Glucose sensing mediated by portal glucagon-like peptide 1 receptor is markedly impaired in insulin-resistant obese animals
Open accessAbstract
The glucose portal sensor informs the brain of changes in glucose inflow through vagal afferents that require an activated glucagon-like peptide 1 receptor (GLP-1r). The GLP-1 system is known to be impaired in insulin-resistant conditions, and we sought to understand the consequences of GLP-1 resistance on glucose portal signaling. GLP-1–dependent portal glucose signaling was identified, in vivo, using a novel 68Ga-labeled GLP-1r positron-emitting probe that supplied a quantitative in situ tridimensional representation of the portal sensor with specific reference to the receptor density expressed in binding potential units. It also served as a map for single-neuron electrophysiology driven by an image-based abdominal navigation. We determined that in insulin-resistant animals, portal vagal afferents failed to inhibit their spiking activity during glucose infusion, a GLP-1r–dependent function. This reflected a reduction in portal GLP-1r binding potential, particularly between the splenic vein and the entrance of the liver. We propose that insulin resistance, through a reduction in GLP-1r density, leads to functional portal desensitization with a consequent suppression of vagal sensitivity to portal glucose.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The glucose portal sensor plays an integral role in glucose homeostasis, and GLP-1Rs in portal glucose sensing are associated with GLP-1 being required for portal glucose to stimulate insulin response.
“Several studies have also demonstrated the integral role that the glucose portal sensor plays in glucose homeostasis, and the association of GLP-1Rs in portal glucose sensing where GLP-1 is required for portal glucose to stimulate insulin response.8”
From GLP-1 single, dual, and triple receptor agonists for treating type 2 diabetes and obesity: a narrative review (2024) · cites this paper as [8]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Consensus Nomenclature for <i>in vivo</i> Imaging of Reversibly Binding Radioligands
Innis, R. B., Cunningham, V. J., Delforge, J., Fujita, M., Gjedde, A., Gunn, R. N., Holden, J., Houle, S., Huang, S.-C., Ichise, M., et al. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600493 · Cited by 1,955 · see citing works
Glucagon-like peptide 1 (GLP-1)
Müller, T. D., Finan, B., Bloom, S. R., D'Alessio, D., Drucker, D. J., Flatt, P. R., Fritsche, A., Gribble, F., Grill, H. J., Habener, J. F., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.09.010 · Cited by 1,868 · see citing works
Functional and chemical anatomy of the afferent vagal system
Berthoud, H.-R., & Neuhuber, W. L. (2000) · Autonomic Neuroscience · doi:10.1016/s1566-0702(00)00215-0 · Cited by 1,280 · see citing works
Genetic identification of vagal sensory neurons that control feeding
Bai, L., Mesgarzadeh, S., Ramesh, K. S., Huey, E. L., Liu, Y., Gray, L. A., Aitken, T. J., Chen, Y., Beutler, L. R., Ahn, J. S., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.031 · Cited by 494 · see citing works
Vahl, T. P., Tauchi, M., Durler, T. S., Elfers, E. E., Fernandes, T. M., Bitner, R. D., Ellis, K. S., Woods, S. C., Seeley, R. J., Herman, J. P., et al. (2007) · Endocrinology · doi:10.1210/en.2006-0153 · Cited by 318 · see citing works
Knockdown of GLP-1 Receptors in Vagal Afferents Affects Normal Food Intake and Glycemia
Krieger, J.-P., Arnold, M., Pettersen, K. G., Lossel, P., Langhans, W., & Lee, S. J. (2016) · Diabetes · doi:10.2337/db15-0973 · Cited by 269 · see citing works
Preitner, F., Ibberson, M. R., Franklin, I., Binnert, C., Pende, M., Gjinovci, A., Hansotia, T., Drucker, D. J., Wollheim, C. B., Burcelin, R., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20518 · Cited by 254 · see citing works
The pig model in brain imaging and neurosurgery
Sauleau, P., Lapouble, E., Val‐Laillet, D., & Malbert, C. (2009) · animal · doi:10.1017/s1751731109004649 · Cited by 253 · see citing works
Self-citationBurcelin, R., Costa, A. D., Drucker, D. J., & Thorens, B. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1720 · Cited by 251 · see citing works
Glucose‐sensitive afferent nerve fibres in the hepatic branch of the vagus nerve in the guinea‐pig.
