Pilot study of resveratrol in older adults with impaired glucose tolerance
Open accessAbstract
BACKGROUND: Resveratrol, a plant-derived polyphenol, has shown promising effects on insulin sensitivity and glucose tolerance in animal models and is also reported to have cardioprotective properties, but human studies are limited. In a pilot study, we tested the hypothesis that resveratrol improves glucose metabolism and vascular function in older adults with impaired glucose tolerance (IGT). METHODS: Ten subjects aged 72 ± 3 years (M ± SD) with IGT were enrolled in a 4-week open-label study of resveratrol (daily dose 1, 1.5, or 2 g). Following a standard mixed meal (110 g carbohydrate, 20 g protein, 20 g fat), we measured 3-hour glucose and insulin area under the curve (AUC), insulin sensitivity (Matsuda index), and secretion (corrected insulin response at 30 minutes). Endothelial function was assessed by reactive hyperemia peripheral arterial tonometry (reactive hyperemia index) before and 90 minutes postmeal. Results did not differ by dose, so data were combined for analysis. RESULTS: At baseline, body mass index was 29 ± 5 kg/m(2), fasting plasma glucose 110 ± 13 mg/dL, and 2-hour glucose 183 ± 33 mg/dL. After 4 weeks of resveratrol, fasting plasma glucose was unchanged, but peak postmeal (185 ± 10 vs 166 ± 9 mg/dL, p = .003) and 3-hour glucose AUC (469 ± 23 vs 428 ± 19, p = .001) declined. Matsuda index improved (3.1 ± 0.5 vs 3.8 ± 0.5, p = .03), and corrected insulin response at 30 minutes was unchanged (0.6 ± 0.1 vs 0.5 ± 0.5, p = .49). There was a trend toward improved postmeal reactive hyperemia index (baseline vs resveratrol postmeal delta -0.4 ± 0.2 vs 0.2 ± 0.3, p = .06). Weight, blood pressure, and lipids were unchanged. CONCLUSIONS: At doses between 1 and 2 g/day, resveratrol improves insulin sensitivity and postmeal plasma glucose in subjects with IGT. These preliminary findings support the conduct of larger studies to further investigate the effects of resveratrol on metabolism and vascular function.
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In that 2011 pilot, resveratrol significantly decreased postprandial glucose peak.
“Resveratrol had no significant effect on fasting blood glucose levels, insulin secretion, HOMA index, blood pressure, fasting lipid profile, c-reactive protein, adiponectin, and body weight, but significantly decreased postprandial glucose peak.”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [33]
In that 2011 pilot, one patient reported only mild diarrhea.
“Regarding adverse reactions, one patient reported only mild diarrhea [33].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [33]
In a 2011 uncontrolled, open-label pilot study, 10 overweight/obese adults (72 ± 3 years) with moderate insulin-resistance were randomly assigned to take resveratrol at doses of 1, 1.5, or 2 g once a day for 4 weeks.
“In 2011, in an uncontrolled, open-label pilot study, 10 overweight/obese adults (72 ± 3 years) with moderate insulin-resistance, diagnosed after a 75 g oral glucose tolerance test, were randomly assigned to take resveratrol at the doses of 1, 1.5, or 2 g once a day for 4 weeks [33].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [33]
In that 2011 pilot, endothelial function improved but not significantly.
“Endothelial function, assessed by reactive hyperemia of peripheral arterial tonometry, improved but not significantly.”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [33]
In that 2011 pilot, resveratrol had no significant effect on fasting blood glucose, insulin secretion, HOMA index, blood pressure, fasting lipid profile, c-reactive protein, adiponectin, and body weight.
“Resveratrol had no significant effect on fasting blood glucose levels, insulin secretion, HOMA index, blood pressure, fasting lipid profile, c-reactive protein, adiponectin, and body weight, but significantly decreased postprandial glucose peak.”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [33]
The antiandrogenic effects of resveratrol in PCOS women are probably indirect and driven by the reduction of insulin resistance, in contrast to pharmacologic intervention with metformin.
“Given that chronic hyperinsulinemia can stimulate an excessive production of androgens in PCOS women, the antiandrogenic effects of resveratrol are probably indirect and driven by the reduction of IR in these patients [141,142,143,144], in contrast to pharmacologic intervention with metformin [145,146].”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [141]
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- Authors
- Crandall, J. P., Oram, V., Trandafirescu, G., Reid, M., Kishore, P., Hawkins, M., Cohen, H. W., & Barzilai, N.
- Affiliations
- Albert Einstein College of Medicine (US)
- Venue
- The Journals of Gerontology: Series A
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-01-04
- Volume
- 67
- Issue
- 12
- Pages
- 1307-1312
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- PMC
- PMC3670158
- OpenAlex
- W2120007830
- Cited by
- 281
- References
- 40
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 9 · 2023: 4 · 2022: 11 · 2021: 9 · 2020: 20 · 2019: 9 · 2018: 20 · 2017: 30 · 2016: 30 · 2015: 34 · 2014: 40 · 2013: 40 · 2012: 17
- FWCI
- 20.58
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- National Institutes of Health (5p60md000514-09)
- National Center for Research Resources
- National Institute on Minority Health and Health Disparities (P60 MD-000514)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- resveratrol, impaired glucose tolerance, insulin sensitivity, postprandial blood glucose, Matsuda index, endothelial function, reactive hyperemia, older adults, polyphenols, glucose metabolism, vascular function, dose-response relationship, cardioprotection, prediabetes, type 2 diabetes prevention, mixed meal tolerance test, insulin secretion, reactive hyperemia peripheral arterial tonometry, body mass index
- MeSH terms
- Resveratrol, Aged, Antioxidants, Blood Glucose, Endothelium, Vascular, Female, Homeostasis, Humans, Male, Pilot Projects, Stilbenes, Glucose Intolerance
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