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Pulsatile Insulin Has Greater Hypoglycemic Effect Than Continuous Delivery
Abstract
The relative hypoglycemic effects of pulsatile versus steadily infused insulin have been examined in six normal subjects in whom pancreatic insulin output was suppressed by somatostatin-14. Soluble insulin was infused continuously overnight on one occasion and on another occasion the same quantity was given in pulses of 2-min duration with a gap of 11 min. The mean plasma glucose concentrations were lower when pulsed insulin was given [mean for the last hour: 4.66 ± 0.08 mmol/L (±SEM) versus 5.53 ± 0.06 mmol/L (±SEM) for steady infusion], diverging significantly (P < 0.05 paired t test) 7 h after the start of the study. The specific binding of 125I(A14)mono-iodo-insulin to monocytes was greater after pulsed insulin (2.9% with pulsed versus 2.4% with steadily infused insulin at tracer-only point; P < 0.02 paired t test). Thus, intravenous insulin has greater hypoglycemic effect when pulsed, possibly mediated by greater insulin receptor binding.
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Cited by
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Self-citationInsulin Resistance and Hyperinsulinemia
Shanik, M. H., Xu, Y., Škrha, J., Dankner, R., Zick, Y., & Roth, J. (2008) · Diabetes Care · doi:10.2337/dc08-s264 · Cited by 791
Impaired Pulsatile Secretion of Insulin in Relatives of Patients with Non-Insulin-Dependent Diabetes
O'Rahilly, S., Turner, R. C., & Matthews, D. R. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805123181902 · Cited by 540
Self-citationThe crucial role of pulsatile activity of the HPA axis for continuous dynamic equilibration
Lightman, S. L., & Conway-Campbell, B. L. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2914 · Cited by 390
Dynamics of insulin secretion and the clinical implications for obesity and diabetes
Seino, S., Shibasaki, T., & Minami, K. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45680 · Cited by 364
Meier, J. J., Veldhuis, J. D., & Butler, P. C. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1649 · Cited by 261
The significance of glucocorticoid pulsatility
Lightman, S. L., Wiles, C. C., Atkinson, H. C., Henley, D. E., Russell, G. M., Leendertz, J. A., McKenna, M. A., Spiga, F., Wood, S. A., & Conway-Campbell, B. L. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.073 · Cited by 241
Pulsatile Insulin Secretion: Detection, Regulation, and Role in Diabetes
Pørksen, N., Hollingdal, M., Juhl, C., Butler, P., Veldhuis, J. D., & Schmitz, O. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s245 · Cited by 223
Motivations and Methods for Analyzing Pulsatile Hormone Secretion
Veldhuis, J. D., Keenan, D. M., & Pincus, S. M. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0005 · Cited by 223
Pulsatile Portal Vein Insulin Delivery Enhances Hepatic Insulin Action and Signaling
Matveyenko, A. V., Liuwantara, D., Gurlo, T., Kirakossian, D., Dalla Man, C., Cobelli, C., White, M. F., Copps, K. D., Volpi, E., Fujita, S., et al. (2012) · Diabetes · doi:10.2337/db11-1462 · Cited by 163
SIMON, C., BRANDENBERGER, G., & FOLLENIUS, M. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-4-669 · Cited by 147
Development of an automated blood sampling system for use in humans
Henley, D. E., Leendertz, J. A., Russell, G. M., Wood, S. A., Taheri, S., Woltersdorf, W. W., & Lightman, S. L. (2009) · Journal of Medical Engineering & Technology · doi:10.1080/03091900802185970 · Cited by 108
Quesada, I., Todorova, M. G., Alonso-Magdalena, P., Beltrá, M., Carneiro, E. M., Martin, F., Nadal, A., & Soria, B. (2006) · Diabetes · doi:10.2337/db06-0272 · Cited by 104
Pulsatility of insulin release – a clinically important phenomenon
Hellman, B. (2009) · Upsala Journal of Medical Sciences · doi:10.3109/03009730903366075 · Cited by 77
Feldberg, D., Dicker, D., Samuel, N., Peleg, D., Karp, M., Goldman, J. A., & Goldman, J. A. (1988) · Acta Obstetricia et Gynecologica Scandinavica · doi:10.3109/00016348809004231 · Cited by 33
Lightman, S., & Terry, J. R. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70182-7 · Cited by 28
Metadata
- Authors
- Matthews, D. R., Naylor, B. A., Jones, R. G., Ward, G. M., & Turner, R. C.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1983-07-01
- Volume
- 32
- Issue
- 7
- Pages
- 617-621
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2152187001
- Cited by
- 257
- References
- 0
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
