Acute Metabolic Effects of Human Growth Hormone

Fineberg, S Edwin; Merimee, Thomas J

doi:10.2337/diab.23.6.499

Cited by 101Growth Hormone and Insulin-like Growth FactorsPancreatic function and diabetesDiabetes, Cardiovascular Risks, and Lipoproteins

Acute Metabolic Effects of Human Growth Hormone

Fineberg, S Edwin, Merimee, Thomas J·1974·Diabetes

DOI 10.2337/diab.23.6.499

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Abstract

These studies were done to clarify the actions of human growth hormone (HGH) during the two hours after concentrations were increased. These effects cannot be attributed to generation of somatomedin. Mean systemic levels of HGH were increased to 92.6 ng. per milliliter by the intravenous infusion of 4 mg. of HGH over thirty minutes. During the first hour, mean plasma glucose and free fatty acid (FFA) concentrations decreased by 9.5 ± 1.9 per cent and 21.2 ± 3.6 per cent, respectively. After two hours, FFA concentrations rose to 145 per cent of basal. An identical preparation of HGH was then perfused across forearm tissues at mean forearm venous concentrations of 28.4 ± 1.5 ng. per milliliter or 200.3 ± 7.9 ng. per milliliter. Glucose uptake was acutely decreased (by 30 per cent) by both doses of HGH; neither dose had significant effects upon lipolysis. Therefore, neither physiologic nor supraphysiologic concentrations of HGH had an insulin-like effect upon peripheral muscle or adipose tissue. Small increases in peripheral HGH concentrations had virtually identical effects upon enhancement of potassium uptake and reduction of glucose uptake across muscle as mean concentrations ten times higher.

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Most reports have shown that in man exogenous growth hormone augments lipolysis.
“Most [9,10], but not all [3] reports, have shown that in man exogenous GH augments lipolysis”
From Effects of growth hormone on insulin sensitivity and forearm metabolism in normal man (1989) · cites this paper as [9]
Forearm studies have suggested that growth hormone acutely decreases peripheral disposal of glucose.
“whereas forearm studies have suggested that GH acutely decreases peripheral disposal of glucose [8,9].”
From Effects of growth hormone on insulin sensitivity and forearm metabolism in normal man (1989) · cites this paper as [9]

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Authors: Fineberg, S. E., & Merimee, T. J.
Affiliations: Boston University (US)
Venue: Diabetes
Publisher: American Diabetes Association
Published: 1974-06-01
Volume: 23
Issue: 6
Pages: 499-504
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diab.23.6.499
OpenAlex: W2160436622
Cited by: 101
References: 0
Citations by year: 2025: 1 · 2023: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 1
FWCI: 1.45
Type: journal article
Language: en
Open access: closed
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Funders: NIH Clinical Center
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: human growth hormone, plasma glucose, free fatty acids, glucose uptake, lipolysis, insulin-like activity, insulin-like growth factor, muscle, adipose tissue, potassium uptake, hyperinsulinemic-euglycemic clamp
MeSH terms: Adipose Tissue, Adult, Arteries, Blood Flow Velocity, Blood Glucose, Fasting, Fatty Acids, Nonesterified, Female, Forearm, Humans, Injections, Intra-Arterial, Injections, Intravenous, Male, Perfusion, Potassium, Growth Hormone, Time Factors, Veins

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Acute Metabolic Effects of Human Growth Hormone

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