The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Effect of a High-Protein, Low-Carbohydrate Diet on Blood Glucose Control in People With Type 2 Diabetes
Open accessAbstract
There has been interest in the effect of various types and amounts of dietary carbohydrates and proteins on blood glucose. On the basis of our previous data, we designed a high-protein/low-carbohydrate, weight-maintaining, nonketogenic diet. Its effect on glucose control in people with untreated type 2 diabetes was determined. We refer to this as a low-biologically-available-glucose (LoBAG) diet. Eight men were studied using a randomized 5-week crossover design with a 5-week washout period. The carbohydrate:protein:fat ratio of the control diet was 55:15:30. The test diet ratio was 20:30:50. Plasma and urinary β-hydroxybutyrate were similar on both diets. The mean 24-h integrated serum glucose at the end of the control and LoBAG diets was 198 and 126 mg/dl, respectively. The percentage of glycohemoglobin was 9.8 ± 0.5 and 7.6 ± 0.3, respectively. It was still decreasing at the end of the LoBAG diet. Thus, the final calculated glycohemoglobin was estimated to be ∼6.3–5.4%. Serum insulin was decreased, and plasma glucagon was increased. Serum cholesterol was unchanged. Thus, a LoBAG diet ingested for 5 weeks dramatically reduced the circulating glucose concentration in people with untreated type 2 diabetes. Potentially, this could be a patient-empowering way to ameliorate hyperglycemia without pharmacological intervention. The long-term effects of such a diet remain to be determined.
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“whereas low carbohydrate diet may reverse these serious metabolic abnormalities [10,27,43-46]”
From The case for low carbohydrate diets in diabetes management (2005) · cites this paper as [44]
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An increase in dietary protein improves the blood glucose response in persons with type 2 diabetes
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Self-citationComparison of Percent Total GHb With Percent HbA1c in People With and Without Known Diabetes
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Self-citationInsulin and Glucose Responses to Various Starch-Containing Foods in Type II Diabetic Subjects
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Self-citationCarbohydrate Metabolism of the Liver in Normal Man under Varying Dietary Conditions
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Self-citationThe metabolic response to various doses of fructose in type II diabetic subjects
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Bantle (2008) · doi:10.2337/dc08-s061 · Cited by 1,795
Westman, E. C., Yancy, W. S., Mavropoulos, J. C., Marquart, M., & McDuffie, J. R. (2008) · Nutrition & Metabolism · doi:10.1186/1743-7075-5-36 · Cited by 475
“Clinical studies that have lowered the percentage of dietary carbohydrate and/or the glycemic index of the carbohydrate have consistently shown improvements in glycemic control among individuals with type 2 diabetes [4-8].”
BackgroundKrieger, J. W., Sitren, H. S., Daniels, M. J., & Langkamp-Henken, B. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.2.260 · Cited by 466
Millward, D. J., Layman, D. K., Tomé, D., & Schaafsma, G. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1576s · Cited by 359
Effect of low-calorie versus low-carbohydrate ketogenic diet in type 2 diabetes
Hussain, T. A., Mathew, T. C., Dashti, A. A., Asfar, S., Al-Zaid, N., & Dashti, H. M. (2012) · Nutrition · doi:10.1016/j.nut.2012.01.016 · Cited by 329
Metadata
- Authors
- Gannon, M. C., & Nuttall, F. Q.
- Affiliations
- University of Minnesota (US)
- ORCID
- Gannon, Mary C.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2004-09-01
- Volume
- 53
- Issue
- 9
- Pages
- 2375-2382
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2140156866
- Cited by
- 428
- References
- 29
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 15 · 2023: 10 · 2022: 15 · 2021: 28 · 2020: 70 · 2019: 18 · 2018: 23 · 2017: 20 · 2016: 13 · 2015: 18 · 2014: 12 · 2013: 19 · 2012: 24
- FWCI
- 9.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- Topics
- Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Keywords
- type 2 diabetes, high-protein low-carbohydrate diet, glycemic control, glycohemoglobin, serum insulin, plasma glucagon, beta-hydroxybutyrate, ketosis, hyperglycemia, dietary intervention
- MeSH terms
- Aged, Aged, 80 and over, Blood Glucose, Body Weight, Diabetes Mellitus, Type 2, Dietary Carbohydrates, Dietary Proteins, Glycated Hemoglobin, Humans, Ketones, Male, Middle Aged, Cross-Over Studies, 3-Hydroxybutyric Acid
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