Niijima, A. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014415 · Cited by 236 · see citing works
Vagal hepatopancreatic reflex effect evoked by intraportal appearance of tGLP-1
Nakabayashi, H., NISHIZAWA, M., Nakagawa, A., Takeda, R., & Niijima, A. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.271.5.e808 · Cited by 203 · see citing works
Portal GLP-1 administration in rats augments the insulin response to glucose via neuronal mechanisms
Balkan, B., & Li, X. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.4.r1449 · Cited by 201 · see citing works
Anatomy and function of sensory hepatic nerves
Berthoud, H. (2004) · The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology · doi:10.1002/ar.a.20088 · Cited by 196 · see citing works
Heller, R. S., Kieffer, T. J., & Habener, J. F. (1997) · Diabetes · doi:10.2337/diab.46.5.785 · Cited by 179 · see citing works
The Integrative Role of CNS Fuel-Sensing Mechanisms in Energy Balance and Glucose Regulation
Sandoval, D., Cota, D., & Seeley, R. J. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.120806.095256 · Cited by 178 · see citing works
Gut-Brain Glucose Signaling in Energy Homeostasis
Soty, M., Gautier‐Stein, A., Rajas, F., & Mithieux, G. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.032 · Cited by 163 · see citing works
Exendin-4–Based Radiopharmaceuticals for Glucagonlike Peptide-1 Receptor PET/CT and SPECT/CT
Wild, D., WICKI, A. N., Mansi, R., Béhé, M. P., Keil, B. R., Bernhardt, P., Christofori, G., Ell, P. J., & Mäcke, H. R. (2010) · Journal of Nuclear Medicine · doi:10.2967/jnumed.110.074914 · Cited by 155 · see citing works
The Glucagon-Like Peptide-1 Receptor—or Not?
Pyke, C., & Knudsen, L. B. (2013) · Endocrinology · doi:10.1210/en.2012-2124 · Cited by 154 · see citing works
Burcelin, R., Dolci, W., & Thorens, B. (2000) · Diabetes · doi:10.2337/diabetes.49.10.1635 · Cited by 137 · see citing works
Is <scp>GLP</scp>‐1 a hormone: Whether and When?
D'Alessio, D. (2016) · Journal of Diabetes Investigation · doi:10.1111/jdi.12466 · Cited by 130 · see citing works
The composition of the vagus nerve of the cat
Mei, N., Condamin, M., & Boyer, A. (1980) · Cell and Tissue Research · doi:10.1007/bf00234756 · Cited by 120 · see citing works
Glucagon-Like-Peptide-1 Receptor Expression in Normal and Diseased Human Thyroid and Pancreas
Waser, B., Blank, A., Karamitopoulou, E., Perren, A., & Reubi, J. C. (2015) · Modern Pathology · doi:10.1038/modpathol.2014.113 · Cited by 119 · see citing works
Nishizawa, M., Nakabayashi, H., Kawai, K., Ito, T., Kawakami, S., Nakagawa, A., Niijima, A., & Uchida, K. (2000) · Journal of the Autonomic Nervous System · doi:10.1016/s0165-1838(99)00086-7 · Cited by 110 · see citing works
PET quantification: strategies for partial volume correction
Bettinardi, V., Castiglioni, I., De Bernardi, E., & Gilardi, M. C. (2014) · Clinical and Translational Imaging · doi:10.1007/s40336-014-0066-y · Cited by 105 · see citing works
Varin, E. M., Mulvihill, E. E., Baggio, L. L., Koehler, J. A., Cao, X., Seeley, R. J., & Drucker, D. J. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.055 · Cited by 104 · see citing works
Shikora, S. A., Toouli, J., Herrera, M. F., Kulseng, B. E., Zulewski, H., Brancatisano, R., Kow, L., Pantoja, J. P., Johnsen, G., Brancatisano, A., et al. (2013) · Journal of Obesity · doi:10.1155/2013/245683 · Cited by 100 · see citing works
Sensory nerves contribute to insulin secretion by glucagon-like peptide-1 in mice
Åhrén, B. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00423.2003 · Cited by 99 · see citing works
Selvaraju, R. K., Velikyan, I., Johansson, L., Wu, Z., Todorov, I., Shively, J. E., KANDEEL, F. R., Korsgren, O., & Eriksson, O. (2013) · Journal of Nuclear Medicine · doi:10.2967/jnumed.112.114066 · Cited by 98 · see citing works
