Does Treatment With Duloxetine for Neuropathic Pain Impact Glycemic Control?
Abstract
OBJECTIVE—We examined changes in metabolic parameters in clinical trials of duloxetine for diabetic peripheral neuropathic pain (DPNP). RESEARCH DESIGN AND METHODS—Data were pooled from three similarly designed clinical trials. Adults with diabetes and DPNP (n = 1,024) were randomized to 60 mg duloxetine q.d., 60 mg b.i.d., or placebo for 12 weeks. Subjects (n = 867) were re-randomized to 60 mg duloxetine b.i.d. or routine care for an additional 52 weeks. Mean changes in plasma glucose, lipids, and weight were evaluated. Regression and subgroup analyses were used to identify relationships between metabolic measures and demographic, clinical, and electrophysiological parameters. RESULTS—Duloxetine treatment resulted in modest increases in fasting plasma glucose in short- and long-term studies (0.50 and 0.67 mmol/l, respectively). A1C did not increase in placebo-controlled studies; however, a greater increase was seen relative to routine care in long-term studies (0.52 vs. 0.19%). Short-term duloxetine treatment resulted in mean weight loss (−1.03 kg; P < 0.001 vs. placebo), whereas slight, nonsignificant weight gain was seen in both duloxetine and routine care groups with longer treatment. Between-group differences were seen for some lipid parameters, but these changes were generally small. Metabolic changes did not appear to impact improvement in pain severity seen with duloxetine, and nerve conduction was also not significantly impacted by treatment. CONCLUSIONS—Duloxetine treatment was associated with modest changes in glycemia in patients with DPNP. Other metabolic changes were limited and of uncertain significance. These changes did not impact the significant improvement in pain observed with duloxetine treatment.
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Poor management of pain may itself impact treatment adherence and management of other physical conditions, whereas improving neuropathic pain may promote improvements in glycaemic control.
“Poor management of pain may itself impact treatment adherence and management of other physical conditions, whereas improving neuropathic pain may promote improvements in glycaemic control [35].”
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- Authors
- Hardy, T., Sachson, R., Shen, S., Armbruster, M., & Boulton, A. J. M.
- Affiliations
- Eli Lilly (United States) (US)
- The University of Texas Southwestern Medical Center (US)
- University of Miami (US)
- ORCID
- Boulton, Andrew J.M.
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2007-01-01
- Volume
- 30
- Issue
- 1
- Pages
- 21-26
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2112241702
- Cited by
- 79
- References
- 28
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 8 · 2019: 6 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 1 · 2013: 8 · 2012: 4
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Keywords
- duloxetine, diabetic peripheral neuropathic pain, glycemic control, fasting blood glucose, HbA1c, weight change, lipid changes, nerve conduction, pain intensity
- MeSH terms
- Duloxetine Hydrochloride, Adult, Blood Glucose, Clinical Trials as Topic, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetic Neuropathies, Double-Blind Method, Female, Glycated Hemoglobin, Humans, Lipids, Male, Middle Aged, Neuritis, Placebos, Thiophenes, Randomized Controlled Trials as Topic, Selective Serotonin Reuptake Inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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