Cited by 422Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Association Between Adiponectin and Mediators of Inflammation in Obese Women

Open access

Engeli, Stefan, Feldpausch, Mareike, Gorzelniak, Kerstin, Hartwig, Frauke, Heintze, Ute, Janke, Jürgen, Möhlig, Matthias, Pfeiffer, Andreas F.H., Luft, Friedrich C., Sharma, Arya M.·2003·Diabetes

DOI 10.2337/diabetes.52.4.942

Open this paper in CoChat — free account Open PDF

Abstract

Low plasma levels of the anti-inflammatory factor adiponectin characterize obesity and insulin resistance. To elucidate the relationship between plasma levels of adiponectin, adiponectin gene expression in adipose tissue, and markers of inflammation, we obtained blood samples, anthropometric measures, and subcutaneous adipose tissue samples from 65 postmenopausal healthy women. Adiponectin plasma levels and adipose-tissue gene expression were significantly lower in obese subjects and inversely correlated with obesity-associated variables, including high-sensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6). Despite adjustment for obesity-associated variables, plasma levels of adiponectin were significantly correlated to adiponectin gene expression (partial r = 0.38, P < 0.05). Furthermore, the inverse correlation between plasma levels of hs-CRP and plasma adiponectin remained significant despite correction for obesity-associated variables (partial r = −0.32, P < 0.05), whereas the inverse correlation between adiponectin plasma levels or adiponectin gene expression in adipose tissue with plasma IL-6 were largely dependent on the clustering of obesity-associated variables. In conclusion, our data suggest a transcriptional mechanism leading to decreased adiponectin plasma levels in obese women and demonstrate that low levels of adiponectin are associated with higher levels of hs-CRP and IL-6, two inflammatory mediators and markers of increased cardiovascular risk.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.2337/diabetes.52.4.942

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238
Comparison of C-Reactive Protein and Low-Density Lipoprotein Cholesterol Levels in the Prediction of First Cardiovascular Events
Ridker, P. M., Rifai, N., Rose, L., Buring, J. E., & Cook, N. R. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021993 · Cited by 3,604
Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance and Hyperinsulinemia
Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matsuzawa, Y., Pratley, R. E., & Tataranni, P. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7463 · Cited by 3,541
Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1595 · Cited by 3,133
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
Berg, A. H., Combs, T. P., Du, X., Brownlee, M., & Scherer, P. E. (2001) · Nature Medicine · doi:10.1038/90992 · Cited by 2,526
C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction: A Potential Role for Cytokines Originating From Adipose Tissue?
Yudkin, J. S., Stehouwer, C. D. A., Emeis, J. J., & Coppack, S. W. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.4.972 · Cited by 2,465
Plasma Concentration of Interleukin-6 and the Risk of Future Myocardial Infarction Among Apparently Healthy Men
Ridker, P. M., Rifai, N., Stampfer, M. J., & Hennekens, C. H. (2000) · Circulation · doi:10.1161/01.cir.101.15.1767 · Cited by 2,429
AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity
Hu, E., Liang, P., & Spiegelman, B. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.18.10697 · Cited by 2,261

Show all 51 references

Sorted by citations

Items 101–200 of 417

Subcutaneous Rather than Visceral Adipose Tissue Is Associated with Adiponectin Levels and Insulin Resistance in Young Men
Frederiksen, L., Nielsen, T. L., Wraae, K., Hagen, C., Frystyk, J., Flyvbjerg, A., Brixen, K., & Andersen, M. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0980 · Cited by 96
The complexities of obesity and diabetes with the development and progression of pancreatic cancer