Martiniova, L., Palatis, L. D., Etchebehere, E., & RAVIZZINI, G. C. (2016) · Current Radiopharmaceuticals · doi:10.2174/1874471009666161028150654 · Cited by 96 · see citing works
The Hepatic Vagus Nerve and the Neural Regulation of Insulin Secretion*
Lee, K. C., & Miller, R. E. (1985) · Endocrinology · doi:10.1210/endo-117-1-307 · Cited by 93 · see citing works
Dissecting the Physiology and Pathophysiology of Glucagon-Like Peptide-1
Paternoster, S., & Falasca, M. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00584 · Cited by 91 · see citing works
Guiraud, D., Andreu, D., Bonnet, S., Carrault, G., Couderc, P., Hagège, A. A., Henry, C., Hernandez, A. I., Karam, N., Rolle, V. L., et al. (2016) · Journal of Neural Engineering · doi:10.1088/1741-2560/13/4/041002 · Cited by 88 · see citing works
Self-citationCustusX: an open-source research platform for image-guided therapy
Askeland, C., Solberg, O. V., Bakeng, J. B. L., Reinertsen, I., Tangen, G. A., Hofstad, E. F., Iversen, D. H., Våpenstad, C., Selbekk, T., Langø, T., et al. (2015) · International Journal of Computer Assisted Radiology and Surgery · doi:10.1007/s11548-015-1292-0 · Cited by 87 · see citing works
Glucose sensing and the pathogenesis of obesity and type 2 diabetes
Thorens, B. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.208 · Cited by 78 · see citing works
Lu, Y., Fontaine, K. M., Mulnix, T., Onofrey, J. A., Ren, S., Panin, V., Jones, J. P., Casey, M., Barnett, R., Kench, P. L., et al. (2018) · Journal of Nuclear Medicine · doi:10.2967/jnumed.117.203000 · Cited by 76 · see citing works
van Leeuwen, M. S., Noordzij, J., Fernandez, M. A., Hennipman, A., Feldberg, M. A. M., & Dillon, E. H. (1994) · American Journal of Roentgenology · doi:10.2214/ajr.163.6.7992736 · Cited by 72 · see citing works
The incretins: a link between nutrients and well-being
Burcelin, R. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20041340 · Cited by 71 · see citing works
Nishizawa, M., Nakabayashi, H., Uehara, K., Nakagawa, A., Uchida, K., & Koya, D. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00565.2012 · Cited by 64 · see citing works
Combination of Obesity and High-Fat Feeding Diminishes Sensitivity to GLP-1R Agonist Exendin-4
Duca, F. A., Sakar, Y., & Covașă, M. (2013) · Diabetes · doi:10.2337/db12-1204 · Cited by 64 · see citing works
Malbert, C., Picq, C. A., Divoux, J., Henry, C., & Horowitz, M. (2017) · Diabetes · doi:10.2337/db16-0847 · Cited by 60 · see citing works
Self-citationHerzberg-Schäfer, S. A., Heni, M., Stefan, N., Häring, H., & Fritsche, A. (2012) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2012.01648.x · Cited by 56 · see citing works
Bohland, M., Matveyenko, A. V., Saberi, M., Khan, A. M., Watts, A. G., & Donovan, C. M. (2014) · Diabetes · doi:10.2337/db13-1600 · Cited by 54 · see citing works
PET imaging for receptor occupancy: meditations on calculation and simplification
Zhang, Y., & Fox, G. B. (2012) · Journal of Biomedical Research · doi:10.1016/s1674-8301(12)60014-1 · Cited by 52 · see citing works
Hong, Y. T., & Fryer, T. D. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.02.013 · Cited by 51 · see citing works
Nalin, L., Selvaraju, R. K., Velikyan, I., Berglund, M., Andréasson, S., Wikstrand, A., Rydén, A., Lubberink, M., KANDEEL, F. R., Nyman, G. C., et al. (2014) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-014-2745-3 · Cited by 48 · see citing works
Discordance between GLP-1R gene and protein expression in mouse pancreatic islet cells
Gray, S. M., Xin, Y., Ross, E. C., Chazotte, B. M., Capozzi, M. E., EL, K. M., Svendsen, B., Ravn, P., Sloop, K. W., Tong, J., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.014368 · Cited by 40 · see citing works
