Metagenomic Analysis of the Gut Microbiome Reveals Enrichment of Menaquinones (Vitamin K2) Pathway in Diabetes Mellitus
Open accessAbstract
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease with a high prevalence worldwide, especially among overweight and obese populations. T2DM is multifactorial with several genetic and acquired risk factors that lead to insulin resistance. Mounting evidence indicates that alteration of gut microbiome composition contribute to insulin resistance and inflammation. However, the precise link between T2DM and gut microbiome role and composition remains unknown. METHODS: We evaluated the metabolic capabilities of the gut microbiome of twelve T2DM and six healthy individuals through shotgun metagenomics using MiSeq platform. RESULTS: We identified no significant differences in the overall taxonomic composition between healthy and T2DM subjects when controlling for differences in diet. However, results showed that T2DM enriched in metabolic pathways involved in menaquinone (vitamin K2) superpathway biosynthesis (PWY-5838) as compared to healthy individuals. Covariance analysis between the bacterial genera and metabolic pathways displaying difference in abundance (analysis of variance P<0.05) in T2DM as compared to healthy subjects revealed that genera belonging Firmicutes, Actinobacteria, and Bacteroidetes phyla contribute significantly to vitamin K2 biosynthesis. Further, the microbiome corresponding to T2DM with high glycosylated hemoglobin (HbA1c) (>6.5%) exhibit high abundance of genes involved in lysine biosynthesis and low abundance of genes involved in creatinine degradation as compared to T2DM with lower HbA1c (<6.5%). CONCLUSION: The identified differences in metabolic capabilities provide important information that may eventually lead to the development of novel biomarkers and more effective management strategies to treat T2DM.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Menaquinol synthesis pathways are enriched in various chronic inflammatory and cardiovascular diseases.
“Menaquinol synthesis pathways are enriched in various chronic inflammatory and cardiovascular diseases28–31.”
From Longitudinal gut microbiome changes in immune checkpoint blockade-treated advanced melanoma (2024) · cites this paper as [30]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Trimmomatic: a flexible trimmer for Illumina sequence data
Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548 · see citing works
FLASH: fast length adjustment of short reads to improve genome assemblies
Magoč, T., & Salzberg, S. L. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr507 · Cited by 15,366 · see citing works
Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences
Langille, M. G. I., Zaneveld, J., Caporaso, J. G., McDonald, D., Knights, D., Reyes, J. A., Clemente, J. C., Burkepile, D. E., Vega Thurber, R. L., Knight, R., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2676 · Cited by 9,116 · see citing works
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815 · see citing works
A metagenome-wide association study of gut microbiota in type 2 diabetes
Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762 · see citing works
Functional interactions between the gut microbiota and host metabolism
Tremaroli, V., & Bäckhed, F. (2012) · Nature · doi:10.1038/nature11552 · Cited by 4,387 · see citing works
Caspi, R., Billington, R., Ferrer, L., Foerster, H., Fulcher, C. A., Keseler, I. M., Kothari, A., Krummenacker, M., Latendresse, M., Mueller, L. A., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkv1164 · Cited by 3,395 · see citing works
Gut microbiota composition correlates with diet and health in the elderly
Claesson, M. J., Jeffery, I. B., Conde, S., Power, S. E., O’Connor, E. M., Cusack, S., Harris, H. M. B., Coakley, M., Lakshminarayanan, B., O’Sullivan, O., et al. (2012) · Nature · doi:10.1038/nature11319 · Cited by 3,314 · see citing works
Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults
Larsen, N., Vogensen, F. K., van den Berg, F. W. J., Nielsen, D. S., Andreasen, A. S., Pedersen, B. K., Al-Soud, W. A., Sørensen, S. J., Hansen, L. H., & Jakobsen, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009085 · Cited by 2,952 · see citing works
MetaPhlAn2 for enhanced metagenomic taxonomic profiling
Truong, D. T., Franzosa, E. A., Tickle, T. L., Scholz, M., Weingart, G., Pasolli, E., Tett, A., Huttenhower, C., & Segata, N. (2015) · Nature Methods · doi:10.1038/nmeth.3589 · Cited by 2,185 · see citing works
Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota
MetaHIT consortium, Forslund, K., Hildebrand, F., Nielsen, T., Falony, G., Le Chatelier, E., Sunagawa, S., Prifti, E., Vieira-Silva, S., Gudmundsdottir, V., et al. (2015) · Nature · doi:10.1038/nature15766 · Cited by 2,116 · see citing works
Human gut microbiota in obesity and after gastric bypass
Zhang, H., DiBaise, J. K., Zuccolo, A., Kudrna, D., Braidotti, M., Yu, Y., Parameswaran, P., Crowell, M. D., Wing, R., Rittmann, B. E., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812600106 · Cited by 1,880 · see citing works
Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease
Palm, N. W., de Zoete, M. R., Cullen, T. W., Barry, N. A., Stefanowski, J., Hao, L., Degnan, P. H., Hu, J., Peter, I., Zhang, W., et al. (2014) · Cell · doi:10.1016/j.cell.2014.08.006 · Cited by 1,286 · see citing works
Revealing the Bacterial Butyrate Synthesis Pathways by Analyzing (Meta)genomic Data
Vital, M., Howe, A. C., & Tiedje, J. M. (2014) · mBio · doi:10.1128/mbio.00889-14 · Cited by 1,189 · see citing works
Human Gut Microbiota Changes Reveal the Progression of Glucose Intolerance
Zhang, X., Shen, D., Fang, Z., Jie, Z., Qiu, X., Zhang, C., Chen, Y., & Ji, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071108 · Cited by 946 · see citing works
Cani, P. D., Osto, M., Geurts, L., & Everard, A. (2012) · Gut Microbes · doi:10.4161/gmic.19625 · Cited by 864 · see citing works
Microbiota and diabetes: an evolving relationship
Tilg, H., & Moschen, A. R. (2014) · Gut · doi:10.1136/gutjnl-2014-306928 · Cited by 853 · see citing works
Intestinal Microbiota, Microbial Translocation, and Systemic Inflammation in Chronic HIV Infection
Dinh, D. M., Volpe, G. E., Duffalo, C., Bhalchandra, S., Tai, A., Kane, A. V., WANKE, C. A., & Ward, H. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu409 · Cited by 531 · see citing works
Schaubeck, M., Clavel, T., Calasan, J., Lagkouvardos, I., Haange, S. B., Jehmlich, N., Basic, M., Dupont, A., Hornef, M., Bergen, M. V., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-309333 · Cited by 447 · see citing works
Metagenome-wide association studies: fine-mining the microbiome
Wang, J., & Jia, H. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.83 · Cited by 429 · see citing works
Unlocking the potential of metagenomics through replicated experimental design
Knight, R. D., Jansson, J. K., Field, D., Fierer, N., Desai, N., Fuhrman, J. A., Hugenholtz, P., van der Lelie, D., Meyer, F., Stevens, R. L., et al. (2012) · Nature Biotechnology · doi:10.1038/nbt.2235 · Cited by 278 · see citing works
The impact of gut microbiota on gender-specific differences in immunity
Fransen, F., van Beek, A. A., Borghuis, T., Meijer, B., Hugenholtz, F., van der Gaast-de Jongh, C., Savelkoul, H. F., de Jonge, M. I., Faas, M. M., Boekschoten, M. V., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00754 · Cited by 266 · see citing works
Osteocalcin in Human Serum: A Circadian Rhythm*
Gundberg, C. M., MARKOWITZ, M. E., Mizruchi, M. S., & Rosen, J. F. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-60-4-736 · Cited by 261 · see citing works
The Importance of Menaquinones in Human Nutrition
Suttie, J. W. (1995) · Annual Review of Nutrition · doi:10.1146/annurev.nu.15.070195.002151 · Cited by 231 · see citing works
Age-dependent changes in GI physiology and microbiota: time to reconsider?
