Cited by 114Diabetes, Cardiovascular Risks, and LipoproteinsAdipokines, Inflammation, and Metabolic DiseasesDiabetes Management and Research

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Delayed Transcapillary Transport of Insulin to Muscle Interstitial Fluid in Obese Subjects

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Sjöstrand, Mikaela, Gudbjörnsdottir, Soffia, Holmäng, Agneta, Lönn, Lars, Strindberg, Lena, Lönnroth, Peter·2002·Diabetes

DOI 10.2337/diabetes.51.9.2742

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Abstract

Insulin-resistant subjects have a slow onset of insulin action, and the underlying mechanism has not been determined. To evaluate whether a delayed transcapillary transport is part of the peripheral insulin resistance, we followed the kinetics of infused insulin and inulin in plasma and muscle interstitial fluid in obese insulin-resistant patients and control subjects. A total of 10 lean and 10 obese men (BMI 24 ± 0.8 vs. 32 ± 0.8 kg/m2, P < 0.001) was evaluated during a hyperinsulinemic-euglycemic clamp (insulin infusion rate 120 mU · m−2 · min−1) combined with an inulin infusion. Measurements of insulin and inulin in plasma were taken by means of arterial-venous catheterization of the forearm and microdialysis in brachioradialis muscle combined with forearm blood flow measurements with vein occlusion pletysmography. The obese subjects had a significantly lower steady-state glucose infusion rate and, moreover, demonstrated a delayed appearance of insulin (time to achieve half-maximal concentration [T1/2] 72 ± 6 vs. 46 ± 6 min in control subjects, P < 0.05) as well as inulin (T1/2 83 ± 3 vs. 53 ± 7 min, P < 0.01) in the interstitial fluid. Also, the obese subjects had a delayed onset of insulin action (T1/2 70 ± 9 vs. 45 ± 5 min in control subjects, P < 0.05), and their forearm blood flow rate was significantly lower. These results demonstrate a delayed transcapillary transport of insulin and inulin from plasma to the muscle interstitial fluid and a delayed onset of insulin action in insulin-resistant obese subjects.

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Authors: Sjöstrand, M., Gudbjörnsdottir, S., Holmäng, A., Lönn, L., Strindberg, L., & Lönnroth, P.
Affiliations: Lundberg Laboratory for Diabetes Research, Sahlgrenska University Hospital, Göteborg, Sweden
Wallenberg Laboratory, Sahlgrenska University Hospital, Göteborg, Sweden
Department of Radiology, Sahlgrenska University Hospital, Göteborg, Sweden
Sahlgrenska University Hospital (SE)
ORCID: Strindberg, Lena
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2002-09-01
Volume: 51
Issue: 9
Pages: 2742-2748
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.51.9.2742
OpenAlex: W2141757949
Cited by: 114
References: 51
Citations by year: 2026: 2 · 2025: 4 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 6 · 2017: 2 · 2016: 7 · 2015: 7 · 2014: 8 · 2013: 9 · 2012: 9
FWCI: 3.04
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Funders: Novo Nordisk
Vetenskapsrådet (12206)
Novo Nordisk Pharma
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: insulin resistance, obesity, transcapillary transport, insulin kinetics, hyperinsulinemic-euglycemic clamp, forearm blood flow, microdialysis, brachioradialis muscle
MeSH terms: Adult, Blood Glucose, Capillaries, Extracellular Space, Forearm, Humans, Insulin, Insulin Resistance, Inulin, Male, Obesity, Reference Values, Regional Blood Flow, Thinness, Glucose Clamp Technique, Muscle, Skeletal

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Delayed Transcapillary Transport of Insulin to Muscle Interstitial Fluid in Obese Subjects

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