Jodal, A., Lankat–Buttgereit, B., Brom, M., Schibli, R., & Béhé, M. P. (2014) · EJNMMI Research · doi:10.1186/s13550-014-0031-9 · Cited by 37 · see citing works
Niijima, A. (2005) · Chemical Senses · doi:10.1093/chemse/bjh172 · Cited by 35 · see citing works
Pre-clinical evaluation of [68Ga]Ga-DO3A-VS-Cys40-Exendin-4 for imaging of insulinoma
Selvaraju, R. K., Velikyan, I., Asplund, V., Johansson, L., Wu, Z., Todorov, I., Shively, J. E., KANDEEL, F. R., Eriksson, B. K., Korsgren, O., et al. (2014) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2014.03.017 · Cited by 34 · see citing works
Selvaraju, R. K., Bulenga, T. N., Espes, D., Lubberink, M., Sørensen, J. C. H., Eriksson, B. K., Estrada, S., Velikyan, I., & Eriksson, O. (2015) · Europe PMC (PubMed Central) · Cited by 32 · see citing works
Monami, M., Dicembrini, I., Nreu, B., Andreozzi, F., Sesti, G., & Mannucci, E. (2017) · Acta Diabetologica · doi:10.1007/s00592-017-1054-2 · Cited by 32 · see citing works
Piro, S., Mascali, L. G., Urbano, F., Filippello, A., Malaguarnera, R., Calanna, S., Rabuazzo, A. M., & Purrello, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090093 · Cited by 31 · see citing works
Desensitization of ileal vagal receptors by short-chain fatty acids in pigs
Cuche, G., Blat, S., & Malbert, C. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.5.g1013 · Cited by 30 · see citing works
Self-citationSpecies differences in pancreatic binding of DO3A-VS-Cys40-Exendin4
Eriksson, O., Rosenström, U., Selvaraju, R. K., Eriksson, B. K., & Velikyan, I. (2017) · Acta Diabetologica · doi:10.1007/s00592-017-1046-2 · Cited by 29 · see citing works
Fully automated GMP production of [68Ga]Ga-DO3A-VS-Cys40-Exendin-4 for clinical use.
Velikyan, I., Rosenström, U., & Eriksson, O. (2017) · PubMed Central · Cited by 28 · see citing works
Metabolic Sensors Mediate Hypoglycemic Detection at the Portal Vein
Matveyenko, A. V., & Donovan, C. M. (2006) · Diabetes · doi:10.2337/db05-1665 · Cited by 27 · see citing works
Glucose Sensors in Viscera and Control of Blood Glucose Level
Niijima, A., & Mei, N. (1987) · Physiology · doi:10.1152/physiologyonline.1987.2.5.164 · Cited by 23 · see citing works
Rapid hepatic metabolism blunts the endocrine action of portally infused GLP-1 in male rats
Aulinger, B. A., Perabò, M., Seeley, R. J., Parhofer, K. G., & D’Alessio, D. A. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00298.2019 · Cited by 19 · see citing works
Fully automated GMP production of [Ga-68]Ga-DO3A-VS-Cys(40)-Exendin-4 for clinical use
Velikyan, I., Rosenström, U., & Eriksson, O. (2017) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 19 · see citing works
Electric field stimulation of excitable tissue
Plonsey, R., & Burr, R. C. (1998) · IEEE Engineering in Medicine and Biology Magazine · doi:10.1109/51.715497 · Cited by 18 · see citing works
Bahri, S., Horowitz, M., & Malbert, C. (2018) · Obesity · doi:10.1002/oby.22243 · Cited by 18 · see citing works
Self-citationComputerized tomography–based anatomic description of the porcine liver
Bekheit, M., Bucur, P. O., Wartenberg, M., & Vibert, É. (2016) · Journal of Surgical Research · doi:10.1016/j.jss.2016.11.004 · Cited by 17 · see citing works
Ståhle, M. R., Kytö, V., Kiugel, M., Liljenbäck, H., Metsälä, O., Käkelä, M., Li, X., Oikonen, V., Saukko, P. J., Nuutila, P., et al. (2018) · Journal of Nuclear Cardiology · doi:10.1007/s12350-018-01547-1 · Cited by 17 · see citing works
Malbert, C., Horowitz, M., & Young, R. L. (2019) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-019-04430-4 · Cited by 17 · see citing works
Self-citationReduced GLP-1R Expression in Gastric Glands of Patients With Type 2 Diabetes Mellitus
Broide, E., Bloch, O., Ben-Yehudah, G., Cantrell, D., Shirin, H., & Rapoport, M. J. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1114 · Cited by 15 · see citing works