Bao, B., Wang, Z., Li, Y., Kong, D., Ali, S. S., Banerjee, S., Ahmad, A., & Sarkar, F. H. (2010) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2010.11.003 · Cited by 94
Adiponectin Is Inversely Associated with Renal Function in Type 1 Diabetic Patients
Schalkwijk, C. G., Chaturvedi, N., Schram, M. T., Fuller, J., & Stehouwer, C. D. A. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1117 · Cited by 94
C‐reactive protein in children with obstructive sleep apnea and the effects of treatment
Li, A. M., Chan, M. H. M., Yin, J., So, H., Ng, S. K., Chan, I. H. S., Lam, C. W. K., Wing, Y. K., & Ng, P. C. (2007) · Pediatric Pulmonology · doi:10.1002/ppul.20732 · Cited by 93
The Relationships of Plasma Adiponectin with a Favorable Lipid Profile, Decreased Inflammation, and Less Ectopic Fat Accumulation Depend on Adiposity
Kantartzis, K., Rittig, K., Balletshofer, B. M., Machann, J., Schick, F., Porubská, K., Fritsche, A., Häring, H., & Stefan, N. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2006.067397 · Cited by 90
Resistin and adiponectin levels in subjects with coronary artery disease and type 2 diabetes
Yaturu, S., Daberry, R. P., Rains, J., & Jain, S. K. (2006) · Cytokine · doi:10.1016/j.cyto.2006.05.005 · Cited by 91
Angiotensin type 1 receptor antagonists induce human in-vitro adipogenesis through peroxisome proliferator-activated receptor-γ activation
Janke, J., Schupp, M., Engeli, S., Gorzelniak, K., Boschmann, M., Sauma, L., Nyström, F. H., Jordan, J., Luft, F. C., & Sharma, A. M. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000242405.68461.84 · Cited by 89
Self-citation
Association of Visceral Fat Accumulation and Adiponectin Levels with Colorectal Neoplasia
Erarslan, E., Türkay, C., Köktener, A., Koca, C., Uz, B., & Bavbek, N. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-008-0440-6 · Cited by 84
Protective roles of adiponectin in obesity-related fatty liver diseases: mechanisms and therapeutic implications
Wang, Y., Zhou, M., Lam, K. S. L., & Xu, A. (2009) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302009000200012 · Cited by 90
Nutritional intervention to reduce the n−6/n−3 fatty acid ratio increases adiponectin concentration and fatty acid oxidation in healthy subjects
Guebre‐Egziabher, F., RABASA-LHORET, R. P. R., Bonnet, F., Jp, B., Desage, M., Skilton, M. R., Vidal, H., & Laville, M. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602857 · Cited by 88
Women and Ischemic Heart Disease
Quyyumi, A. A. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.11.075 · Cited by 86
Neuroendocrine factors in the regulation of inflammation: Excessive adiposity and calorie restriction
Fontana, L. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2008.04.005 · Cited by 81
Exercise Training Modifies Ghrelin and Adiponectin Concentrations and Is Related to Inflammation in Older Adults
Markofski, M. M., Carrillo, A. E., Timmerman, K. L., Jennings, K., Coen, P. M., Pence, B. D., & Flynn, M. G. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glt132 · Cited by 80
The Relationship Between Insulin Sensitivity and Serum Adiponectin Levels in Three Population Groups
Ferris, W. F., Naran, N. H., Crowther, N. J., Rheeder, P., van der Merwe, L., & Chetty, N. (2005) · Hormone and Metabolic Research · doi:10.1055/s-2005-870580 · Cited by 78
Genistein ameliorated obesity accompanied with adipose tissue browning and attenuation of hepatic lipogenesis in ovariectomized rats with high-fat diet
Shen, H., Huang, S.-Y., Kung, C.-W., Chen, S., Chen, Y., Cheng, P., Lam, K., & Lee, Y. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.02.001 · Cited by 78
Adiponectin, insulin resistance, and C-reactive protein in postpubertal Asian Indian adolescents
Vikram, N. K., Misra, A., Pandey, R. M., Dwivedi, M., & Luthra, K. (2004) · Metabolism · doi:10.1016/j.metabol.2004.05.010 · Cited by 78
Alterations in peripheral blood lymphocyte cytokine expression in obesity
O’Rourke, R. W., Kay, T., Lyle, E. A., Traxler, S., Deveney, C. W., Jobe, B. A., Roberts, C. T., Marks, D. L., & Rosenbaum, J. T. (2006) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03186.x · Cited by 76
