Metabolic Syndrome: Adenosine Monophosphate‐activated Protein Kinase and Malonyl Coenzyme A

Role of Insulin Resistance in Human Disease

Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154 · see citing works

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197 · see citing works

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093 · see citing works

Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome

Isomaa, B., Almgren, P., Tuomi, T., Forsén, B., Lahti, K., Nissén, M., Taskinen, M.-R., & Groop, L. (2001) · Diabetes Care · doi:10.2337/diacare.24.4.683 · Cited by 4,760 · see citing works

Cellular mechanisms of insulin resistance

Shulman, G. I. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10583 · Cited by 2,714 · see citing works

Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes

Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321 · see citing works

Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes

Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0039 · Cited by 2,232 · see citing works

Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes

Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193 · see citing works

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107 · see citing works

Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α (PGC-1α): Transcriptional Coactivator and Metabolic Regulator

Puigserver, P., & Spiegelman, B. M. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0012 · Cited by 2,076 · see citing works

Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice

Fruebis, J., Tsao, T., Javorschi, S., Ebbets-Reed, D., Erickson, M., Yen, F. T., Bihain, B. E., & Lodish, H. F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.2005 · Cited by 1,987 · see citing works

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of <i>PGC1</i> and <i>NRF1</i>

Patti, M. E., Butte, A. J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., Miyazaki, Y., Kohane, I., Costello, M., Saccone, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1032913100 · Cited by 1,952 · see citing works

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of <i>Ikkβ</i>

Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.-W., Karin, M., & Shoelson, S. E. (2001) · Science · doi:10.1126/science.1061620 · Cited by 1,884 · see citing works

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y.-B., Lee, A., Xue, B., Mu, J., Foufelle, F., Ferré, P., Birnbaum, M. J., et al. (2004) · Nature · doi:10.1038/nature02440 · Cited by 1,637 · see citing works

Increasing Prevalence of the Metabolic Syndrome Among U.S. Adults

Ford, E. S., Giles, W. H., & Mokdad, A. H. (2004) · Diabetes Care · doi:10.2337/diacare.27.10.2444 · Cited by 1,488 · see citing works

NCEP-Defined Metabolic Syndrome, Diabetes, and Prevalence of Coronary Heart Disease Among NHANES III Participants Age 50 Years and Older

Alexander, C. M., Landsman, P. B., Teutsch, S. M., & Haffner, S. M. (2003) · Diabetes · doi:10.2337/diabetes.52.5.1210 · Cited by 1,475 · cited 1× · see citing works

Banting Lecture 2001

McGarry, J. D. (2002) · Diabetes · doi:10.2337/diabetes.51.1.7 · Cited by 1,435 · see citing works

Inflammation and Activated Innate Immunity in the Pathogenesis of Type 2 Diabetes

Pickup, J. C. (2004) · Diabetes Care · doi:10.2337/diacare.27.3.813 · Cited by 1,414 · see citing works

Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α

Itani, S. I., Ruderman, N. B., Schmieder, F., & Boden, G. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2005 · Cited by 1,390 · see citing works

Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β‐cell dysfunction

Boden, G., & Shulman, G. I. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.32.s3.3.x · Cited by 1,300 · see citing works

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

Griffin, M. E., Marcucci, M. J., Cline, G. W., Bell, K., Barucci, N., Lee, D., Goodyear, L. J., Kraegen, E. W., White, M. F., & Shulman, G. I. (1999) · Diabetes · doi:10.2337/diabetes.48.6.1270 · Cited by 1,267 · see citing works

Interleukin-6-deficient mice develop mature-onset obesity

Wallenius, V., Wallenius, K., Ahrén, B., Rudling, M., Carlsten, H., Dickson, S. L., Ohlsson, C., & Jansson, J.-O. (2002) · Nature Medicine · doi:10.1038/nm0102-75 · Cited by 1,213 · see citing works

A Role for AMP-Activated Protein Kinase in Contraction- and Hypoxia-Regulated Glucose Transport in Skeletal Muscle

Mu, J., Brozinick, J. T., Valladares, O., Bucan, M., & Birnbaum, M. J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00251-9 · Cited by 924 · see citing works

Management of cellular energy by the AMP‐activated protein kinase system

Hardie, D. G., Scott, J. W., Pan, D. A., & Hudson, E. R. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00560-x · Cited by 855 · see citing works

