatoxin Receptor Is a Key Mediator of Insulin Resistance and Functions by Modulating Adipose Tissue Macrophage Infiltration and Activation

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Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice

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Role of tumor-associated macrophages in the progression of hepatocellular carcinoma

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