Vitamin K2 Supplementation Improves Insulin Sensitivity via Osteocalcin Metabolism: A Placebo-Controlled Trial
Open accessAbstract
Undercarboxylated osteocalcin (ucOC) is reported to function as an endocrine hormone, affecting glucose metabolism in mice (1,2). Vitamin K, which converts ucOC to carboxylated osteocalcin (cOC), has been suggested to regulate glucose metabolism by modulating osteocalcin and/or proinflammatory pathway (3–5). We studied whether modulation of ucOC via vitamin K2 supplementation for 4 weeks affects β-cell function and/or insulin sensitivity in healthy young male subjects. Forty-two healthy young male volunteers received vitamin K2 (menatetrenone; 30 mg; Eisai Co., Japan) or placebo t.i.d. for 4 weeks. Frequently sampled intravenous glucose tolerance test was performed to determine insulin sensitivity index ( S i), acute insulin response to glucose (AIRg), and disposition index (DI) before and after treatment. Adiponectin, interleukin (IL)-6, C-reactive protein (CRP), ucOC, and cOC …
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Bacterial cultures used for fermentation synthesize vitamin K2 (menaquinones), which may improve insulin sensitivity.
“Bacterial cultures used for fermentation synthesize vitamin K2 (menaquinones), which may improve insulin sensitivity.230, 231”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [231]
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Endocrine regulation of energy metabolism by the skeleton
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Effect of Vitamin K Supplementation on Insulin Resistance in Older Men and Women
Yoshida, M., Jacques, P. F., Meigs, J. B., Saltzman, E., Shea, M. K., Gundberg, C., Dawson-Hughes, B., Dallal, G., & Booth, S. L. (2008) · Diabetes Care · doi:10.2337/dc08-1204 · Cited by 177 · see citing works
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Mozaffarian, D. (2016) · Circulation · doi:10.1161/circulationaha.115.018585 · Cited by 2,216 · see citing works
“Bacterial cultures used for fermentation can synthesize vitamin K2 (menaquinones), which may improve insulin sensitivity.(230,231) These findings suggest that the health effects of dairy may depend on multiple complex characteristics, eg, probiotics in yogurt, fermentation of cheese.”
Dash, N. R., & Al Bataineh, M. T. (2021) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2019.0202 · Cited by 37 · see citing works
- Authors
- Choi, H. J., Yu, J., Choi, H., An, J. H., Kim, S. W., Park, K. S., Jang, H. C., Kim, S. Y., & Shin, C. S.
- Affiliations
- Seoul National University (KR)
- Corresponding author
- Shin, Chan Soo
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2011-08-19
- Volume
- 34
- Issue
- 9
- Pages
- e147-e147
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- PMC
- PMC3161300
- OpenAlex
- W2160738475
- Cited by
- 106
- References
- 5
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 8 · 2023: 8 · 2022: 11 · 2021: 14 · 2020: 13 · 2019: 4 · 2018: 8 · 2017: 9 · 2016: 4 · 2015: 10 · 2014: 3 · 2013: 3 · 2012: 3
- FWCI
- 2.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Diabetes Care (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin K Research Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- vitamin K2, menatetrenone, undercarboxylated osteocalcin, insulin sensitivity, beta-cell function, glucose metabolism, insulin resistance, adiponectin, interleukin-6, C-reactive protein, disposition index, acute insulin response
- MeSH terms
- Adult, Humans, Insulin Resistance, Male, Osteocalcin, Vitamin K 2, Insulin-Secreting Cells, Young Adult
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