An, R., Wilms, E., Masclee, A. A. M., Smidt, H., Zoetendal, E. G., & Jonkers, D. (2018) · Gut · doi:10.1136/gutjnl-2017-315542 · Cited by 209 · see citing works
Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women
Knapen, M. H. J., Braam, L. A. J. L. M., Drummen, N. E. A., Bekers, O., Hoeks, A. P. G., & Vermeer, C. (2015) · Thrombosis and Haemostasis · doi:10.1160/th14-08-0675 · Cited by 193 · see citing works
Effect of Vitamin K Supplementation on Insulin Resistance in Older Men and Women
Yoshida, M., Jacques, P. F., Meigs, J. B., Saltzman, E., Shea, M. K., Gundberg, C., Dawson-Hughes, B., Dallal, G., & Booth, S. L. (2008) · Diabetes Care · doi:10.2337/dc08-1204 · Cited by 177 · see citing works
Dietary Phylloquinone and Menaquinones Intakes and Risk of Type 2 Diabetes
Beulens, J. W. J., van der A, D. L., Grobbee, D. E., Sluijs, I., Spijkerman, A. M. W., & van der Schouw, Y. T. (2010) · Diabetes Care · doi:10.2337/dc09-2302 · Cited by 177 · see citing works
Gut Microbiota, Low-grade Inflammation, and Metabolic Syndrome
Chassaing, B., & Gewirtz, A. T. (2013) · Toxicologic Pathology · doi:10.1177/0192623313508481 · Cited by 174 · see citing works
Creatinine Metabolism in Humans with Decreased Renal Function: Creatinine Deficit
Jones, J. D., & Burnett, P. C. (1974) · Clinical Chemistry · doi:10.1093/clinchem/20.9.1204 · Cited by 166 · see citing works
Aging and the human gut microbiota—from correlation to causality
Saraswati, S., & Sitaraman, R. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00764 · Cited by 153 · see citing works
Conly, J. M., & Stein, K. (1993) · PubMed · Cited by 141 · see citing works
Thakore, A. H., Guo, C., Larson, M. G., Corey, D., Wang, T. J., Vasan, R. S., D’Agostino, R. B., Lipinska, I., Keaney, J. F., Benjamin, E. J., et al. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.01.036 · Cited by 131 · see citing works
Glucose metabolism: Focus on gut microbiota, the endocannabinoid system and beyond
Cani, P. D., Geurts, L., Matamoros, S., Plovier, H., & Duparc, T. (2014) · Diabetes & Metabolism · doi:10.1016/j.diabet.2014.02.004 · Cited by 130 · see citing works
Yamaguchi, M. (2010) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2010.562 · Cited by 115 · see citing works
Increased intestinal permeability to oral chromium ( 51 Cr) ‐ EDTA in human Type 2 diabetes
Horton, F., Wright, J., Smith, L., Hinton, P. J., & Robertson, M. D. (2013) · Diabetic Medicine · doi:10.1111/dme.12360 · Cited by 112 · see citing works
Choi, H. J., Yu, J., Choi, H., An, J. H., Kim, S. W., Park, K. S., Jang, H. C., Kim, S. Y., & Shin, C. S. (2011) · Diabetes Care · doi:10.2337/dc11-0551 · Cited by 106 · see citing works
Determining Microbial Products and Identifying Molecular Targets in the Human Microbiome
Cordy, R. J., Yasuda, K., Shafquat, A., Morgan, X. C., & Huttenhower, C. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.10.003 · Cited by 100 · see citing works
Pimentel, M., Mathur, R., & Chang, C. C.-C. (2013) · Current Gastroenterology Reports · doi:10.1007/s11894-013-0356-y · Cited by 88 · see citing works
Diabetes Induces Lysine Acetylation of Intermediary Metabolism Enzymes in the Kidney
Kosanam, H., Thai, K., Zhang, Y., Advani, A., Connelly, K. A., Diamandis, E. P., & Gilbert, R. E. (2014) · Diabetes · doi:10.2337/db12-1770 · Cited by 72 · see citing works
