The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Temperature-Acclimated Brown Adipose Tissue Modulates Insulin Sensitivity in Humans
Open accessAbstract
In rodents, brown adipose tissue (BAT) regulates cold- and diet-induced thermogenesis (CIT; DIT). Whether BAT recruitment is reversible and how it impacts on energy metabolism have not been investigated in humans. We examined the effects of temperature acclimation on BAT, energy balance, and substrate metabolism in a prospective crossover study of 4-month duration, consisting of four consecutive blocks of 1-month overnight temperature acclimation (24°C [month 1] → 19°C [month 2] → 24°C [month 3] → 27°C [month 4]) of five healthy men in a temperature-controlled research facility. Sequential monthly acclimation modulated BAT reversibly, boosting and suppressing its abundance and activity in mild cold and warm conditions (P < 0.05), respectively, independent of seasonal fluctuations (P < 0.01). BAT acclimation did not alter CIT but was accompanied by DIT (P < 0.05) and postprandial insulin sensitivity enhancement (P < 0.05), evident only after cold acclimation. Circulating and adipose tissue, but not skeletal muscle, expression levels of leptin and adiponectin displayed reciprocal changes concordant with cold-acclimated insulin sensitization. These results suggest regulatory links between BAT thermal plasticity and glucose metabolism in humans, opening avenues to harnessing BAT for metabolic benefits.
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Brown Adipose Tissue: Function and Physiological Significance
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Mapping of human brown adipose tissue in lean and obese young men
Leitner, B. P., Huang, S., Brychta, R. J., Duckworth, C. J., Baskin, A. S., McGehee, S., Tal, I., Dieckmann, W., Gupta, G., Kolodny, G. M., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705287114 · Cited by 530
Impaired adipogenesis and dysfunctional adipose tissue in human hypertrophic obesity
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Metadata
- Authors
- Lee, P., Smith, S., Linderman, J., Courville, A. B., Brychta, R. J., Dieckmann, W., Werner, C. D., Chen, K. Y., & Celi, F. S.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2014-10-13
- Volume
- 63
- Issue
- 11
- Pages
- 3686-3698
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2134757118
- Cited by
- 398
- References
- 52
- FWCI
- 25.07
- Type
- journal article
- Language
- en
- Open access
- green
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