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Postprandial Hyperglycemia and Diabetes Complications
Abstract
Increasing evidence suggests that the postprandial state is a contributing factor to the development of atherosclerosis. In diabetes, the postprandial phase is characterized by a rapid and large increase in blood glucose levels, and the possibility that the postprandial “hyperglycemic spikes” may be relevant to the onset of cardiovascular complications has recently received much attention. Epidemiological studies and preliminary intervention studies have shown that postprandial hyperglycemia is a direct and independent risk factor for cardiovascular disease (CVD). Most of the cardiovascular risk factors are modified in the postprandial phase in diabetic subjects and directly affected by an acute increase of glycemia. The mechanisms through which acute hyperglycemia exerts its effects may be identified in the production of free radicals. This alarmingly suggestive body of evidence for a harmful effect of postprandial hyperglycemia on diabetes complications has been sufficient to influence guidelines from key professional scientific societies. Correcting the postprandial hyperglycemia may form part of the strategy for the prevention and management of CVDs in diabetes.
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“Postprandial hyperglycemia can impact microand macro-vascular complications of diabetes more than elevated fasting glucose levels, making adequate glucose control after meals beneficial.”
From The Impact of Physical Activity in Patients With Type 2 Diabetes (2025) · cites this paper as [91]
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Metadata
- Authors
- Ceriello, A.
- Affiliations
- University of Udine (IT)
- Corresponding author
- Ceriello, Antonio
- ORCID
- Ceriello, Antonio
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2005-01-01
- Volume
- 54
- Issue
- 1
- Pages
- 1-7
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2120704605
- Cited by
- 945
- References
- 95
- Citations by year
- 2026: 18 · 2025: 27 · 2024: 29 · 2023: 30 · 2022: 34 · 2021: 46 · 2020: 43 · 2019: 46 · 2018: 49 · 2017: 51 · 2016: 43 · 2015: 45 · 2014: 43 · 2013: 71 · 2012: 43
- FWCI
- 6.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- postprandial hyperglycemia, diabetes complications, cardiovascular risk, atherosclerosis, free radicals, oxidative stress, cardiovascular risk factors, diabetes management
- MeSH terms
- Arteriosclerosis, Cardiovascular Diseases, Diabetes Mellitus, Diabetes Mellitus, Type 2, Diabetic Angiopathies, DNA Damage, Humans, Hyperglycemia, Models, Biological, Oxidative Stress, Postprandial Period
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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