Two-Hour Seven-Sample Oral Glucose Tolerance Test and Meal Protocol

Quantitative estimation of insulin sensitivity.

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Quantification of the relationship between insulin sensitivity and β-cell function in human subjects: evidence for a hyperbolic function

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Mechanisms of the Age-Associated Deterioration in Glucose Tolerance

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Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function

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Oral Glucose Tolerance Test Minimal Model Indexes of β-Cell Function and Insulin Sensitivity

Breda, E., Cavaghan, M. K., Toffolo, G., Polonsky, K. S., & Cobelli, C. (2001) · Diabetes · doi:10.2337/diabetes.50.1.150 · Cited by 320 · see citing works

The oral glucose minimal model: Estimation of insulin sensitivity from a meal test

Della Man, C., Caumo, A., & Cobelli, C. (2002) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.995680 · Cited by 241 · see citing works

Minimal model estimation of glucose absorption and insulin sensitivity from oral test: validation with a tracer method

Dalla Man, C., Caumo, A., Basu, R., Rizza, R., Toffolo, G., & Cobelli, C. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00319.2003 · Cited by 198 · see citing works

Quantitative indexes of β-cell function during graded up&down glucose infusion from C-peptide minimal models

Toffolo, G., Breda, E., Cavaghan, M. K., Ehrmann, D. A., Polonsky, K. S., & Cobelli, C. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.1.e2 · Cited by 112 · see citing works

Splanchnic Cortisol Production Occurs in Humans

Basu, R., Singh, R., Basu, A., Chittilapilly, E. G., Johnson, C. M., TOFFOLO, G. M., Cobelli, C., & Rizza, R. A. (2004) · Diabetes · doi:10.2337/diabetes.53.8.2051 · Cited by 111 · see citing works

Insulin release in impaired glucose tolerance: oral minimal model predicts normal sensitivity to glucose but defective response times.

Breda, E., Toffolo, G., Polonsky, K., & Cobelli, C. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s227 · Cited by 62 · see citing works

Evaluation of Insulin Sensitivity and β-Cell Function Indexes Obtained From Minimal Model Analysis of a Meal Tolerance Test

Steil, G. M., Hwu, C.-M., Janowski, R., Hariri, F., Jinagouda, S. D., Darwin, C. H., Tadros, S. S., Rebrin, K., & Saad, M. F. (2004) · Diabetes · doi:10.2337/diabetes.53.5.1201 · Cited by 62 · see citing works

Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage

Muniyappa, R., Lee, S., Chen, H., & Quon, M. J. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00645.2007 · Cited by 1,643 · see citing works

The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome

Petersen, K. F., Dufour, S., Savage, D. B., Bilz, S., Solomon, G., Yonemitsu, S., Cline, G. W., Befroy, D., Zemany, L., Kahn, B. B., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705408104 · Cited by 759 · see citing works

Surrogate markers of insulin resistance: A review

Singh, B. (2010) · World Journal of Diabetes · doi:10.4239/wjd.v1.i2.36 · Cited by 622 · see citing works

Diabetes: Models, Signals, and Control

Cobelli, C., Dalla Man, C., Sparacino, G., Magni, L., De Nicolao, G., & Kovatchev, B. P. (2009) · IEEE Reviews in Biomedical Engineering · doi:10.1109/rbme.2009.2036073 · Cited by 511 · see citing works

Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men

Petersen, K. F., Dufour, S., Feng, J., Befroy, D., Dziura, J., Man, C. D., Cobelli, C., & Shulman, G. I. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608537103 · Cited by 403 · see citing works

Hyperbolic Relationship Between Insulin Secretion and Sensitivity on Oral Glucose Tolerance Test

Retnakaran, R. R., Shen, S., Hanley, A. J., Vuksan, V. V. V., Hamilton, J. K., & Zinman, B. (2008) · Obesity · doi:10.1038/oby.2008.307 · Cited by 364 · see citing works

