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Exosomes From Adipose-Derived Stem Cells Attenuate Adipose Inflammation and Obesity Through Polarizing M2 Macrophages and Beiging in White Adipose Tissue
Abstract
Adipose-derived stem cells (ADSCs) play critical roles in controlling obesity-associated inflammation and metabolic disorders. Exosomes from ADSCs exert protective effects in several diseases, but their roles in obesity and related pathological conditions remain unclear. In this study, we showed that treatment of obese mice with ADSC-derived exosomes facilitated their metabolic homeostasis, including improved insulin sensitivity (27.8% improvement), reduced obesity, and alleviated hepatic steatosis. ADSC-derived exosomes drove alternatively activated M2 macrophage polarization, inflammation reduction, and beiging in white adipose tissue (WAT) of diet-induced obese mice. Mechanistically, exosomes from ADSCs transferred into macrophages to induce anti-inflammatory M2 phenotypes through the transactivation of arginase-1 by exosome-carried active STAT3. Moreover, M2 macrophages induced by ADSC-derived exosomes not only expressed high levels of tyrosine hydroxylase responsible for catecholamine release, but also promoted ADSC proliferation and lactate production, thereby favoring WAT beiging and homeostasis in response to high-fat challenge. These findings delineate a novel exosome-mediated mechanism for ADSC–macrophage cross talk that facilitates immune and metabolic homeostasis in WAT, thus providing potential therapy for obesity and diabetes.
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“The smart exosomes reduced WAT inflammation, improved energy expenditure and resilience to obesity progression [136].”
From Exosome for mRNA delivery: Strategies and therapeutic applications (2024) · cites this paper as [136]
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Cites
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles
Colombo, M., Raposo, G., & Théry, C. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122326 · Cited by 6,186
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664
Extracellular vesicles: biology and emerging therapeutic opportunities
EL Andaloussi, S., Mäger, I., Breakefield, X. O., & Wood, M. J. A. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3978 · Cited by 3,571
Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
Wu, J., Boström, P., Sparks, L. M., Li, Y., Choi, J. H., Giang, A.-H., Khandekar, M. J., Virtanen, K. A., Nuutila, P., Schaart, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.05.016 · Cited by 3,406
Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury
Lai, R. C., Arslan, F., Lee, M. M., Sze, N. S. K., Choo, A., Chen, T. S., Salto-Tellez, M., Timmers, L., Lee, C. N., El Oakley, R. M., et al. (2010) · Stem Cell Research · doi:10.1016/j.scr.2009.12.003 · Cited by 2,215
Obesity and Diabetes in the Developing World — A Growing Challenge
Hossain, P., Kawar, B., & El Nahas, M. (2007) · New England Journal of Medicine · doi:10.1056/nejmp068177 · Cited by 2,200
Adipose tissue remodeling and obesity
Sun, K., Kusminski, C. M., & Scherer, P. E. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45887 · Cited by 1,941
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Castaño, C., Novials, A., & Párrizas, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032071 · Cited by 14
Adipocyte-Derived Extracellular Vesicles: Small Vesicles with Big Impact
Li, Y., Xue Ming, T. A. N. G., Gu, Y., & Zhou, G. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2807149 · Cited by 13
Wang, S., Zhang, L., Jin, Z., Wang, Y., Zhang, B., & Zhao, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1194738 · Cited by 13
