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Cited by 114Diabetes, Cardiovascular Risks, and LipoproteinsAdipokines, Inflammation, and Metabolic DiseasesDiabetes Management and Research

The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.

Delayed Transcapillary Transport of Insulin to Muscle Interstitial Fluid in Obese Subjects

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Sjöstrand, Mikaela, Gudbjörnsdottir, Soffia, Holmäng, Agneta, Lönn, Lars, Strindberg, Lena, Lönnroth, Peter·2002·Diabetes
DOI 10.2337/diabetes.51.9.2742
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Abstract

Insulin-resistant subjects have a slow onset of insulin action, and the underlying mechanism has not been determined. To evaluate whether a delayed transcapillary transport is part of the peripheral insulin resistance, we followed the kinetics of infused insulin and inulin in plasma and muscle interstitial fluid in obese insulin-resistant patients and control subjects. A total of 10 lean and 10 obese men (BMI 24 ± 0.8 vs. 32 ± 0.8 kg/m2, P < 0.001) was evaluated during a hyperinsulinemic-euglycemic clamp (insulin infusion rate 120 mU · m−2 · min−1) combined with an inulin infusion. Measurements of insulin and inulin in plasma were taken by means of arterial-venous catheterization of the forearm and microdialysis in brachioradialis muscle combined with forearm blood flow measurements with vein occlusion pletysmography. The obese subjects had a significantly lower steady-state glucose infusion rate and, moreover, demonstrated a delayed appearance of insulin (time to achieve half-maximal concentration [T1/2] 72 ± 6 vs. 46 ± 6 min in control subjects, P < 0.05) as well as inulin (T1/2 83 ± 3 vs. 53 ± 7 min, P < 0.01) in the interstitial fluid. Also, the obese subjects had a delayed onset of insulin action (T1/2 70 ± 9 vs. 45 ± 5 min in control subjects, P < 0.05), and their forearm blood flow rate was significantly lower. These results demonstrate a delayed transcapillary transport of insulin and inulin from plasma to the muscle interstitial fluid and a delayed onset of insulin action in insulin-resistant obese subjects.

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Metadata

Authors
Sjöstrand, M., Gudbjörnsdottir, S., Holmäng, A., Lönn, L., Strindberg, L., & Lönnroth, P.
Affiliations
  • Lundberg Laboratory for Diabetes Research, Sahlgrenska University Hospital, Göteborg, Sweden
  • Wallenberg Laboratory, Sahlgrenska University Hospital, Göteborg, Sweden
  • Department of Radiology, Sahlgrenska University Hospital, Göteborg, Sweden
  • Sahlgrenska University Hospital (SE)
ORCID
Strindberg, Lena
Venue
Diabetes
Publisher
American Diabetes Association
Published
2002-09-01
Volume
51
Issue
9
Pages
2742-2748
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/diabetes.51.9.2742
OpenAlex
W2141757949
Cited by
114
References
51
Citations by year
2026: 2 · 2025: 4 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 6 · 2017: 2 · 2016: 7 · 2015: 7 · 2014: 8 · 2013: 9 · 2012: 9
FWCI
3.04
Type
journal article
Language
en
Open access
Locations
  • Diabetes (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Novo Nordisk
  • Vetenskapsrådet (12206)
  • Novo Nordisk Pharma
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
insulin resistance, obesity, transcapillary transport, insulin kinetics, hyperinsulinemic-euglycemic clamp, forearm blood flow, microdialysis, brachioradialis muscle
MeSH terms
Adult, Blood Glucose, Capillaries, Extracellular Space, Forearm, Humans, Insulin, Insulin Resistance, Inulin, Male, Obesity, Reference Values, Regional Blood Flow, Thinness, Glucose Clamp Technique, Muscle, Skeletal

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