AMP-activated Protein Kinase Plays a Role in the Control of Food Intake

Andersson-Hall, U. K., Filipsson, K., Abbott, C. R., Woods, A., Smith, K. L., Bloom, S. R., Carling, D., & Small, C. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c300557200 · Cited by 756 · see citing works

Regulation of Fasted Blood Glucose by Resistin

Banerjee, R. R., Rangwala, S. M., Shapiro, J. S., Rich, A. S., Rhoades, B., Qi, Y., Wang, J., Rajala, M. W., Pocai, A., Scherer, P. E., et al. (2004) · Science · doi:10.1126/science.1092341 · Cited by 727 · see citing works

Selective Suppression of Endothelial Cell Apoptosis by the High Molecular Weight Form of Adiponectin

Kobayashi, H., Ouchi, N., Kihara, S., Walsh, K., Kumada, M., Abe, Y., Funahashi, T., & Matsuzawa, Y. (2004) · Circulation Research · doi:10.1161/01.res.0000119921.86460.37 · Cited by 658 · see citing works

Malonyl-CoA, fuel sensing, and insulin resistance

Ruderman, N. B., Saha, A. K., Vavvas, D. G., & Witters, L. A. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.1.e1 · Cited by 644 · see citing works

Effects of fat on insulin-stimulated carbohydrate metabolism in normal men.

Boden, G., Jadali, F., White, J. V., Liang, Y. T., Mozzoli, M. A., Chen, X., Coleman, E., & Smith, C. R. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115399 · Cited by 500 · see citing works

Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?

Prentki, M., & Corkey, B. E. (1996) · Diabetes · doi:10.2337/diab.45.3.273 · Cited by 478 · see citing works

AMP-activated protein kinase, super metabolic regulator

Kemp, B. E., Stapleton, D., Campbell, D. J., Chen, Z.-P., Murthy, S., Walter, M., Gupta, A., Adams, J. J., Katsis, F., van Denderen, B., et al. (2003) · Biochemical Society Transactions · doi:10.1042/bst0310162 · Cited by 474 · see citing works

AMP-activated Protein Kinase Is Required for the Lipid-lowering Effect of Metformin in Insulin-resistant Human HepG2 Cells

Zang, M., Zuccollo, A., Hou, X., Nagata, D., Walsh, K., Herscovitz, H., Brecher, P. I., Ruderman, N. B., & Cohen, R. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408149200 · Cited by 453 · see citing works

AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome

Ruderman, N., & Prentki, M. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1344 · Cited by 451 · see citing works

Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

An, J., Muoio, D. M., Shiota, M., Fujimoto, Y., Cline, G. W., Shulman, G. I., Koves, T. R., Stevens, R., Millington, D., & Newgard, C. B. (2004) · Nature Medicine · doi:10.1038/nm995 · Cited by 450 · see citing works

Malonyl-CoA Signaling, Lipid Partitioning, and Glucolipotoxicity

Prentki, M., Joly, E. C., El-Assaad, W., & Roduit, R. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s405 · Cited by 428 · see citing works

AMPK, the metabolic syndrome and cancer

Luo, Z., Saha, A. K., Xiang, X., & Ruderman, N. B. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.12.011 · Cited by 426 · see citing works

Mechanisms of Liver and Muscle Insulin Resistance Induced by Chronic High-Fat Feeding

Oakes, N. D., Cooney, G. J., Camilleri, S., Chisholm, D. J., & Kraegen, E. W. (1997) · Diabetes · doi:10.2337/diab.46.11.1768 · Cited by 414 · see citing works

Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction

Krauss, S., Zhang, C., Scorrano, L., Dalgaard, L. T., St‐Pierre, J., Grey, S. T., & Lowell, B. B. (2003) · Journal of Clinical Investigation · doi:10.1172/jci19774 · Cited by 401 · see citing works

Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction

Krauss, S., Zhang, C.-Y., Scorrano, L., Dalgaard, L. T., St-Pierre, J., Grey, S. T., & Lowell, B. B. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319774 · Cited by 401 · see citing works

Hyperglycemia-Induced Apoptosis in Human Umbilical Vein Endothelial Cells

Ido, Y., Carling, D., & Ruderman, N. B. (2002) · Diabetes · doi:10.2337/diabetes.51.1.159 · Cited by 323 · see citing works

Activation of p38 MAP kinase enhances sensitivity of muscle glucose transport to insulin

Geiger, P. C., Wright, D. C., Han, D., & Holloszy, J. O. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00477.2004 · Cited by 306 · see citing works

AICAR Administration Causes an Apparent Enhancement of Muscle and Liver Insulin Action in Insulin-Resistant High-Fat-Fed Rats

Iglesias, M. A., Ye, J.-M., Frangioudakis, G., Saha, A. K., Tomas, E., Ruderman, N. B., Cooney, G. J., & Kraegen, E. W. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2886 · Cited by 290 · see citing works

AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise.