Self-citationPan, S., Chen, Y., Yan, J., Li, F., Chen, X., Xu, X., & Hua, X. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.975334 · Cited by 13
Macrophage Phenotypic Switch and Obesity‐Associated Metabolic Risk: Mechanisms and Targets
Vera, K., Hemakumar, C., Bilachi, R. S., Ramírez, D. C., & Gomez-Mejiba, S. (2025) · Oxidative Medicine and Cellular Longevity · doi:10.1155/omcl/6710641 · Cited by 12
Liu, C., Liu, X., Li, H., & Kang, Z. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1173904 · Cited by 12
Yang, F., Li, Z., Cai, Z., He, Y., Chen, K., Wang, J., Lin, M. S., & Li, L. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s435106 · Cited by 12
Self-citationDiStefano, J. K., Piras, I. S., Wu, X., Sharma, R., Garcia‐Mansfield, K., Willey, M., Lovell, B., Pirrotte, P., Olson, M. L., & Shaibi, G. Q. (2024) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2024.02.024 · Cited by 12
Regulatory role of exosome-derived miRNAs and other contents in adipogenesis
Song, X., Song, Y., Zhang, J., Hu, Y., Zhang, L., Huang, Z., Raza, S. H. A., Jiang, C., Ma, Y., Ma, Y., et al. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.114168 · Cited by 12
Self-citationYin, J., Zhu, Y., Liu, R., Wang, W., Wang, Z., & Wang, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1599956 · Cited by 12
The Development of Extracellular Vesicle-Integrated Biomaterials for Bone Regeneration
Zhou, Y., & Xiao, Y. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-3262-7_7 · Cited by 12
Signal transduction mechanism of exosomes in diabetic complications (Review)
Li, X., Shi, S., Jing, D., Li, X., Zhang, B., & Bie, Q. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.11078 · Cited by 12
Koivunotko, E., Kiiskinen, J., Merivaara, A., Harjumäki, R., Rautiainen, S., Kelloniemi, M., Kuismanen, K., Miettinen, S., Yliperttula, M. L., & Koivuniemi, R. (2022) · Biomedicines · doi:10.3390/biomedicines10102584 · Cited by 14
Li, Q., Li, Q., Hao, Z., Zheng, X., & He, W. (2018) · RSC Advances · doi:10.1039/c8ra02923g · Cited by 12
Anti-obesity effect and mechanism of mesenchymal stem cells influence on obese mice
Xie, Z., Cheng, Y., Zhang, Q., Hao, H., Yin, Y., Zang, L., Wang, X., & Mu, Y. (2021) · Open Life Sciences · doi:10.1515/biol-2021-0061 · Cited by 12
Self-citationAdipose tissue and adipose secretome in systemic sclerosis
Brezovec, N., Burja, B., & Lakota, K. (2021) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000838 · Cited by 12
Zheng, Q., Zhang, J., Liu, Y., Dong, W., Dai, X., Du, X., & Gu, D. (2023) · Clinical & Translational Oncology · doi:10.1007/s12094-023-03185-7 · Cited by 11
Sharifi‐Zahabi, E., Hajizadeh‐Sharafabad, F., Nachvak, S. M., Mirzaeian, S., Darbandi, S., & Shidfar, F. (2023) · Phytotherapy Research · doi:10.1002/ptr.7916 · Cited by 11
Yang, H., Li, C., Che, M., Liang, J., Tian, X., Yang, G., & Sun, C. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.128852 · Cited by 11
Wang, Q., Hartig, S. M., Ballantyne, C. M., & Wu, H. (2024) · Immunological Reviews · doi:10.1111/imr.13338 · Cited by 11
Self-citationSigdel, S., Udoh, G., Albalawy, R., & Wang, J. (2024) · Cells · doi:10.3390/cells13161309 · Cited by 12
Carciero, L., Giuseppe, G. D., Piazza, E. D., Parand, E., Soldovieri, L., Ciccarelli, G., Brunetti, M., Gasbarrini, A., Nista, E. C., Pani, G., et al. (2024) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2024.111837 · Cited by 11
The Potential of Mesenchymal Stem Cell-Derived Exosomes to Treat Diabetes Mellitus
Kim, J.-E., Lee, J. W., Cha, G. D., & Yoon, J. (2025) · Biomimetics · doi:10.3390/biomimetics10010049 · Cited by 11