Adipokines promote chronic kidney disease
Rüster, C., & Wolf, G. (2013) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gft191 · Cited by 77
Quantification of Hepatic Steatosis with 3-T MR Imaging: Validation inob/obMice
Hines, C. D. G., Yu, H., Shimakawa, A. S., McKenzie, C. A., WARNER, T. F. C. S., Brittain, J. H., & Reeder, S. B. (2009) · Radiology · doi:10.1148/radiol.09090131 · Cited by 76
Adiponectin Suppresses Pathological Microvessel Formation in Retina Through Modulation of Tumor Necrosis Factor-α Expression
Higuchi, A., Ohashi, K., Kihara, S., Walsh, K., & Ouchi, N. (2009) · Circulation Research · doi:10.1161/circresaha.109.194506 · Cited by 76
Obesity, Inflammation, and Lung Injury (OILI): The Good
Wang, C. (2014) · Mediators of Inflammation · doi:10.1155/2014/978463 · Cited by 78
Acute exercise increases circulating inflammatory markers in overweight and obese compared with lean subjects
Christiansen, T., Bruun, J. M., Paulsen, S. K., Ølholm, J., Overgaard, K., Pedersen, S. B., & Richelsen, B. (2013) · European Journal of Applied Physiology · doi:10.1007/s00421-013-2592-0 · Cited by 73
CRP reduction following gastric bypass surgery is most pronounced in insulin-sensitive subjects
Holdstock, C., Lind, L., Engstrom, B. E., Ohrvall, M., Sundbom, M., Larsson, A., & Karlsson, F. A. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803000 · Cited by 73
Adiponectin plays a protective role in caerulein-induced acute pancreatitis in mice fed a high-fat diet
Araki, H., Nishihara, T., Matsuda, M., Fukuhara, A., Kihara, S., Funahashi, T., Kataoka, T. R., Kamada, Y., Kiyohara, T., Tamura, S., et al. (2008) · Gut · doi:10.1136/gut.2007.135665 · Cited by 73
Obesity and the development of type 2 diabetes: the effects of fatty tissue inflammation
Schuster, D. (2010) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmsott.s7354 · Cited by 99
Diabetes Mellitus in the Hispanic/Latino Population: An Increasing Health Care Challenge in the United States
Umpierrez, G. E., Gonzalez, A., Umpierrez, D., & Pimentel, D. (2007) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e3180a6efe3 · Cited by 70
Relation Between Plasma Adiponectin, High-Sensitivity C-Reactive Protein, and Coronary Plaque Components in Patients With Acute Coronary Syndrome
Otake, H., Shite, J., Shinke, T., Watanabe, S., Tanino, Y., Ogasawara, D., Sawada, T., Hirata, K., & Yokoyama, M. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.07.041 · Cited by 71
Visceral fat decreased by long-term interdisciplinary lifestyle therapy correlated positively with interleukin-6 and tumor necrosis factor–α and negatively with adiponectin levels in obese adolescents
Lira, F. S., Neto, J. C. R., dos Santos, R. V. T., Venâncio, D. P., Carnier, J., Sanches, P. D. L., do Nascimento, C. M. O., de Piano, A., Tock, L., Tufik, S., et al. (2010) · Metabolism · doi:10.1016/j.metabol.2010.02.017 · Cited by 67
The IL-6 Paradox: Context Dependent Interplay of SOCS3 and AMPK
Sarvas, J. L. (2013) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.s13-003 · Cited by 69
Is There an Interaction Between Polycystic Ovary Syndrome and Gingival Inflammation?
Özçaka, Ö., Ceyhan, B. Ö., Akcalı, A., Bıçakçı, N., Lappin, D. F., & Buduneli, N. (2012) · Journal of Periodontology · doi:10.1902/jop.2012.110588 · Cited by 65
Reduced gene expression of adiponectin in fat tissue from patients with end-stage renal disease
Marchlewska, A., Stenvinkel, P., Lindholm, B., Danielsson, A., Pecoits‐Filho, R., Lönnqvist, F., Schalling, M., Heimbürger, O., & Nordfors, L. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00705.x · Cited by 65
Role of Perivascular Adipose Tissue in Health and Disease
Fernández‐Alfonso, M. S., Somoza, B., Tsvetkov, D., Kuczmanski, A., Dashwood, M. R., & Gil‐Ortega, M. (2017) · Comprehensive physiology · doi:10.1002/cphy.c170004 · Cited by 71
Adiponectin is associated with low bone mineral density in elderly men.
