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Adiponectin Expression From Human Adipose Tissue
Open accessAbstract
Adiponectin is a 29-kDa adipocyte protein that has been linked to the insulin resistance of obesity and lipodystrophy. To better understand the regulation of adiponectin expression, we measured plasma adiponectin and adipose tissue adiponectin mRNA levels in nondiabetic subjects with varying degrees of obesity and insulin resistance. Plasma adiponectin and adiponectin mRNA levels were highly correlated with each other (r = 0.80, P < 0.001), and obese subjects expressed significantly lower levels of adiponectin. However, a significant sex difference in adiponectin expression was observed, especially in relatively lean subjects. When men and women with a BMI <30 kg/m2 were compared, women had a twofold higher percent body fat, yet their plasma adiponectin levels were 65% higher (8.6 ± 1.1 and 14.2 ± 1.6 μg/ml in men and women, respectively; P < 0.02). Plasma adiponectin had a strong association with insulin sensitivity index (SI) (r = 0.67, P < 0.0001, n = 51) that was not affected by sex, but no relation with insulin secretion. To separate the effects of obesity (BMI) from SI, subjects who were discordant for SI were matched for BMI, age, and sex. Using this approach, insulin-sensitive subjects demonstrated a twofold higher plasma level of adiponectin (5.6 ± 0.6 and 11.2 ± 1.1 μg/ml in insulin-resistant and insulin-sensitive subjects, respectively; P < 0.0005). Adiponectin expression was not related to plasma levels of leptin or interleukin-6. However, there was a significant inverse correlation between plasma adiponectin and tumor necrosis factor (TNF)-α mRNA expression (r = −0.47, P < 0.005), and subjects with the highest levels of adiponectin mRNA expression secreted the lowest levels of TNF-α from their adipose tissue in vitro. Thus, adiponectin expression from adipose tissue is higher in lean subjects and women, and is associated with higher degrees of insulin sensitivity and lower TNF-α expression.
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“Increased inflammatory cytokines and decreased total and HMW adiponectin concentrations have been associated with obesity (45,46), intra-abdominal fat accumulation (47), insulin resistance (48), the metabolic syndrome (49), and cardiovascular disease (50).”
From Age, Obesity, and Sex Effects on Insulin Sensitivity and Skeletal Muscle Mitochondrial Function (2010) · cites this paper as [46]
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Citations
Cites
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Prevalence and trends in obesity among US adults, 1999–2000
Flegal, K. M. (2002) · JAMA · doi:10.1001/jama.288.14.1723 · Cited by 6,190
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
A simple, rapid, and sensitive DNA assay procedure
Labarca, C. G., & Paigen, K. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90165-7 · Cited by 4,870
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856
DeFronzo, R. A., & Ferrannini, E. (1991) · Diabetes Care · doi:10.2337/diacare.14.3.173 · Cited by 4,555
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543
Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matsuzawa, Y., Pratley, R. E., & Tataranni, P. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7463 · Cited by 3,541
Obesity and insulin resistance
Kahn, B. B., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10842 · Cited by 3,345
A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes
Scherer, P. E., Williams, S. P., Fogliano, M., Baldini, G., & Lodish, H. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26746 · Cited by 3,238
Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1595 · Cited by 3,133
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
Berg, A. H., Combs, T. P., Du, X., Brownlee, M., & Scherer, P. E. (2001) · Nature Medicine · doi:10.1038/90992 · Cited by 2,526
The Spread of the Obesity Epidemic in the United States, 1991-1998
Mokdad, A. H. (1999) · JAMA · doi:10.1001/jama.282.16.1519 · Cited by 2,384
Protection from obesity-induced insulin resistance in mice lacking TNF-α function
Uysal, K. T., Wiesbrock, S. M., Marino, M. W., & Hotamisligil, G. S. (1997) · Nature · doi:10.1038/39335 · Cited by 2,234
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
Maeda, N., Shimomura, I., Kishida, K., Nishizawa, H., Matsuda, M., Nagaretani, H., Furuyama, N., Kondo, H., Takahashi, M., Arita, Y., et al. (2002) · Nature Medicine · doi:10.1038/nm724 · Cited by 2,114
Fruebis, J., Tsao, T., Javorschi, S., Ebbets-Reed, D., Erickson, M., Yen, F. T., Bihain, B. E., & Lodish, H. F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.2005 · Cited by 2,007
Kern, P. A., Ranganathan, S., Li, C., Wood, L., & Ranganathan, G. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.5.e745 · Cited by 1,883
Self-citationDeFronzo, R. A., Jacot, E., Jequier, E., Maeder, E., Wahren, J., & Felber, J. P. (1981) · Diabetes · doi:10.2337/diab.30.12.1000 · Cited by 1,770
Maeda, N., Takahashi, M., Funahashi, T., Kihara, S., Nishizawa, H., Kishida, K., Nagaretani, H., Matsuda, M., Komuro, R., Ouchi, N., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.9.2094 · Cited by 1,673
Bergman, R. N., Phillips, L. S., & Cobelli, C. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110398 · Cited by 1,640 · cited 6×
“The measurement of in vivo insulin sensitivity was performed in the fasting state using the classic tolbutamidemodified minimal model analysis of the FSIVGT (19,20), which has been validated against the euglycemic clamp (21,22).”