Long, Q., Liu, C., Zheng, H., Wang, M., Liu, H., Liu, Y., Cao, Z., Sun, Y., Mo, Q., Backman, L. J., et al. (2025) · Advanced Science · doi:10.1002/advs.202417447 · Cited by 11
Zhu, Y., Fang, X., Zhang, S., Liao, Y., Lin, H., Chen, P., Yang, M., Huang, J. J., & Wang, X. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s589123 · Cited by 14
Zhu, L., Feng, Z., Shu, X. Y., Gao, Q., Wu, J., Du, Z., Li, R., Wang, L., Chen, N., Li, Y., et al. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02494-4 · Cited by 11
Extracellular Vesicles in Pathogenesis and Treatment of Metabolic Associated Fatty Liver Disease
Sun, J., Zhang, D., & Li, Y. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.909518 · Cited by 12
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Lee, J., Jeong, I., & Kim, O. (2022) · Nutrients · doi:10.3390/nu14235124 · Cited by 12
Knowledge mapping of exosomes in metabolic diseases: a bibliometric analysis (2007-2022)
Xu, F., Xia, C., Dou, L., & Huang, X. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1176430 · Cited by 11
Turano, E., Scambi, I., Bonafede, R., Dusi, S., Angelini, G., Lopez, N., Marostica, G., Rossi, B., Furlan, R., Constantin, G., et al. (2024) · Cytotherapy · doi:10.1016/j.jcyt.2023.12.007 · Cited by 11
English, J., Orofino, J., Cederquist, C., Paul, I., Li, H., Auwerx, J. H., Emili, A., Belkina, A. C., Cardamone, M. D., & Perissi, V. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101682 · Cited by 11
Karam, M., Najjar, H., El-Sabban, M. E., Hamadé, A., & Najjar, F. (2023) · Stem Cell Reviews and Reports · doi:10.1007/s12015-023-10505-5 · Cited by 10
Souza, I. L. M., Suzukawa, A. A., Josino, R., Marcon, B. H., Robert, A. W., Shigunov, P., Correa, A., & Stimamiglio, M. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147605 · Cited by 10
Li, P. A., Cao, L., Liu, T., Lu, X., Ma, Y., & Wang, H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020479 · Cited by 10
Wang, Z., Ren, Y., Li, Y., Zhang, Y., Bai, S., Hou, W., Zhang, W., Yao, Y., Zhao, H., Wang, M., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114107 · Cited by 10
Self-citationWang, B., Pi, Q., Mohsin, A., Gao, W., Guo, M., & Xu, H. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.05.049 · Cited by 10
Wang, Y., Hu, M., Spanos, M., Xu, S., Song, J., Li, G., Crețoiu, D., & Xiao, J. (2026) · 中国科学通报：英文版 · doi:10.1016/j.scib.2026.01.067 · Cited by 10
Goudreau, A. D., Everest, C., Nagpal, T. S., Puranda, J. L., Bhattacharjee, J., Vasanthan, T., & Adamo, K. B. (2021) · American Journal of Reproductive Immunology · doi:10.1111/aji.13488 · Cited by 12
Clinical Translational Potentials of Stem Cell-Derived Extracellular Vesicles in Type 1 Diabetes
Hu, W., Song, X. H., Yu, H., Sun, J., Wang, H., & Zhao, Y. L. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.682145 · Cited by 10
Wu, Z., Xia, M., Salas, S. S., Almanza, M. C. T., Martínez-Aguilar, M., Arroyave-Ospina, J. C., Wang, J., Arrese, M. A., Sydor, S., Bechmann, L. P., et al. (2022) · Exploration of Digestive Diseases · doi:10.37349/edd.2022.00002 · Cited by 10
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Roles of extracellular vesicles on macrophages in inflammatory bone diseases
Lin, Y., Wang, Z., Liu, S., Liu, J., Zhang, Z., Ouyang, Y., Su, Z., Chen, D., Guo, L., & Luo, T. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04809-w · Cited by 10
Li, N., Hu, L., Li, J., Yang, Y., Bao, Z., Xu, Z., Chen, D., Tang, J., & Gu, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1357378 · Cited by 10
Zhang, N., Chen, Y., Huang, C., Wei, M., Li, T., Lv, Y., Song, Q., & Mo, S. (2022) · Aging · doi:10.18632/aging.203964 · Cited by 10
Stem cell transplantation for treating liver diseases: progress and remaining challenges.