Effects of Age and Sex on Postprandial Glucose Metabolism

Basu, R., Dalla Man, C., Campioni, M., Basu, A., Klee, G., Toffolo, G., Cobelli, C., & Rizza, R. A. (2006) · Diabetes · doi:10.2337/db05-1692 · Cited by 334 · see citing works

Type 2 Diabetes in Youth: Epidemiology and Pathophysiology

D’Adamo, E., & Caprio, S. (2011) · Diabetes Care · doi:10.2337/dc11-s212 · Cited by 315 · see citing works

Assessment of beta-cell function in humans, simultaneously with insulin sensitivity and hepatic extraction, from intravenous and oral glucose tests.

Cobelli, C., Toffolo, G., Man, C. D., Campioni, M., Denti, P., Caumo, A., Butler, P., & Rizza, R. (2007) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00421.2006 · Cited by 320 · see citing works

Assessment of Insulin Secretion and Insulin Resistance in Human

Park, S. Y., Gautier, J., & Chon, S. (2021) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2021.0220 · Cited by 258 · see citing works

Pilot study of resveratrol in older adults with impaired glucose tolerance

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New markers of insulin resistance in polycystic ovary syndrome

Polak, K., Czyzyk, A., Simoncini, T., & Męczekalski, B. (2016) · Journal of Endocrinological Investigation · doi:10.1007/s40618-016-0523-8 · Cited by 258 · see citing works

Are we optimizing gestational diabetes treatment with glyburide? The pharmacologic basis for better clinical practice

Hebert, M., Ma, X., Naraharisetti, S., Krudys, K., Umans, J., Hankins, G., Caritis, S., Miodovnik, M., Mattison, D., Unadkat, J., et al. (2009) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2009.5 · Cited by 252 · see citing works

The Spectrum of Achalasia: Lessons From Studies of Pathophysiology and High-Resolution Manometry

Kahrilas, P. J., & Boeckxstaens, G. E. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.08.038 · Cited by 234 · see citing works

The Oral Minimal Model Method

Cobelli, C., Dalla Man, C., Toffolo, G., Basu, R., Vella, A., & Rizza, R. (2014) · Diabetes · doi:10.2337/db13-1198 · Cited by 216 · see citing works

A randomized controlled trial contrasting the effects of 4 low-calorie sweeteners and sucrose on body weight in adults with overweight or obesity

Higgins, K., & Mattes, R. D. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy381 · Cited by 162 · see citing works

Effects of Bariatric Surgery on Glucose Homeostasis and Type 2 Diabetes

Bradley, D. P., Magkos, F., & Klein, S. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.07.114 · Cited by 153 · see citing works

Primary Defects in β-Cell Function Further Exacerbated by Worsening of Insulin Resistance Mark the Development of Impaired Glucose Tolerance in Obese Adolescents

Cali, A. M. G., Man, C. D., Cobelli, C., Dziura, J., Seyal, A., Shaw, M., Allen, K., Chen, S., & Caprio, S. (2009) · Diabetes Care · doi:10.2337/dc08-1274 · Cited by 125 · see citing works

Metabolic and hormonal effects of ‘catch‐up’ sleep in men with chronic, repetitive, lifestyle‐driven sleep restriction

Killick, R., Hoyos, C. M., Melehan, K. L., Dungan, G. C., Poh, J., & Liu, P. Y. (2015) · Clinical Endocrinology · doi:10.1111/cen.12747 · Cited by 108 · see citing works

Metabolic aspects of pig-to-monkey (Macaca fascicularis) islet transplantation: implications for translation into clinical practice

Casu, A., Bottino, R., Balamurugan, A. N., Hara, H., van der Windt, D. J., Campanile, N., Smetanka, C., Cooper, D. K. C., & Trucco, M. (2007) · Diabetologia · doi:10.1007/s00125-007-0844-4 · Cited by 95 · see citing works