BackgroundMethodInfluentialAssociation of Hypoadiponectinemia With Coronary Artery Disease in Men
Kumada, M., Kihara, S., Sumitsuji, S., Kawamoto, T., Matsumoto, S., Ouchi, N., Arita, Y., Okamoto, Y., Shimomura, I., Hiraoka, H., et al. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000048856.22331.50 · Cited by 1,419
Tumor Necrosis Factor α: A Key Component of the Obesity-Diabetes Link
Hotamışlıgil, G. S., & Spiegelman, B. M. (1994) · Diabetes · doi:10.2337/diab.43.11.1271 · Cited by 1,353
Kern, P. A., Saghizadeh, M., Ong, J. M., Bosch, R. J., Deem, R., & Simsolo, R. B. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117899 · Cited by 1,305
Self-citationACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism
Berg, A. H., Combs, T. P., & Scherer, P. E. (2002) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(01)00524-0 · Cited by 1,211
Yang, W.-S., Lee, W.-J., Funahashi, T., Tanaka, S., Matsuzawa, Y., Chao, C.-L., Chen, C.-L., Tai, T.-Y., & Chuang, L.-M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.8.3815 · Cited by 1,181
Assessment of Insulin Sensitivityin Vivo*
Bergman, R. N., Finegood, D. T., & Ader, M. (1985) · Endocrine Reviews · doi:10.1210/edrv-6-1-45 · Cited by 1,072
Hotta, K., Funahashi, T., Bodkin, N. L., Ortmeyer, H. K., Arita, Y., Hansen, B. C., & Matsuzawa, Y. (2001) · Diabetes · doi:10.2337/diabetes.50.5.1126 · Cited by 1,072
The spread of the obesity epidemic in the United States
Mokdad, A. H., Serdula, M. K., & Dietz, W. H. (1999) · Cited by 985
Endogenous glucose production is inhibited by the adipose-derived protein Acrp30
Combs, T. P., Berg, A. H., Obici, S., Scherer, P. E., & Rossetti, L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14120 · Cited by 955
Unger, R. H. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.104057 · Cited by 875
Carey, V. J., Walters, E. E., Colditz, G. A., Solomon, C. G., Willet, W. C., Rosner, B. A., Speizer, F. E., & Manson, J. E. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009158 · Cited by 827
Hotamisligil, G. S., Budavari, A., Murray, D., & Spiegelman, B. M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117495 · Cited by 819
Bergman, R. N., Prager, R., Volund, A., & Olefsky, J. M. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112886 · Cited by 772
Havel, P. J. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200202000-00008 · Cited by 575
Estimation of human body composition by electrical impedance methods: a comparative study
Segal, K. R., Gutin, B., Presta, E., Wang, J., & Itallie, T. B. V. (1985) · Journal of Applied Physiology · doi:10.1152/jappl.1985.58.5.1565 · Cited by 463
Diabetes in America: Epidemiology and Scope of the Problem
Harris, M. I. (1998) · Diabetes Care · doi:10.2337/diacare.21.3.c11 · Cited by 438
Yang, W., Jeng, C.-Y., Wu, T.-J., Tanaka, S., Funahashi, T., Matsuzawa, Y., Wang, J.-P., Chen, C., Tai, T., & Chuang, L. (2002) · Diabetes Care · doi:10.2337/diacare.25.2.376 · Cited by 402
A simple method to determine fat cell size and number in four mammalian species
GIROLAMO, M. D., Mendlinger, S., & Fertig, J. (1971) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1971.221.3.850 · Cited by 370
Tumor necrosis factor alpha: a key component of the obesity-diabetes link
Hotamışlıgil, G. S., & Spiegelman, B. M. (1994) · Diabetes · doi:10.2337/diabetes.43.11.1271 · Cited by 354
WELCH, S., Gebhart, S. S. P., Bergman, R. N., & Phillips, L. S. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-6-1508 · Cited by 340
The adipocyte: Storage depot or node on the energy information superhighway?