SAKAMOTO, N., Nishiike, T., Iguchi, H., & SAKAMOTO, K. (2000) · Clinical Nutrition · doi:10.1054/clnu.2000.0102 · Cited by 43 · see citing works
Validity and Reproducibility of a Habitual Dietary Fibre Intake Short Food Frequency Questionnaire
Healey, G. R., Brough, L., Murphy, R., HEDDERLEY, D. I., Butts, C. A., & Coad, J. (2016) · Nutrients · doi:10.3390/nu8090558 · Cited by 40 · see citing works
Metagenomic systems biology and metabolic modeling of the human microbiome
Levy, R., & Borenstein, E. (2014) · Gut Microbes · doi:10.4161/gmic.28261 · Cited by 39 · see citing works
Abul‐Hajj, Y. J. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38081-x · Cited by 34 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance
Suez, J., Cohen, Y., Valdés‐Mas, R., Mor, U., Dori-Bachash, M., Federici, S., Zmora, N., Leshem, A., Heinemann, M., Linevsky, R., et al. (2022) · Cell · doi:10.1016/j.cell.2022.07.016 · Cited by 431 · see citing works
Longitudinal gut microbiome changes in immune checkpoint blockade-treated advanced melanoma
Björk, J. R., Bolte, L. A., Maltez Thomas, A., Lee, K. A., Rossi, N., Wind, T. T., Smit, L. M., Armanini, F., Asnicar, F., Blanco-Miguez, A., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-02803-3 · Cited by 156 · see citing works
Unraveling metagenomics through long-read sequencing: a comprehensive review
Kim, C., Pongpanich, M., & Porntaveetus, T. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-04917-1 · Cited by 129 · see citing works
Vitamin K2 Holds Promise for Alzheimer’s Prevention and Treatment
Popescu, A., & German, M. (2021) · Nutrients · doi:10.3390/nu13072206 · Cited by 55 · see citing works
Roth‐Schulze, A. J., Penno, M. A. S., Ngui, K., Oakey, H., Bandala‐Sanchez, E., Smith, A. D., Allnutt, T. R., Thomson, R. L., Vuillermin, P., Craig, M. E., et al. (2021) · Microbiome · doi:10.1186/s40168-021-01104-y · Cited by 40 · see citing works
Bataineh, M. T. A., Künstner, A., Dash, N. R., AlSafar, H. S., Ragab, M., Schmelter, F., Sina, C., Busch, H. S., & Ibrahim, S. M. (2023) · Scientific Reports · doi:10.1038/s41598-023-45066-7 · Cited by 41 · see citing works
Self-citationFunctional alterations and predictive capacity of gut microbiome in type 2 diabetes
Dash, N. R., Bataineh, M. T. A., Alili, R., Safar, H. A., Alkhayyal, N., Prifti, E., Zucker, J., Belda, E., & Clément, K. (2023) · Scientific Reports · doi:10.1038/s41598-023-49679-w · Cited by 40 · see citing works
Self-citationThe gut microbiota pathway mechanisms of diabetes
Bajinka, O., Tan, Y., Darboe, A., Ighaede-Edwards, I. G., & Abdelhalim, K. A. (2023) · AMB Express · doi:10.1186/s13568-023-01520-3 · Cited by 38 · see citing works
Adiposity is associated with expansion of the genus Dialister in rheumatoid arthritis patients
Vázquez, N. M., Ruiz‐Limón, P., Moreno‐Indias, I., Arija, S. M., Lisbona-Montañez, J. M., Rioja, J., Mucientes, A., Martín‐Núñez, G. M., Cano‐García, L., Tinahones, F. J., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114388 · Cited by 26 · see citing works
Wang, H., Chen, Z., Wang, M., Long, M., Ren, T., Chen, C., Dai, X., Yang, S., & Tan, S. (2022) · Foods · doi:10.3390/foods11121747 · Cited by 26 · see citing works
