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Impaired Insulin-Mediated Skeletal Muscle Blood Flow in Patients With NIDDM
Abstract
Patients with non-insulin-dependent diabetes metlitus (NIDDM) exhibit decreased rates of skeletal muscle insulin-mediated glucose uptake (IMGU). Because IMGU is equal to the product of the arteriovenous glucose difference (AVGΔ) across and blood flow (F) into muscle (IMGU = AVGΔ × F), reduced tissue permeability (AVGΔ) and/or glucose and insulin delivery (F) can potentially lead to decreased IMGU. The components of skeletal muscle IMGU were studied in six obese NIDDM subjects (103 ± 9 kg) and compared with those previously determined in six lean (weight 68 ± 3 kg), and six obese (94 ± 3 kg) with normal glucose tolerance. The insulin dose-response curves for whole body and leg muscle IMGU were constructed using the combined euglycemic clamp and leg balance techniques during sequential insulin infusions (range of serum insulin 130–80,000 pmol/L). In lean, obese, and NIDDM subjects, whole body IMGU, femoral AVGΔ, and leg IMGU increased in a dose-dependent fashion over the range of insulin with an ED50 of 400–500 pmol/L in lean, 1000–1200 pmol/L in obese, and 4000–7000 pmol/L in NIDDM subjects (P < 0.01 lean vs. obese and NIDDM). In lean and obese subjects, maximally effective insulin concentrations increased leg blood flow ∼2-fold from basal with an ED50 of 266 pmol/L and 957 pmol/L, respectively (P < 0.01 lean vs. obese). In contrast, leg F did not increase from the basal value in NIDDM subjects (2.7 ± 0.1 vs. 3.5 ± 0.5 dl/min, NS). In the physiological range of insulin concentrations NIDDM subjects had lower body IMGU, leg F, femoral AVGΔ, and leg IMGU than obese and lean subjects, but at maximally effective insulin concentrations, femoral AVGA did not differ between obese and NIDDM subjects. Thus, 1) both reduced skeletal muscle tissue permeability and blood flow are found in NIDDM subjects and 2) impaired insulin-mediated augmentation of skeletal muscle blood flow in obese NIDDM patients is due to the diabetic state per se and not to the obesity status. Whether reduced skeletal muscle blood flow is the result or the cause of insulin resistance in patients with NIDDM remains to be elucidated.
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“subjects with prediabetes require more glucose than a subject with overt type 2 diabetes mellitus (T2DM).”
From The Vasculature in Prediabetes (2018) · cites this paper as [7]
In the citing paper
“Attenuated increases in insulin-stimulated limb blood flow result in decreased limb glucose uptake.”
From The Vasculature in Prediabetes (2018) · cites this paper as [7]
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Galletti, F., Strazzullo, P., Capaldo, B., Carretta, R., Fabris, F. M., Ferrara, L. A., Glorioso, N., Semplicini, A., & Mancini, M. (1999) · Journal of Hypertension · doi:10.1097/00004872-199917030-00018 · Cited by 39
Insulin-Stimulated Glucose Transport Inhibits Ca 2+ Influx and Contraction in Vascular Smooth Muscle
Kahn, A. M., Lichtenberg, R. A., Allen, J. C., Seidel, C. L., & Song, T. (1995) · Circulation · doi:10.1161/01.cir.92.6.1597 · Cited by 39
Role of habitual physical activity in modulating vascular actions of insulin
Padilla, J., Olver, T. D., Thyfault, J. P., & Fadel, P. J. (2015) · Experimental Physiology · doi:10.1113/ep085107 · Cited by 38
“There has been renewed interest in this area since the early 1990s when Baron, Laakso and colleagues (Laakso et al. 1990, 1992) produced similar observations when performing euglycaemic, hyperinsulinaemic clamps and noted that insulin-induced vasodilatation was impaired in insulin-resistant states.”
