Possible role of oxidative stress in the pathogenesis of hypertension
Abstract
Recently oxidative stress has been proposed as the cause of hypertension. An imbalance in superoxide and nitric oxide production may account for reduced vasodilation, which in turn can favor the development of hypertension. In vitro and in human studies support this hypothesis. The supplementation of antioxidants, particularly in the form of fresh fruit and vegetables, reduces blood pressure, supporting a role for free radicals in hypertension.
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Oxidative stress may play a role in the development of vascular complications that promote cardiovascular disease by contributing to the pathogenesis of hypertension and atherosclerosis.
“Oxidative stress may play a role in the development of vascular complications that promote cardiovascular disease by contributing to the pathogenesis of hypertension [143,144] and atherosclerosis [145].”
From Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022) · cites this paper as [143]
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- Authors
- Ceriello, A.
- Affiliations
- University Hospital Coventry (GB)
- Corresponding author
- Ceriello, Antonio
- ORCID
- Ceriello, Antonio
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2008-02-01
- Volume
- 31
- Issue
- Supplement_2
- Pages
- S181-S184
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2137194544
- Cited by
- 215
- References
- 54
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 11 · 2023: 10 · 2022: 12 · 2021: 13 · 2020: 8 · 2019: 12 · 2018: 10 · 2017: 21 · 2016: 10 · 2015: 7 · 2014: 21 · 2013: 14 · 2012: 16
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (University of Udine) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- oxidative stress, hypertension pathogenesis, superoxide, nitric oxide, vasodilation, antioxidants, free radicals, blood pressure reduction
- MeSH terms
- Antihypertensive Agents, Antioxidants, Diabetic Angiopathies, Humans, Hypertension, NADP, Incidence, Reactive Oxygen Species, Oxidative Stress
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