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Cited by 179Pancreatic function and diabetesDiabetes, Cardiovascular Risks, and LipoproteinsDiabetes Management and Research

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Two-Hour Seven-Sample Oral Glucose Tolerance Test and Meal Protocol

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Dalla Man, Chiara, Campioni, Marco, Polonsky, Kenneth S., Basu, Rita, Rizza, Robert A., Toffolo, Gianna, Cobelli, Claudio·2005·Diabetes
DOI 10.2337/diabetes.54.11.3265
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Abstract

Highly informative yet simple protocols to assess insulin secretion and action would considerably enhance the quality of epidemiological and large-scale clinical trials. In an effort to develop such protocols, a 5-h, 11-sample oral glucose tolerance test (OGTT) was performed in 100 individuals and a 7-h, 21-sample meal in another 100. Plasma glucose, insulin, and C-peptide concentrations were measured. We show that virtually the same minimal model assessment of β-cell responsivity (dynamic [Φd] and static [Φs]), insulin sensitivity (Si), and disposition index (DI) can be obtained with a reduced seven-sample 2-h protocol: Φd, reduced versus full: 871.50 vs. 873.32, r = 0.98 in OGTT and 494.88 vs. 477.99 10−9, r = 0.91 in meal; Φs: 42.36 vs. 44.35, r = 0.88 in OGTT and 35.31 vs. 35.37 10−9 min−1, r = 0.90 in meal; Si: 24.33 vs. 22.77 10−5 dl · kg−1 · min−1 per pmol/l, r = 0.89 in OGTT and 19.03 vs. 19.77 10−5 dl · kg−1 · min−1 per pmol/l, r = 0.85 in meal; and DI: 1,282.26 vs. 1,273.23, r = 0.84 in OGTT and 726.92 vs. 776.97 10−14 dl · kg−1 · min−2 per pmol/l, r = 0.84 in meal. This reduced protocol will facilitate the study of insulin secretion and action under physiological conditions in nondiabetic humans.

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Metadata

Authors
Dalla Man, C., Campioni, M., Polonsky, K. S., Basu, R., Rizza, R. A., Toffolo, G., & Cobelli, C.
Affiliations
  • Department of Information Engineering, University of Padova, Padova, Italy
  • University of Padua (IT)
  • Washington University in St. Louis (US)
  • Mayo Clinic (US)
ORCID
Venue
Diabetes
Publisher
American Diabetes Association
Published
2005-11-01
Volume
54
Issue
11
Pages
3265-3273
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/diabetes.54.11.3265
OpenAlex
W2141363931
Cited by
179
References
12
Citations by year
2026: 8 · 2025: 6 · 2024: 9 · 2023: 6 · 2022: 8 · 2021: 14 · 2020: 10 · 2019: 8 · 2018: 16 · 2017: 8 · 2016: 9 · 2015: 6 · 2014: 8 · 2013: 9 · 2012: 8
FWCI
6.34
Type
journal article
Language
en
Open access
Locations
  • Diabetes (publishedVersion)
  • PubMed (publishedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion)
Funders
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK29953-23)
  • National Institute of Biomedical Imaging and Bioengineering (EB 01975, P41EB001975)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
oral glucose tolerance test, insulin secretion, insulin sensitivity, insulin sensitivity index, disposition index, minimal model analysis, C-peptide, plasma glucose
MeSH terms
Insulin Secretion, Adult, Aged, 80 and over, Blood Glucose, C-Peptide, Diet, Glucose Tolerance Test, Humans, Insulin, Insulin Resistance, Middle Aged, Models, Biological, Time Factors, Insulin-Secreting Cells

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