Complex physiology and clinical implications of time-restricted eating

Petersen, M. C., Gallop, M. R., Ramos, S. F., Zarrinpar, A., Broussard, J. L., Chondronikola, M., Chaix, A., & Klein, S. (2022) · Physiological Reviews · doi:10.1152/physrev.00006.2022 · Cited by 91 · see citing works

The future of open‐ and closed‐loop insulin delivery systems

Farmer, T. G., Edgar, T., & Peppas, N. (2008) · The Journal of pharmacy and pharmacology · doi:10.1211/jpp.60.1.0001 · Cited by 84 · see citing works

Modeling a simplified regulatory system of blood glucose at molecular levels.

Liu, W.-J., & Tang, F. (2008) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2008.02.021 · Cited by 85 · see citing works

Low-Dose Persistent Organic Pollutants Impair Insulin Secretory Function of Pancreatic β-Cells: Human and In Vitro Evidence

Lee, Y., Ha, C., Kim, S.-A., Thoudam, T., Yoon, Y.-R., Kim, D. J., Kim, H. C., Moon, H., Park, S., Lee, I., et al. (2017) · Diabetes · doi:10.2337/db17-0188 · Cited by 74 · see citing works

Physiological modeling, tight glycemic control, and the ICU clinician: what are models and how can they affect practice?

Chase, J. G., Compte, A. J. L., Preiser, J.-C., Shaw, G. M., Penning, S., & Desaive, T. (2011) · Annals of Intensive Care · doi:10.1186/2110-5820-1-11 · Cited by 73 · see citing works

Measures of insulin sensitivity.

Bloomgarden, Z. (2006) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2006.06.007 · Cited by 65 · see citing works

Gut Hormone Pharmacology of a Novel GPR119 Agonist (GSK1292263), Metformin, and Sitagliptin in Type 2 Diabetes Mellitus: Results from Two Randomized Studies

Nunez, D. J., Bush, M., Collins, D. A., McMullen, S. L., Gillmor, D., Apseloff, G., Atiee, G. J., Corsino, L., Morrow, L., & Feldman, P. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092494 · Cited by 65 · see citing works

Lifestyle intervention to improve quality of life and prevent weight gain after renal transplantation: Design of the Active Care after Transplantation (ACT) randomized controlled trial

Klaassen, G., Zelle, D. M., Navis, G. J., Dijkema, D., Bemelman, F. J., Bakker, S. J. L., & Corpeleijn, E. (2017) · BMC Nephrology · doi:10.1186/s12882-017-0709-0 · Cited by 62 · see citing works

Impaired insulin signaling in unaffected siblings and patients with first-episode psychosis

Chouinard, V., Henderson, D. C., Man, C. D., Valeri, L., Gray, B. E., Ryan, K. P., Cypess, A. M., Cobelli, C., Cohen, B. M., & Öngür, D. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0045-1 · Cited by 62 · see citing works

Calorie Restriction and Matched Weight Loss From Exercise: Independent and Additive Effects on Glucoregulation and the Incretin System in Overweight Women and Men

Weiss, E. P., Albert, S. G., Reeds, D. N., Kress, K. S., Ezekiel, U. R., McDaniel, J. L., Patterson, B. W., Klein, S., & Villareal, D. T. (2015) · Diabetes Care · doi:10.2337/dc14-2913 · Cited by 60 · see citing works

Indices of insulin sensitivity and secretion from a standard liquid meal test in subjects with type 2 diabetes, impaired or normal fasting glucose

Maki, K. C., McKenney, J. M., Farmer, M. V., Reeves, M. S., & Dicklin, M. R. (2009) · Nutrition Journal · doi:10.1186/1475-2891-8-22 · Cited by 59 · see citing works

Modeling the physiological glucose-insulin system on normal and diabetic subjects

Chen, C.-L., & Tsai, H.-W. (2010) · Comput. Methods Programs Biomed. · doi:10.1016/j.cmpb.2009.06.005 · Cited by 54 · see citing works