BackgroundInfluentialMultiple mechanisms involved in obesity-induced hypertension
Antic, V., Dulloo, A. G., & Montani, J. (2003) · Heart Lung and Circulation · doi:10.1046/j.1444-2892.2003.00200.x · Cited by 39
Arbin, V., Claperon, N., Fournié‐Zaluski, M., Roques, B. P., & Peyroux, J. (2003) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200302000-00015 · Cited by 37
“These findings are in agreement with previous reports concerning other insulin-resistant animal models (15) or human patients (17,18).”
BackgroundResultRennings, A. J. M., Smits, P., Stewart, M. W., & Tack, C. J. (2006) · Diabetes Care · doi:10.2337/diacare.29.03.06.dc05-01467 · Cited by 37
“As there was no association between changes in the metabolic and vascular actions of insulin, our results do not support the view that insulin-induced glucose disposal is the consequence of enhanced total muscle blood flow (18).”
BackgroundResultPerticone, F., Ceravolo, R., Iacopino, S., Cloro, C., Ventura, G., Maio, R., Gulletta, E., Perrotti, N., & Mattioli, P. L. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.1.7117 · Cited by 39
“Moreover, the fact that IR is found among normotensive relatives of hypertensive patients implies that the predisposition to IR might be inherited ( 17 ).”
BackgroundResultCharacterization of the Prediabetic State
Groop, L. (1997) · American Journal of Hypertension · doi:10.1016/s0895-7061(97)00149-0 · Cited by 37
“insulin to the target tissue through reductions in blood flow could explain insulin resistance.(31) Three findings”
BackgroundAkakabe, Y., Koide, M., Kitamura, Y., Matsuo, K., Ueyama, T., Matoba, S., Yamada, H., Miyata, K., Oike, Y., & Ikeda, K. (2013) · Nature Communications · doi:10.1038/ncomms3389 · Cited by 36
Effect of salt-loading on blood pressure, insulin sensitivity and limb blood flow in normal subjects
Foo, M. W. Y., Denver, A. E., Coppack, S. W., & Yudkin, J. S. (1998) · Clinical Science · doi:10.1042/cs0950157 · Cited by 36
Effects of thiazolidinediones on blood pressure
Giles, T. D., & Sander, G. E. (2007) · Current Hypertension Reports · doi:10.1007/s11906-007-0060-0 · Cited by 35
“The presence of insulin resistance is also associated with a reduction in the ability of insulin to cause endothelium-dependent vasodilatation, as is found in normal subjects [ 13 ].”
Direct vasodilatory effect of insulin on isolated retinal arterioles.
Su, E.-N., Yu, D., Alder, V. A., et al. (1996) · PubMed · Cited by 35
Sjöstrand, M., Guðbjörnsdóttir, S., Strindberg, L., & Lönnroth, P. (2005) · Diabetes · doi:10.2337/diabetes.54.1.152 · Cited by 34
“It has been suggested that the slow rate of insulin delivery in insulin-resistant states might be due to reduced capillary density (14) or capillary recruitment (15,16) or the diminished vasodilative response of insulin (17,18).”
BackgroundRetractedAcute Inactivity Impairs Glycemic Control but Not Blood Flow to Glucose Ingestion
Reynolds, L. J., Credeur, D. P., Holwerda, S. W., Leidy, H. J., Fadel, P. J., & Thyfault, J. P. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000508 · Cited by 34
Walters, J. M., Ward, G. M., Barton, J., et al. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90146-3 · Cited by 34
FFAs: Do they play a role in vascular disease in the insulin resistance syndrome?
Shankar, S. S., & Steinberg, H. O. (2005) · Current Diabetes Reports · doi:10.1007/s11892-005-0064-6 · Cited by 34
“Moreover, insulin-mediated vasodilation is impaired in obesity and type 2 diabetes, both conditions characterized by elevated FFA levels [ 31 ].”