Basurto, L., Galván, R., Córdova, N., Saucedo, R., Vargas, C., Campos, S., Halley, E., Avelar, F., & Zarate, A. (2008) · European Journal of Endocrinology · doi:10.1530/eje-08-0569 · Cited by 65
Obesity, metabolic dysregulation and oxidative stress in asthma
Lugogo, N. L., Bappanad, D., & Kraft, M. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.09.004 · Cited by 64
Systemic Inflammation and Lung Function Impairment in Morbidly Obese Subjects with the Metabolic Syndrome
van Huisstede, A., Cabezas, M. C., Birnie, E., van de Geijn, G. M., Rudolphus, A., Mannaerts, G. H. H., Njo, T. L., Hiemstra, P. S., & Braunstahl, G. (2013) · Journal of Obesity · doi:10.1155/2013/131349 · Cited by 62
High-intensity endurance training improves adiponectin mRNA and plasma concentrations
Moghadasi, M., Mohebbi, H., Rahmani-Nia, F., Hassan‐Nia, S., Noroozi, H., & Pirooznia, N. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-2073-2 · Cited by 63
Adiponectin--an adipokine with unique metabolic properties
Wiecek, A., Adamczak, M., & Chudek, J. T. (2007) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfl814 · Cited by 63
Association between hypoadiponectinemia and cardiovascular risk factors in nonobese healthy adults
Im, J., Kim, S.-H., Lee, J., Shim, J., Lee, H.-R., & Lee, D. (2006) · Metabolism · doi:10.1016/j.metabol.2006.06.027 · Cited by 61
Plasma and urine levels of resistin and adiponectin in chronic kidney disease
Yaturu, S., Dhanireddy, R., Rains, J., & Jain, S. K. (2007) · Cytokine · doi:10.1016/j.cyto.2007.02.003 · Cited by 60
Adiponectin and resistin serum levels in women with polycystic ovary syndrome during oral glucose tolerance test: A significant reciprocal correlation between adiponectin and resistin independent of insulin resistance indices
Lewandowski, K. C., Szosland, K., O’Callaghan, C. J., Tan, B. K., Randeva, H. S., & Lewiñski, A. (2005) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2004.12.014 · Cited by 62
Teasaponin Reduces Inflammation and Central Leptin Resistance in Diet-Induced Obese Male Mice
Yu, Y., Wu, Y., Szabo, A., Wu, Z., Wang, H., Li, D., & Huang, X. (2013) · Endocrinology · doi:10.1210/en.2013-1218 · Cited by 60
Metabolic complications of obesity: inflated or inflamed?
Chandalia, M., & Abate, N. I. (2007) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2006.10.004 · Cited by 59
Inverse association between adiponectin and C-reactive protein in substantially healthy Japanese men
Matsushita, K., Yatsuya, H., Tamakoshi, K., Wada, K., Otsuka, R., Zhang, H., Sugiura, K., Kondo, T., Murohara, T., & Toyoshima, H. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.10.031 · Cited by 59
Dangers, and benefits of the cytokine mediated response to injury and infection
Soeters, P. B., & Grimble, R. F. (2009) · Clinical Nutrition · doi:10.1016/j.clnu.2009.05.014 · Cited by 57
Dysregulation of Leukocyte Trafficking in Type 2 Diabetes: Mechanisms and Potential Therapeutic Avenues
Pezhman, L., Tahrani, A. A., & Chimen, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.624184 · Cited by 61
Depression and serum adiponectin and adipose omega-3 and omega-6 fatty acids in adolescents
Mamalakis, G., Kiriakakis, M., Tsibinos, G., Hatzis, C., FLOURI, S., Mantzoros, C. S., & Kafatos, A. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.10.008 · Cited by 56
MicroRNA-378 Regulates Adiponectin Expression in Adipose Tissue: A New Plausible Mechanism
Ishida, M., Shimabukuro, M., Yagi, S., Nishimoto, S., Kozuka, C., Fukuda, D., Soeki, T., Masuzaki, H., Tsutsui, M., & Sata, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111537 · Cited by 55
Increased cardiovascular risk markers in obesity are associated with body adiposity: Role of leptin
Gómez‐Ambrosi, J., Salvador, J., Silva, C., Pastor, C., Rotellar, F., Gil, M., Cienfuegos, J. A., & Frühbeck, G. (2006) · Thrombosis and Haemostasis · doi:10.1160/th06-02-0079 · Cited by 55
Heme oxygenase, a novel target for the treatment of hypertension and obesity?