Kelly, M., Keller, C., Avilucea, P. R., Keller, P., Luo, Z., Xiang, X., Giralt, M., Hidalgo, J., Saha, A. K., Pedersen, B. K., et al. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.05.188 · Cited by 289 · see citing works

Minireview: Malonyl CoA, AMP-Activated Protein Kinase, and Adiposity

Ruderman, N. B., Saha, A. K., & Kraegen, E. W. (2003) · Endocrinology · doi:10.1210/en.2003-0849 · Cited by 266 · see citing works

Activation of AMP kinase enhances sensitivity of muscle glucose transport to insulin

Fisher, J. S., Gao, J., Han, D.-H., Holloszy, J. O., & Nolte, L. A. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2002.282.1.e18 · Cited by 244 · see citing works

Isozyme-nonselective N-Substituted Bipiperidylcarboxamide Acetyl-CoA Carboxylase Inhibitors Reduce Tissue Malonyl-CoA Concentrations, Inhibit Fatty Acid Synthesis, and Increase Fatty Acid Oxidation in Cultured Cells and in Experimental Animals

Harwood, H. J., Petras, S. F., Shelly, L. D., Zaccaro, L. M., Perry, D. A., Makowski, M. R., Hargrove, D. M., Martin, K. A., Tracey, W. R., Chapman, J. G., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304481200 · Cited by 242 · see citing works

Long-Term AICAR Administration Reduces Metabolic Disturbances and Lowers Blood Pressure in Rats Displaying Features of the Insulin Resistance Syndrome

Buhl, E. S., Jessen, N., Pold, R., Ledet, T., Flyvbjerg, A., Pedersen, S. B., Pedersen, O. B., Schmitz, O., & Lund, S. A. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2199 · Cited by 241 · see citing works

Rapid transformation of white adipocytes into fat-oxidizing machines

Orci, L., Cook, W. S., Ravazzola, M., Wang, M.-Y., Park, B.-H., Montesano, R., & Unger, R. H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308258100 · Cited by 234 · see citing works

AMPK inhibits fatty acid-induced increases in NF-κB transactivation in cultured human umbilical vein endothelial cells

Cacicedo, J. M., Yagihashi, N., Keaney, J. F., Ruderman, N. B., & Ido, Y. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.09.177 · Cited by 233 · see citing works

Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity.

Itani, S. I., Zhou, Q., Pories, W. J., MacDonald, K. G., & Dohm, G. L. (2000) · Diabetes · doi:10.2337/diabetes.49.8.1353 · Cited by 230 · see citing works

Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo

Saha, A. K., Avilucea, P. R., Ye, J.-M., Assifi, M. M., Kraegen, E. W., & Ruderman, N. B. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.12.120 · Cited by 218 · see citing works

Long-Term AICAR Administration and Exercise Prevents Diabetes in ZDF Rats

Pold, R., Jensen, L. S., Jessen, N., Buhl, E. S., Schmitz, O., Flyvbjerg, A., FUJII, N. L., Goodyear, L. J., Gotfredsen, C. F., Brand, C. L., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.4.928 · Cited by 216 · see citing works

UCP-3 expression in skeletal muscle: effects of exercise, hypoxia, and AMP-activated protein kinase

Zhou, M., Lin, B.-Z., Coughlin, S., Vallega, G., & Pilch, P. F. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.3.e622 · Cited by 166 · see citing works

Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites

Lam, T. K. T., van de Werve, G., & Giacca, A. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00332.2002 · Cited by 157 · see citing works

AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed rats

Assifi, M. M., Suchánková, G., Constant, S., Prentki, M., Saha, A. K., & Ruderman, N. B. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00144.2005 · Cited by 155 · see citing works

Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition

Yu, X., McCorkle, S. K., Wang, M., Lee, Y., Li, J., Saha, A. K., Unger, R. H., & Ruderman, N. B. (2004) · Diabetologia · doi:10.1007/s00125-004-1570-9 · Cited by 149 · see citing works

Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes

Ruderman, N. B., Cacicedo, J. M., Itani, S. I., Yagihashi, N., Saha, A. K., Ye, J. M., Chen, K., Zou, M., Carling, D., Boden, G., et al. (2003) · Biochemical Society Transactions · doi:10.1042/bst0310202 · Cited by 138 · see citing works

Direct demonstration of lipid sequestration as a mechanism by which rosiglitazone prevents fatty-acid-induced insulin resistance in the rat: comparison with metformin

Ye, J.-M., Dzamko, N. L., Cleasby, M. E., Hegarty, B. D., Furler, S. M., Cooney, G. J., & Kraegen, E. W. (2004) · Diabetologia · doi:10.1007/s00125-004-1436-1 · Cited by 137 · see citing works

Glucagon Represses Signaling through the Mammalian Target of Rapamycin in Rat Liver by Activating AMP-activated Protein Kinase

Kimball, S. R., Siegfried, B. A., & Jefferson, L. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410755200 · Cited by 133 · see citing works

A malonyl-CoA fuel-sensing mechanism in muscle: effects of insulin, glucose, and denervation

Saha, A. K., Kurowski, T. G., & Ruderman, N. B. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.269.2.e283 · Cited by 125 · see citing works

Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats

Kraegen, E. W., Saha, A. K., Preston, E., Wilks, D. L., Hoy, A. J., Cooney, G. J., & Ruderman, N. B. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00316.2005 · Cited by 124 · see citing works

Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: An in vivo analysis in MIRKO mice

Yechoor, V. K., Patti, M., Ueki, K., Laustsen, P. G., Saccone, R., Rauniyar, R. K., & Kahn, C. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407574101 · Cited by 106 · see citing works

Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem

Gao, S., & Lane, M. D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1031698100 · Cited by 106 · see citing works

Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle.

Kurowski, T. G., Lin, Y., Luo, Z., Tsichlis, P. N., Buse, M. G., Heydrick, S. J., & Ruderman, N. B. (1999) · Diabetes · doi:10.2337/diabetes.48.3.658 · Cited by 103 · see citing works

Increased protein kinase C theta in skeletal muscle of diabetic patients

Itani, S. I., Pories, W. J., MacDonald, K. G., & Dohm, G. L. (2001) · Metabolism · doi:10.1053/meta.2001.22512 · Cited by 101 · see citing works

Glucose Autoregulates Its Uptake in Skeletal Muscle

Itani, S. I., Saha, A. K., Kurowski, T. G., Coffin, H. R., Tornheim, K., & Ruderman, N. B. (2003) · Diabetes · doi:10.2337/diabetes.52.7.1635 · Cited by 96 · see citing works

Enhanced Stimulation of Diacylglycerol and Lipid Synthesis by Insulin in Denervated Muscle: Altered Protein Kinase C Activity and Possible Link to Insulin Resistance

Heydrick, S. J., Ruderman, N. B., Kurowski, T. G., Adams, H. B., & Chen, K. S. (1991) · Diabetes · doi:10.2337/diab.40.12.1707 · Cited by 89 · see citing works

Time course of exercise-induced decline in malonyl-CoA in different muscle types

Winder, W. W., AROGYASAMI, J., Elayan, I., & Cartmill, D. C. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.259.2.e266 · Cited by 83 · see citing works

Sarcomere dynamics during isotonic velocity transients in single frog muscle fibers

Granzier, H. L. M., MATTIAZZI, A. R., & Pollack, G. H. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.259.2.c266 · Cited by 79 · see citing works

Insulin resistance of denervated rat muscle: a model for impaired receptor-function coupling

Burant, C., Lemmon, S. K., Treutelaar, M. K., & Buse, M. G. (1984) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1984.247.5.e657 · Cited by 77 · see citing works

Exercise and insulin signaling: a historical perspective

Tomás, E., Zorzano, A., & Ruderman, N. B. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00267.2002 · Cited by 43 · see citing works

Enhanced stimulation of diacylglycerol and lipid synthesis by insulin in denervated muscle. Altered protein kinase C activity and possible link to insulin resistance

Heydrick, S. J., Ruderman, N. B., Kurowski, T. G., et al. (1991) · Diabetes · doi:10.2337/diabetes.40.12.1707 · Cited by 25 · see citing works

