Cited by 875Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismRegulation of Appetite and Obesity

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Adiponectin Expression From Human Adipose Tissue

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Kern, Philip A., Di Gregorio, Gina B., Lu, Tong, Rassouli, Negah, Ranganathan, Gouri·2003·Diabetes

DOI 10.2337/diabetes.52.7.1779

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Abstract

Adiponectin is a 29-kDa adipocyte protein that has been linked to the insulin resistance of obesity and lipodystrophy. To better understand the regulation of adiponectin expression, we measured plasma adiponectin and adipose tissue adiponectin mRNA levels in nondiabetic subjects with varying degrees of obesity and insulin resistance. Plasma adiponectin and adiponectin mRNA levels were highly correlated with each other (r = 0.80, P < 0.001), and obese subjects expressed significantly lower levels of adiponectin. However, a significant sex difference in adiponectin expression was observed, especially in relatively lean subjects. When men and women with a BMI <30 kg/m2 were compared, women had a twofold higher percent body fat, yet their plasma adiponectin levels were 65% higher (8.6 ± 1.1 and 14.2 ± 1.6 μg/ml in men and women, respectively; P < 0.02). Plasma adiponectin had a strong association with insulin sensitivity index (SI) (r = 0.67, P < 0.0001, n = 51) that was not affected by sex, but no relation with insulin secretion. To separate the effects of obesity (BMI) from SI, subjects who were discordant for SI were matched for BMI, age, and sex. Using this approach, insulin-sensitive subjects demonstrated a twofold higher plasma level of adiponectin (5.6 ± 0.6 and 11.2 ± 1.1 μg/ml in insulin-resistant and insulin-sensitive subjects, respectively; P < 0.0005). Adiponectin expression was not related to plasma levels of leptin or interleukin-6. However, there was a significant inverse correlation between plasma adiponectin and tumor necrosis factor (TNF)-α mRNA expression (r = −0.47, P < 0.005), and subjects with the highest levels of adiponectin mRNA expression secreted the lowest levels of TNF-α from their adipose tissue in vitro. Thus, adiponectin expression from adipose tissue is higher in lean subjects and women, and is associated with higher degrees of insulin sensitivity and lower TNF-α expression.

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Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Prevalence and trends in obesity among US adults, 1999–2000
Flegal, K. M. (2002) · JAMA · doi:10.1001/jama.288.14.1723 · Cited by 6,190
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
A simple, rapid, and sensitive DNA assay procedure
Labarca, C. G., & Paigen, K. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90165-7 · Cited by 4,870
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856
Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease
DeFronzo, R. A., & Ferrannini, E. (1991) · Diabetes Care · doi:10.2337/diacare.14.3.173 · Cited by 4,555
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543
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Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matsuzawa, Y., Pratley, R. E., & Tataranni, P. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7463 · Cited by 3,541
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Kahn, B. B., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10842 · Cited by 3,345
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Scherer, P. E., Williams, S. P., Fogliano, M., Baldini, G., & Lodish, H. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26746 · Cited by 3,238

