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Cited by 314

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How are free fatty acids transported in membranes? Is it by proteins or by free diffusion through the lipids?

Hamilton, J A, Kamp, F·1999·Diabetes
DOI 10.2337/diabetes.48.12.2255
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Abstract

Although transport of long-chain free fatty acids (FFAs) into cells is often analyzed in the same way as glucose transport, we argue that the transport of the lipid-soluble amphipathic FFA molecule must be viewed differently. The partitioning of FFAs into phospholipid bilayers and their interfacial ionization are particularly relevant to transport. We summarize new data supporting the diffusion hypothesis in simple lipid bilayers and in plasma membranes of cells. Along with previous supporting data, the new data indicate that transport of FFAs through membranes could occur rapidly by flip-flop of the un-ionized form of the FFA. It appears that, at least for the adipocyte, passive diffusion guarantees fast entry and exit of FFAs at both low and high concentrations. Although there are several candidate proteins for the membrane transport of FFAs, most of these proteins have other established functions. Thus, unlike the glucose transporters, these proteins would not be single-function proteins. Definitive proof of their function as FFA transporters awaits their reconstitution into simple model systems.

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Metadata

Authors
Hamilton, J. A., & Kamp, F.
Venue
Diabetes
Publisher
American Diabetes Association
Published
1999-12-01
Volume
48
Issue
12
Pages
2255-2269
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/diabetes.48.12.2255
OpenAlex
W2123276507
Cited by
314
References
0
FWCI
6.52
Type
journal article
Language
en
Open access
closed

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