Malbert, C., Bobillier, É., Picq, C. A., Divoux, J., Guiraud, D., & Henry, C. (2017) · Brain stimulation · doi:10.1016/j.brs.2017.04.126 · Cited by 15 · see citing works
Self-citationIonut, V., Castro, A. V., Woolcott, O. O., Stefanovski, D., Iyer, M. S., Broussard, J. L., Burch, M. A., Elazary, R., Kolka, C. M., Mkrtchyan, H., et al. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00244.2014 · Cited by 14 · see citing works
Effect of Portal Glucose Sensing on Systemic Glucose Levels in SD and ZDF Rats
Pal, A., Rhoads, D. B., & Tavakkoli, A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165592 · Cited by 14 · see citing works
Dali, M., Picq, C. A., Rossel, O., Maciejasz, P., Malbert, C., & Guiraud, D. (2019) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2019.02.017 · Cited by 14 · see citing works
Self-citationHepatic Denervation Alters the Disposition of an Enteral Glucose Load in Conscious Dogs
Pagliassotti, M. J., Tarumi, C., Neal, D. W., & Cherrington, A. D. (1991) · Journal of Nutrition · doi:10.1093/jn/121.8.1255 · Cited by 12 · see citing works
IS d-GLUCOSE ABSORBED FROM THE STOMACH OF THE DOG?
MADDOCK, S. J., Trimble, H. C., & Carey, B. W. (1933) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)70825-2 · Cited by 12 · see citing works
Nielsen, M. F., Roelsgaard, K., Keiding, S., Brodersen, K., Møller, N., Vyberg, M., & Vilstrup, H. (2015) · Journal of Clinical & Translational Endocrinology · doi:10.1016/j.jcte.2015.08.004 · Cited by 6 · see citing works
Annual Congress of the European Association of Nuclear Medicine
Mikecz, P., Miklovicz, T., Galuska, L., Krasznai, Z. T., Herzog, H., Szabó, G. J., & Márián, T. (2008) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-008-0897-8 · Cited by 5 · see citing works
AniMate - An open source software for absolute PET quantification
Malbert, C. (2016) · HAL · Cited by 3 · see citing works
Self-citationSensing of blood glucose by the nervous system: why, where, how?
Mithieux, G. (2020) · Annales de biologie clinique · doi:10.1684/abc.2020.1531 · Cited by 1 · see citing works
Bilateral stimulation of the abdominal vagus modifies dopamine connectivity in acquired obesity
Malbert, C., Picq, C. A., Divoux, J., & Henry, C. (2017) · HAL · Cited by 1 · see citing works
Self-citation
Flagged first, then by citations
4 of the 80 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Mithieux G. Détection du glucose sanguin par le système nerveux: pourquoi, où, comment? Ann Biol Clin (Paris) 2020;78:134-138 [in French]
- Ga-DO3A-VS-Cys(40)-Exendin-4 for imaging of insulinoma. Nucl Med Biol 2014; 41:471-476
- Ga]Ga-DO3A-VS-Cys 40 -Exendin-4 for clinical use. Am J Nucl Med Mol Imaging 2017;7:111-125
Cited by
Sorted by citations
Alfaris, N., Waldrop, S., Johnson, V., Boaventura, B., Kendrick, K., & Stanford, F. C. (2024) · EClinicalMedicine · doi:10.1016/j.eclinm.2024.102782 · Cited by 224 · see citing works
Overgaard, R. V., HERTZ, C. L., Ingwersen, S. H., Navarria, A., & Drucker, D. J. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100387 · Cited by 102 · see citing works
Maternal nutrient metabolism in the liver during pregnancy
Fang, H., Li, Q., Wang, H., Ren, Y., Zhang, L., & Yang, L. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1295677 · Cited by 35 · see citing works
Mechanistic insights into the liver–brain axis during chronic liver disease
Siddle, M. R., Durán, R. G., Goel, D., Renquist, B. J., Holt, M. K., & Hadjihambi, A. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01142-z · Cited by 33 · see citing works
Anastasiou, I. A., Argyrakopoulou, G., Dalamaga, Μ., & Kokkinos, A. D. (2025) · Current Obesity Reports · doi:10.1007/s13679-025-00623-1 · Cited by 26 · see citing works