Flier, J. S. (1995) · Cell · doi:10.1016/0092-8674(95)90445-x · Cited by 290
Higa, M., Zhou, Y.-T., Ravazzola, M., Baetens, D., Orci, L., & Unger, R. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11513 · Cited by 233
Modulation of Circulating and Adipose Tissue Adiponectin Levels by Antidiabetic Therapy
Phillips, S. A., Ciaraldi, T. P., Kong, A. P. S., Bandukwala, R., Aroda, V. R., Carter, L., Baxi, S. C., Mudaliar, S. R. D., & Henry, R. R. (2003) · Diabetes · doi:10.2337/diabetes.52.3.667 · Cited by 228
Elbein, S. C., Hasstedt, S. J., Wegner, K., & Kahn, S. E. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.4.5604 · Cited by 154
Effect of Obesity on Insulin Resistance in Normal Subjects and Patients With NIDDM
Ludvik, B. H., Nolan, J. J., Baloga, J., Sacks, D. A., & Olefsky, J. M. (1995) · Diabetes · doi:10.2337/diab.44.9.1121 · Cited by 138
The missing link with obesity?
Flier, J. S. (2001) · Nature · doi:10.1038/35053251 · Cited by 108
Potential Role of TNFα and Lipoprotein Lipase as Candidate Genes for Obesity ,
Kern, P. A. (1997) · Journal of Nutrition · doi:10.1093/jn/127.9.1917s · Cited by 92
Self-citationEffect of obesity on insulin resistance in normal subjects and patients with NIDDM
Ludvik, B. H., Nolan, J. J., Baloga, J., et al. (1995) · Diabetes · doi:10.2337/diabetes.44.9.1121 · Cited by 43
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Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961
Mechanisms of fatty acid-induced inhibition of glucose uptake.
Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,720
Jung, U. J., & Choi, M. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15046184 · Cited by 1,971
Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men
Pischon, T. (2004) · JAMA · doi:10.1001/jama.291.14.1730 · Cited by 1,782
Chait, A., & den Hartigh, L. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00022 · Cited by 1,529
Metadata
- Authors
- Kern, P. A., Di Gregorio, G. B., Lu, T., Rassouli, N., & Ranganathan, G.
- Affiliations
- Central Arkansas Veterans Healthcare System (US)
- Central Arkansas Veterans Healthcare System and the Department of Medicine, Division of Endocrinology, University of Arkansas for Medical Sciences, Little Rock, Arkansas
- ORCID
- Kern, Philip A.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2003-07-01
- Volume
- 52
- Issue
- 7
- Pages
- 1779-1785
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2470404765
- Cited by
- 875
- References
- 48
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 13 · 2023: 23 · 2022: 26 · 2021: 25 · 2020: 34 · 2019: 33 · 2018: 37 · 2017: 37 · 2016: 37 · 2015: 36 · 2014: 48 · 2013: 47 · 2012: 52
- FWCI
- 35.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- UKnowledge (University of Kentucky) (submittedVersion)
- Funders
- University of Arkansas
- University of Arkansas for Medical Sciences
- National Institutes of Health
- School of Medicine, Indiana University
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 39176)
- National Center for Research Resources (M01RR014288)
- NIH Clinical Center
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- adiponectin, adipose tissue, obesity, insulin resistance, sex differences, insulin sensitivity index, TNF-α, plasma adiponectin, leptin, interleukin-6
- MeSH terms
- Adipose Tissue, Female, Humans, Insulin Resistance, Male, Obesity, Proteins, Reference Values, RNA, Messenger, Sex Characteristics, Tumor Necrosis Factor-alpha, Body Mass Index, Intercellular Signaling Peptides and Proteins, Adiponectin
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