BackgroundKurioka, S., Koshimura, K., Murakami, Y., Nishiki, M., & Kato, Y. (2000) · Endocrine Journal · doi:10.1507/endocrj.47.77 · Cited by 33
Effects of insulin on regional blood flow and glucose uptake in Wistar and Sprague-Dawley rats
Gaudreault, N., Santuré, M., Pǐtre, M., Nadeau, A., Marette, A., & Bachelard, H. (2001) · Metabolism · doi:10.1053/meta.2001.18569 · Cited by 33
Zhang, S., Yang, Y. Y., Kone, B. C., Allen, J. C., & Kahn, A. M. (2003) · Circulation · doi:10.1161/01.cir.0000056766.45109.c1 · Cited by 33
Insulin-Induced Biphasic Responses in Rat Mesenteric Vascular Bed
Misurski, D. A., Wu, S.-Q., McNeill, J. R., Wilson, T. W., & Gopalakrishnan, V. (2001) · Hypertension · doi:10.1161/01.hyp.37.5.1298 · Cited by 33
IGF-I increases forearm blood flow without increasing forearm glucose uptake
Pendergrass, M., Fazioni, E., Collins, D., & DeFronzo, R. A. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.2.e345 · Cited by 33
Tsurutani, Y., Sugisawa, C., Ishida, A., Inoue, K., Saito, J., Omura, M., Nagasaka, S., & Nishikawa, T. (2017) · Endocrine Journal · doi:10.1507/endocrj.ej16-0500 · Cited by 32
“Skeletal muscle insulin-mediated glucose uptake is equal to the product of arteriovenous glucose difference across and blood flow into muscle [25, 26].”
BackgroundInsulin resistance in vascular endothelial cells promotes intestinal tumour formation
Wang, X., Häring, M.-F., Rathjen, T., Lockhart, S. M., Sørensen, D., Ussar, S., Rasmussen, L. M., Bertagnolli, M. M., Kahn, C. R., & Rask‐Madsen, C. (2017) · Oncogene · doi:10.1038/onc.2017.107 · Cited by 32
Insulin-induced vasodilatation of internal carotid artery
Chaudhuri, A., Kanjwal, Y., Mohanty, P., Rao, S. G., Sung, B. H., Wilson, M. F., & Dandona, P. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90161-0 · Cited by 32
Ueda, S., Petrie, J. R., Cleland, S. J., Elliott, H. L., & Connell, J. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4897 · Cited by 33
“This would reconcile two apparently conflicting observations: in patients with noninsulin-dependent diabetes mellitus, insulin-mediated vasodilation is blunted with respect to controls when glucose levels are clamped at euglycemia (5.2 mmol/L) ( 34 ), but insulin-mediated vasodilation is maintained when each patient’s…”
ResultInfluentialInsulin resistance syndrome: possible key role of blood flow in resting muscle
Ganrot, P. O. (1993) · Diabetologia · doi:10.1007/bf00400365 · Cited by 32
“Leg blood flow response during the clamp was much lower than in non-diabetic subjects [20, 21].”
BackgroundMetabolic Inflexibility in Skeletal Muscle: A Prelude to the Cardiometabolic Syndrome?
Thyfault, J. P., Rector, R. S., & Noland, R. C. (2006) · Journal of the CardioMetabolic Syndrome · doi:10.1111/j.1559-4564.2006.05629.x · Cited by 31
Mikus, C. R., Roseguini, B. T., Uptergrove, G. M., Morris, E. M., Rector, R. S., Libla, J. L., Oberlin, D. J., Borengasser, S. J., Taylor, A. M., Ibdah, J. A., et al. (2012) · Microcirculation · doi:10.1111/j.1549-8719.2012.00210.x · Cited by 31
“However, vasoreactivity to insulin is impaired in obesity and type-II diabetes, and decrements in insulin-stimulated blood flow correlate strongly with reductions in insulin-mediated glucose uptake [3, 18, 36, 37].”
BackgroundLimberg, J. K., Soares, R. N., & Padilla, J. (2022) · Current Diabetes Reports · doi:10.1007/s11892-022-01456-1 · Cited by 34
Beneficial haemodynamic effects of insulin in chronic heart failure
Parsonage, W. A. (2001) · Heart · doi:10.1136/heart.85.5.508 · Cited by 31
Chien, W., Yang, K., Eng, H.-L., Hu, Y.-H., Lee, P. Y., Wang, S., & Wang, P. W. (2005) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70168-4 · Cited by 30
“Recent experimental findings on insulinmediated vasodilation have suggested that vascular insensitivity is also a component of IR [3-5].”
