Cited by 875Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismRegulation of Appetite and Obesity

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Adiponectin Expression From Human Adipose Tissue

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Kern, Philip A., Di Gregorio, Gina B., Lu, Tong, Rassouli, Negah, Ranganathan, Gouri·2003·Diabetes

DOI 10.2337/diabetes.52.7.1779

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Abstract

Adiponectin is a 29-kDa adipocyte protein that has been linked to the insulin resistance of obesity and lipodystrophy. To better understand the regulation of adiponectin expression, we measured plasma adiponectin and adipose tissue adiponectin mRNA levels in nondiabetic subjects with varying degrees of obesity and insulin resistance. Plasma adiponectin and adiponectin mRNA levels were highly correlated with each other (r = 0.80, P < 0.001), and obese subjects expressed significantly lower levels of adiponectin. However, a significant sex difference in adiponectin expression was observed, especially in relatively lean subjects. When men and women with a BMI <30 kg/m2 were compared, women had a twofold higher percent body fat, yet their plasma adiponectin levels were 65% higher (8.6 ± 1.1 and 14.2 ± 1.6 μg/ml in men and women, respectively; P < 0.02). Plasma adiponectin had a strong association with insulin sensitivity index (SI) (r = 0.67, P < 0.0001, n = 51) that was not affected by sex, but no relation with insulin secretion. To separate the effects of obesity (BMI) from SI, subjects who were discordant for SI were matched for BMI, age, and sex. Using this approach, insulin-sensitive subjects demonstrated a twofold higher plasma level of adiponectin (5.6 ± 0.6 and 11.2 ± 1.1 μg/ml in insulin-resistant and insulin-sensitive subjects, respectively; P < 0.0005). Adiponectin expression was not related to plasma levels of leptin or interleukin-6. However, there was a significant inverse correlation between plasma adiponectin and tumor necrosis factor (TNF)-α mRNA expression (r = −0.47, P < 0.005), and subjects with the highest levels of adiponectin mRNA expression secreted the lowest levels of TNF-α from their adipose tissue in vitro. Thus, adiponectin expression from adipose tissue is higher in lean subjects and women, and is associated with higher degrees of insulin sensitivity and lower TNF-α expression.

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Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Prevalence and trends in obesity among US adults, 1999–2000
Flegal, K. M. (2002) · JAMA · doi:10.1001/jama.288.14.1723 · Cited by 6,190
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
A simple, rapid, and sensitive DNA assay procedure
Labarca, C. G., & Paigen, K. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90165-7 · Cited by 4,870
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856
Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease
DeFronzo, R. A., & Ferrannini, E. (1991) · Diabetes Care · doi:10.2337/diacare.14.3.173 · Cited by 4,555
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543
Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance and Hyperinsulinemia
Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matsuzawa, Y., Pratley, R. E., & Tataranni, P. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7463 · Cited by 3,541
Obesity and insulin resistance
Kahn, B. B., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10842 · Cited by 3,345
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Scherer, P. E., Williams, S. P., Fogliano, M., Baldini, G., & Lodish, H. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26746 · Cited by 3,238