Dynamic assessment of insulin secretion and insulin resistance in Asians with prediabetes

Magkos, F., Lee, M. H., Lim, M., Cook, A. R., Chhay, V., Loh, T. P., Chia, K. S., Baig, S., Ang, I. Y. H., Tay, J., et al. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154957 · Cited by 49 · see citing works

A systems biology approach to understand gut microbiota and host metabolism in morbid obesity: design of the BARIA Longitudinal Cohort Study

van Olden, C. C., van de Laar, A. W. J. M., Meijnikman, A. S., Aydin, Ö., van Olst, N., Hoozemans, J., de Brauw, L. M., Bruin, S., Acherman, Y. I. Z., Verheij, J., et al. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13157 · Cited by 48 · see citing works

A concerted decline in insulin secretion and action occurs across the spectrum of fasting and postchallenge glucose concentrations

Sathananthan, A., Man, C. D., Zinsmeister, A. R., Camilleri, M., Rodeheffer, R. J., TOFFOLO, G. M., Cobelli, C., Rizza, R. A., & Vella, A. V. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04159.x · Cited by 43 · see citing works

A molecular mathematical model of glucose mobilization and uptake.

Liu, W.-J., Hsin, C.-M., & Tang, F. (2009) · Mathematical Biosciences · doi:10.1016/j.mbs.2009.07.005 · Cited by 42 · see citing works

Selenium supplementation and insulin resistance in a randomized, clinical trial

Jacobs, E. T., Lance, P., Mandarino, L. J., Ellis, N. A., Chow, H.-H. S., Foote, J., Martinez, J. A., Hsu, C.-H. P., Batai, K., Saboda, K., et al. (2019) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2018-000613 · Cited by 41 · see citing works

Prospective evaluation of insulin and incretin dynamics in obese adults with and without diabetes for 2 years after Roux-en-Y gastric bypass

Purnell, J. Q., Johnson, G., Wahed, A. S., Man, C. D., Piccinini, F., Cobelli, C., Prigeon, R. L., Goodpaster, B. H., Kelley, D. E., Staten, M. A., et al. (2018) · Diabetologia · doi:10.1007/s00125-018-4553-y · Cited by 40 · see citing works

The time has come to test the beta cell preserving effects of exercise in patients with new onset type 1 diabetes

Narendran, P., Solomon, T. P. J., Kennedy, A., Chimen, M., & Andrews, R. C. (2014) · Diabetologia · doi:10.1007/s00125-014-3412-8 · Cited by 40 · see citing works

Assessment of insulin action on carbohydrate metabolism: physiological and non-physiological methods

Dube, S., Errázuriz, I., Cobelli, C., Basu, R., & Basu, A. (2013) · Diabetic Medicine · doi:10.1111/dme.12189 · Cited by 34 · see citing works

Validation of Insulin Sensitivity and Secretion Indices Derived from the Liquid Meal Tolerance Test

Maki, K. C., Kelley, K., Lawless, A. L., Hubacher, R., Schild, A. L., Dicklin, M., & Rains, T. M. (2011) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2010.0240 · Cited by 38 · see citing works

The effect of chromium on inflammatory markers, 1st and 2nd phase insulin secretion in type 2 diabetes

Chen, Y.-L., Lin, J.-D., Hsia, T., Mao, F. C., Hsu, C.-H., & Pei, D. (2013) · European Journal of Nutrition · doi:10.1007/s00394-013-0508-8 · Cited by 39 · see citing works

Men Are from Mars, Women Are from Venus: Sex Differences in Insulin Action and Secretion

Basu, A., Dube, S., & Basu, R. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-70178-3_4 · Cited by 38 · see citing works

Regulation of glucose metabolism in nondiabetic, metabolically obese normal-weight Asians

Ding, C., Chan, Z., Chooi, Y. C., Choo, J., Sadananthan, S. A., Chang, A., Sasikala, S., Michael, N., Velan, S. S., & Magkos, F. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00382.2017 · Cited by 38 · see citing works