BackgroundChronic adrenergic receptor blockade does not prevent hyperinsulinemia-induced hypertension in rats
KEEN, H., BRANDS, M., Alonso‐Galicia, M., & Hall, J. E. (1996) · American Journal of Hypertension · doi:10.1016/s0895-7061(96)00254-3 · Cited by 31
Martin, J. S., Padilla, J., Jenkins, N. T., Crissey, J. M., Bender, S. B., Rector, R. S., Thyfault, J. P., & Laughlin, M. H. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00823.2012 · Cited by 30
“flow and contributing to insulin resistance (20, 22, 40).”
BackgroundNew insights into mechanisms of endothelial insulin resistance in type 2 diabetes
Padilla, J., Manrique‐Acevedo, C., & Martinez‐Lemus, L. A. (2022) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00537.2022 · Cited by 29
Kino, M., Yamato, T., & Aomine, M. (2003) · Neurochemistry International · doi:10.1016/s0197-0186(03)00125-6 · Cited by 30
Increased endothelial shear stress improves insulin‐stimulated vasodilatation in skeletal muscle
Walsh, L. K., Ghiarone, T., Olver, T. D., Medina‐Hernandez, A., Edwards, J. C., Thorne, P. K., Emter, C. A., Lindner, J. R., Manrique‐Acevedo, C., Martinez‐Lemus, L. A., et al. (2018) · The Journal of Physiology · doi:10.1113/jp277050 · Cited by 30
“Vascular insulin signalling and its consequent vasodilatory effects facilitate delivery of glucose and insulin to skeletal muscle, contributing to glucose uptake and homeostasis (Baron et al. 1991; Laakso et al. 1992; Womack et al. 2009).”
BackgroundAlterations of Glucose Metabolism in Type 2 Diabetes Mellitus. An Overview
Bonadonna, R. C. (2004) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/b:remd.0000021429.89218.c6 · Cited by 29
Triggle, C. R., Howarth, A. G., Cheng, Z. J., & Ding, H. (2005) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y05-069 · Cited by 29
“Baron’s pioneering work (Laakso et al. 1990, 1992) indicates that within a physiological concentration range, insulin increased total skeletal muscle blood flow in healthy human subjects in a fashion that paralleled the actions of insulin to increase glucose disposal.”
BackgroundBuse, J. B., Polonsky, K. S., & Burant, C. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00031-6 · Cited by 28
Valensi, P. E., Nguyen, T. N., Idriss, S., Cazes, P., Karam, G., Pariès, J., Miossec, P., & Attali, J. R. (1998) · Metabolism · doi:10.1016/s0026-0495(98)90347-x · Cited by 28
Dandona, P., & Aljada, A. (2004) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(02)00259-3 · Cited by 28
Williams, I. M., & Wasserman, D. H. (2021) · Endocrinology · doi:10.1210/endocr/bqab252 · Cited by 27
Contreras, C., Sánchez, A., García‐Sacristán, A., Martínez, M. C., Andriantsitohaina, R., & Prieto, D. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.03.036 · Cited by 27
Effects of L-arginine on blood pressure and metabolic changes in fructose-hypertensive rats
Tay, A., Ozcelikay, A. T., & ALTAN, V. M. (2002) · American Journal of Hypertension · doi:10.1016/s0895-7061(01)02231-2 · Cited by 27
Blood Pressure Increase With Impaired Glucose Tolerance in Young Adult American Blacks
Falkner, B. E., Sherif, K., Sumner, A. E., et al. (1999) · Hypertension · doi:10.1161/01.hyp.34.5.1086 · Cited by 27
Contribution of blood flow to leg glucose uptake during a mixed meal
Hernandez Mijares, A., & Jensen, M. D. (1995) · Diabetes · doi:10.2337/diabetes.44.10.1165 · Cited by 29
McMahon, G. T., Plutzky, J., Daher, E., Bhattacharyya, T., Grunberger, G., & DiCarli, M. F. (2005) · Diabetes Care · doi:10.2337/diacare.28.5.1145 · Cited by 26
“Those with insulin resistance demonstrate impaired endothelial function (7,9) even before diabetes is diagnosed, and insulin induces vasodilation via endothelial nitric oxide release (10,11).”