Trzaskalski, N. A., Vulesevic, B., Nguyen, M.-A., Jeraj, N., Fadzeyeva, E., Morrow, N. M., Locatelli, C. A. A., Travis, N., Hanson, A. A., Nunes, J. R. C., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.154314 · Cited by 21 · see citing works
Hepatic interoception in health and disease
Berthoud, H., Münzberg, H., Morrison, C. D., & Neuhuber, W. (2024) · Autonomic Neuroscience · doi:10.1016/j.autneu.2024.103174 · Cited by 17 · see citing works
Ahrén, B., Yamada, Y., & Seino, Y. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.665537 · Cited by 15 · see citing works
New, R. R. C., Bogus, M., Travers, G. N., Hahn, U., Vaiceliunaite, A., Burnet, M. W. M., Wang, J. H., & Wen, H. (2024) · Frontiers in Drug Delivery · doi:10.3389/fddev.2024.1456654 · Cited by 6 · see citing works
Pancreas-derived DPP4 is not essential for glucose homeostasis under metabolic stress
Fadzeyeva, E., Locatelli, C. A. A., Trzaskalski, N. A., Nguyen, M.-A., Capozzi, M. E., Vulesevic, B., Morrow, N. M., Ghorbani, P., Hanson, A. A., Lorenzen‐Schmidt, I., et al. (2023) · iScience · doi:10.1016/j.isci.2023.106748 · Cited by 5 · see citing works
The Impact of PET Imaging on Translational Medicine: Insights from Large-Animal Disease Models
Deng, Z., Xi, P., Zheng, D., Xie, Z., Meng, X., & Ren, Q. (2025) · Biomolecules · doi:10.3390/biom15070919 · Cited by 4 · see citing works
Vagally Mediated Gut-Brain Relationships in Appetite Control-Insights from Porcine Studies
Malbert, C. (2021) · Nutrients · doi:10.3390/nu13020467 · Cited by 4 · see citing works
Self-citationGLP-1 and GIP in Type 1 Diabetes Therapy: A Time for Reappraisal?
Piras, G., Brasili, S., Demontis, D., Sala, L. D., Cocchiara, F., Maggi, D. C., & Arecco, A. (2026) · Diabetology · doi:10.3390/diabetology7030050 · Cited by 2 · see citing works
Zhang, X., Guérin, S., Launay, Y., Serrand, Y., Coquery, N., & Val‐Laillet, D. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/4384693 · Cited by 1 · see citing works
Vagal GABAergic signaling in autonomic control of cardiometabolic function
Boychuk, C. R., & Wang, Y. B. (2026) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00790.2025 · Cited by 1 · see citing works
Lee, O., Son, Y., López-Gil, J. F., Rahmati, M., Kang, J., Lee, J.-S., & Yon, D. K. (2026) · Diabetes Obesity and Metabolism · doi:10.1111/dom.71325 · Cited by 1 · see citing works
Glucagon-like peptide-1 and beta cell glucose sensitivity - a glucose ramp study in mice
Åhrén, B. (2021) · Peptides · doi:10.1016/j.peptides.2021.170650 · Cited by 1 · see citing works
Endocrine and Metabolic Effects on Maternal-fetal and Neonatal Outcomes, Volume II
(2024) · Frontiers research topics · doi:10.3389/978-2-8325-5459-3
Hussein, M., Ahmed, A. I., & Syam, H. S. (2025) · Advances in Animal and Veterinary Sciences · doi:10.17582/journal.aavs/2025/13.s1.56.69
- Authors
- Malbert, C.-H., Chauvin, A., Horowitz, M., & Jones, K. L.
- Affiliations
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- The University of Adelaide (AU)
- Corresponding author
- Malbert, Charles-Henri
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2020-10-16
- Volume
- 70
- Issue
- 1
- Pages
- 99-110
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W3093250197
- Cited by
- 18
- References
- 80
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 1 · 2022: 2 · 2021: 4
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- BPI France
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- GLP-1 receptor, glucose detection, insulin resistance, obesity, vagal afferents, receptor binding potential, splenic vein, single-neuron electrophysiology
- MeSH terms
- Glucagon-Like Peptide-1 Receptor, Insulin Secretion, Animals, Body Composition, Glucose, Insulin, Insulin Resistance, Obesity, Portal Vein, Swine, Swine, Miniature, Positron-Emission Tomography
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