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The contribution of visceral fat to improved insulin signaling in Ames dwarf mice
Menon, V., Zhi, X., Hossain, T., Bartke, A., Spong, A., Gesing, A., & Masternak, M. M. (2014) · Aging Cell · doi:10.1111/acel.12201 · Cited by 52
Cross‐Sectional Associations of Computed Tomography (CT)‐Derived Adipose Tissue Density and Adipokines: The Framingham Heart Study
Lee, J., Pedley, A., Hoffmann, U., Massaro, J. M., Keaney, J. F., Vasan, R. S., & Fox, C. S. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002545 · Cited by 53
High Molecular Mass Multimer Complexes and Vascular Expression Contribute to High Adiponectin in the Fetus
Pınar, H., Basu, S., Hotmire, K., Laffineuse, L., Presley, L. H., Carpenter, M. W., Catalano, P. M., & Mouzon, S. H. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0009 · Cited by 53
The Effect of Dietary Supplements Containing Green Tea, Capsaicin and Ginger Extracts on Weight Loss and Metabolic Profiles in Overweight Women: A Randomized Double-Blind Placebo-Controlled Clinical Trial
Taghizadeh, M., Farzin, N., Taheri, S., Mahlouji, M., Akbari, H., Karamali, F., & Asemi, Z. (2017) · Annals of Nutrition and Metabolism · doi:10.1159/000471889 · Cited by 51
DNA damage in obesity: Initiator, promoter and predictor of cancer
Usman, M., & Volpi, E. V. (2018) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2018.08.002 · Cited by 52
Adiponectin Suppresses Human Pancreatic Cancer Growth through Attenuating the β-Catenin Signaling Pathway
Jiang, J., Fan, Y., Zhang, W., Shen, Y., Liu, T., Yao, M., Gu, J., Tu, H., & Gan, Y. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.27420 · Cited by 51
Circulating Adiponectin Is Associated with Obesity and Serum Lipids in West Africans
Meilleur, K. G., Doumatey, A. P., Huang, H., Charles, B. A., Chen, G., Zhou, J., Shriner, D., Adeyemo, A., & Rotimi, C. N. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2765 · Cited by 51
Expression of the adiponectin receptors AdipoR1 and AdipoR2 in lean rats and in obese Zucker rats
Beylot, M., Pinteur, C., & Peroni, O. D. (2006) · Metabolism · doi:10.1016/j.metabol.2005.09.016 · Cited by 51
Adiponectin multimers in maternal plasma
Mazaki‐Tovi, S., Romero, R. J., Kusanovic, J. P., Erez, O., Vaisbuch, E., Gotsch, F., Mittal, P., Than, N. G., Nhan-Chang, C. L., Chaiworapongsa, T., et al. (2008) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050802266881 · Cited by 53
Supplementation ofLactobacillus plantarumK68 and Fruit-Vegetable Ferment along with High Fat-Fructose Diet Attenuates Metabolic Syndrome in Rats with Insulin Resistance
Huang, H.-Y., Korivi, M., Tsai, C.-H., Yang, J.-H., & Tsai, Y.-C. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/943020 · Cited by 51
Perirenal fat associated with microalbuminuria in obese rats
Hou, N., Han, F., Wang, M., Huang, N., Zhao, J., Liu, X., & Sun, X. (2014) · International Urology and Nephrology · doi:10.1007/s11255-014-0656-7 · Cited by 50
Inhibition of the phosphatidylinositol 3′-kinase signaling pathway leads to decreased insulin-stimulated adiponectin secretion from 3T3-L1 adipocytes
Pereira, R. I., & Draznin, B. (2005) · Metabolism · doi:10.1016/j.metabol.2005.07.002 · Cited by 50
The Expression of Adiponectin Receptors and the Effects of Adiponectin and Leptin on Airway Smooth Muscle Cells
Shin, J. H., Kim, J. H., Lee, W., & Shim, J. Y. (2008) · Yonsei Medical Journal · doi:10.3349/ymj.2008.49.5.804 · Cited by 50
Profile of Inflammatory Mediators in Gestational Diabetes Mellitus: Phenotype and Genotype
Gueuvoghlanian‐Silva, B. Y., Torloni, M. R., Mattar, R., de Oliveira, L. S., Scomparini, F. B., Nakamura, M. U., & Daher, S. (2011) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2011.01090.x · Cited by 49
The evolving obesity challenge: targeting the vagus nerve and the inflammatory reflex in the response
Pavlov, V. A. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107794 · Cited by 50
Total and high molecular weight adiponectin are elevated in patients with Laron syndrome despite marked obesity
Kanety, H., Hemi, R., Ginsberg, S., Pariente, C., Yissachar, E., Barhod, E., Funahashi, T., & Laron, Z. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0419 · Cited by 49
Adolescent Sex Differences in Adiponectin Are Conditional on Pubertal Development and Adiposity
Woo, J. G., Dolan, L. M., Daniels, S. R., Goodman, E., & Martin, L. J. (2005) · Obesity Research · doi:10.1038/oby.2005.260 · Cited by 49
Adiponectin and Leptin in Relation to Insulin Sensitivity
Soodini, G. R., & Hamdy, O. (2004) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2004.2.114 · Cited by 48
Sialic Acid Modification of Adiponectin Is Not Required for Multimerization or Secretion but Determines Half-Life in Circulation
Richards, A. A., Colgrave, M. L., Zhang, J., Webster, J. A., Simpson, F., Preston, E., Wilks, D. L., Hoehn, K. L., Stephenson, M., Macdonald, G. A., et al. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0133 · Cited by 49
ER stress in adipocytes and insulin resistance: Mechanisms and significance (Review)
Khan, S. M., & WANG, C. H. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2532 · Cited by 48
Hormonal Mechanisms Underlying the Relationship Between Obesity and Breast Cancer
Perks, C. M., & Holly, J. M. P. (2011) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2011.05.010 · Cited by 48
cGMP-dependent protein kinase (PKG) mediates the anticontractile capacity of perivascular adipose tissue
Withers, S., Simpson, L., Fattah, S., Werner, M. E., & Heagerty, A. M. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt229 · Cited by 48
Potential Mechanisms of Muscle Mitochondrial Dysfunction in Aging and Obesity and Cellular Consequences
Chanséaume, E., & Morio, B. (2009) · International Journal of Molecular Sciences · doi:10.3390/ijms10010306 · Cited by 50
Cytokine and adipokine are biofactors can act in blood and colostrum of obese mothers
Fujimori, M., França, E. L., Morais, T. C., Fiorin, V., de Abreu, L. C., & Honório‐França, A. C. (2016) · BioFactors · doi:10.1002/biof.1339 · Cited by 48
Effects of ERβ and ERα on OVX-induced changes in adiposity and insulin resistance
Zidon, T. M., Padilla, J., Fritsche, K. L., Welly, R. J., McCabe, L., Stricklin, O. E., Frank, A. P., Park, Y.-M., Clegg, D. J., Lubahn, D. B., et al. (2020) · Journal of Endocrinology · doi:10.1530/joe-19-0321 · Cited by 48
Pattern of expression of adiponectin receptors in human adipose tissue depots and its relation to the metabolic state
Nannipieri, M., Bonotti, A., Anselmino, M., Cecchetti, F., Madec, S., Mancini, E., Baldi, S., Santini, F., Pinchera, A., Rossi, M., et al. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803676 · Cited by 48
Adipose tissue activity in relation to overweight or obesity.
Gnacińska, M., Małgorzewicz, S., Guzek, M., Łysiak−Szydłowska, W., & Sworczak, K. (2010) · PubMed · Cited by 47
Involvement of adiponectin in early stage of colorectal carcinogenesis
Tae, C. H., Kim, S., Jung, S.-A., Joo, Y.-H., Shim, K., Jung, H., Kim, T. H., Cho, M.-S., Kim, K. H., & Kim, J. S. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-811 · Cited by 47
Effect of Endoplasmic Reticulum Stress on Inflammation and Adiponectin Regulation in Human Adipocytes
Mondal, A. K., Das, S. K., Varma, V., Nolen, G. T., McGehee, R. E., Elbein, S. C., Wei, J. Y., & Ranganathan, G. (2012) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2012.0002 · Cited by 47
Self-citation
Correlates of Age Onset of Type 2 Diabetes Among Relatively Young Black and White Adults in a Community
Nguyen, Q. M., Xu, J.-H., Chen, W., Srinivasan, S. R., & Berenson, G. S. (2012) · Diabetes Care · doi:10.2337/dc11-1818 · Cited by 47
Expression of Obesity Markers and Persistent Organic Pollutants Levels in Adipose Tissue of Obese Patients: Reinforcing the Obesogen Hypothesis?
Pereira-Fernandes, A., Dirinck, E. L., Dirtu, A. C., Malarvannan, G., Covaci, A., Gaal, L. V., Vanparys, C., Jorens, P. G., & Blust, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084816 · Cited by 49
Adiponectin isoform distribution in women—relationship to female sex steroids and insulin sensitivity
Leung, K., Xu, A., Craig, M. E., Martin, A. M., Lam, K. S. L., & O’Sullivan, A. (2009) · Metabolism · doi:10.1016/j.metabol.2008.09.020 · Cited by 47

