Cited by 292Metabolism, Diabetes, and CancerAdipose Tissue and MetabolismNatural Antidiabetic Agents Studies

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AICAR Administration Causes an Apparent Enhancement of Muscle and Liver Insulin Action in Insulin-Resistant High-Fat-Fed Rats

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Iglesias, Miguel A., Ye, Ji-Ming, Frangioudakis, Georgia, Saha, Asish K., Tomas, Eva, Ruderman, Neil B., Cooney, Gregory J., Kraegen, Edward W.·2002·Diabetes

DOI 10.2337/diabetes.51.10.2886

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Abstract

Exercise improves insulin sensitivity. As AMP-activated protein kinase (AMPK) plays an important role in muscle metabolism during exercise, we investigated the effects of the AMPK activator 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) on insulin action in insulin-resistant high-fat-fed (HF) rats. Rats received a subcutaneous injection of 250 mg/kg AICAR (HF-AIC) or saline (HF-Con). The next day, euglycemic-hyperinsulinemic clamp studies were performed. Glucose infusion rate during the clamp was enhanced (50%) in HF-AIC compared with HF-Con rats. Insulin-stimulated glucose uptake was improved in white but not in red quadriceps, whereas glycogen synthesis was improved in both red and white quadriceps of HF-AIC rats. HF-AIC rats also showed increased insulin suppressibility of hepatic glucose output (HGO). AICAR-induced responses in both liver and muscle were accompanied by reduced malonyl-CoA content. Clamp HGO correlated closely with hepatic triglyceride content (r = 0.67, P < 0.01). Thus, a single dose of AICAR leads to an apparent enhancement in whole-body, muscle, and liver insulin action in HF rats that extends beyond the expected time of AMPK activation. Whether altered tissue lipid metabolism mediates AICAR effects on insulin action remains to be determined. Follow-up studies suggest that at least some of the post-AICAR insulin-enhancing effects also occur in normal rats. Independent of this, the results suggest that pharmacological activation of AMPK may have potential in treating insulin-resistant states and type 2 diabetes.

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Association of nonalcoholic fatty liver disease with insulin resistance
Marchesini, G., Brizi, M., Morselli‐Labate, A. M., Bianchi, G. P., Bugianesi, E., McCullough, A. J., Forlani, G., & Melchionda, N. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00271-5 · Cited by 1,570
The AMP‐Activated Protein Kinase: Fuel Gauge of the Mammalian Cell?
Hardie, D. G., & Carling, D. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00259.x · Cited by 1,317
Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diab.46.6.983 · Cited by 1,179
Skeletal muscle triglyceride levels are inversely related to insulin action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diabetes.46.6.983 · Cited by 1,179
Exercise, Glucose Transport, and Insulin Sensitivity
Goodyear, L. J., & Kahn, B. B. (1998) · Annual Review of Medicine · doi:10.1146/annurev.med.49.1.235 · Cited by 1,056
AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle
Merrill, G. F., Kurth, E. J., Hardie, D. G., & Winder, W. W. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.6.e1107 · Cited by 1,048
AMP-activated protein kinase, a metabolic master switch: possible roles in Type 2 diabetes
Winder, W. W., & Hardie, D. G. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.1.e1 · Cited by 1,000
Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport
Hayashi, T., Hirshman, M. F., Kurth, E. J., Winder, W. W., & Goodyear, L. J. (1998) · Diabetes · doi:10.2337/diab.47.8.1369 · Cited by 774
Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport
Hayashi, T., Hirshman, M. F., Kurth, E. J., Winder, W. W., & Goodyear, L. J. (1998) · Diabetes · doi:10.2337/diabetes.47.8.1369 · Cited by 774
5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle.
Kurth-Kraczek, E. J., Hirshman, M. F., Goodyear, L. J., & Winder, W. W. (1999) · Diabetes · doi:10.2337/diabetes.48.8.1667 · Cited by 715