Malonyl coenzyme A and adiposity in the dahl salt-sensitive rat: Effects of pioglitazone

Kurowski, T. G., Saha, A. K., Cunningham, B. A., Holbert, R., Colca, J. R., Corkey, B. E., & Ruderman, N. B. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90230-9 · Cited by 14 · see citing works

Gut Microbiota, Lipopolysaccharides, and Innate Immunity in the Pathogenesis of Obesity and Cardiovascular Risk

Manco, M., Putignani, L., & Bottazzo, G. F. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0030 · Cited by 479 · see citing works

Leptin and the Central Nervous System Control of Glucose Metabolism

Morton, G. J., & Schwartz, M. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00007.2010 · Cited by 338 · see citing works

Differential miRNA Expression in Omental Adipose Tissue and in the Circulation of Obese Patients Identifies Novel Metabolic Biomarkers

Heneghan, H., Miller, N., McAnena, O. J., O’Brien, T., & Kerin, M. J. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2701 · Cited by 222 · see citing works

Free fatty acids and skeletal muscle insulin resistance

Kraegen, E. W., & Cooney, G. J. (2008) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000319118.44995.9a · Cited by 206 · see citing works

Redox regulation of mitochondrial biogenesis

Piantadosi, C. A., & Suliman, H. B. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.09.014 · Cited by 178 · see citing works

AMPK exerts dual regulatory effects on the PI3K pathway

Tao, R., Gong, J., Luo, X., Zang, M., Guo, W., Wen, R., & Luo, Z. (2010) · Journal of Molecular Signaling · doi:10.1186/1750-2187-5-1 · Cited by 142 · see citing works

Getting the message across: mechanisms of physiological cross talk by adipose tissue

Lee, D.-E., Kehlenbrink, S., Lee, H., Hawkins, M. A., & Yudkin, J. S. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00015.2009 · Cited by 137 · see citing works

AMP activated protein kinase: a next generation target for total metabolic control

Misra, P. (2007) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.12.1.91 · Cited by 117 · see citing works

AMP-Activated Protein Kinase Activation by 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) Inhibits Palmitate-Induced Endothelial Cell Apoptosis Through Reactive Oxygen Species Suppression

Kim, J.-E., Kim, Y., Lee, I. K., Kim, J., Kang, Y. J., & Park, S. (2008) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fp0071857 · Cited by 90 · see citing works

Adiponectin inhibits palmitate-induced apoptosis through suppression of reactive oxygen species in endothelial cells: involvement of cAMP/protein kinase A and AMP-activated protein kinase

Kim, J.-E., Song, S. E., Kim, Y., Kim, J., Park, S., Park, Y.-K., Baek, S., Lee, I. K., & Park, S. (2010) · Journal of Endocrinology · doi:10.1677/joe-10-0093 · Cited by 88 · see citing works

3,5-Diiodo- l -thyronine rapidly enhances mitochondrial fatty acid oxidation rate and thermogenesis in rat skeletal muscle: AMP-activated protein kinase involvement

Lombardi, A., de Lange, P., Silvestri, E., Busiello, R. A., Lanni, A., Goglia, F., & Moreno, M. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90642.2008 · Cited by 81 · see citing works

Insulin resistance and fuel homeostasis: the role of AMP‐activated protein kinase

Hegarty, B. D., Turner, N. A., Cooney, G. J., & Kraegen, E. W. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01968.x · Cited by 77 · see citing works

The AMP-activated protein kinase: more than an energy sensor

Hue, L., & Rider, M. H. (2007) · Essays in Biochemistry · doi:10.1042/bse0430121 · Cited by 74 · see citing works

Minireview: Adenosine 5′-Monophosphate-Activated Protein Kinase Regulation of Fatty Acid Oxidation in Skeletal Muscle

Osler, M. E., & Zierath, J. R. (2007) · Endocrinology · doi:10.1210/en.2007-1441 · Cited by 71 · see citing works

AMPK and ACC phosphorylation: Effect of leptin, muscle fibre type and obesity

Janovská, A., Hatzinikolas, G., Staikopoulos, V., McInerney, J. K., Mano, M. T., & Wittert, G. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.12.013 · Cited by 68 · see citing works

Reactive Oxygen Species-Mediated Control of Mitochondrial Biogenesis

Yoboue, E. D., & Devin, A. (2012) · International Journal of Cell Biology · doi:10.1155/2012/403870 · Cited by 60 · see citing works

Validated Comprehensive Analytical Method for Quantification of Coenzyme A Activated Compounds in Biological Tissues by Online Solid-Phase Extraction LC/MS/MS

Magnes, C., Suppan, M., Pieber, T. R., Moustafa, T., Trauner, M. A., & Sinner, F. M. (2008) · Analytical Chemistry · doi:10.1021/ac800031u · Cited by 53 · see citing works

Astragalus Polysaccharide Improves Palmitate-Induced Insulin Resistance by Inhibiting PTP1B and NF-κB in C2C12 Myotubes

Zhao, M., Zhang, Z.-F., Ding, Y., Wang, J.-B., & Li, Y. (2012) · Molecules · doi:10.3390/molecules17067083 · Cited by 50 · see citing works

Chronic caffeine intake reverses age-induced insulin resistance in the rat: effect on skeletal muscle Glut4 transporters and AMPK activity

Guarino, M. P., Ribeiro, M. J., Sacramento, J. F., & Conde, S. V. (2012) · AGE · doi:10.1007/s11357-012-9475-x · Cited by 43 · see citing works

Adenosine A2areceptors and O2sensing in development

Koos, B. J. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00664.2010 · Cited by 43 · see citing works

Insulin resistance in Alzheimer’s disease: The genetics and metabolomics links

Amin, A. M., Mostafa, H. M. A., & Khojah, H. M. J. (2022) · Clinica Chimica Acta · doi:10.1016/j.cca.2022.12.016 · Cited by 43 · see citing works

Effect of Iodothyronines on Thermogenesis: Focus on Brown Adipose Tissue

Cioffi, F., Gentile, A., Silvestri, E., Goglia, F., & Lombardi, A. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00254 · Cited by 42 · see citing works

Glucose Enhances Leptin Signaling through Modulation of AMPK Activity

Su, H., Jiang, L., Carter‐Su, C., & Rui, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031636 · Cited by 41 · see citing works

The Role of Skeletal Muscle Sphingolipids in the Development of Insulin Resistance

Strączkowski, M., & Kowalska, I. (2008) · The Review of Diabetic Studies · doi:10.1900/rds.2008.5.13 · Cited by 41 · see citing works

Modulation of AT-1R/AMPK-MAPK cascade plays crucial role for the pathogenesis of diabetic cardiomyopathy in transgenic type 2 diabetic (Spontaneous Diabetic Torii) rats

Lakshmanan, A. P., Harima, M., Sukumaran, V., Soetikno, V., Thandavarayan, R. A., Suzuki, K., Kodama, M., Nagata, M., Takagi, R., & Watanabe, K. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.11.018 · Cited by 39 · see citing works

Dietary leucine improves whole-body insulin sensitivity independent of body fat in diet-induced obese Sprague–Dawley rats

Eller, L. K., Saha, D. C., Shearer, J., & Reimer, R. A. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.10.004 · Cited by 38 · see citing works

Sleep Patterns, Eating Behavior and the Risk of Noncommunicable Diseases

Gomes, S., Ramalhete, C., Ferreira, I., Bicho, M., & Valente, A. (2023) · Nutrients · doi:10.3390/nu15112462 · Cited by 39 · see citing works

Voluntary exercise increases adult hippocampal neurogenesis by increasing GSK-3β activity in mice

Zang, J., Liu, Y., Li, W., Xiao, D., Zhang, Y., Luo, Y., Liang, W., Liu, F., & Wei, W. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.04.024 · Cited by 35 · see citing works

Differential expression of skeletal muscle proteins in high‐fat diet‐fed rats in response to capsaicin feeding

Kim, D. H., Joo, J. I., Choi, J., & Yun, J. W. (2010) · PROTEOMICS · doi:10.1002/pmic.200900815 · Cited by 33 · see citing works

Dexamethasone facilitates lipid accumulation and mild feed restriction improves fatty acids oxidation in skeletal muscle of broiler chicks (Gallus gallus domesticus)

Wang, X., Lin, H., Song, Z., & Jiao, H. (2010) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2010.01.010 · Cited by 32 · see citing works

Effects of Fatty Acid Treatments on the Dexamethasone-Induced Intramuscular Lipid Accumulation in Chickens

Wang, X. J., Wei, D. L., Song, Z., Jiao, H., & Lin, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036663 · Cited by 31 · see citing works

