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Cited by 74Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismDiabetes, Cardiovascular Risks, and Lipoproteins

Insulin Binding and Responsiveness in Fat Cells from Patients with Reduced Glucose Tolerance and Type II Diabetes

Lönnroth, Peter, Digirolamo, Mario, Krotkiewski, Marcin, Smith, Ulf·1983·Diabetes
DOI 10.2337/diab.32.8.748
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Abstract

Adipose tissue was obtained from 66 individuals including 21 patients with type II diabetes of different severity (16 SU-treated and 5 diet-treated only) as well as 9 obese subjects with reduced glucose tolerance. Adi-pocyte insulin binding, antilipolytic effect of insulin, and glucose incorporation into triglycerides were measured in the diabetic and the obese subjects and the data compared with that of normal controls of similar age and relative weight. Insulin binding per cell was normal in the diabetic patients and was significantly increased at low insulin concentrations in the obese patients with reduced glucose tolerance, suggesting increased affinity. Furthermore, insulin binding correlated negatively with age but, when age was corrected for, did not correlate significantly with fasting insulin or glucose levels, relative body weight, or fat cell size. Insulin sensitivity, measured as the antilipolytic effect of insulin, was similar in all patient groups. Patients with the most severe type II diabetes (SU-treated group) demonstrated, in contrast to the less severely diabetic patients, a marked reduction in both basal and insulin-stimulated glucose incorporation into triglycerides showing the presence of a pronounced postreceptor defect. The insulin effect on glucose incorporation correlated negatively with the fasting glucose levels, suggesting that the postreceptor defect seen in the adipocyte reflectsperturbations in other organs, like muscle or liver, of greater importance for glUCOSe homeostasis.

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  • A decrease in insulin receptor number cannot be demonstrated in over half of type 2 diabetic subjects, and reduced insulin binding correlates poorly with severity of insulin resistance.

    “a decrease in insulin receptor number cannot be demonstrated in over half of type 2 diabetic subjects, and it has been difficult to demonstrate a correlation between reduced insulin binding and the severity of insulin resistance [156–158].”

    From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [157]

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Authors
Lönnroth, P., Digirolamo, M., Krotkiewski, M., & Smith, U.
Affiliations
  • Sahlgrenska University Hospital (SE)
  • Emory University (US)
ORCID
Smith, Ulf
Venue
Diabetes
Publisher
American Diabetes Association
Published
1983-08-01
Volume
32
Issue
8
Pages
748-754
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/diab.32.8.748
OpenAlex
W2110291358
Cited by
74
References
0
Citations by year
2021: 2 · 2020: 1 · 2018: 4 · 2015: 1
FWCI
8.59
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
insulin binding, adipocytes, type 2 diabetes, obesity, insulin sensitivity, antilipolytic effect
MeSH terms
Adipose Tissue, Adolescent, Adult, Aged, Diabetes Mellitus, Female, Glucose, Humans, Insulin, Insulin Resistance, Lipolysis, Male, Middle Aged, Obesity, Triglycerides

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