BackgroundMcCarty, M. F. (1999) · Medical Hypotheses · doi:10.1054/mehy.1998.0758 · Cited by 27
Insulin inhibits serotonin-induced Ca2+ influx in vascular smooth muscle.
Kahn, A. M., Allen, J. C., Seidel, C. L., & Song, T. (1994) · Circulation · doi:10.1161/01.cir.90.1.384 · Cited by 25
Epidemiology of Macrovascular Disease and Hypertension in Diabetes Mellitus
Tuomilehto, J. O., Rastenytė, D., Qiao, Q., & Jakovljević, D. (2003) · Wiley eBooks · doi:10.1002/0470862092.d1002 · Cited by 25
Hansen, S. L., Bojsen-Møller, K. N., Lundsgaard, A., Hendrich, F. L., Nilas, L., Sjøberg, K. A., Hingst, J. R., Serup, A. K., Henríquez‐Olguín, C., Carl, C. S., et al. (2020) · Diabetes · doi:10.2337/db20-0062 · Cited by 24
Mahajan, H., Richards, S. M., Rattigan, S., & Clark, M. G. (2004) · Diabetologia · doi:10.1007/s00125-004-1580-7 · Cited by 24
Browne, D., Meeking, D. R., Shaw, K. M., & Cummings, M. H. (2003) · The British Journal of Diabetes · doi:10.1177/14746514030030010401 · Cited by 24
Chen, H.-H. (2010) · The Chinese Journal of Physiology · doi:10.4077/cjp.2010.amk042 · Cited by 24
Gans, R. O. B., Bilo, H. J. G., & Donker, A. J. M. (1996) · Nephrology Dialysis Transplantation · doi:10.1093/oxfordjournals.ndt.a027401 · Cited by 24
“The observations that essential hypertension and diabetes mellitus are characterized by impaired endothelium-dependent relaxation and insulin resistance [51,52], and that the vasodilatory action of insulin is impaired in these conditions, at least in skeletal muscle [53,54], make additional studies that include proper…”
BackgroundHypertension in patients with diabetes mellitus
Skyler, J. S., MARKS, J., & Schneiderman, N. (1995) · American Journal of Hypertension · doi:10.1016/0895-7061(95)00307-x · Cited by 24
Takagawa, Y., Berger, M. E., Tuck, M. L., & Golub, M. S. (2002) · Hypertension Research · doi:10.1291/hypres.25.197 · Cited by 24
“ten observed in obesity and type 2 diabetes, blood vessels become desensitized to insulin’s vasodilator effect (5, 6).”
BackgroundPark, L. K., Parks, E. J., Pettit‐Mee, R. J., Woodford, M. L., Ghiarone, T., Smith, J. A. H., Sales, A. R. K., Martinez‐Lemus, L. A., Manrique‐Acevedo, C., & Padilla, J. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00174.2020 · Cited by 23
Exercise and Vascular Insulin Sensitivity in the Skeletal Muscle and Brain
Olver, T. D., Laughlin, M. H., & Padilla, J. (2019) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000182 · Cited by 23
Wiecha, J., Reineker, K., Reitmayer, M., et al. (1998) · Growth Hormone & IGF Research · doi:10.1016/s1096-6374(98)80108-1 · Cited by 23
Insulin and Forearm Vasodilation in Hypertension-Prone Men
Hulthén, U. L., Endre, T., Mattiasson, I., & Berglund, G. L. (1995) · Hypertension · doi:10.1161/01.hyp.25.2.214 · Cited by 23
Abbink, E. J., Walker, A. J., van der Sluijs, H. A., Tack, C. J., & Smits, P. (2002) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.269 · Cited by 22
“In insulinresistant persons, such as patients with type 2 diabetes mellitus, this insulininduced vasodilation is reduced [6,7].”
