Cited by 951Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and ManagementDiabetes Management and Research

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Postprandial Hyperglycemia and Diabetes Complications

Ceriello, Antonio·2005·Diabetes

DOI 10.2337/diabetes.54.1.1

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Abstract

Increasing evidence suggests that the postprandial state is a contributing factor to the development of atherosclerosis. In diabetes, the postprandial phase is characterized by a rapid and large increase in blood glucose levels, and the possibility that the postprandial “hyperglycemic spikes” may be relevant to the onset of cardiovascular complications has recently received much attention. Epidemiological studies and preliminary intervention studies have shown that postprandial hyperglycemia is a direct and independent risk factor for cardiovascular disease (CVD). Most of the cardiovascular risk factors are modified in the postprandial phase in diabetic subjects and directly affected by an acute increase of glycemia. The mechanisms through which acute hyperglycemia exerts its effects may be identified in the production of free radicals. This alarmingly suggestive body of evidence for a harmful effect of postprandial hyperglycemia on diabetes complications has been sufficient to influence guidelines from key professional scientific societies. Correcting the postprandial hyperglycemia may form part of the strategy for the prevention and management of CVDs in diabetes.

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Authors: Ceriello, A.
Affiliations: University of Udine (IT)
Corresponding author: Ceriello, Antonio
ORCID: Ceriello, Antonio
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2005-01-01
Volume: 54
Issue: 1
Pages: 1-7
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.54.1.1
OpenAlex: W2120704605
Cited by: 945
References: 95
Citations by year: 2026: 18 · 2025: 27 · 2024: 29 · 2023: 30 · 2022: 34 · 2021: 46 · 2020: 43 · 2019: 46 · 2018: 49 · 2017: 51 · 2016: 43 · 2015: 45 · 2014: 43 · 2013: 71 · 2012: 43
FWCI: 6.59
Type: journal article
Language: en
Open access: closed
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: postprandial hyperglycemia, diabetes complications, cardiovascular risk, atherosclerosis, free radicals, oxidative stress, cardiovascular risk factors, diabetes management
MeSH terms: Arteriosclerosis, Cardiovascular Diseases, Diabetes Mellitus, Diabetes Mellitus, Type 2, Diabetic Angiopathies, DNA Damage, Humans, Hyperglycemia, Models, Biological, Oxidative Stress, Postprandial Period

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Postprandial Hyperglycemia and Diabetes Complications

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