Hosick, P. A., & Stec, D. E. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00517.2011 · Cited by 54
Different spexin level in obese vs normal weight children and its relationship with obesity related risk factors
Behrooz, M., Vaghef‐Mehrabany, E., & Ostadrahimi, A. (2019) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2019.11.008 · Cited by 54
Iron status in athletic females, a shift in perspective on an old paradigm
Badenhorst, C. E., Goto, K., O’Brien, W. J., & Sims, S. T. (2021) · Journal of Sports Sciences · doi:10.1080/02640414.2021.1885782 · Cited by 54
The adiponectin-to-leptin ratio in women with polycystic ovary syndrome: relation to insulin resistance and proinflammatory markers
Xita, N. V., Papassotiriou, I., Georgiou, I. A., Vounatsou, M., Margeli, A., & Tsatsoulis, A. A. (2007) · Metabolism · doi:10.1016/j.metabol.2007.01.008 · Cited by 51
Energy balance adiposity and breast cancer – energy restriction strategies for breast cancer prevention
Harvie, M., & Howell, A. (2006) · Obesity Reviews · doi:10.1111/j.1467-789x.2006.00207.x · Cited by 51
The SNP276G>T polymorphism in the adiponectin (ACDC) gene is more strongly associated with insulin resistance and cardiovascular disease risk than SNP45T>G in nonobese/nondiabetic Korean men independent of abdominal adiposity and circulating plasma adiponectin
Jang, Y., Lee, J. H., Kim, O., Koh, S. J., Chae, J. S., Woo, J. H., Cho, H., Lee, J. E., & Ordovás, J. M. (2005) · Metabolism · doi:10.1016/j.metabol.2005.07.007 · Cited by 51
Metabolic syndrome in pediatric cancer survivors: A mechanistic review
Rosen, G. P., Nguyen, H.-T., & Shaibi, G. Q. (2013) · Pediatric Blood & Cancer · doi:10.1002/pbc.24703 · Cited by 51
Adiponectin levels and cardiovascular risk factors in hypothyroidism and hyperthyroidism
Altınova, A. E., Törüner, F. B., Aktürk, M., Bukan, N. C., Çakır, N., Ayvaz, G., & Arslan, M. (2006) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02628.x · Cited by 50
Effects of Roux-en-Y gastric bypass on fasting and postprandial inflammation-related parameters in obese subjects with normal glucose tolerance and in obese subjects with type 2 diabetes
Bovbjerg, K. K. L., Jørgensen, N. B., Just, R., Heegaard, P. M. H., & Madsbad, S. (2015) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-015-0012-9 · Cited by 50
The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review
Mukherjee, A. G., Wanjari, U. R., Kannampuzha, S., Murali, R., Namachivayam, A., Ganesan, R., Dey, A., Babu, A., Renu, K., Vellingiri, B., et al. (2023) · Metabolites · doi:10.3390/metabo13010129 · Cited by 56
Long-term treatment with an angiotensin II receptor blocker decreases adipocyte size and improves insulin signaling in obese Zucker rats
Muñoz, M. C., Giani, J. F., Dominici, F. P., Turyn, D., & Toblli, J. E. (2009) · Journal of Hypertension · doi:10.1097/hjh.0b013e3283310e1b · Cited by 49
Direct and indirect effects of obesity on the kidney.
Alicic, R. Z., Patakoti, R., & Tuttle, K. R. (2013) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2012.12.006 · Cited by 43
Impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men
Berthier, M., Houde, A., Côté, M., Paradis, A.-M., Mauriège, P., Bergeron, J., Gaudet, D., Després, J., & Vohl, M. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400135-jlr200 · Cited by 50
Associations of adiponectin with metabolic and vascular risk parameters in the British Regional Heart Study reveal stronger links to insulin resistance-related than to coronory heart disease risk-related parameters
Wannamethee, S. G., Tchernova, J., Whincup, P. H., Lowe, G. D. O., Rumley, A., Brown, K. E., Cherry, L., & Sattar, N. A. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803544 · Cited by 48
The Potential Benefits and Adverse Effects of Phytic Acid Supplement in Streptozotocin-Induced Diabetic Rats
Omoruyi, F. O., Budiaman, A., Eng, Y., Olumese, F. E., Hoesel, J. L., Ejilemele, A., & Okorodudu, A. O. (2013) · Advances in Pharmacological Sciences · doi:10.1155/2013/172494 · Cited by 47
Expression of Obesity Markers and Persistent Organic Pollutants Levels in Adipose Tissue of Obese Patients: Reinforcing the Obesogen Hypothesis?