Moderate Weight Loss Improves Body Composition and Metabolic Function in Metabolically Unhealthy Lean Subjects

Chooi, Y. C., Ding, C., Chan, Z., Choo, J., Sadananthan, S. A., Michael, N., Lee, Y., Velan, S. S., & Magkos, F. (2018) · Obesity · doi:10.1002/oby.22185 · Cited by 37 · see citing works

Insulin Promoter-Driven Gaussia Luciferase-Based Insulin Secretion Biosensor Assay for Discovery of β-Cell Glucose-Sensing Pathways

Kalwat, M. A., Wichaidit, C., Garcia, A. Y. N., McCoy, M. K., McGlynn, K., Hwang, I. H., MacMillan, J. B., Posner, B. A., & Cobb, M. H. (2016) · ACS Sensors · doi:10.1021/acssensors.6b00433 · Cited by 37 · see citing works

Effects of delayed gastric emptying on postprandial glucose kinetics, insulin sensitivity, and β-cell function

Hinshaw, L., Schiavon, M., Mallad, A., Man, C. D., Basu, R., Bharucha, A. E., Cobelli, C., Carter, R. E., Basu, A., & Kudva, Y. C. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00199.2014 · Cited by 35 · see citing works

Methods for Measuring Risk for Type 2 Diabetes in Youth: the Oral Glucose Tolerance Test (OGTT)

Chen, M. E., Aguirre, R. S., & Hannon, T. S. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1023-3 · Cited by 35 · see citing works

Increased oral processing and a slower eating rate increase glycaemic, insulin and satiety responses to a mixed meal tolerance test

Goh, A. T., Choy, M. J. Y., Chua, X. H., Ponnalagu, S., Khoo, C. M., Whitton, C., van Dam, R. M., & Forde, C. G. (2021) · European Journal of Nutrition · doi:10.1007/s00394-020-02466-z · Cited by 35 · see citing works

A Blood Glucose Control Framework Based on Reinforcement Learning With Safety and Interpretability: In Silico Validation

Lim, M. H., Lee, W., Jeon, B., & Kim, S. (2021) · IEEE Access · doi:10.1109/access.2021.3100007 · Cited by 31 · see citing works

Modeling the physiological glucose-insulin dynamic system on diabetics.

Chen, C.-L., Tsai, H.-W., & Wong, S. (2010) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2010.05.002 · Cited by 35 · see citing works

Sex Differences in Glucose and Fatty Acid Metabolism in Asians Who Are Nonobese

Chan, Z., Chooi, Y. C., Ding, C., Choo, J., Sadananthan, S. A., Michael, N., Velan, S. S., Leow, M. K., & Magkos, F. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01421 · Cited by 34 · see citing works

Co-occurrence of Risk Alleles in or Near Genes Modulating Insulin Secretion Predisposes Obese Youth to Prediabetes

Giannini, C., Man, C. D., Groop, L., Cobelli, C., Zhao, H., Shaw, M. M., Duran, E. J., Pierpont, B. M., Bale, A. E., Caprio, S., et al. (2013) · Diabetes Care · doi:10.2337/dc13-1458 · Cited by 34 · see citing works

Impaired Insulin Action Is Associated With Increased Glucagon Concentrations in Nondiabetic Humans

Sharma, A. R., Varghese, R. T., Shah, M., Man, C. D., Cobelli, C., Rizza, R. A., Bailey, K. R., & Vella, A. V. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01197 · Cited by 34 · see citing works

Decision support for optimized blood glucose control and nutrition in a neurotrauma intensive care unit: preliminary results of clinical advice and prediction accuracy of the Glucosafe system

Pielmeier, U., Rousing, M. L., Andreassen, S., Nielsen, B. S., & Haure, P. (2012) · Journal of Clinical Monitoring and Computing · doi:10.1007/s10877-012-9364-y · Cited by 33 · see citing works

