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Cited by 788Adipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and LipoproteinsInflammatory Biomarkers in Disease Prognosis

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Inflammatory Markers and Risk of Developing Type 2 Diabetes in Women

Hu, Frank B., Meigs, James B., Li, Tricia Y., Rifai, Nader, Manson, JoAnn E.·2004·Diabetes
DOI 10.2337/diabetes.53.3.693
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Abstract

We conducted a prospective, nested, case-control study of inflammatory markers as predictors of type 2 diabetes among 32,826 women who provided blood samples in 1989 through 1990 in the Nurses’ Health Study. Among women free of diabetes, cardiovascular disease, or cancer at baseline, 737 had developed diabetes by 2000. Control women (n = 785) were selected matched on age, fasting status, race, and BMI for cases in the top BMI decile. Baseline levels of tumor necrosis factor (TNF)-α receptor 2, interleukin (IL)-6, and C-reactive protein (CRP) were significantly higher among case than control subjects (all P ≤ 0.001). After adjusting for BMI and other lifestyle factors, all three biomarkers significantly predicted diabetes risk; the odds ratios (ORs) comparing extreme quintiles were 1.64 (95% CI 1.10–2.45) for TNF-αR2, 1.91 (1.27–2.86) for IL-6, and 4.36 (2.80–6.80) for CRP (P for trend <0.001 for all biomarkers). In a multivariate model simultaneously including the three biomarkers, only CRP levels were significantly associated with risk of diabetes (OR comparing extreme quintiles of CRP = 3.99, P for trend <0.001). These data support the role of inflammation in the pathogenesis of type 2 diabetes. Elevated CRP levels are a strong independent predictor of type 2 diabetes and may mediate associations of TNF-αR2 and IL-6 with type 2 diabetes.

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  1. SAS Institute Inc: SAS/STAT User’s Guide. V. 6, 4th ed., vol. 1. Cary, NC, SAS Institute Inc.,1989

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Metadata

Authors
Hu, F. B., Meigs, J. B., Li, T. Y., Rifai, N., & Manson, J. E.
Affiliations
  • Brigham and Women's Hospital (US)
  • Harvard University (US)
ORCID
Venue
Diabetes
Publisher
American Diabetes Association
Published
2004-03-01
Volume
53
Issue
3
Pages
693-700
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/diabetes.53.3.693
OpenAlex
W2153214557
Cited by
788
References
51
Citations by year
2026: 7 · 2025: 17 · 2024: 20 · 2023: 22 · 2022: 33 · 2021: 32 · 2020: 25 · 2019: 34 · 2018: 41 · 2017: 48 · 2016: 39 · 2015: 42 · 2014: 55 · 2013: 42 · 2012: 57
FWCI
25.01
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Cancer Institute (CA-87969, P01CA087969)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK058845, DK58845)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
Keywords
type 2 diabetes, inflammatory markers, C-reactive protein, interleukin-6, inflammation, diabetes risk prediction, women, Nurses' Health Study, body mass index
MeSH terms
Adult, Body Constitution, C-Reactive Protein, Diabetes Mellitus, Type 2, Female, Humans, Inflammation, Insulin, Menopause, Middle Aged, Risk Factors, Smoking, United States, Cohort Studies, Biomarkers, Antigens, CD, Interleukin-6, Body Mass Index, Receptors, Tumor Necrosis Factor, Receptors, Tumor Necrosis Factor, Type II

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