Pereira-Fernandes, A., Dirinck, E. L., Dirtu, A. C., Malarvannan, G., Covaci, A., Gaal, L. V., Vanparys, C., Jorens, P. G., & Blust, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084816 · Cited by 49
Cytokine and adipokine are biofactors can act in blood and colostrum of obese mothers
Fujimori, M., França, E. L., Morais, T. C., Fiorin, V., de Abreu, L. C., & Honório‐França, A. C. (2016) · BioFactors · doi:10.1002/biof.1339 · Cited by 48
Low plasma adiponectin levels are associated with presence of thin-cap fibroatheroma in men with stable coronary artery disease
Sawada, T., Shite, J., Shinke, T., Otake, H., Tanino, Y., Ogasawara, D., Kawamori, H., Kato, H., Miyoshi, N., Yoshino, N., et al. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2008.12.216 · Cited by 46
Moderate obesity and endothelial dysfunction in humans: influence of gender and systemic inflammation
Suboc, T. M. B., Dharmashankar, K., Wang, J., Ying, R., Couillard, A. B., Tanner, M. J., & Widlansky, M. E. (2013) · Physiological Reports · doi:10.1002/phy2.58 · Cited by 47
Differential response of the natriuretic peptide system to weight loss and exercise in overweight or obese patients
Haufe, S., Kaminski, J., Utz, W., Haas, V., Mähler, A., Daniels, M. A., Birkenfeld, A. L., Lichtinghagen, R., Luft, F. C., Schulz-Menger, J., et al. (2015) · Journal of Hypertension · doi:10.1097/hjh.0000000000000573 · Cited by 41
Self-citation
Adipose Tissue Metabolism and CD11b Expression on Monocytes in Obese Hypertensives
Boschmann, M., Engeli, S., Adams, F., Gorzelniak, K., Franke, G., Klaua, S., Kreuzberg, U., Luedtke, S., Kettritz, R., Sharma, A. M., et al. (2005) · Hypertension · doi:10.1161/01.hyp.0000171477.63859.b2 · Cited by 45
Self-citation
The Adipose Tissue as an Endocrine Organ – A Nephrologists’ Perspective
Chudek, J. T., Adamczak, M., Nieszporek, T., & Więcek, A. (2006) · KARGER eBooks · doi:10.1159/000095320 · Cited by 46
Hypoadiponectinemia and Proinflammatory State: Two Sides of the Same Coin?
Herder, C., Hauner, H., Haastert, B., Röhrig, K., Köenig, W., Kolb, H., Müller-Scholze, S., Thorand, B., Holle, R., & Rathmann, W. (2006) · Diabetes Care · doi:10.2337/dc05-1900 · Cited by 44
Adiponectin: is it a biomarker for assessing the disease severity in knee osteoarthritis patients?
COŞKUN, N. C., Ay, S., Evcik, F. D., & Öztuna, D. (2015) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.12790 · Cited by 44
Maternal obesity increases insulin resistance, low-grade inflammation and osteochondrosis lesions in foals and yearlings until 18 months of age
Robles, M., Nouveau, E., Gautier, C., Mendoza, L., Dubois, C., Dahirel, M., Lagofun, B., Aubrière, M.-C., Lejeune, J.-P., Caudron, I., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190309 · Cited by 44
Leptin, Adiponectin, and Obesity among Caucasian and Asian Women
Conroy, S. M., Chai, W., Lim, U., Franke, A. A., Cooney, R. V., & Maskarinec, G. (2011) · Mediators of Inflammation · doi:10.1155/2011/253580 · Cited by 43
Adipokines and the insulin resistance syndrome in familial partial lipodystrophy caused by a mutation in lamin A/C
Wong, S., Huda, M. S. B., English, P., Bargiotta, A., Wilding, J. P. H., Johnson, A., Corrall, R. J. M., & Pinkney, J. H. (2005) · Diabetologia · doi:10.1007/s00125-005-0038-x · Cited by 42
Differential roles of CIDEA and CIDEC in insulin-induced anti-apoptosis and lipid droplet formation in human adipocytes
Ito, M., Nagasawa, M., Hara, T., Ide, T., & Murakami, K. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m002147 · Cited by 44
Low levels of adiponectin predict worsening of arterial morphology and function
Störk, S., Bots, M. L., Angerer, P., von Schacky, C., Grobbee, D. E., Angermann, C. E., & Seufert, J. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.11.044 · Cited by 42
