Newborn Adiposity and Cord Blood C-Peptide as Mediators of the Maternal Metabolic Environment and Childhood Adiposity

Josefson, Jami L.; Scholtens, Denise M.; Kuang, Alan; Catalano, Patrick M.; Lowe, Lynn P.; Dyer, Alan R.; Petito, Lucia C.; Lowe, William L.; Metzger, Boyd E.; HAPO Follow-up Study Cooperative Research Group; Deerochanawong, Chaicharn; Tanaphonpoonsuk, Thadchanan; Chotigeat, Sukeeta Binratkaew Uraiwan; Manyam, Wanee; Forde, Martinette; Greenidge, Andre; Neblett, Kathleen; Lashley, Paula Michele; Walcott, Desiree; Corry, Katie; Francis, Loraine; Irwin, Jo-anne; Langan, Anne; McCance, David R.; Mousavi, Maureen; Young, Ian; Gutierrez, Jennifer; Jimenez, Jennifer; Lawrence, Jean M.; Sacks, David A.; Takhar, Harpreet S.; Tanton, Elizabeth; Brickman, Wendy J.; Howard, Jennifer; Josefson, Jami L.; Miller, Lauren; Bjaloncik, Jacqui; Catalano, Patrick M.; Davis, Ajuah; Koontz, Michaela; Presley, Larraine; Smith, Shoi; Tyhulski, Amanda; Li, Albert Martin; Ma, Ronald C.; Ozaki, Risa; Tam, Wing Hung; Wong, Michelle; Yuen, Cindy Siu Man; Clayton, Peter E.

doi:10.2337/dc20-2398

Newborn Adiposity and Cord Blood C-Peptide as Mediators of the Maternal Metabolic Environment and Childhood Adiposity

OBJECTIVE Excessive childhood adiposity is a risk factor for adverse metabolic health. The objective was to investigate associations of newborn body composition and cord C-peptide with childhood anthropometrics and explore whether these newborn measures mediate associations of maternal midpregnan…