Cited by 178Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesMetabolism, Diabetes, and Cancer

The Integrative Role of CNS Fuel-Sensing Mechanisms in Energy Balance and Glucose Regulation

Sandoval, Darleen, Cota, Daniela, Seeley, Randy J.·2008·Annual Review of Physiology

Abstract

The incidences of both obesity and type 2 diabetes mellitus are rising at epidemic proportions. Despite this, the balance between caloric intake and expenditure is tremendously accurate under most circumstances. Growing evidence suggests that nutrient and hormonal signals converge and directly act on brain centers, leading to changes in fuel metabolism and, thus, stable body weight over time. Growing evidence also suggests that these same signals act on the central nervous system (CNS) to regulate glucose metabolism independently. We propose that this is not coincidental and that the CNS responds to peripheral signals to orchestrate changes in both energy and glucose homeostasis. In this way the CNS ensures that the nutrient demands of peripheral tissues (and likely of the brain itself) are being met. Consequently, dysfunction of the ability of the CNS to integrate fuel-sensing signals may underlie the etiology of metabolic diseases such as obesity and diabetes.

Integrity signals

Registry

Crossref · 10.1146/annurev.physiol.70.120806.095256

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167 of 167 references verified0 citation errors · 0 not checkable

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  • Central brain-endocrine crosstalk plays a critical role in glucose homeostasis.

    “In addition to peripheral GIG interactions, the recently recognized central brain-endocrine crosstalk also plays a critical role in glucose homeostasis [1].”

    From A mathematical model of brain glucose homeostasis (2009) · cites this paper as [1]

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Authors
Sandoval, D., Cota, D., & Seeley, R. J.
Affiliations
University of Cincinnati (US)
Venue
Annual Review of Physiology
Published
2008-03-01
Volume
70
Issue
1
Pages
513-535
ISSN
  • 0066-4278 (ISSN-L)
  • 1545-1585
OpenAlex
W2135960244
Cited by
178
References
167
Citations by year
2026: 2 · 2025: 4 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 12 · 2020: 9 · 2019: 5 · 2018: 5 · 2017: 7 · 2016: 12 · 2015: 10 · 2014: 7 · 2013: 12 · 2012: 20
FWCI
1.26
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK 075365, R01DK054890, P01DK056863, DK-54890, K01DK075365, DK-56863)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
energy homeostasis, glucose homeostasis, central nervous system, obesity, type 2 diabetes, nutrient signaling, metabolic disorders, brain glucose metabolism
MeSH terms
Animals, Blood Glucose, Diabetes Mellitus, Type 2, Energy Metabolism, Humans, Hypothalamus, Obesity, Signal Transduction

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