Tsiantas, K., Konteles, S. J., Kritsi, E., Sinanoglou, V. J., Tsiaka, T., & Zoumpoulakis, P. G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084070 · Cited by 25 · see citing works
Murga-Garrido, S. M., Ulloa‐Pérez, E., Díaz-Benítez, C. E., Orbe-Orihuela, Y. C., Cornejo‐Granados, F., Ochoa‐Leyva, A., Sánchez‐Flores, A., Cruz, M., Castañeda-Márquez, A. C., Plett-Torres, T., et al. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.03382-22 · Cited by 23 · see citing works
Vitamin biosynthesis in the gut: interplay between mammalian host and its resident microbiota
Tarracchini, C., Lordan, C., Milani, C., Moreira, L. D. P. D., Alabedallat, Q. M., de LeBlanc, A. D. M., Turroni, F., Lugli, G. A., Mancabelli, L., Longhi, G., et al. (2025) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00184-23 · Cited by 29 · see citing works
Vu, V., Muthuramalingam, K., Singh, V., Choi, C., Kim, Y. M., Unno, T., & Cho, M. (2022) · Applied Biological Chemistry · doi:10.1186/s13765-022-00680-3 · Cited by 22 · see citing works
Microbial vitamin production mediates dietary effects on diabetic risk
Wang, D., Pham, V. T., Steinert, R. E., Zhernakova, A., & Fu, J. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2154550 · Cited by 18 · see citing works
Castillo, D., Denson, L. A., Haslam, D. B., Hommel, K. A., Ollberding, N. J., Sahay, R. D., & Santucci, N. R. (2023) · Neurogastroenterology & Motility · doi:10.1111/nmo.14573 · Cited by 17 · see citing works
Kupai, K., Várkonyi, T. T., Török, S., Gáti, V., Czimmerer, Z., Puskás, L. G., & Szebeni, G. J. (2022) · Life · doi:10.3390/life12081205 · Cited by 16 · see citing works
From One-Size-Fits-All to Precision Medicine: The Promise of Personalized Probiotics
Montazeri‐Najafabady, N. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10815-9 · Cited by 14 · see citing works
Clinical benefits of β-glucan supplementation in children: a review
Bhoite, R., Satyavrat, V., & Sadananda, M. P. (2022) · Discover Food · doi:10.1007/s44187-022-00038-0 · Cited by 13 · see citing works
Vitamin K2 Enhances Fat Degradation to Improve the Survival of C. elegans
Qu, Z., Zhang, L., Huang, W. M., & Zheng, S. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.858481 · Cited by 13 · see citing works
Microbial Communities in Home-Made and Commercial Kefir and Their Hypoglycemic Properties
Yılmaz, B., Elibol, E., Shangpliang, H. N. J., Özoğul, F., & Tamang, J. P. (2022) · Fermentation · doi:10.3390/fermentation8110590 · Cited by 13 · see citing works
Banimfreg, B. H., Alshraideh, H. A., Shamayleh, A., Guella, A., Semreen, M. H., Bataineh, M. T. A., & Soares, N. C. (2022) · Biomolecules · doi:10.3390/biom12070962 · Cited by 10 · see citing works
Li, P., Tong, T., Wu, Y., Zhou, X., Zhang, M., Liu, J., She, Y., Li, Z., & Li, Y. (2023) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2304.04039 · Cited by 9 · see citing works
Alarifi, S. N., Alyamani, E. J., Alarawi, M. S., Alquait, A. A., Alolayan, M. A., Aldossary, A. M., EL-Rahman, R. A. A., & Mir, R. (2024) · Metabolites · doi:10.3390/metabo14120720 · Cited by 7 · see citing works
Sarkar, A., Khan, A. S., Kaul, R., Lee, S., Kamal, I., Paul, P., Laws, S., & Châari, A. (2024) · Discover Public Health · doi:10.1186/s12982-024-00213-x · Cited by 5 · see citing works
Zhang, Y., He, J., Chen, L., & Wang, W. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106095 · Cited by 5 · see citing works