Authors: Kern, P. A., Di Gregorio, G. B., Lu, T., Rassouli, N., & Ranganathan, G.
Affiliations: Central Arkansas Veterans Healthcare System (US)
Central Arkansas Veterans Healthcare System and the Department of Medicine, Division of Endocrinology, University of Arkansas for Medical Sciences, Little Rock, Arkansas
ORCID: Kern, Philip A.
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2003-07-01
Volume: 52
Issue: 7
Pages: 1779-1785
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.52.7.1779
OpenAlex: W2470404765
Cited by: 875
References: 48
Citations by year: 2026: 9 · 2025: 13 · 2024: 13 · 2023: 23 · 2022: 26 · 2021: 25 · 2020: 34 · 2019: 33 · 2018: 37 · 2017: 37 · 2016: 37 · 2015: 36 · 2014: 48 · 2013: 47 · 2012: 52
FWCI: 35.75
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
UKnowledge (University of Kentucky) (submittedVersion)
Funders: University of Arkansas
University of Arkansas for Medical Sciences
National Institutes of Health
School of Medicine, Indiana University
National Institute of Diabetes and Digestive and Kidney Diseases (DK 39176)
National Center for Research Resources (M01RR014288)
NIH Clinical Center
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: adiponectin, adipose tissue, obesity, insulin resistance, sex differences, insulin sensitivity index, TNF-α, plasma adiponectin, leptin, interleukin-6
MeSH terms: Adipose Tissue, Female, Humans, Insulin Resistance, Male, Obesity, Proteins, Reference Values, RNA, Messenger, Sex Characteristics, Tumor Necrosis Factor-alpha, Body Mass Index, Intercellular Signaling Peptides and Proteins, Adiponectin

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Adiponectin Expression From Human Adipose Tissue

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