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Maldonado‐Ruiz, R., Montalvo-Martínez, L., Fuentes‐Mera, L., & Camacho‐Morales, A. (2017) · Nutrition and Diabetes · doi:10.1038/nutd.2017.10 · Cited by 87
Mechanisms of hypertension in the cardiometabolic syndrome
Redón, J., Cífková, R., Laurent, S., Nilsson, P. M., Narkiewicz, K., Erdine, S. E., & Mancia, G. (2009) · Journal of Hypertension · doi:10.1097/hjh.0b013e32831e13e5 · Cited by 86
Impact of HDL on adipose tissue metabolism and adiponectin expression
Linthout, S. V., Foryst‐Ludwig, A., Spillmann, F., Peng, J., Feng, Y., Meloni, M., Craeyveld, E. V., Kintscher, U., Schultheiß, H., Geest, B. D., et al. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.01.001 · Cited by 85
Periodontitis and Insulin Resistance: Casual or Causal Relationship?
Gurav, A. N. (2012) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2012.36.6.404 · Cited by 83
Differential effects of 1α,25-dihydroxycholecalciferol on MCP-1 and adiponectin production in human white adipocytes
Lorente‐Cebrián, S., Eriksson, A., Dunlop, T. W., Mejhert, N., Dahlman, I. A., Åström, G., Sjölin, E., Wåhlén, K., Carlberg, C., Laurencikiene, J., et al. (2011) · European Journal of Nutrition · doi:10.1007/s00394-011-0218-z · Cited by 86
Paradoxical Hyperadiponectinemia is Associated With the Metabolically Healthy Obese (MHO) Phenotype in African Americans
Doumatey (2012) · Journal of Endocrinology and Metabolism · doi:10.4021/jem95w · Cited by 82
Adiponectin and Leptin Concentrations May Aid in Discriminating Disease Forms in Children and Adolescents With Type 1 and Type 2 Diabetes
Morales, A. E., Wasserfall, C. H., Brusko, T. M., Carter, C., Schatz, D., Silverstein, J. H., Ellis, T., & Atkinson, M. A. (2004) · Diabetes Care · doi:10.2337/diacare.27.8.2010 · Cited by 82
Low Physical Activity and Obesity
Telford, R. D. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31806215b7 · Cited by 83
Pathogenesis of hepatic steatosis: The link between hypercortisolism and non-alcoholic fatty liver disease
Tarantino, G. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i40.6735 · Cited by 81
Antidiabetic effects of hesperidin and naringin in type 2 diabetic rats.
Ahmed, O. M., Mahmoud, A. M., Abdel‐Moneim, A., & Ashour, M. B. (2012) · Diabetologia Croatica · Cited by 81
Abdominal subcutaneous fat gene expression and circulating levels of leptin and adiponectin in polycystic ovary syndrome
Lecke, S. B., Mattei, F. N., Morsch, D. M., & Spritzer, P. M. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.02.041 · Cited by 82
Obesity-related Differential Gene Expression in the Visceral Adipose Tissue
Baranova, A. V., Collantes, R. S., Gowder, S., Elariny, H. A., Schlauch, K. A., Younoszai, A., King, S., Randhawa, M., Pusulury, S., Alsheddi, T., et al. (2005) · Obesity Surgery · doi:10.1381/0960892054222876 · Cited by 80
Proinflammatory, anti-inflammatory cytokines and adiponkines in students with central obesity
Elwakkad, A., Hassan, N. E., Sibaii, H., & El-Zayat, S. R. (2013) · Cytokine · doi:10.1016/j.cyto.2012.11.010 · Cited by 80
Is atopic dermatitis associated with obesity? A systematic review of observational studies
Ali, Z., Ulrik, C. S., Agner, T., & Thomsen, S. F. (2018) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.14879 · Cited by 79
Adipose tissues as endocrine target organs
Lanthier, N., & Leclercq, I. A. (2014) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2014.07.002 · Cited by 82
Adiponectin Antagonizes Stimulatory Effect of Tumor Necrosis Factor-α on Vascular Smooth Muscle Cell Calcification: Regulation of Growth Arrest-Specific Gene 6-Mediated Survival Pathway by Adenosine 5′-Monophosphate-Activated Protein Kinase
Son, B., Akishita, M., Iijima, K., Kozaki, K., Maemura, K., Eto, M., & Ouchi, Y. (2008) · Endocrinology · doi:10.1210/en.2007-1021 · Cited by 78
Exercise training intensity/volume affects plasma and tissue adiponectin concentrations in the male rat
Garekani, E. T., Mohebbi, H., Kraemer, R. R., & Fathi, R. (2011) · Peptides · doi:10.1016/j.peptides.2011.01.027 · Cited by 77
CDH13 gene coding t-cadherin influences variations in plasma adiponectin levels in the Japanese population
Morisaki, H., Yamanaka, I., Iwai, N., Miyamoto, Y., Kokubo, Y., Okamura, T., Okayama, A., & Morisaki, T. (2011) · Human Mutation · doi:10.1002/humu.21652 · Cited by 77
Adiponectin in childhood
Jeffery, A., Murphy, M. J., Metcalf, B. S., Hosking, J., Voss, L. D., English, P., Sattar, N. A., & Wilkin, T. J. (2008) · International Journal of Pediatric Obesity · doi:10.1080/17477160801954538 · Cited by 78
Tomato Powder Inhibits Hepatic Steatosis and Inflammation Potentially Through Restoring SIRT1 Activity and Adiponectin Function Independent of Carotenoid Cleavage Enzymes in Mice
Li, C., Liu, C., Fu, M., Hu, K., Aizawa, K., Takahashi, S., Suganuma, H., Cheng, J., Lintig, J. V., & Wang, X. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700738 · Cited by 79
The multimerization and secretion of adiponectin are regulated by TNF-alpha
He, Y., Lu, L., Wei, X., Jin, D., Qian, T., An, Y., Sun, J., Cui, J., & Yang, Z. (2015) · Endocrine · doi:10.1007/s12020-015-0741-4 · Cited by 77
Mediterranean diet and the metabolic syndrome
Esposito, K., Ciotola, M., & Giugliano, D. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600297 · Cited by 77
ER Stress and Lipid Metabolism in Adipocytes
Zha, B. S., & Zhou, H. (2012) · Biochemistry Research International · doi:10.1155/2012/312943 · Cited by 76
Influence of Exercise Intensity on Abdominal Fat and Adiponectin in Elderly Adults
Coker, R. H., Williams, R. H., KORTEBEIN, P. M., Sullivan, D. H., & Evans, W. J. (2009) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2008.0060 · Cited by 73
Maternal obesity and inflammatory mediators: A controversial association
Pendeloski, K. P. T., Ono, É., Torloni, M. R., Mattar, R., & Daher, S. (2017) · American Journal of Reproductive Immunology · doi:10.1111/aji.12674 · Cited by 72
Adiponectin: a key fat-derived molecule regulating inflammation
Tilg, H., & Wolf, A. M. (2005) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.9.2.245 · Cited by 71
Leptin, adiponectin, and asthma: findings from a population-based cohort study
Sutherland, T., Sears, M. R., McLachlan, C. R., Poulton, R., & Hancox, R. J. (2009) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)60161-5 · Cited by 71

