The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Association Between Adiponectin and Mediators of Inflammation in Obese Women
Open accessAbstract
Low plasma levels of the anti-inflammatory factor adiponectin characterize obesity and insulin resistance. To elucidate the relationship between plasma levels of adiponectin, adiponectin gene expression in adipose tissue, and markers of inflammation, we obtained blood samples, anthropometric measures, and subcutaneous adipose tissue samples from 65 postmenopausal healthy women. Adiponectin plasma levels and adipose-tissue gene expression were significantly lower in obese subjects and inversely correlated with obesity-associated variables, including high-sensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6). Despite adjustment for obesity-associated variables, plasma levels of adiponectin were significantly correlated to adiponectin gene expression (partial r = 0.38, P < 0.05). Furthermore, the inverse correlation between plasma levels of hs-CRP and plasma adiponectin remained significant despite correction for obesity-associated variables (partial r = −0.32, P < 0.05), whereas the inverse correlation between adiponectin plasma levels or adiponectin gene expression in adipose tissue with plasma IL-6 were largely dependent on the clustering of obesity-associated variables. In conclusion, our data suggest a transcriptional mechanism leading to decreased adiponectin plasma levels in obese women and demonstrate that low levels of adiponectin are associated with higher levels of hs-CRP and IL-6, two inflammatory mediators and markers of increased cardiovascular risk.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Increased inflammatory cytokines and decreased total and HMW adiponectin concentrations have been associated with obesity (45,46), intra-abdominal fat accumulation (47), insulin resistance (48), the metabolic syndrome (49), and cardiovascular disease (50).”
From Age, Obesity, and Sex Effects on Insulin Sensitivity and Skeletal Muscle Mitochondrial Function (2010) · cites this paper as [45]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856
Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238
Ridker, P. M., Rifai, N., Rose, L., Buring, J. E., & Cook, N. R. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021993 · Cited by 3,604
Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matsuzawa, Y., Pratley, R. E., & Tataranni, P. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7463 · Cited by 3,541
Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1595 · Cited by 3,133
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
Berg, A. H., Combs, T. P., Du, X., Brownlee, M., & Scherer, P. E. (2001) · Nature Medicine · doi:10.1038/90992 · Cited by 2,526
Yudkin, J. S., Stehouwer, C. D. A., Emeis, J. J., & Coppack, S. W. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.4.972 · Cited by 2,465
Ridker, P. M., Rifai, N., Stampfer, M. J., & Hennekens, C. H. (2000) · Circulation · doi:10.1161/01.cir.101.15.1767 · Cited by 2,429
AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity
Hu, E., Liang, P., & Spiegelman, B. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.18.10697 · Cited by 2,261
Cited by
Sorted by citations
Items 401–417 of 417
Sticherling, C., & Osswald, S. (2017)
Naffouje, S. A., & Salti, G. I. (2018) · Springer eBooks · doi:10.1007/978-3-319-93545-4_40
Insulin sensitivity is mediated by glucose in the hepatoportal region in the rat
Johnson, H. M. (2017) · The Sydney eScholarship Repository (The University of Sydney)
Habibian, M., & Mousavi, S. A. R. (2019) · The Journal of Qazvin University of Medical Sciences · doi:10.32598/jqums.23.5.418
Obesity-Related Myocardiopathy
Hernández, M. A. L. (2020) · IntechOpen · doi:10.5772/intechopen.85949
Visceral Fat Quantitated From CT Colonography Is Associated With the Presence of Colorectal Polyps
Srirattanapong, S., Panyawaraporn, Y., Prasertsilpakul, W., & Laothamatas, J. (2020) · Ramathibodi Medical Journal · doi:10.33165/rmj.2020.43.2.240071
BARIATRIC SURGERY AND PERIODONTAL DISEASE / CIRURGIA BARIÁTRICA E DOENÇA PERIODONTAL
Soledade, K. R., Borges-Paluch, L. R., de Souza, A. F., dos Santos, M. A., Júnior, J. C. B. A., Sampaio, C., Barbosa, M. D. S., & Gomes‐Filho, I. S. (2020) · Brazilian Journal of Health Review · doi:10.34119/bjhrv3n6-186
Harm and benefit of the inflammatory response
Soeters, P. B., & de Leeuw, P. W. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820205-0.00023-2
Composizione corporea con tecnica DXA
Albanese, C. V., Renzo, L. D., & LORENZO, A. D. (2009) · Springer eBooks · doi:10.1007/978-88-470-1357-5_36
Current literature in diabetes
(2003) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.349
Prosolenko, K., Lapshyna, K., & Ryabuha, V. V. (2022) · Shidnoevropejskij zurnal vnutrisnoi ta simejnoi medicini · doi:10.15407/internalmed2022.01.055
Kumar, R., Priyadarshini, I., Goyal, A., Swarn, S., & Singh, S. K. (2023) · International Journal of Advances in Medicine · doi:10.18203/2349-3933.ijam20233885
Skurk, T., Blüher, M., & Engeli, S. (2024) · Springer eBooks · doi:10.1007/978-3-662-58895-6_15
Self-citationGupta, A. K., Singh, A. K., Gupta, P., Gupta, V., & Ojha, A. (2025) · Diabetes Technology and Obesity Medicine · doi:10.1089/dtom.2025.0014
Lecoutre, S. (2017) · theses.fr (ABES) · doi:10.70675/65a35937ze6d1z436ezb142z7812e3f38007
Adipokines and Their Role in Women\'s Health: A Comprehensive Review
Naorem, S., Kshetrimayum, V., Ashem, N., Laishram, S., Devi, M. P., & Rosyka, L. (2026) · Journal of Applied Biochemistry & Laboratory Medicine · doi:10.5005/jablm-11031-0022
Metadata
- Authors
- Engeli, S., Feldpausch, M., Gorzelniak, K., Hartwig, F., Heintze, U., Janke, J., Möhlig, M., Pfeiffer, A. F. H., Luft, F. C., & Sharma, A. M.
- Affiliations
- Max Delbrück Center (DE)
- HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charité, Humboldt University of Berlin, and Max Delbrück Center for Molecular Medicine, Berlin, Germany
- German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany
- German Institute of Human Nutrition (DE)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2003-04-01
- Volume
- 52
- Issue
- 4
- Pages
- 942-947
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2120192015
- Cited by
- 422
- References
- 51
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 2 · 2023: 11 · 2022: 9 · 2021: 14 · 2020: 11 · 2019: 12 · 2018: 13 · 2017: 9 · 2016: 13 · 2015: 12 · 2014: 19 · 2013: 27 · 2012: 21
- FWCI
- 25.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bundesministerium für Bildung und Forschung (01KW0011)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adiponectin, obesity, postmenopausal women, inflammation, C-reactive protein, interleukin-6, adipose tissue gene expression, insulin resistance, cardiovascular risk
- MeSH terms
- Adipose Tissue, Blood Pressure, Body Composition, Body Constitution, C-Reactive Protein, Female, Humans, Lipids, Middle Aged, Obesity, Proteins, Tumor Necrosis Factor-alpha, Interleukin-6, Gene Expression, Body Mass Index, Postmenopause, Inflammation Mediators, Intercellular Signaling Peptides and Proteins, Adiponectin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