New Frontiers for the Use of IP6 and Inositol Combination in Treating Diabetes Mellitus: A Review
Omoruyi, F. O., Stennett, D., Foster, S. R., & Dilworth, L. (2020) · Molecules · doi:10.3390/molecules25071720 · Cited by 43
Adipokine signatures of subcutaneous and visceral abdominal fat in normal-weight and obese women with different metabolic profiles
Korać, A., Srdić, B., Stančić, A., Otašević, V., Korać, B., & Janković, A. (2021) · Archives of Medical Science · doi:10.5114/aoms/92118 · Cited by 48
Reciprocal Association of Plasma Adiponectin and Serum C-Reactive Protein Concentration in Haemodialysis Patients with End-Stage Kidney Disease – A Follow-Up Study
Ignacy, W., Chudek, J. T., Adamczak, M., Funahashi, T., Matsuzawa, Y., Kokot, F., & Więcek, A. (2005) · Nephron Clinical Practice · doi:10.1159/000085707 · Cited by 42
The therapeutic potential of interleukin-6 in treating obesity
Wallenius, K., Jansson, J., & Wallenius, V. (2003) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.3.7.1061 · Cited by 41
Adiponectin Expression and Adipose Tissue Lipolytic Activity in Lean and Obese Women
Bulló, M., Salas‐Salvadó, J., & García‐Lorda, P. (2005) · Obesity Surgery · doi:10.1381/0960892053576776 · Cited by 42
Adipokines and cardiometabolic function: How are they interlinked?
Schutte, A. E., Huisman, H. W., Schutte, R., van Rooyen, J. M., Malan, L., Fourie, C. M. T., & Malan, N. T. (2010) · Regulatory Peptides · doi:10.1016/j.regpep.2010.06.008 · Cited by 41
Haptoglobin release by human adipose tissue in primary culture
Fain, J. N., Bahouth, S. W., & Madan, A. K. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300406-jlr200 · Cited by 41
A polymorphism in the adiponectin gene influences adiponectin expression levels in visceral fat in obese subjects
Fredriksson, J., Carlsson, E., Orho‐Melander, M., Groop, L., & Ridderstråle, M. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803138 · Cited by 41
Changes in insulin and IGF-I receptor expression during differentiation of human preadipocytes
Bäck, K., & Arnqvist, H. J. (2009) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2008.06.004 · Cited by 40
Idiopathic nodular glomerulosclerosis: a clinicopathologic study of 15 cases
Li, W., & Verani, R. R. (2008) · Human Pathology · doi:10.1016/j.humpath.2008.05.004 · Cited by 40
Insulin Resistance Syndrome in the Elderly
Banks, W. A., Willoughby, L. M., Thomas, D. R., & Morley, J. E. (2007) · Diabetes Care · doi:10.2337/dc07-0649 · Cited by 40
CEACAM1 loss links inflammation to insulin resistance in obesity and non-alcoholic steatohepatitis (NASH)
Najjar, S. M., & Russo, L. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0407-3 · Cited by 40
Low serum adiponectin is a predictor of progressing to nonalcoholic fatty liver disease
Zhang, H., Niu, Y., Gu, H., Lü, S., Zhang, W., Li, X., YANG, Z. K., Qin, L., & Su, Q. (2018) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.22709 · Cited by 39
Association of plasma total and high-molecular-weight adiponectin with risk of colorectal cancer: an observational study in Chinese male
Chen, M.-W., Ye, S., Zhao, L., Wang, S.-Y., Li, Y., Yu, C., Xie, H., & Wang, Y. (2012) · Medical Oncology · doi:10.1007/s12032-012-0280-2 · Cited by 39
HMGB1 is secreted by 3T3‐L1 adipocytes through JNK signaling and the secretion is partially inhibited by adiponectin
Shimizu, T., Yamakuchi, M., Biswas, K. K., Aryal, B., Yamada, S., Hashiguchi, T., & Maruyama, I. (2016) · Obesity · doi:10.1002/oby.21549 · Cited by 41
Predictors of epicardial adipose tissue in patients with type 2 diabetes mellitus
Akbaş, E. M., Hamur, H., Demirtaş, L., Bakırcı, E. M., Özçiçek, A., Özçıçek, F., Kuyrukluyıldız, U., & Türkmen, K. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-55 · Cited by 37