Li, S., Bi, Y., Duan, Z., Chang, Y.-K., Hong, F., & Chen, Y. (2021) · PubMed Central · Cited by 10
Sung, S., Seo, M., Kang, K., Choi, J.-H., Lee, S., Sung, M. K., Kim, K., Lee, G. W., Lim, J., Yang, S. Y., et al. (2021) · Veterinary Sciences · doi:10.3390/vetsci8090182 · Cited by 10
Adipose tissue-derived stem cells, in vivo and in vitro models for metabolic diseases
Navarro-Perez, J., & Carobbio, S. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116108 · Cited by 10
He, J., Shan, S., Jiang, T., Zhou, S., Qin, J., Li, Q., Yu, Z., Cao, D., & Fang, B. (2024) · The FASEB Journal · doi:10.1096/fj.202300586r · Cited by 9
Lee, S. H., Koh, A., Lee, S. J., Lee, H., & Kim, K. W. (2025) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.66.6.35 · Cited by 9
Nanomaterials for the treatment and monitoring of obesity: Targeting adipose tissue macrophages
Tang, Y., Chen, O., Dong, B., Liu, L., Ying, W., & Liu, H. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.09.052 · Cited by 10
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Deng, H., Liu, Q., Gong, Y., & Qiu, Y. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07331-3 · Cited by 9
Zhao, H., Wu, M., Tang, X., Li, Q., Yi, X., Zhao, W., & Sun, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.889439 · Cited by 9
Self-citationRen, H., Liu, M., Jihu, Y., Zeng, H., Yao, C., & Yan, H. (2023) · Acta Histochemica · doi:10.1016/j.acthis.2023.152042 · Cited by 9
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Han, Y., Tian, M., Wang, R., Guo, D., Zhang, D., & Liu, L. (2023) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23343 · Cited by 9
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Lin, D., Li, Z., Hao, J., Xu, X., Li, X., Feng, Y., Lu, X., Yao, F., Zhang, H., & Li, J. (2026) · Materials · doi:10.3390/ma19020445 · Cited by 8
Self-citationRagni, E., Orfei, C. P., Sinigaglia, F., & de Girolamo, L. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14071400 · Cited by 8
Injectable carrier hydrogel for diabetic foot ulcer wound repair
Wang, S., Zhang, J., Zhou, W., Liu, W., Ou, Y., Zheng, X., Yang, H., & Wang, T. (2023) · Journal of Materials Science · doi:10.1007/s10853-023-08730-x · Cited by 8
Shafiei, G., Saheli, M., Ganjalikhan-Hakemi, S., Haghpanah, T., & Nematollahi‐Mahani, S. N. (2023) · Journal of Ovarian Research · doi:10.1186/s13048-023-01317-9 · Cited by 8
Li, X., Zhang, G., Wang, M., Lu, C., Zhang, G., Chen, Z., & Ji, Y. (2024) · Adipocyte · doi:10.1080/21623945.2024.2360037 · Cited by 8
Dabravolski, S. A., Popov, M. A., Utkina, A. S., Babayeva, G. A., Maksaeva, A. O., Sukhorukov, V. N., & Orekhov, A. N. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05285-0 · Cited by 8
Afrisham, R., Sadegh‐Nejadi, S., Meshkani, R., Emamgholipour, S., Bagherieh, M., & Paknejad, M. (2020) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530320666200505121426 · Cited by 8
Liu, X., Chu, H., Ji, Y., Bosnjak, Z., Ao, H., & Li, T. (2022) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s345890 · Cited by 9
Fernandes, S., Srivastava, N., Pedicone, C., Sudan, R., Luke, E., Dungan, O. M., Pacherille, A., Meyer, S. T., Dormann, S., Schurmans, S., et al. (2022) · iScience · doi:10.1016/j.isci.2023.106071 · Cited by 8
New Progress of Adipose-derived Stem Cells in the Therapy of Hypertrophic Scars
Shi, J., Hu, D., He, X., Zhang, J., & Luo, L. (2019) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x14666190904125800 · Cited by 8
Antiobesity Effects of Adipose‐Derived Stromal/Stem Cells in a Naturally Aged Mouse Model
Wu, Q., He, S., Zhu, Y., Pu, S., & Zhou, Z. (2020) · Obesity · doi:10.1002/oby.23036 · Cited by 8
Shi, Y., Liu, Z., Gai, L., Gao, Y. M., He, Y., Liu, C., Zhang, C., Zhou, G., Yuan, D., & Yuan, C. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104369 · Cited by 8
Lu, X., Wang, Y., Piao, C., Li, P. A., Cao, L., Liu, T., Ma, Y., & Wang, H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252313069 · Cited by 7
Osseointegration-Related Exosomes for Surface Functionalization of Titanium Implants
Li, B., Chen, H., & Hang, R. (2024) · Biomaterials Research · doi:10.34133/bmr.0124 · Cited by 7
Zhang, Y., Zhang, L., Li, P., Qiu, L., Qu, Y., Wu, Y., & Song, H. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113860 · Cited by 7
Self-citationLei, Y., Sung, H. K., Burger, D. E., & Sweeney, G. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102823 · Cited by 7
Shi, X., Wu, X., Zhang, D., Du, F., Hu, J., Wang, Z., Liu, Y., Li, S., Zhao, S., Li, W., et al. (2025) · Regenerative Biomaterials · doi:10.1093/rb/rbaf103 · Cited by 7
Boulet, N., Luijten, I. H. N., Cannon, B., & Nedergaard, J. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00352.2020 · Cited by 7
Ghnaimawi, S., Zhang, S., Baum, J., & Huang, Y. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.881624 · Cited by 8
Ghosh, S., Bhatti, G. K., Sharma, P. K., Kandimalla, R. J. L., Mastana, S. S., & Bhatti, J. S. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01434-5 · Cited by 7
Modulation of adipose tissue metabolism by exosomes in obesity
Xu, Y., Huang, L., Zhuang, Y., & Huang, H. (2024) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00155.2023 · Cited by 7
Effectiveness and Safety of Different Methods of Assisted Fat Grafting: A Network Meta-Analysis
Dong, Y., Huang, Y., Hou, T., & Li, P. (2024) · Aesthetic Plastic Surgery · doi:10.1007/s00266-024-04060-8 · Cited by 7
Obesity and atherosclerosis: the exosome link
Reiss, A. B., Glass, D. S., Voloshyna, I., Glass, A. D., Kasselman, L. J., & Leon, J. D. (2020) · Vessel Plus · doi:10.20517/2574-1209.2020.04 · Cited by 7
Extraction of Exosomes and Exosomal miRNA from Mesenchymal Stem Cells
Zhao, L., Wong, A. P., & Alam, S. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2128-8_25 · Cited by 7
Wen, J.-P., Ou, S., Liu, J., Zhang, W., Qu, Y., Li, J.-X., Xia, C.-L., Yang, Y., Qi, Y., & Xu, C. (2024) · World Journal of Diabetes · doi:10.4239/wjd.v15.i7.1627 · Cited by 7
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Thakkar, N., Shin, Y. B., & Sung, H. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.803280 · Cited by 7
Chung, W. Y., Lam, S., Pernari, B., Kim, Y., Cho, S., Burger, D. E., & Sweeney, G. (2025) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2025.112078 · Cited by 6
Wang, C., Chen, J., Guo, J., Li, G., Yi, K., Jiang, T., Kang, Y., Guo, G., Yan, C., Xu, Y., et al. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202501044 · Cited by 6
Extracellular vesicle-based therapies for neurodegenerative diseases
Hu, G., Gogzheyan, C., Panja, S., Sil, S., & Gendelman, H. E. (2025) · NeuroImmune Pharmacology and Therapeutics · doi:10.1515/nipt-2025-0016 · Cited by 6
Zhang, Z., Zhu, D., Liu, C., Gan, L., Zhao, J., Meng, Z., Yao, P., Liu, D., Gu, G., Lopez, B. M., et al. (2026) · Circulation · doi:10.1161/circulationaha.125.076372 · Cited by 6
Zhang, H., Zhou, M., Wang, Y., Zhang, D., Qi, B., & Yu, A. (2023) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000010226 · Cited by 6
Self-citationTIAN, X., HE, X., QIAN, S., Zou, R., CHEN, K., ZHU, C., & YIN, Z. (2023) · Biocell · doi:10.32604/biocell.2023.027090 · Cited by 6
Saito, R., Inagaki, A., Nakamura, Y., Imura, T., Kanai, N., Mitsugashira, H., Kumata, Y. E., Katano, T., Suzuki, S., Tokodai, K., et al. (2024) · Cell Transplantation · doi:10.1177/09636897241251621 · Cited by 6
Cui, Y., He, J., Yu, Z., Zhou, S., Cao, D., Jiang, T., Fang, B., & Li, G. (2024) · Skin Research and Technology · doi:10.1111/srt.13918 · Cited by 6
Yuan, Y., & Liu, T. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.114263 · Cited by 6
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Ning, J., Sah, R. K., & Wang, J. (2025) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2025.103531 · Cited by 6
Transplantation of adipose derived stem cells in diabetes mellitus; limitations and achievements
Tajali, R., Eidi, A., Tafti, H. A., Pazouki, A., Kamarul, T., & Sharifi, A. M. (2023) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-023-01280-8 · Cited by 6
Wu, B., Cen, W., Liu, C., Wang, T., Wei, J., Wang, S., Zhang, D., & Li, C. (2023) · Aesthetic Plastic Surgery · doi:10.1007/s00266-023-03782-5 · Cited by 6
miRNAs as Interconnectors between Obesity and Cancer
González–Sánchez, G. D., Granados‐López, A. J., López‐Hernández, Y., García-Robles, M. J., & López, J. A. (2024) · Non-Coding RNA · doi:10.3390/ncrna10020024 · Cited by 6
Yunusova, N. V., Dandarova, E. E., Svarovsky, D. A., Denisov, N. S., Kostromitsky, D. N., Patysheva, M. R., Cheremisina, O. V., & Spirina, L. V. (2021) · Biomeditsinskaya Khimiya · doi:10.18097/pbmc20216706465 · Cited by 6
Bai, X., He, T., Liu, M., Li, L., Chen, J., Cao, M., Liu, Y., Chen, Y., Jia, W., Tao, K., et al. (2020) · Inflammation · doi:10.1007/s10753-020-01345-3 · Cited by 6
Metadata
- Authors
- Zhao, H., Shang, Q., Pan, Z., Bai, Y., Li, Z., Zhang, H., Zhang, Q., Guo, C., Zhang, L., & Wang, Q.
- Affiliations
- Shandong University (CN)
- Corresponding author
- Wang, Qun
- ORCID
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2017-11-13
- Volume
- 67
- Issue
- 2
- Pages
- 235-247
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2769957434
- Cited by
- 657
- References
- 50
- Citations by year
- 2026: 53 · 2025: 74 · 2024: 98 · 2023: 83 · 2022: 108 · 2021: 94 · 2020: 77 · 2019: 50 · 2018: 19
- FWCI
- 16.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81770838, 81471065, 81270923)
- Shandong Major Research Program (2016GSF201005)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- adipose-derived stem cells, exosomes, obesity, adipose tissue inflammation, M2 macrophage polarization, insulin sensitivity, hepatic steatosis, arginase-1, STAT3, tyrosine hydroxylase, catecholamine release, metabolic homeostasis
- MeSH terms
- Adipocytes, Beige, Animals, Cell Communication, Cells, Cultured, Insulin Resistance, Macrophage Activation, Male, Mice, Inbred C57BL, Microscopy, Fluorescence, Obesity, Phagocytosis, Biomarkers, Cell Polarity, Macrophages, Peritoneal, Microscopy, Electron, Transmission, Cell Proliferation, Adipogenesis, Adipocytes, White, Adult Stem Cells, Exosomes, Diet, High-Fat, Non-alcoholic Fatty Liver Disease
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