A link between sleep loss, glucose metabolism and adipokines

Padilha, H. G., Crispim, C. A., Zimberg, I. Z., De-Souza, D. A., Waterhouse, J. M., Tufik, S., & de-Mello, M. T. (2011) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2011007500113 · Cited by 31 · see citing works

Glucose Rapidly Induces Different Forms of Excitatory Synaptic Plasticity in Hypothalamic POMC Neurons

Hu, J., Jiang, L., Low, M. J., & Rui, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105080 · Cited by 30 · see citing works

Metabolic reprogramming in cancer and senescence

Zhang, Y., Tang, J., Jiang, C., Yi, H., Shu, G., Yin, G., & Wang, M. (2025) · MedComm · doi:10.1002/mco2.70055 · Cited by 25 · see citing works

Human Serum Proteome Analysis: New Source of Markers in Metabolic Disorders

Girolamo, F. D., CHIERICO, F. D., Caenaro, G., Lante, I., Muraca, M., & Putignani, L. (2012) · Biomarkers in Medicine · doi:10.2217/bmm.12.92 · Cited by 22 · see citing works

Reduced malonyl-CoA content in recovery from exercise correlates with improved insulin-stimulated glucose uptake in human skeletal muscle

Frøsig, C., Roepstorff, C., Brandt, N., Maarbjerg, S. J., Birk, J. B., Wojtaszewski, J. F. P., Richter, E. A., & Kiens, B. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90556.2008 · Cited by 21 · see citing works

Melatonin‐mediated insulin synthesis during endoplasmic reticulum stress involves HuD expression in rat insulinoma INS ‐1E cells

Yoo, Y. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12064 · Cited by 20 · see citing works

Dexamethasone facilitates lipid accumulation in chicken skeletal muscle

Wang, X. J., Song, Z., Jiao, H., & Lin, H. (2011) · Stress · doi:10.3109/10253890.2011.639413 · Cited by 18 · see citing works

Diabetes, insulin and cancer risk

Yang, X. (2012) · World Journal of Diabetes · doi:10.4239/wjd.v3.i4.60 · Cited by 17 · see citing works

Mechanisms and biological effects of Caffeine on substrate metabolism homeostasis: A systematic review

da Silva, L. A., Wouk, J., Weber, V. M. R., Eltchechem, C. D. L., de Almeida, P., Martins, J. C. L., Malfatti, C. R. M., & Osiecki, R. (2017) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2017.70632 · Cited by 16 · see citing works

Skeletal muscle fatty acids shift from oxidation to storage upon dexamethasone treatment in chickens

Wang, X. J., Song, Z., Jiao, H., & Lin, H. (2012) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2012.09.013 · Cited by 15 · see citing works

AMP-activated protein kinase and muscle insulin resistance

Edward, W. K. (2009) · Frontiers in bioscience · doi:10.2741/3558 · Cited by 15 · see citing works

Hypoglycemic effects of brassinosteroid in diet-induced obese mice

Esposito, D., Kizelsztein, P., Komarnytsky, S., & Raskin, I. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00024.2012 · Cited by 14 · see citing works

In Vitro Modeling of Diabetes Impact on Vascular Endothelium: Are Essentials Engaged to Tune Metabolism?

Vorotnikov, A. V., Khapchaev, A. Y., Nickashin, A. V., & Shirinsky, V. P. (2022) · Biomedicines · doi:10.3390/biomedicines10123181 · Cited by 12 · see citing works

AICAR enhances insulin signaling via downregulation of miR-29

Liu, J., Ye, C., Liu, W., Zhao, W., Zhang, Y., Zhang, H., & Ying, H. (2015) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2015-0159 · Cited by 8 · see citing works

Central Apolipoprotein A-IV Stimulates Thermogenesis in Brown Adipose Tissue

Pence, S., LaRussa, Z., Shen, Z., Liu, M., Coschigano, K. T., Shi, H., & Lo, C. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031221 · Cited by 8 · see citing works

Caffeine, Insulin Resistance, and Hypertension

Guarino, M. P., Sacramento, J. F., Ribeiro, M. J., & Conde, S. V. (2014) · Coffee in Health and Disease Prevention · doi:10.1016/b978-0-12-409517-5.00083-8 · Cited by 7 · see citing works

Comparative Study Between Conventional Fasting Versus Overnight Infusion of Lipid or Carbohydrate on Insulin and Free Fatty Acids in Obese Patients Undergoing Elective On-pump Coronary Artery Bypass Grafting. A Prospective Randomized Trial

Hosny, H., Ibrahim, M. Y., El-Siory, W., & Abdelmonem, A. (2017) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2017.11.020 · Cited by 6 · see citing works

Metabolic elasticity — a new trait associated with health?