Repeatability of Indices of Insulin Sensitivity and Secretion from Standard Liquid Meal Tests in Subjects with Type 2 Diabetes Mellitus or Normal or Impaired Fasting Glucose

Maki, K. C., Rains, T. M., Dicklin, M. R., & Bell, M. (2010) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2010.0083 · Cited by 32 · see citing works

Effect of Slow Wave Sleep Disruption on Metabolic Parameters in Adolescents

Shaw, N. D., McHill, A. W., Schiavon, M., Kangarloo, T., Mankowski, P. W., Cobelli, C., Klerman, E. B., & Hall, J. E. (2016) · SLEEP · doi:10.5665/sleep.6028 · Cited by 32 · see citing works

Serum ferritin is associated with non-alcoholic fatty liver disease and decreased Β-cell function in non-diabetic men and women

Utzschneider, K. M., Largajolli, A., Bertoldo, A., Marcovina, S., Nelson, J. E., Yeh, M. M., Kowdley, K. V., & Kahn, S. E. (2013) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2013.11.007 · Cited by 31 · see citing works

Recognizing the Role of Insulin Resistance in Polycystic Ovary Syndrome: A Paradigm Shift from a Glucose-Centric Approach to an Insulin-Centric Model

Parker, J., Briden, L., & Gersh, F. L. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14124021 · Cited by 29 · see citing works

Randomized controlled study of metformin and sitagliptin on long-term normoglycemia remission in African American patients with hyperglycemic crises

Vellanki, P., Smiley, D. D., Stefanovski, D., Anzola, I., Duan, W., Hudson, M., Peng, L., Pasquel, F. J., & Umpierrez, G. E. (2016) · Diabetes Care · doi:10.2337/dc16-0406 · Cited by 28 · see citing works

Quantifying beta cell function in the preclinical stages of type 1 diabetes

Galderisi, A., Carr, A. L. J., Martino, M., Taylor, P., Senior, P. A., & Dayan, C. M. (2023) · Diabetologia · doi:10.1007/s00125-023-06011-5 · Cited by 28 · see citing works

Clamping Cortisol and Testosterone Mitigates the Development of Insulin Resistance during Sleep Restriction in Men

Liu, P. Y., Lawrence-Sidebottom, D., Piotrowska, K., Zhang, W., Iranmanesh, A., Auchus, R. J., Veldhuis, J. D., & Van Dongen, H. P. A. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab375 · Cited by 28 · see citing works

NEFA minimal model parameters estimated from the oral glucose tolerance test and the meal tolerance test

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Imatinib and Type 2 Diabetes

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Comparison of β-cell function between overweight/obese adults and adolescents across the spectrum of glycemia

Chen, M. E., Chandramouli, A. G., Considine, R. V., Hannon, T. S., & Mather, K. J. (2018) · Diabetes Care · doi:10.2337/dc17-1373 · Cited by 26 · see citing works

Diabetes-associated genetic variation in TCF7L2 alters pulsatile insulin secretion in humans

LAURENTI, M. C., Man, C. D., Varghese, R. T., Andrews, J. C., Rizza, R. A., Matveyenko, A. V., Nicolao, G. D., Cobelli, C., & Vella, A. V. (2020) · JCI Insight · doi:10.1172/jci.insight.136136 · Cited by 25 · see citing works

Mathematical model for glucose regulation in the whole-body system

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The Resist Diabetes trial: Rationale, design, and methods of a hybrid efficacy/effectiveness intervention trial for resistance training maintenance to improve glucose homeostasis in older prediabetic adults

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Hepatic insulin sensitivity in healthy and prediabetic subjects: from a dual- to a single-tracer oral minimal model

VISENTIN, R., Man, C. D., Basu, R., Basu, A., Rizza, R. A., & Cobelli, C. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00358.2014 · Cited by 23 · see citing works

Oral histidine affects gut microbiota and MAIT cells improving glycemic control in type 2 diabetes patients

