Cited by 422Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

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Association Between Adiponectin and Mediators of Inflammation in Obese Women

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Engeli, Stefan, Feldpausch, Mareike, Gorzelniak, Kerstin, Hartwig, Frauke, Heintze, Ute, Janke, Jürgen, Möhlig, Matthias, Pfeiffer, Andreas F.H., Luft, Friedrich C., Sharma, Arya M.·2003·Diabetes

DOI 10.2337/diabetes.52.4.942

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Abstract

Low plasma levels of the anti-inflammatory factor adiponectin characterize obesity and insulin resistance. To elucidate the relationship between plasma levels of adiponectin, adiponectin gene expression in adipose tissue, and markers of inflammation, we obtained blood samples, anthropometric measures, and subcutaneous adipose tissue samples from 65 postmenopausal healthy women. Adiponectin plasma levels and adipose-tissue gene expression were significantly lower in obese subjects and inversely correlated with obesity-associated variables, including high-sensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6). Despite adjustment for obesity-associated variables, plasma levels of adiponectin were significantly correlated to adiponectin gene expression (partial r = 0.38, P < 0.05). Furthermore, the inverse correlation between plasma levels of hs-CRP and plasma adiponectin remained significant despite correction for obesity-associated variables (partial r = −0.32, P < 0.05), whereas the inverse correlation between adiponectin plasma levels or adiponectin gene expression in adipose tissue with plasma IL-6 were largely dependent on the clustering of obesity-associated variables. In conclusion, our data suggest a transcriptional mechanism leading to decreased adiponectin plasma levels in obese women and demonstrate that low levels of adiponectin are associated with higher levels of hs-CRP and IL-6, two inflammatory mediators and markers of increased cardiovascular risk.

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Authors: Engeli, S., Feldpausch, M., Gorzelniak, K., Hartwig, F., Heintze, U., Janke, J., Möhlig, M., Pfeiffer, A. F. H., Luft, F. C., & Sharma, A. M.
Affiliations: Max Delbrück Center (DE)
HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charité, Humboldt University of Berlin, and Max Delbrück Center for Molecular Medicine, Berlin, Germany
German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany
German Institute of Human Nutrition (DE)
ORCID: Engeli, Stefan
Pfeiffer, Andreas F.H.
Luft, Friedrich C.
Sharma, Arya M.
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2003-04-01
Volume: 52
Issue: 4
Pages: 942-947
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.52.4.942
OpenAlex: W2120192015
Cited by: 422
References: 51
Citations by year: 2026: 4 · 2025: 7 · 2024: 2 · 2023: 11 · 2022: 9 · 2021: 14 · 2020: 11 · 2019: 12 · 2018: 13 · 2017: 9 · 2016: 13 · 2015: 12 · 2014: 19 · 2013: 27 · 2012: 21
FWCI: 25.49
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Funders: Bundesministerium für Bildung und Forschung (01KW0011)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: adiponectin, obesity, postmenopausal women, inflammation, C-reactive protein, interleukin-6, adipose tissue gene expression, insulin resistance, cardiovascular risk
MeSH terms: Adipose Tissue, Blood Pressure, Body Composition, Body Constitution, C-Reactive Protein, Female, Humans, Lipids, Middle Aged, Obesity, Proteins, Tumor Necrosis Factor-alpha, Interleukin-6, Gene Expression, Body Mass Index, Postmenopause, Inflammation Mediators, Intercellular Signaling Peptides and Proteins, Adiponectin

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Association Between Adiponectin and Mediators of Inflammation in Obese Women

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