Pathak, G., Mangla, S., Bhan, V., Ahlawat, Y. K., Sharma, N., Malik, A., Gautam, P., Verma, R., Gupta, S., & Bisht, K. (2026) · Phytotherapy Research · doi:10.1002/ptr.70213 · Cited by 5 · see citing works
Oluwaloni, F. O., Yakubu, O. F., Adebayo, A. H., Koyejo, O. D., & Lawal, A. K. (2023) · Tropical Journal of Natural Product Research · doi:10.26538/tjnpr/v7i6.2 · Cited by 3 · see citing works
Micronutrients and the gut microbiome: a bidirectional interaction
Kodentsova, V. M., & Risnik, D. V. (2024) · Medical alphabet · doi:10.33667/2078-5631-2024-16-40-46 · Cited by 1 · see citing works
Wang, X.-Y., Zhang, Y., Liu, L., Ma, H., Wei, C., Xu, X., Zhang, J., Pan, S.-J., Zhang, Y., Chen, J., et al. (2025) · Food & Function · doi:10.1039/d5fo01613d · Cited by 1 · see citing works
Biosynthesis and therapeutic applications of MK-7: A comprehensive review
Maneesha, M., & Devi, C. S. (2025) · Cogent Food & Agriculture · doi:10.1080/23311932.2025.2509677
Zhao, Y., Naidoo, J., Conroy, M. R., Ferri, J. T., Gills, J. J., Chen, K. Y., White, J. R., Glass, S., Assan, W. O., Peloza, K. E., et al. (2025) · medRxiv · doi:10.1101/2025.10.01.25336378
Roth‐Schulze, A. J., Penno, M. A. S., Ngui, K., Oakey, H., Bandala‐Sanchez, E., Smith, A. D., Allnutt, T. R., Thomson, R. L., Vuillermin, P. J., Craig, M. E., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15128280
Microbial Genomics: Unraveling the Healthomic Code
Sultana, M., Hossain, A., Noor-E-Meem, & Begum, A. (2026) · Interdisciplinary biotechnological advances · doi:10.1007/978-981-95-3612-2_2
Role of lipid metabolites in mediating causal effects of gut microbiota on type 2 diabetes mellitus
Li, L., Tang, S., Liu, F., & Yang, M. (2026) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2026.108955
Depletion of Blautia wexlerae and Parabacteroides distasonis in adiposity-related prehypertension
Luo, L., Cheng, K., Chen, B., Li, Y., Ruan, L., Li, Z., Zhu, S., Zhao, L., Zhang, C., Liu, Y., et al. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1873803
Uriz-Martínez, M., Ansorena, D., Astiasarán, I., Sáinź, N., Lópeź‐Yoldi, M., & Aranaz, P. (2026) · Future Foods · doi:10.1016/j.fufo.2026.101124
- Authors
- Dash, N. R., & Al Bataineh, M. T.
- Affiliations
- University of Sharjah (AE)
- Venue
- Diabetes & Metabolism Journal
- Publisher
- Korean Diabetes Association
- Published
- 2021-01-31
- Volume
- 45
- Issue
- 1
- Pages
- 77-85
- ISSN
- 2233-6079 (ISSN-L)
- 2233-6087
- PMC
- PMC7850878
- OpenAlex
- W3024695169
- Cited by
- 37
- References
- 44
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 6 · 2023: 8 · 2022: 10 · 2021: 3
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Diabetes & Metabolism Journal (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- University of Sharjah (P1701090226)
- Boehringer Ingelheim (2016-17)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- type 2 diabetes, gut microbiota, menaquinone biosynthesis, vitamin K2, metabolic pathways, insulin resistance, HbA1c, lysine biosynthesis, Firmicutes, actinobacteria, Bacteroidetes, biomarkers
- MeSH terms
- Gastrointestinal Microbiome, Diabetes Mellitus, Type 2, Humans, Vitamin K 2, Metagenome, Metagenomics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review