Fernández‐Verdejo, R., & Galgani, J. E. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00914-4 · Cited by 5 · see citing works

Effect of nutritional support on glucose control

Seematter, G., & Tappy, L. (2007) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3280147711 · Cited by 5 · see citing works

Actions and interactions of AMPK with insulin, the peroxisomal-proliferator activated receptors and sirtuins

Holness, M. J., Sugden, P. H., Silvestre, M. P., & Sugden, M. C. (2012) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.12.9 · Cited by 4 · see citing works

Hormonal Regulation of Fuel Metabolism

GOODMAN, H. M. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-373975-9.00008-2 · Cited by 4 · see citing works

Effects of Teucrium polium aerial parts extracts on malonyl-CoA decarboxylase level

Qujeq, D., Tatar, M., Feizi, F., Parsian, H., & Halalkhor, S. (2013) · Molecular biology research communications/‏‫‬‭Molecular biology research communications · doi:10.22099/mbrc.2013.1751 · Cited by 2 · see citing works

Caffeine prevents exercise-induced hypoglycemia in trained runners

Weber, V. M. R., Queiróga, M. R., Kiihn, A. L., Malfatti, C. R. M., Wouk, J., Ferreira, S. A., & da Silva, L. A. (2018) · Journal of Human Sport and Exercise · doi:10.14198/jhse.2019.142.07 · Cited by 2 · see citing works

Sleep Deprivation and Metabolic Syndrome

Mugnai, G., & Danese, A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-420168-2.00020-x · Cited by 2 · see citing works

Dim light melatonin onset following simulated eastward travel is earlier in young males genotyped as PER35/5 than PER34/4

Kunorozva, L., Rae, D. E., & Roden, L. C. (2022) · Chronobiology International · doi:10.1080/07420528.2022.2139184 · Cited by 1 · see citing works

Genotype X–(UV) Environment Interaction-Based Trait Expression in Plants

Mandi, S. S. (2016) · Springer eBooks · doi:10.1007/978-81-322-2767-0_6 · Cited by 1 · see citing works

Molecular Mechanisms of AMPK- and Akt- Dependent Survival of Glucose-Starved Cardiac Myocytes

Chopra, I. (2012) · Cited by 1 · see citing works

Liquid Chromatography-Mass Spectrometry of Acyl-CoAs

Magnes, C., & Sinner, F. M. (2016) · Springer eBooks · doi:10.1007/978-94-007-7864-1_106-1 · Cited by 1 · see citing works

Analysis of MiRNA Expression and Biomarker Potential in Common Diseases: Breast Cancer and Obesity

Heneghan, H. (2012) · ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) · doi:10.13025/15973

Liquid Chromatography-Mass Spectrometry of Acyl-CoAs

Magnes, C., & Sinner, F. M. (2017) · Springer eBooks · doi:10.1007/978-94-007-7864-1_106-2

Current World Literature

(2007) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3282c3a898

AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome

Ruderman, N., & Prentki, M. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1344 · Cited by 451 · see citing works

The role of AMPactivated protein kinase in the metabolic syndrome

Crain, M. C., Kola, B., Grossman, A. B., Korbonits, M., & LOLLI, F. (2007) · IRIS Research product catalog (Sapienza University of Rome)

Alterations in plasma and tissue lipids associated with obesity and metabolic syndrome

Aguilera, C. M., Gil‐Campos, M., Cañete, R., & Gil, Á. (2008) · Clinical Science · doi:10.1042/cs20070115 · Cited by 109 · see citing works

Minireview: Malonyl CoA, AMP-Activated Protein Kinase, and Adiposity

Ruderman, N. B., Saha, A. K., & Kraegen, E. W. (2003) · Endocrinology · doi:10.1210/en.2003-0849 · Cited by 266 · see citing works

AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases

Srivastava, R. A. K., Pinkosky, S. L., Filippov, S. I., Hanselman, J. C., Cramer, C. T., & Newton, R. S. (2012) · Journal of Lipid Research · doi:10.1194/jlr.r025882 · Cited by 297 · see citing works