BackgroundExercise Interventions to Prevent and Manage Type 2 Diabetes: Physiological Mechanisms
Dela, F., Prats, C., & Helge, J. W. (2014) · Medicine and sport science/Medicine and sport · doi:10.1159/000357334 · Cited by 24
A case of insulin edema with inappropriate hyperaldosteronism
Kalambokis, G. N., Tsatsoulis, A., Economou, G., et al. (2004) · Journal of Endocrinological Investigation · doi:10.1007/bf03347540 · Cited by 21
Olver, T. D., Grunewald, Z. I., Ghiarone, T., Restaino, R. M., Sales, A. R. K., Park, L. K., Thorne, P. K., Ganga, R., Emter, C. A., Lemon, P. W. R., et al. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00464.2019 · Cited by 21
“Obesity and insulin resistance are associated with impaired insulin-stimulated vasodilation (10, 23, 24, 33, 34, 36, 38, 39, 41, 42) and limited delivery of insulin and glucose to the target organs (4–6, 18).”
BackgroundEndothelium, Inflammation, and Diabetes
Aljada, A. (2003) · Metabolic Syndrome and Related Disorders · doi:10.1089/154041903321648225 · Cited by 21
“159,160 This may have implications for the previously reported impaired increments in leg blood flow following insulin 161 and the defects in cerebral blood flow in diabetics.”
ACE Gene Polymorphism and Insulin Action in Older Subjects and Healthy Centenarians
Paolisso, G., Tagliamonte, M. R., Lucia, D. D., Palmieri, F., Manzella, D., Rinaldi, C., Bossone, A., Colaizzo, D., Margaglione, M., & Varricchio, M. (2001) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2001.49122.x · Cited by 21
Relationship between insulin's haemodynamic effects and insulin‐mediated glucose uptake
ter Maaten, J. C., Voorburg, de Vries, P. M., ter Wee, P. M., Donker, & Gans, R. O. B. (1998) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.1998.00273.x · Cited by 21
Effect of Insulin and Angiotensin II on Cell Calcium in Human Skin Fibroblasts
Ceolotto, G., Valente, R., Baritono, E., et al. (2001) · Hypertension · doi:10.1161/01.hyp.37.6.1486 · Cited by 21
Ghiarone, T., Castorena‐Gonzalez, J. A., Foote, C. A., Ramirez‐Perez, F. I., Ferreira‐Santos, L., Cabral-Amador, F. J., de la Torre, R. A., Ganga, R., Wheeler, A. A., Manrique‐Acevedo, C., et al. (2022) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00039.2022 · Cited by 22
Limberg, J. K., Smith, J. A. H., Soares, R. N., Harper, J. L., Houghton, K. N., Jacob, D. W., Mozer, M. T., Grunewald, Z. I., Johnson, B. D., Curry, T. B., et al. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00250.2020 · Cited by 20
Tsukahara, H., Kikuchi, K., Tsumura, K., Kimura, K., Hata, I., Hiraoka, M., & Sudo, M. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90056-1 · Cited by 20
Regulation of Muscle Glucose Uptake In Vivo
Mandarino, L. J., Bonadonna, R. C., McGuinness, O. P., Halseth, A. E., & Wasserman, D. H. (2001) · Comprehensive physiology · doi:10.1002/cphy.cp070227 · Cited by 19
“Nevertheless, glycogen synthase mRNA in muscle under basal conditions is reduced in NIDDM (307).”
InfluentialJenkins, N. T., Padilla, J., Martin, J. S., Crissey, J. M., Thyfault, J. P., Rector, R. S., & Laughlin, M. H. (2013) · Experimental Physiology · doi:10.1113/expphysiol.2013.074047 · Cited by 19
“This phenomenon of ‘pathway selective insulin resistance’ in endothelial cells is thought to contribute to impairments in insulin-stimulated increases in blood flow and glucose uptake by target tissues, such as skeletal muscle (Laakso et al. 1992; Mather et al. 2004; Muniyappa & Quon, 2007).”