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Differential contribution of alpha and beta cell dysfunction to impaired fasting glucose and impaired glucose tolerance

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Minimal and Maximal Models to Quantitate Glucose Metabolism: Tools to Measure, to Simulate and to Run in Silico Clinical Trials

Cobelli, C., & Man, C. D. (2021) · Journal of Diabetes Science and Technology · doi:10.1177/19322968211015268 · Cited by 18 · see citing works

Metabolic surgery improves insulin resistance through the reduction of gut-secreted heat shock proteins

Angelini, G., Salinari, S., BERTUZZI, A., Iaconelli, A., & Mingrone, G. (2018) · Communications Biology · doi:10.1038/s42003-018-0069-8 · Cited by 21 · see citing works

β‐Cell Function and Insulin Sensitivity in Adolescents From an OGTT

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Effect of High-dose Vitamin D Supplementation on Beta Cell Function in Obese Asian-Indian Children and Adolescents: A Randomized, Double Blind, Active Controlled Study

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Protein supplementation changes gut microbial diversity and derived metabolites in subjects with type 2 diabetes

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Effects of a hypercaloric diet on β‐cell responsivity in lean healthy men

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Pharmacodynamics of Glyburide, Metformin, and Glyburide/Metformin Combination Therapy in the Treatment of Gestational Diabetes Mellitus

Shuster, D. L., Shireman, L. M., Ma, X., Shen, D. D., Flood-Nichols, S. K., Ahmed, M. S., Clark, S. M., Caritis, S. N., Venkataramanan, R., Haas, D. M., et al. (2019) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.1749 · Cited by 18 · see citing works

DAISY: An efficient tool to test global identifiability. Some case studies

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Liver triacylglycerol content and gestational diabetes: effects of moderate energy restriction

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Associations between oral processing, saliva, and bolus properties on daily glucose excursions amongst people at risk of type-2 diabetes

Goh, A. T., Yao, J., Chua, X. H., Whitton, C., van Dam, R. M., & Forde, C. G. (2023) · Food & Function · doi:10.1039/d2fo03060h · Cited by 16 · see citing works

A Hepatocyte FOXN3-α Cell Glucagon Axis Regulates Fasting Glucose

Karanth, S., Adams, J. D., Serrano, M. D. L. Á., Quittner-Strom, E. B., Simcox, J., Villanueva, C. J., Özcan, L., Holland, W. L., Yost, H. J., Vella, A. V., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.06.039 · Cited by 15 · see citing works

Ectopic fat and aerobic fitness are key determinants of glucose homeostasis in nonobese Asians

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The effect of vagal nerve blockade using electrical impulses on glucose metabolism in nondiabetic subjects

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Insulin action and secretion in hypertension in the absence of metabolic syndrome: model-based assessment from oral glucose tolerance test.

Burattini, R., di Nardo, F., Casagrande, F., Boemi, M., & Morosini, P. (2009) · Metabolism: Clinical and Experimental · doi:10.1016/j.metabol.2008.08.010 · Cited by 19 · see citing works

A glucose-insulin pharmacodynamic surface modeling validation and comparison of metabolic system models

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Visceral adipose tissue tracks more closely with metabolic dysfunction than intrahepatic triglyceride in lean Asians without diabetes

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Oral minimal model-based estimates of insulin sensitivity in obese youth depend on oral glucose tolerance test protocol duration

Bartlette, K., Carreau, A., Xie, D., Garcia‐Reyes, Y., Rahat, H., Pyle, L. L., Nadeau, K. J., Cree‐Green, M., & Behn, C. D. (2021) · Metabolism Open · doi:10.1016/j.metop.2021.100078 · Cited by 14 · see citing works

Assessment of insulin resistance: From the bench to bedside

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Increased Prevalence of Beta-Cell Dysfunction despite Normal HbA1c in Youth and Young Adults with Turner Syndrome

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A mathematical model for the robust blood glucose tracking

