CoChat
Sign Up
Cited by 70Lipid metabolism and biosynthesisAdipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Meal Fatty Acid Uptake in Visceral Fat in Women

Open access
Votruba, Susanne B., Mattison, Rebecca S., Dumesic, Daniel A., Koutsari, Christina, Jensen, Michael D.·2007·Diabetes
DOI 10.2337/db07-0439
Open this paper in CoChat — free accountOpen PDF

Abstract

OBJECTIVE—Differential meal fat uptake into adipose tissue depots may be a determinant of body fat distribution. RESEARCH DESIGN AND METHODS—We used the meal fat tracer/adipose tissue biopsy approach to compare the effects of meal fat content on the fat uptake into visceral and upper and lower body subcutaneous fat depots in 21 premenopausal women. [3H]triolein was used to trace the fate of fatty acids from a normal-fat or high-fat meal. RESULTS—The proportion of dietary fat uptake into the three depots did not differ between meals; visceral fat accounted for only ∼5% of meal fat disposal irrespective of visceral fat mass. For the women consuming the normal-fat meal, the uptake of meal fatty acid into femoral fat (milligrams meal fat per gram lipid) increased as a function of leg fat mass (r = 0.68, P < 0.05), which we interpret as increased efficiency of uptake. The opposite pattern was seen in omental fat with the normal-fat meal and in all depots after the high-fat meal. For both meals, ∼40% of meal fat was oxidized (3H2O production) after 24 h. CONCLUSIONS—We conclude that greater thigh adipose tissue in women is associated with greater efficiency of meal fat storage under conditions of energy balance, whereas the opposite is seen with visceral fat. These findings imply that different mechanisms may regulate fatty acid uptake in different depots, which may in turn impact on body fat distribution.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.2337/db07-0439

Cites

23 of 23 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • No sex differences were found in hepatic palmitate uptake in a bariatric surgery population with Class III obesity.

    “We found no sex-differences in hepatic palmitate uptake in a bariatric surgery population (Class III obesity) (76).”

    From Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans (2025) · cites this paper as [76]

    The Results and Meal fatty acid disposal sections report palmitate concentrations and fatty acid uptake into adipose tissue, not hepatic palmitate uptake. The Discussion describes this as a study in women, so it provides no male–female comparison. Searches for hepatic palmitate uptake and bariatric surgery found no passage supporting the stated result. (LLM, conf=0.78)

    Experimental — accuracy not yet measured

  • In a bariatric surgery population, VLDL-TG fatty acid storage in subcutaneous and omental fat was not different between men and women.

    “When studied in a bariatric surgery population, VLDL-TG fatty acid storage in subcutaneous and omental fat was not different between men and women (76).”

    From Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans (2025) · cites this paper as [76]

    The Research Design and Methods describe 21 women undergoing tubal ligation or research laparoscopy, not a bariatric surgery population including men. The Discussion reports dietary fatty acid uptake and identifies uptake from VLDL-TG as a question for future research; our copy therefore provides no VLDL-TG storage comparison between men and women in subcutaneous or omental fat. (LLM, conf=0.78)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 24 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Votruba, S. B., Mattison, R. S., Dumesic, D. A., Koutsari, C., & Jensen, M. D.
Affiliations
Mayo Clinic (US)
ORCID
Venue
Diabetes
Publisher
American Diabetes Association
Published
2007-10-01
Volume
56
Issue
10
Pages
2589-2597
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/db07-0439
OpenAlex
W2134001501
Cited by
70
References
24
Citations by year
2026: 1 · 2025: 4 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 5 · 2016: 3 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 6
FWCI
2.90
Type
journal article
Language
en
Open access
Locations
  • Diabetes (publishedVersion)
  • PubMed (publishedVersion)
Funders
Deutsches Krebsforschungszentrum
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
visceral fat, subcutaneous adipose tissue, body fat distribution, high-fat meal, premenopausal women, omental fat, fat oxidation, adipose tissue depots, energy balance
MeSH terms
Adipose Tissue, Biological Transport, Body Weight, Dietary Fats, Fatty Acids, Female, Humans, Polycystic Ovary Syndrome, Radioisotope Dilution Technique, Sterilization, Tubal, Triolein, Tritium, Premenopause

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review