Cited by 128Nitric Oxide and Endothelin EffectsRedox biology and oxidative stressNeutrophil, Myeloperoxidase and Oxidative Mechanisms

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Phagocytic NADPH Oxidase Overactivity Underlies Oxidative Stress in Metabolic Syndrome

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Fortuño, Ana, San José, Gorka, Moreno, María U., Beloqui, Oscar, Díez, Javier, Zalba, Guillermo·2006·Diabetes

DOI 10.2337/diabetes.55.01.06.db05-0751

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Abstract

Oxidative stress plays a critical role in the pathogenesis of atherosclerosis in patients with metabolic syndrome. This study aimed to investigate whether a relationship exists between phagocytic NADPH oxidase activity and oxidative stress and atherosclerosis in metabolic syndrome patients. The study was performed in 56 metabolic syndrome patients (metabolic syndrome group), 99 patients with one or two cardiovascular risk factors (cardiovascular risk factor group), and 28 healthy subjects (control group). NADPH oxidase expression and activity was augmented (P < 0.05) in metabolic syndrome compared with cardiovascular risk factor and control groups. Insulin was enhanced (P < 0.05) in metabolic syndrome patients compared with cardiovascular risk factor and control groups and correlated with NADPH oxidase activity in the overall population. Insulin stimulated NADPH oxidase activity; this effect was abolished by a specific protein kinase C inhibitor. Oxidized LDL and nitrotyrosine levels and carotid intima-media thickness were increased (P < 0.05) in the metabolic syndrome group compared with cardiovascular risk factor and control groups and correlated with NADPH oxidase activity in the overall population. These findings suggest that phagocytic NADPH oxidase overactivity is involved in oxidative stress and atherosclerosis in metabolic syndrome patients. Our findings also suggest that hyperinsulinemia may contribute to oxidative stress in metabolic syndrome patients through activation of NADPH oxidase.

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Authors: Fortuño, A., San José, G., Moreno, M. U., Beloqui, O., Díez, J., & Zalba, G.
Affiliations: Division of Cardiovascular Sciences, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
Department of Internal Medicine, University Clinic, University of Navarra, Pamplona, Spain
Centro de Investigación Médica Aplicada (ES)
ORCID: Zalba, Guillermo
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2006-01-01
Volume: 55
Issue: 1
Pages: 209-215
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.55.01.06.db05-0751
OpenAlex: W2120390713
Cited by: 128
References: 48
Citations by year: 2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 5 · 2021: 9 · 2020: 7 · 2019: 5 · 2018: 1 · 2017: 5 · 2016: 6 · 2015: 5 · 2014: 8 · 2013: 9 · 2012: 8
FWCI: 8.91
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
UCLA - Biblioteca de Ciencias de la Salud (submittedVersion)
Deposito Adademico Digital Universidad De Navarra (University of Navarra) (submittedVersion)
Funders: Gobierno de Navarra
Instituto de Salud Carlos III (C03/01)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords: NADPH oxidase, phagocytes, oxidative stress, metabolic syndrome, atherosclerosis, hyperinsulinemia, protein kinase C, oxidized LDL, nitrotyrosine, carotid intima-media thickness, cardiovascular risk factors
MeSH terms: Female, Humans, Lymphocytes, Male, Middle Aged, Monocytes, Phagocytes, Tetradecanoylphorbol Acetate, Biomarkers, Gene Expression Regulation, Enzymologic, Oxidative Stress, NADPH Oxidases, Metabolic Syndrome, Atherosclerosis

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Phagocytic NADPH Oxidase Overactivity Underlies Oxidative Stress in Metabolic Syndrome

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