Authors: Kern, P. A., Di Gregorio, G. B., Lu, T., Rassouli, N., & Ranganathan, G.
Affiliations: Central Arkansas Veterans Healthcare System (US)
Central Arkansas Veterans Healthcare System and the Department of Medicine, Division of Endocrinology, University of Arkansas for Medical Sciences, Little Rock, Arkansas
ORCID: Kern, Philip A.
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2003-07-01
Volume: 52
Issue: 7
Pages: 1779-1785
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.52.7.1779
OpenAlex: W2470404765
Cited by: 875
References: 48
Citations by year: 2026: 9 · 2025: 13 · 2024: 13 · 2023: 23 · 2022: 26 · 2021: 25 · 2020: 34 · 2019: 33 · 2018: 37 · 2017: 37 · 2016: 37 · 2015: 36 · 2014: 48 · 2013: 47 · 2012: 52
FWCI: 35.75
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
UKnowledge (University of Kentucky) (submittedVersion)
Funders: University of Arkansas
University of Arkansas for Medical Sciences
National Institutes of Health
School of Medicine, Indiana University
National Institute of Diabetes and Digestive and Kidney Diseases (DK 39176)
National Center for Research Resources (M01RR014288)
NIH Clinical Center
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: adiponectin, adipose tissue, obesity, insulin resistance, sex differences, insulin sensitivity index, TNF-α, plasma adiponectin, leptin, interleukin-6
MeSH terms: Adipose Tissue, Female, Humans, Insulin Resistance, Male, Obesity, Proteins, Reference Values, RNA, Messenger, Sex Characteristics, Tumor Necrosis Factor-alpha, Body Mass Index, Intercellular Signaling Peptides and Proteins, Adiponectin

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Adiponectin Expression From Human Adipose Tissue

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