Cited by 788Adipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and LipoproteinsInflammatory Biomarkers in Disease Prognosis

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Inflammatory Markers and Risk of Developing Type 2 Diabetes in Women

Hu, Frank B., Meigs, James B., Li, Tricia Y., Rifai, Nader, Manson, JoAnn E.·2004·Diabetes

DOI 10.2337/diabetes.53.3.693

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Abstract

We conducted a prospective, nested, case-control study of inflammatory markers as predictors of type 2 diabetes among 32,826 women who provided blood samples in 1989 through 1990 in the Nurses’ Health Study. Among women free of diabetes, cardiovascular disease, or cancer at baseline, 737 had developed diabetes by 2000. Control women (n = 785) were selected matched on age, fasting status, race, and BMI for cases in the top BMI decile. Baseline levels of tumor necrosis factor (TNF)-α receptor 2, interleukin (IL)-6, and C-reactive protein (CRP) were significantly higher among case than control subjects (all P ≤ 0.001). After adjusting for BMI and other lifestyle factors, all three biomarkers significantly predicted diabetes risk; the odds ratios (ORs) comparing extreme quintiles were 1.64 (95% CI 1.10–2.45) for TNF-αR2, 1.91 (1.27–2.86) for IL-6, and 4.36 (2.80–6.80) for CRP (P for trend <0.001 for all biomarkers). In a multivariate model simultaneously including the three biomarkers, only CRP levels were significantly associated with risk of diabetes (OR comparing extreme quintiles of CRP = 3.99, P for trend <0.001). These data support the role of inflammation in the pathogenesis of type 2 diabetes. Elevated CRP levels are a strong independent predictor of type 2 diabetes and may mediate associations of TNF-αR2 and IL-6 with type 2 diabetes.

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Background
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Authors: Hu, F. B., Meigs, J. B., Li, T. Y., Rifai, N., & Manson, J. E.
Affiliations: Brigham and Women's Hospital (US)
Harvard University (US)
ORCID: Hu, Frank B.
Meigs, James B.
Rifai, Nader
Manson, JoAnn E.
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2004-03-01
Volume: 53
Issue: 3
Pages: 693-700
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.53.3.693
OpenAlex: W2153214557
Cited by: 788
References: 51
Citations by year: 2026: 7 · 2025: 17 · 2024: 20 · 2023: 22 · 2022: 33 · 2021: 32 · 2020: 25 · 2019: 34 · 2018: 41 · 2017: 48 · 2016: 39 · 2015: 42 · 2014: 55 · 2013: 42 · 2012: 57
FWCI: 25.01
Type: journal article
Language: en
Open access: closed
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Cancer Institute (CA-87969, P01CA087969)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK058845, DK58845)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
Keywords: type 2 diabetes, inflammatory markers, C-reactive protein, interleukin-6, inflammation, diabetes risk prediction, women, Nurses' Health Study, body mass index
MeSH terms: Adult, Body Constitution, C-Reactive Protein, Diabetes Mellitus, Type 2, Female, Humans, Inflammation, Insulin, Menopause, Middle Aged, Risk Factors, Smoking, United States, Cohort Studies, Biomarkers, Antigens, CD, Interleukin-6, Body Mass Index, Receptors, Tumor Necrosis Factor, Receptors, Tumor Necrosis Factor, Type II

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Inflammatory Markers and Risk of Developing Type 2 Diabetes in Women

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