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The role of AMP kinase in diabetes.
Misra, P., & Chakrabarti, R. (2007) · PubMed · Cited by 78
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Self-citation
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Zhou, L., Wang, X., Shao, L., Yang, Y., Shang, W., Yuan, G., Jiang, B., Li, F., Tang, J., Hua, J., et al. (2008) · Endocrinology · doi:10.1210/en.2007-1752 · Cited by 73
α-Lipoic acid regulates AMP-activated protein kinase and inhibits insulin secretion from beta cells
Targonsky, E. D., Dai, F. F., Koshkin, V., Karaman, G., Gyulkhandanyan, A. V., Zhang, Y., Chan, C. B., & Wheeler, M. B. (2006) · Diabetologia · doi:10.1007/s00125-006-0265-9 · Cited by 74
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Miyamoto, L., Toyoda, T., Hayashi, T., Yonemitsu, S., Nakano, M., Tanaka, S., Ebihara, K., Masuzaki, H., Hosoda, K., Ogawa, Y., et al. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01034.2006 · Cited by 72
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Lee, S. K., Lee, J. O., Kim, J. H., Kim, S. J., You, G. Y., Moon, J. W., Jung, J. H., Park, S. H., Uhm, K., Park, J., et al. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23000 · Cited by 59
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Foretz, M., Taleux, N., Guigas, B., Horman, S., Beauloye, C., Andréelli, F., Bertrand, L., & Viollet, B. (2006) · médecine/sciences · doi:10.1051/medsci/2006224381 · Cited by 73
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Viana, A. Y. I., Sakoda, H., Anai, M., Fujishiro, M., Ono, H., Kushiyama, A., Fukushima, Y., Sato, Y., Oshida, Y., Uchijima, Y., et al. (2006) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2005.12.011 · Cited by 53
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Hassan, W., Ding, L., Gao, R.-Y., Liu, J., & Shang, J. (2014) · Cytokine · doi:10.1016/j.cyto.2013.12.017 · Cited by 51
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Self-citation
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Ju, J.-S., Gitcho, M. A., Casmaer, C. A., Patil, P. B., Han, D.-G., Spencer, S. A., & Fisher, J. S. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00269.2006 · Cited by 47
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Sun, Y., Ren, M., Gao, G.-Q., Gong, B., Xin, W., Guo, H., Zhang, X., Gao, L., & Zhao, J. (2008) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2008.00717.x · Cited by 42
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Shin, E., Shin, S., Kong, H., Lee, S., Do, S., Jo, T. H., Park, Y.-I., Lee, C., Hwang, I. K., & Kim, K. (2011) · Immune Network · doi:10.4110/in.2011.11.2.107 · Cited by 38
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Lin, C., Kuo, Y., & Shih, C. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112314 · Cited by 37
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Yashiro, T., Nanmoku, M., Shimizu, M., Inoue, J., & Sato, R. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.09.033 · Cited by 32
Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human hepatocytes
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Sheldon, R. D., Laughlin, M. H., & Rector, R. S. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01275.2013 · Cited by 33
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Ma, X., Iwanaka, N., Masuda, S., Karaike, K., Egawa, T., Hamada, T., Toyoda, T., Miyamoto, L., Nakao, K., & Hayashi, T. (2008) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2008.11.022 · Cited by 30
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Zhang, L., Xu, L., Zhou, H., Wu, L., Li, Y., Pang, T., Xia, C.-M., Qiu, B., Gu, M., Dong, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072092 · Cited by 30
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Arha, D., Pandeti, S., Mishra, A., Srivastava, S. P., Srivastava, A. K., Narender, T., & Tamrakar, A. K. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.10.055 · Cited by 29
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Alkhateeb, H. H., Chabowski, A., Glatz, J. F. C., Gurd, B. J., Luiken, J. J. F. P., & Bonen, A. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90908.2008 · Cited by 28
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García‐Prieto, C. F., Gil‐Ortega, M., Aránguez, I., Ortiz-Besoain, M., Somoza, B., & Fernández‐Alfonso, M. S. (2015) · Vascular Pharmacology · doi:10.1016/j.vph.2015.02.017 · Cited by 28
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Lan, P., Romero, F. A., Wódka, D., Kassick, A. J., Dang, Q., Gibson, T., Cashion, D. K., Zhou, G., Chen, Y., Zhang, X., et al. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b01344 · Cited by 28
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Yun, H., & Ha, J. (2011) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2011.577069 · Cited by 28
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Authors: Iglesias, M. A., Ye, J.-M., Frangioudakis, G., Saha, A. K., Tomas, E., Ruderman, N. B., Cooney, G. J., & Kraegen, E. W.
Affiliations: Garvan Institute of Medical Research (AU)
Boston University (US)
Garvan Institute of Medical Research, Sydney, New South Wales, Australia
ORCID: Iglesias, Miguel A.
Ye, Ji-Ming
Frangioudakis, Georgia
Saha, Asish K.
Ruderman, Neil B.
Cooney, Gregory J.
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2002-10-01
Volume: 51
Issue: 10
Pages: 2886-2894
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.51.10.2886
OpenAlex: W2114339108
Cited by: 290
References: 50
Citations by year: 2026: 1 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 11 · 2017: 9 · 2016: 4 · 2015: 14 · 2014: 21 · 2013: 15 · 2012: 15
FWCI: 6.72
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
eCite Digital Repository (University of Tasmania) (submittedVersion)
Figshare (submittedVersion, cc-by)
Funders: Medical Research Council
National Health and Medical Research Council
National Medical Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Keywords: AICAR, AMPK, insulin resistance, high-fat feeding, insulin sensitivity, skeletal muscle glucose uptake, hepatic glucose production, glycogen synthesis, malonyl-CoA, hepatic triglycerides, type 2 diabetes, physical activity
MeSH terms: Aminoimidazole Carboxamide, Animals, Blood Glucose, Body Weight, Dietary Fats, Hypoglycemic Agents, Insulin, Insulin Resistance, Liver, Male, Ribonucleotides, Glucose Clamp Technique, Rats, Wistar, Muscle, Skeletal, Rats

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AICAR Administration Causes an Apparent Enhancement of Muscle and Liver Insulin Action in Insulin-Resistant High-Fat-Fed Rats

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