BackgroundNormalization effect of sports training on blood pressure in hypertensives
Chen, Y.-L., Liu, Y.-F., Huang, C., Lee, S., Chan, Y., Chen, C.-C., Harris, M. B., & Kuo, C. (2010) · Journal of Sports Sciences · doi:10.1080/02640410903508862 · Cited by 19
“In clinical studies, type 2 diabetes patients often display a significantly blunted vasodilator response to insulin (Baron et al, 1993 ; Hsieh, Cheng, Liu, Loh, & Chang, 2007 ; Laakso, Edelman, Brechtel, & Baron, 1992 ; Skarfors et al, 1991 ; Taittonen et al, 1996 ).”
Rocchini, A. P., Wilson, R. F., Marker, P. H., & Cervenka, T. (1996) · Hypertension · doi:10.1161/01.hyp.27.3.354 · Cited by 19
Holmäng, A. B., Niklasson, M., Rippe, B., & Lönnroth, P. (2001) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2001.00801.x · Cited by 19
Kahn, A. M., Husid, A., Odebunmi, T., Allen, J. C., Seidel, C. L., & Song, T. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.274.5.e885 · Cited by 19
Advances in diabetes for the millennium: diabetes and the endothelium.
Dandona, P., & Aljada, A. (2004) · PubMed · Cited by 20
Lim, D. H., Shin, K. Y., Han, K., Kang, S. W., Ham, D., Kim, S. J., Park, Y. G., & Chung, T.-Y. (2020) · Translational Vision Science & Technology · doi:10.1167/tvst.9.13.15 · Cited by 17
Shinozaki, K., Nishio, Y., Yoshida, Y., Koya, D., Ayajiki, K., Masada, M., Kashiwagi, A., & Okamura, T. (2005) · Journal of Cardiovascular Pharmacology · doi:10.1097/01.fjc.0000177981.91434.ba · Cited by 18
Role of the arterial baroreflex in the sympathetic response to hyperinsulinemia in adult humans
McMillan, N. J., Soares, R. N., Harper, J. L., Shariffi, B., Moreno‐Cabañas, A., Curry, T. B., Manrique‐Acevedo, C., Padilla, J., & Limberg, J. K. (2022) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00391.2021 · Cited by 18
Metabolic syndrome and retinal microvascular calibre in a high cardiovascular disease risk cohort
Wang, S. B., Mitchell, P. L. R., Plant, A. J. H., et al. (2015) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2015-307637 · Cited by 18
New developments in type 2 diabetes mellitus: Combination therapy with a thiazolidinedione
Braunstein, S. N. (2003) · Clinical Therapeutics · doi:10.1016/s0149-2918(03)80195-9 · Cited by 18
Reneland, R., Andersson, P.-E., Haenni, A., & Lithell, H. (1994) · European Journal of Clinical Pharmacology · doi:10.1007/bf00191906 · Cited by 18
“A link between skeletal muscle blood flow and insulin sensitivity has been described in normal humans [9, 10], obesity [9], non-insulin-dependent diabetes mellitus [11], and essential hypertension (R-E.”
BackgroundCeravolo, R., Maio, R., Cuda, G., Scozzafava, A., Sciacqua, A., Vatrano, M., Bellieni, G., D’Angelo, G., Schipani, F. A., Sesti, G., et al. (2003) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2003.07.043 · Cited by 17
Kahn, A. (2002) · American Journal of Hypertension · doi:10.1016/s0895-7061(01)02289-0 · Cited by 17
Increases in muscle blood flow after a mixed meal are impaired at all stages of type 2 diabetes
Lambadiari, V., Mitrou, P., Maratou, E., Raptis, A., Raptis, S. A., & Dimitriadis, G. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04211.x · Cited by 16
Hyperinsulinemia blunts sympathetic vasoconstriction: a possible role of β-adrenergic activation
Limberg, J. K., Soares, R. N., Power, G. J., Harper, J. L., Smith, J. A. H., Shariffi, B., Jacob, D. W., Manrique‐Acevedo, C., & Padilla, J. (2021) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00018.2021 · Cited by 16
Skeletal Muscle Vascular Function: A Counterbalance of Insulin Action
Mahmoud, A. M., Brown, M. D., Phillips, S. A., & Haus, J. M. (2015) · Microcirculation · doi:10.1111/micc.12205 · Cited by 16
“5 mU/kg/min [43,69,97], whereas other studies reported no effects at similar infusion rates [120,135,191].”