Serum adiponectin level is correlated with the size of HDL and LDL particles determined by high performance liquid chromatography
Tsubakio‐Yamamoto, K., Sugimoto, T., Nishida, M., Okano, R., Monden, Y., Kitazume-Taneike, R., Yamashita, T., Nakaoka, H., Kawase, R., Yuasa‐Kawase, M., et al. (2012) · Metabolism · doi:10.1016/j.metabol.2012.05.011 · Cited by 36
Body Build and Risk of Cardiovascular Events in Hypertension and Left Ventricular Hypertrophy
SIMONE, G. D., Wachtell, K., Palmieri, V., Hille, D. A., Beevers, G., Dahlöf, B., Fairé, U. D., Fyhrquist, F., Ibsen, H., Julius, S., et al. (2005) · Circulation · doi:10.1161/01.cir.0000161799.91577.0a · Cited by 36
Differences and similarities regarding adiponectin investigated in African and Caucasian women
Schutte, A. E., Huisman, H. W., Schutte, R., Malan, L., van Rooyen, J. M., Malan, N. T., & Schwarz, P. E. H. (2007) · European Journal of Endocrinology · doi:10.1530/eje-07-0044 · Cited by 35
Plasma adiponectin levels are related to obesity, inflammation, blood lipids and insulin in type 2 diabetic and non-diabetic Trinidadians
Nayak, B. S., Ramsingh, D., Gooding, S., Legall, G., Bissram, S., Mohammed, A., Raychaudhuri, A., Sahadeo, B., Pandohie, V., & Figaro, K. (2010) · Primary care diabetes · doi:10.1016/j.pcd.2010.05.006 · Cited by 34
The adiponectin gene, ADIPOQ, and genetic susceptibility to colon cancer
Al-Harithy, R. N., & Al-Zahrani, M. H. (2011) · Oncology Letters · doi:10.3892/ol.2011.443 · Cited by 34
The Relationship between Plasma Adiponectin Concentration and Insulin Resistance Is Altered in Smokers
Abbasi, F., Farin, H. M. F., Lamendola, C. A., McLaughlin, T., Schwartz, E. A., Reaven, G. M., & Reaven, P. D. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0419 · Cited by 34
Plasma Adiponectin Decrease in Women with Nonalcoholic Fatty Liver
Matsubara, M. (2004) · Endocrine Journal · doi:10.1507/endocrj.51.587 · Cited by 34

Authors: Engeli, S., Feldpausch, M., Gorzelniak, K., Hartwig, F., Heintze, U., Janke, J., Möhlig, M., Pfeiffer, A. F. H., Luft, F. C., & Sharma, A. M.
Affiliations: Max Delbrück Center (DE)
HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charité, Humboldt University of Berlin, and Max Delbrück Center for Molecular Medicine, Berlin, Germany
German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany
German Institute of Human Nutrition (DE)
ORCID: Engeli, Stefan
Pfeiffer, Andreas F.H.
Luft, Friedrich C.
Sharma, Arya M.
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2003-04-01
Volume: 52
Issue: 4
Pages: 942-947
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.52.4.942
OpenAlex: W2120192015
Cited by: 422
References: 51
Citations by year: 2026: 4 · 2025: 7 · 2024: 2 · 2023: 11 · 2022: 9 · 2021: 14 · 2020: 11 · 2019: 12 · 2018: 13 · 2017: 9 · 2016: 13 · 2015: 12 · 2014: 19 · 2013: 27 · 2012: 21
FWCI: 25.49
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Funders: Bundesministerium für Bildung und Forschung (01KW0011)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: adiponectin, obesity, postmenopausal women, inflammation, C-reactive protein, interleukin-6, adipose tissue gene expression, insulin resistance, cardiovascular risk
MeSH terms: Adipose Tissue, Blood Pressure, Body Composition, Body Constitution, C-Reactive Protein, Female, Humans, Lipids, Middle Aged, Obesity, Proteins, Tumor Necrosis Factor-alpha, Interleukin-6, Gene Expression, Body Mass Index, Postmenopause, Inflammation Mediators, Intercellular Signaling Peptides and Proteins, Adiponectin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Association Between Adiponectin and Mediators of Inflammation in Obese Women

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks