Exosomes From Adipose-Derived Stem Cells Attenuate Adipose Inflammation and Obesity Through Polarizing M2 Macrophages and Beiging in White Adipose Tissue

Obesity is associated with macrophage accumulation in adipose tissue

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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

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Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

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Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

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Obesity and Diabetes in the Developing World — A Growing Challenge

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Adipose tissue remodeling and obesity

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Adipocyte‐derived extracellular vesicles in health and diseases: Nano‐packages with vast biological properties

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Cargo proteins in extracellular vesicles: potential for novel therapeutics in non-alcoholic steatohepatitis

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Recent advances of exosomes in soft tissue injuries in sports medicine: A critical review on biological and biomaterial applications

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Contributions of innate type 2 inflammation to adipose function

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Immune Cells Gate White Adipose Tissue Expansion

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Electrospun nanoyarn and exosomes of adipose-derived stem cells for urethral regeneration: Evaluations in vitro and in vivo

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The Role of Mesenchymal Stromal Cells-Derived Small Extracellular Vesicles in Diabetes and Its Chronic Complications

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The role of adipose-derived stem cells-derived extracellular vesicles in the treatment of diabetic foot ulcer: Trends and prospects

Deng, H., & Chen, Y. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.902130 · Cited by 39

Current Status and Prospect of Delivery Vehicle Based on Mesenchymal Stem Cell-Derived Exosomes in Liver Diseases

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Zinc oxide nanoparticles exacerbate skin epithelial cell damage by upregulating pro-inflammatory cytokines and exosome secretion in M1 macrophages following UVB irradiation-induced skin injury

Wang, B.-J., Chen, Y., Chang, H.-H., Chen, R.-J., Wang, Y., & Lee, Y. (2024) · Particle and Fibre Toxicology · doi:10.1186/s12989-024-00571-z · Cited by 38

Exosomes and Signaling Nanovesicles from the Nanofiltration of Preconditioned Adipose Tissue with Skin-B® in Tissue Regeneration and Antiaging: A Clinical Study and Case Report

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Obesity and Adipose-Derived Extracellular Vesicles: Implications for Metabolic Regulation and Disease

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Extracellular vesicles as critical mediators of maternal-fetal communication during pregnancy and their potential role in maternal metabolism

Nair, S., & Salomón, C. (2020) · Placenta · doi:10.1016/j.placenta.2020.06.011 · Cited by 37

Injection of Leukocyte‐Poor Platelet‐Rich Plasma for Moderate‐to‐Large Rotator Cuff Tears Does Not Improve Clinical Outcomes but Reduces Retear Rates and Fatty Infiltration: A Prospective, Single‐Blinded Randomized Study

Zhang, C., Cai, Y., & Wang, Y. (2022) · Arthroscopy The Journal of Arthroscopic and Related Surgery · doi:10.1016/j.arthro.2022.02.007 · Cited by 37

Supplementation with Extracellular Vesicles Derived from Adipose-Derived Stem Cells Increases Fat Graft Survival and Browning in Mice: A Cell-Free Approach to Construct Beige Fat from White Fat Grafting

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Advances in Mesenchymal stem cells regulating macrophage polarization and treatment of sepsis-induced liver injury

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Mesenchymal Stem Cell‐Derived Exosomes: A Promising Therapeutic Strategy for Age‐Related Diseases

Wei, B., Wei, M., Huang, H., Fan, T., Zhang, Z., & Song, X. (2024) · Cell Proliferation · doi:10.1111/cpr.13795 · Cited by 39

Adipose-Derived Exosomes as Possible Players in the Development of Insulin Resistance

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Adipose Mesenchymal Stromal Cell‐Derived Exosomes Prevent Testicular Torsion Injury via Activating PI3K/AKT and MAPK/ERK1/2 Pathways

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Exosome-Like Vesicles as New Mediators and Therapeutic Targets for Treating Insulin Resistance and β-Cell Mass Failure in Type 2 Diabetes Mellitus

Ge, Q., Xie, X., Xiao, X., & Li, X. (2019) · Journal of Diabetes Research · doi:10.1155/2019/3256060 · Cited by 35

The crosstalk between macrophages and bone marrow mesenchymal stem cells in bone healing

Wang, Y., Zhao, C., Wang, R.-Y., Du, Q.-X., Liu, J., & Pan, J. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03199-y · Cited by 35

Mesenchymal stem cell derived extracellular vesicles: Promising immunomodulators against autoimmune, autoinflammatory disorders and SARS-CoV-2 infection

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Human adipose tissue-derived small extracellular vesicles promote soft tissue repair through modulating M1-to-M2 polarization of macrophages

Dong, J., Wu, B., & Tian, W. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03306-7 · Cited by 34

The therapeutic effects of adipose-derived mesenchymal stem cells on obesity and its associated diseases in diet-induced obese mice

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Exosomes contribution in COVID-19 patients’ treatment

Mazini, L., Rochette, L., & Malka, G. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02884-5 · Cited by 34

The Therapeutic Role of ADSC-EVs in Skin Regeneration

Wang, Y., Cheng, L., Zhao, H., Li, Z., Chen, J., Cen, Y., & Zhang, Z. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.858824 · Cited by 34

Cancer cell-derived exosomal LINC00313 induces M2 macrophage differentiation in non-small cell lung cancer

Kong, W., Zhang, L., Chen, Y., Yu, Z., & Zhao, Z. (2022) · Clinical & Translational Oncology · doi:10.1007/s12094-022-02907-7 · Cited by 34

Therapeutic Potential of Extracellular Vesicles in Aging and Age-Related Diseases

Sanz‐Ros, J., Mas‐Bargues, C., Romero-García, N., Huete-Acevedo, J., Dromant, M., & Borrás, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314632 · Cited by 35

Small extracellular vesicles from Ptpn1-deficient macrophages alleviate intestinal inflammation by reprogramming macrophage polarization via lactadherin enrichment

Han, D., Lu, D., Huang, S., Pang, J., Wu, Y., Hu, J., Zhang, X., Pi, Y., Zhang, G., & Wang, J. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102558 · Cited by 34

Adipose-derived extracellular vesicles – a novel cross-talk mechanism in insulin resistance, non-alcoholic fatty liver disease, and polycystic ovary syndrome

Mladenović, D. R., Vesković, M. N., Šutulović, N., Hrnčić, D., Stanojlović, O. P., Radić, L., Macut, J. B., & Μacut, D. (2024) · Endocrine · doi:10.1007/s12020-024-03702-w · Cited by 32

Photoaging Skin Therapy with PRP and ADSC: A Comparative Study

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Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Enhance Insulin Sensitivity in Insulin Resistant Human Adipocytes

Chen, M., Zhao, Y., Zhou, L., Li, M., Zhang, Q., Han, Q., & Xiao, X. (2021) · Current Medical Science · doi:10.1007/s11596-021-2323-4 · Cited by 32

Multifaceted Roles of Adipose Tissue-Derived Exosomes in Physiological and Pathological Conditions

Liu, Y., Wang, C., Wei, M., Yang, G., & Yuan, L. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.669429 · Cited by 32

Deconstructing Adipose Tissue Heterogeneity One Cell at a Time

Duerre, D. J., & Galmozzi, A. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.847291 · Cited by 35

Pro-Inflammatory Priming of Umbilical Cord Mesenchymal Stromal Cells Alters the Protein Cargo of Their Extracellular Vesicles

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Mesenchymal stem cell‐derived extracellular vesicles: Recent therapeutics and targeted drug delivery advances

Bhat, A., Malik, A., Yadav, P., Ware, W. J., Kakalij, P., & Chand, S. (2024) · Journal of Extracellular Biology · doi:10.1002/jex2.156 · Cited by 34

Epigenetic regulatory mechanism of macrophage polarization in diabetic wound healing (Review)

Song, J., Wu, Y., Chen, Y., Sun, X., & Zhang, Z. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13367 · Cited by 34

Adipose progenitor cell-derived extracellular vesicles suppress macrophage M1 program to alleviate midlife obesity

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A review of adipose-derived mesenchymal stem cells‘ impacts and challenges: metabolic regulation, tumor modulation, immunomodulation, regenerative medicine and genetic engineering therapies

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The Potential Role of Exosomes in Child and Adolescent Obesity

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Exosomal non coding RNAs as a novel target for diabetes mellitus and its complications

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Adipose Tissue Dysfunction and the Role of Adipocyte-Derived Extracellular Vesicles in Obesity and Metabolic Syndrome

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The anti-obesity effects of rhein on improving insulin resistance (IR) and blood lipid levels are involved in endoplasmic reticulum stress (ERs), inflammation, and oxidative stress in vivo and vitro

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Emerging Potential of Exosomes on Adipogenic Differentiation of Mesenchymal Stem Cells

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Adipose-derived exosomes block muscular stem cell proliferation in aged mouse by delivering miRNA Let-7d-3p that targets transcription factor HMGA2

Itokazu, M., Onodera, Y., Mori, T., Inoue, S., Yamagishi, K., Moritake, A., Iwawaki, N., Shigi, K., Takehara, T., Higashimoto, Y., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102098 · Cited by 29

The role and mechanisms of mesenchymal stem cells regulating macrophage plasticity in spinal cord injury

Fu, S.-P., Wu, X.-C., Yang, R., Zhao, D., Cheng, J., Hu, Q., Ao, J., Zhang, Q., & Zhang, T. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115632 · Cited by 30

Key milestones in the diabetes research: A comprehensive update

Gupta, A. K., Behl, T., & Sachdeva, M. (2020) · Obesity Medicine · doi:10.1016/j.obmed.2020.100183 · Cited by 29

Endothelial and macrophage interactions in the angiogenic niche

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Low proliferative potential of adipose-derived stromal cells associates with hypertrophy and inflammation in subcutaneous and omental adipose tissue of patients with type 2 diabetes mellitus

Stafeev, I., Podkuychenko, N. V., Michurina, S. S., Sklyanik, I. A., Сергеевна, П. А., Shestakova, E. A., YAHYAEV, K., Fedenko, V., Ratner, E. I., Vorotnikov, A. V., et al. (2018) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2018.10.011 · Cited by 30

Clinical Potential of Extracellular Vesicles in Type 2 Diabetes

Liu, J., Sun, X., Zhang, F.-L., Jin, H., Yan, X., Huang, S., Guo, Z., & Yang, Y. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.596811 · Cited by 30

Research Progress in the Application of Exosomes in Immunotherapy

Zhang, X., Xu, D., Song, Y., Rong, H., & Wang, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.731516 · Cited by 29

Exosomal noncoding RNA-mediated spatiotemporal regulation of lipid metabolism: Implications in immune evasion and chronic inflammation

Hegde, M., Kumar, A., Girisa, S., Alqahtani, M. S., Abbas, M. A. E., Goel, A., Hui, K. M., Sethi, G., & Kunnumakkara, A. B. (2023) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2023.06.001 · Cited by 28

Exosomes as Mediators of Cell-to-Cell Communication in Thyroid Disease

Wang, Y., Xu, F., Zhong, J., Lin, X., Shan, S., Guo, B., Zheng, M.-H., & Yuan, L. (2020) · International Journal of Endocrinology · doi:10.1155/2020/4378345 · Cited by 28

Exosomes as Promising Therapeutic Tools for Regenerative Endodontic Therapy

Kong, Q., Wang, Y., Jiang, N., Wang, Y., Wang, R., Hu, X., Mao, J., & Shi, X. (2024) · Biomolecules · doi:10.3390/biom14030330 · Cited by 27

Exosomes regulate SIRT3-related autophagy by delivering miR-421 to regulate macrophage polarization and participate in OSA-related NAFLD

Yang, L., Liu, S., He, Y., Gan, L., Ni, Q., Dai, A., Mu, C., Liu, Q., Chen, H., Lu, H., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05283-8 · Cited by 27

Extracellular Vesicle-Mediated Network in the Pathogenesis of Obesity, Diabetes, Steatotic Liver Disease, and Cardiovascular Disease

Lee, J., Choi, W. G., Rhee, M., & Lee, S. (2025) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2025.0184 · Cited by 31

Mitochondrial Dysfunction in the Development and Progression of Cardiometabolic Diseases: A Narrative Review

Pliouta, L., Lampsas, S., Kountouri, A., Korakas, E., Thymis, J., Kassi, E. N., Oikonomou, E. K., Ikonomidis, I., & Lambadiari, V. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14113706 · Cited by 27

Inhibitory effect of melatonin on Mst1 ameliorates myocarditis through attenuating ER stress and mitochondrial dysfunction

Ouyang, H., Zhong, J., Lu, J., Zhong, Y., Hu, Y., & Tan, Y. (2019) · Journal of Molecular Histology · doi:10.1007/s10735-019-09836-w · Cited by 27

Intercellular and inter-organ crosstalk in browning of white adipose tissue: molecular mechanism and therapeutic complications

Cheong, L. Y., & Xu, A. (2021) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjab038 · Cited by 28

Label-free spectroscopic characterization of exosomes reveals cancer cell differentiation

Romanò, S., Giacinto, F. D., Primiano, A., Gervasoni, J., Mazzini, A., Papi, M., Urbani, A., Serafino, A., Spirito, M. D., Krasnowska, E. K., et al. (2021) · Analytica Chimica Acta · doi:10.1016/j.aca.2021.339359 · Cited by 29

Peripheral and central macrophages in obesity

Mukherjee, S., Skrede, S., Haugstøyl, M. E., López, M., & Fernø, J. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1232171 · Cited by 27

Role and therapeutic perspectives of extracellular vesicles derived from liver and adipose tissue in metabolic dysfunction-associated steatotic liver disease

Li, W., & Yu, L. (2024) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2024.2360008 · Cited by 27

Bioactive Materials That Promote the Homing of Endogenous Mesenchymal Stem Cells to Improve Wound Healing

Jiang, Z., Chen, L., Huang, L., Yu, S., Lin, J., Li, M., Gao, Y., & Yang, L. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s455469 · Cited by 28

Exosomes are the novel players involved in the beneficial effects of exercise on type 2 diabetes

Li, G., Liu, H., Ma, C., Chen, Y., Wang, J., & Yang, Y. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28319 · Cited by 28

Hybrid lipid nanoparticles derived from human mesenchymal stem cell extracellular vesicles by microfluidic sonication for collagen I mRNA delivery to human tendon progenitor stem cells

Tello, R. P., Lamparelli, E. P., Ciardulli, M. C., Hirvonen, J. J., Barreto, G., Maffulli, N., Porta, G. D., & Santos, H. A. (2025) · Biomaterials Science · doi:10.1039/d4bm01405g · Cited by 28

The Application of Exosomes From Different Sources Loaded with Natural Small-Molecule Compounds in Disease

Zhang, L., Shi, C., Lan, Y., Zhang, X., Ji, X., Li, L., He, X., Tan, Y., Zhao, N., & Lu, C. C. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s542641 · Cited by 28

Perivascular Adipose-Derived Exosomes Reduce Foam Cell Formation by Regulating Expression of Cholesterol Transporters

Liu, Y., Sun, Y., Lin, X., Zhang, D., Hu, C., Liu, J., Zhu, Y., Gao, A., Han, H., Chai, M., et al. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.697510 · Cited by 26

Effects of Adipose-Derived Biogenic Nanoparticle-Associated microRNA-451a on Toll-like Receptor 4-Induced Cytokines

Wang, X., Pham, A. N., Kang, L., Walker, S. A., Davidovich, I., Iannotta, D., TerKonda, S. P., Shapiro, S. A., Talmon, Y., Pham, S. M., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics14010016 · Cited by 26

A “cell-free treatment” for tendon injuries: adipose stem cell-derived exosomes

Lyu, K., Liu, T., Chen, Y., Lu, J., Jiang, L., Liu, X., Liu, X., Li, Y., & Li, S. (2022) · European journal of medical research · doi:10.1186/s40001-022-00707-x · Cited by 26

Current, emerging, and potential therapies for non-alcoholic steatohepatitis

Yang, Z. L., & Wang, L. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1152042 · Cited by 26

Regulation of Energy Expenditure and Brown/Beige Thermogenic Activity by Interleukins: New Roles for Old Actors

Garcia, M. D. C., Pazos, P., Lima, L., & Diéguez, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092569 · Cited by 27

Extracellular vesicles in age-related diseases: disease pathogenesis, intervention, and biomarker

Putri, P. H. L., Alamudi, S. H., Dong, X., & Fu, Y. L. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04374-7 · Cited by 25

Azithromycin Affords Neuroprotection in Rat Undergone Transient Focal Cerebral Ischemia

Amantea, D., Petrelli, F., Greco, R., Tassorelli, C., Corasaniti, M. T., Tonin, P., & Bagetta, G. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01256 · Cited by 25

Liver regeneration and alcoholic liver disease

Lv, Y., So, K., & Xiao, J. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2020.02.168 · Cited by 25

Diverse RNAs in adipose-derived extracellular vesicles and their therapeutic potential

Hong, P., Yu, M., & Tian, W. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.08.028 · Cited by 26

The therapeutic effect of adipose-derived stem cells on soft tissue injury after radiotherapy and their value for breast reconstruction

Tang, H., He, Y., Liang, Z., Li, J., Dong, Z., & Liao, Y. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02952-7 · Cited by 25

Novel cell-based therapies in inflammatory bowel diseases: the established concept, promising results

Hossein‐Khannazer, N., Torabi, S., Hosseinzadeh, R., Shahrokh, S., Aghdaei, H. A., Memarnejadian, A., Kadri, N., & Vosough, M. (2021) · Human Cell · doi:10.1007/s13577-021-00560-w · Cited by 25

Immunity in adipose tissues: Cutting through the fat

Randall, T. D., & Meza‐Perez, S. (2024) · Immunological Reviews · doi:10.1111/imr.13344 · Cited by 26

Mesenchymal stromal cell-derived extracellular vesicles therapy openings new translational challenges in immunomodulating acute liver inflammation

Sitbon, A., Delmotte, P.-R., Pistorio, V., Halter, S., Gallet, J., Gautheron, J., & Monsel, A. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05282-9 · Cited by 24

Obesity-associated macrophages dictate adipose stem cell ferroptosis and visceral fat dysfunction by propagating mitochondrial fragmentation

Tao, Y., Zang, J., Wang, T., Song, P., Zhou, Z., Li, H., Wang, Y., Liu, Y., Jie, H., Kuang, M., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62690-1 · Cited by 24

Signaling pathways of adipose stem cell-derived exosomes promoting muscle regeneration

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Resveratrol-enriched grape seed oil (Vitis vinifera L.) protects from white fat dysfunction in obese mice

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