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Phagocytic NADPH Oxidase Overactivity Underlies Oxidative Stress in Metabolic Syndrome
Open accessAbstract
Oxidative stress plays a critical role in the pathogenesis of atherosclerosis in patients with metabolic syndrome. This study aimed to investigate whether a relationship exists between phagocytic NADPH oxidase activity and oxidative stress and atherosclerosis in metabolic syndrome patients. The study was performed in 56 metabolic syndrome patients (metabolic syndrome group), 99 patients with one or two cardiovascular risk factors (cardiovascular risk factor group), and 28 healthy subjects (control group). NADPH oxidase expression and activity was augmented (P < 0.05) in metabolic syndrome compared with cardiovascular risk factor and control groups. Insulin was enhanced (P < 0.05) in metabolic syndrome patients compared with cardiovascular risk factor and control groups and correlated with NADPH oxidase activity in the overall population. Insulin stimulated NADPH oxidase activity; this effect was abolished by a specific protein kinase C inhibitor. Oxidized LDL and nitrotyrosine levels and carotid intima-media thickness were increased (P < 0.05) in the metabolic syndrome group compared with cardiovascular risk factor and control groups and correlated with NADPH oxidase activity in the overall population. These findings suggest that phagocytic NADPH oxidase overactivity is involved in oxidative stress and atherosclerosis in metabolic syndrome patients. Our findings also suggest that hyperinsulinemia may contribute to oxidative stress in metabolic syndrome patients through activation of NADPH oxidase.
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“NOX activity has been found to be increased in patients with metabolic syndrome and increased plasma levels of oxidized LDL and nitrotyrosine (Fortuno et al. 2006).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Fortuno et al. 2006
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Metadata
- Authors
- Fortuño, A., San José, G., Moreno, M. U., Beloqui, O., Díez, J., & Zalba, G.
- Affiliations
- Division of Cardiovascular Sciences, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
- Department of Internal Medicine, University Clinic, University of Navarra, Pamplona, Spain
- Centro de Investigación Médica Aplicada (ES)
- ORCID
- Zalba, Guillermo
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2006-01-01
- Volume
- 55
- Issue
- 1
- Pages
- 209-215
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2120390713
- Cited by
- 128
- References
- 48
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 5 · 2021: 9 · 2020: 7 · 2019: 5 · 2018: 1 · 2017: 5 · 2016: 6 · 2015: 5 · 2014: 8 · 2013: 9 · 2012: 8
- FWCI
- 8.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- UCLA - Biblioteca de Ciencias de la Salud (submittedVersion)
- Deposito Adademico Digital Universidad De Navarra (University of Navarra) (submittedVersion)
- Funders
- Gobierno de Navarra
- Instituto de Salud Carlos III (C03/01)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- NADPH oxidase, phagocytes, oxidative stress, metabolic syndrome, atherosclerosis, hyperinsulinemia, protein kinase C, oxidized LDL, nitrotyrosine, carotid intima-media thickness, cardiovascular risk factors
- MeSH terms
- Female, Humans, Lymphocytes, Male, Middle Aged, Monocytes, Phagocytes, Tetradecanoylphorbol Acetate, Biomarkers, Gene Expression Regulation, Enzymologic, Oxidative Stress, NADPH Oxidases, Metabolic Syndrome, Atherosclerosis
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