Liu, W. (2019) · Mathematical Biosciences & Engineering · doi:10.3934/mbe.2019036 · Cited by 12 · see citing works

Metabolic and Genetic Determinants of Glucose Shape After Oral Challenge in Obese Youths: A Longitudinal Study

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β-Cell Function and Insulin Sensitivity in Youth With Early Type 1 Diabetes From a 2-Hour 7-Sample OGTT

Galderisi, A., Evans‐Molina, C., Martino, M., Caprio, S., Cobelli, C., & Moran, A. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac740 · Cited by 12 · see citing works

A Novel Insulin/Glucose Model after a Mixed-Meal Test in Patients with Type 1 Diabetes on Insulin Pump Therapy

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Population insulin sensitivity from sparsely sampled oral glucose tolerance tests

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Good agreement between hyperinsulinemic‐euglycemic clamp and 2 hours oral minimal model assessed insulin sensitivity in adolescents

Carreau, A., Xie, D., Garcia‐Reyes, Y., Rahat, H., Bartlette, K., Behn, C. D., Pyle, L. L., Nadeau, K. J., & Cree‐Green, M. (2020) · Pediatric Diabetes · doi:10.1111/pedi.13072 · Cited by 11 · see citing works

Cardio-metabolic health effects of CPAP treatment for sleep apnoea during weight loss: A randomised controlled pilot trial

Hoyos, C. M., Cayanan, E. A., Yee, B. J., Postnova, S., Marshall, N. S., Markovic, T., Twigg, S. M., Grunstein, R. R., & Phillips, C. L. (2024) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2024.06.003 · Cited by 10 · see citing works

Insulin sensitivity, disposition index and insulin clearance in cystic fibrosis: a cross-sectional study

Nielsen, B. U., Mathiesen, I. H. M., Krogh‐Madsen, R., Katzenstein, T. L., Pressler, T., Shaw, J., Rickels, M. R., Almdal, T., Faurholt‐Jepsen, D., & Stefanovski, D. (2024) · Diabetologia · doi:10.1007/s00125-024-06220-6 · Cited by 10 · see citing works

The effects of laparoscopic Roux-en-Y gastric bypass and one-anastomosis gastric bypass on glycemic control and remission of type 2 diabetes mellitus: study protocol for a multi-center randomized controlled trial (the DIABAR-trial)

van Rijswijk, A.-S., van Olst, N., Meijnikman, A. S., Acherman, Y. I. Z., Bruin, S., van de Laar, A. W. J. M., van Olden, C. C., Aydin, Ö., Börger, H., Beuers, U. H., et al. (2022) · Trials · doi:10.1186/s13063-022-06762-3 · Cited by 10 · see citing works

Model-Based Insulin Therapy Scheduling: A Mixed-Integer Nonlinear Dynamic Optimization Approach

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Insulin secretion rate and ß-cell sensitivity from oral glucose tolerance test in normotensive and normoglycemic humans

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β-Cell Function and Insulin Sensitivity in Youth With Early Type 1 Diabetes From a 2-Hour 7-Sample OGTT

Galderisi, A., Evans‐Molina, C., Martino, M., Caprio, S., Cobelli, C., & Moran, A. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac740 · Cited by 12 · see citing works

Oral Glucose Tolerance Test Minimal Model Indexes of β-Cell Function and Insulin Sensitivity

Breda, E., Cavaghan, M. K., Toffolo, G., Polonsky, K. S., & Cobelli, C. (2001) · Diabetes · doi:10.2337/diabetes.50.1.150 · Cited by 320 · see citing works

β‐Cell Function and Insulin Sensitivity in Adolescents From an OGTT

Sunehag, A. L., Man, C. D., TOFFOLO, G. M., Haymond, M. W., Bier, D. M., & Cobelli, C. (2008) · Obesity · doi:10.1038/oby.2008.496 · Cited by 19 · see citing works

Assessment of β‐cell function during the oral glucose tolerance test by a minimal model of insulin secretion

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