BackgroundResultInfluentialThe Role of Adenosine in Insulin-Induced Vasodilation
Abbink, E. J., Vervoort, G., Tack, C. J., Lutterman, J. A., Schaper, N. C., & Smits, P. (1999) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199909000-00009 · Cited by 16
Wong, F. S.-H., Logan, A. G., & Blendis, L. M. (1996) · Hepatology · doi:10.1002/hep.510230304 · Cited by 16
Clinical review 79: Angiotensin II: an insulin-sensitizing vasoactive hormone?
Morris, A. D., & Donnely, R. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.4.8636320 · Cited by 18
Effects of cyclooxygenase-2 (COX-2) inhibition on plasma and renal renin in diabetes
Komers, R., Tian, W., Lindsley, J. N., et al. (2002) · Journal of Laboratory and Clinical Medicine · doi:10.1067/mlc.2002.128551 · Cited by 15
Insulin and non-insulin mediated vasodilation and glucose uptake in patients with type 2 diabetes
Scheede‐Bergdahl, C., Olsen, D. B., Reving, D., et al. (2009) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2009.06.029 · Cited by 15
Roberts‐Thomson, K. M., Betik, A. C., Premilovac, D., Rattigan, S., Richards, S. M., Ross, R. M., Russell, R., Kaur, G., Parker, L., & Keske, M. A. (2019) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13237 · Cited by 17
Basal and exercise-induced skeletal muscle blood flow is augmented in type I diabetes mellitus
Skyrme-Jones, R. A. P., Berry, K. L., O’Brien, R. C., & Meredith, I. T. (1999) · Clinical Science · doi:10.1042/cs0980111 · Cited by 16
Blood flow is an important determinant of forearm glucose uptake following a mixed meal
FUGMANN, A., Sarabi, M., Karlstr�m, B., Berne, C., Lithell, H., & Lind, L. (2003) · Acta Diabetologica · doi:10.1007/s00592-003-0098-7 · Cited by 15
Insulin Inhibits Dog Vascular Smooth Muscle Contraction and Lowers Ca2+i by Inhibiting Ca2+ Influx
Kahn, A. M., & Song, T. (1995) · Journal of Nutrition · doi:10.1093/jn/125.suppl_6.1732s · Cited by 15
Cardiovascular implications of insulin resistance and non–insulin-dependent diabetes mellitus
McNulty, P. H., Ettinger, S. M., Gilchrist, I. C., Kozak, M., & Chambers, C. E. (2001) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/jcan.2001.28338 · Cited by 15
Metadata
- Authors
- Laakso, M., Edelman, S. V., Brechtel, G., & Baron, A. D.
- Affiliations
- University of California San Diego (US)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1992-09-01
- Volume
- 41
- Issue
- 9
- Pages
- 1076-1083
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W1984231396
- Cited by
- 470
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 10 · 2021: 5 · 2020: 4 · 2019: 10 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 14 · 2014: 7 · 2013: 9 · 2012: 7
- FWCI
- 14.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of California, Irvine
- National Institute of Diabetes and Digestive and Kidney Diseases (DK42469)
- National Center for Research Resources (M-01RR00827, M01RR000827)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- type 2 diabetes, skeletal muscle blood flow, insulin-stimulated glucose uptake, insulin resistance, obesity, arteriovenous glucose difference, insulin dose-response, euglycemic clamp, femoral blood flow, glucose tolerance
- MeSH terms
- Adult, Blood Glucose, Diabetes Mellitus, Type 2, Dose-Response Relationship, Drug, Glucose, Humans, Insulin, Leg, Muscles, Obesity, Regional Blood Flow
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