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Increased Lipid Availability Impairs Insulin-Stimulated ATP Synthesis in Human Skeletal Muscle
Open accessAbstract
Insulin resistance correlates with intramyocellular lipid content (IMCL) and plasma free fatty acids (FFAs) and was recently linked to mitochondrial dysfunction. We examined the underlying relationships by measuring skeletal muscle ATP synthase flux, glucose transport/phosphorylation, and IMCL in response to different plasma insulin and plasma FFA concentrations. Healthy men were studied twice during hyperinsulinemic-euglycemic clamps with (LIP) or without (CON) lipid infusion (plasma FFA: CON ∼36 vs. LIP ∼1,034 μmol/l, P < 0.001). ATP synthase flux, glucose-6-phosphate (G6P), and IMCL were determined before and during the clamp in calf muscle using 31P and 1H magnetic resonance spectroscopy. Plasma lipid elevation resulted in ∼46% reduced whole-body glucose metabolism (180–360 min; P < 0.0001 vs. CON) and a 70% lower rise of G6P (P < 0.05 vs. CON) without significant changes in IMCL (LIP 117 ± 12% vs. CON 93 ± 3% of basal, P = 0.073). During the clamp, ATP synthase flux increased by ∼60% under control conditions (P = 0.02 vs. baseline) and was 24% lower during lipid infusion (LIP 11.0 ± 0.9 vs. CON 14.6 ± 1.2 μmol · g muscle−1 · min−1, P < 0.05). Physiologically increased plasma FFA concentrations reduce insulin-stimulated muscle ATP synthase flux in parallel with induction of insulin resistance.
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“Lastly, experimental induction of insulin resistance in skeletal muscle, by a physiological increase in plasma FFA concentration in lean healthy insulin-sensitive individuals, is associated with a decrease in oxidative phosphorylation flux in skeletal muscle [110].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [110]
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“High levels of free FA (FFA) were shown to alter ATP synthesis in skeletal muscle (30).”
From TFAM Enhances Fat Oxidation and Attenuates High-Fat Diet–Induced Insulin Resistance in Skeletal Muscle (2019) · cites this paper as [30]
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“Moreover, it was shown in a comparable study that short-term elevation of lipid availability reduces insulin-stimulated increase in ATP synthase flux in skeletal muscle (10), although this may mainly reflect an effect of muscular insulin resistance on ATP flux.”
From Prolonged fasting identifies skeletal muscle mitochondrial dysfunction as consequence rather than cause of human insulin resistance (2010) · cites this paper as [10]
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“one cannot completely exclude the possibility that the mitochondrial defect results secondary to insulin resistance.”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [110]
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“a mitochondrial defect similar to that observed in insulin-resistant individuals can be produced in young lean healthy subjects by physiologic elevation of the plasma FFA concentration [110, 131]”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [110]
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“PGC-1α expression (9) and the insulin-stimulated increase in skeletal muscle ATP synthesis (10) were reduced upon lipid infusion.”
From Prolonged fasting identifies skeletal muscle mitochondrial dysfunction as consequence rather than cause of human insulin resistance (2010) · cites this paper as [10]
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Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197
A short questionnaire for the measurement of habitual physical activity in epidemiological studies
Baecke, J. A. H., BUREMA, J., & Frijters, J. E. R. (1982) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/36.5.936 · Cited by 3,950
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844
Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321
Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes
Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193
Mitochondrial dysfunction in the elderly: possible role in insulin resistance
Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107
Mitochondrial dysfunction and type 2 diabetes
Lowell, B. B., & Shulman, G. I. (2005) · Science · doi:10.1126/science.1104343 · Cited by 2,070
Patti, M. E., Butte, A. J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., Miyazaki, Y., Kohane, I., Costello, M., Saccone, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1032913100 · Cited by 1,952
Mechanism of free fatty acid-induced insulin resistance in humans.
Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., & Shulman, G. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118742 · Cited by 1,539
Self-citationItani, S. I., Ruderman, N. B., Schmieder, F., & Boden, G. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2005 · Cited by 1,390
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Self-citationSarra, D. D., Tosi, F., Bonin, C., Fiers, T., Kaufman, J., Signori, C., Zambotti, F., Dall'Alda, M., Caruso, B., Zanolin, M. E., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1161 · Cited by 47
Prikoszovich, T., Winzer, C., Schmid, A. I., Szendroedi, J., Chmelík, M., Pacini, G., Krššák, M., Moser, E., Funahashi, T., Waldhäusl, W. K., et al. (2010) · Diabetes Care · doi:10.2337/dc10-1002 · Cited by 49
Self-citationStephens, N. A., Brouwers, B., Eroshkin, A. M., Yi, F., Cornnell, H. H., Meyer, C., Goodpaster, B. H., Pratley, R. E., Smith, S. R., & Sparks, L. M. (2018) · Diabetes Care · doi:10.2337/dc18-0296 · Cited by 48
Fernyhough, P., & McGavock, J. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53480-4.00027-8 · Cited by 50
Fan, C., Feng, J., Tang, C., Zhang, Z., Feng, Y., Duan, W., Zhai, M., Yan, Z., Zhu, L., Feng, L., et al. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01948-5 · Cited by 45
Jana, B. A., Chintamaneni, P. K., Krishnamurthy, P. T., Wadhwani, A., & Mohankumar, S. K. (2018) · Molecular Biology Reports · doi:10.1007/s11033-018-4551-7 · Cited by 45
Kiefer, L. S., Fabian, J., Rospleszcz, S., Lorbeer, R., Machann, J., Kraus, M. S., Roemer, F. W., Rathmann, W., Meisinger, C., Heier, M., et al. (2021) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14413 · Cited by 43
Kemp, G. J. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00797.2007 · Cited by 43
Gabiatti, C. T. B., Martins, M. C. L., Miyazaki, D. L., Silva, L. P., Juliani, F. L., Macedo, L. T., Mendes, M. C. S., & Carvalheira, J. B. C. (2019) · Cancer Medicine · doi:10.1002/cam4.2593 · Cited by 45
Dietary palmitate and oleate differently modulate insulin sensitivity in human skeletal muscle
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Self-citationSchmid, A. I., Schrauwen‐Hinderling, V. B., Andreas, M., Wolzt, M., Moser, E., & Roden, M. (2011) · Magnetic Resonance in Medicine · doi:10.1002/mrm.23095 · Cited by 40
Self-citationvan den Broek, N. M. A., Čiapaitė, J., Nicolay, K., & Prompers, J. J. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00200.2010 · Cited by 41
The role of mitochondrial-related nuclear genes in age-related common disease
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Oltmanns, K. M., Melchert, U. H., Scholand-Engler, H. G., Howitz, M. C., Schultes, B., Schweiger, U., Hohagen, F., Jan Born, A., Peters, A., & Pellerin, L. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00093.2007 · Cited by 41
Hoeks, J., de Wilde, J., Hulshof, M. F. M., van den Berg, S. A. A., Schaart, G., van Dijk, K. W., Smit, E., & Mariman, E. C. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027274 · Cited by 39
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Connor, T., Martin, S. D., Howlett, K. F., & McGee, S. L. (2014) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12315 · Cited by 37
Chicoric acid mitigates impaired insulin sensitivity by improving mitochondrial function
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Kiefer, L. S., Fabian, J., Rospleszcz, S., Lorbeer, R., Machann, J., Storz, C., Kraus, M. S., Schlett, C. L., Roemer, F. W., Wintermeyer, E., et al. (2018) · European Journal of Radiology · doi:10.1016/j.ejrad.2018.06.023 · Cited by 35
Madlala, H. P., Maarman, G. J., & Ojuka, E. O. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuv111 · Cited by 35
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Self-citationAcute exercise reverses starvation-mediated insulin resistance in humans
Frank, P., Katz, A., Andersson, E. A., & Sahlin, K. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00416.2012 · Cited by 33
Hermes, G. D. A., Reijnders, D., Kootte, R. S., Goossens, G. H., Smidt, H., Nieuwdorp, M., Blaak, E. E., & Zoetendal, E. G. (2020) · Scientific Reports · doi:10.1038/s41598-020-64574-4 · Cited by 33
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Self-citationLei, L., Zhu, Y., Gao, W., Du, X., Zhang, M., Peng, Z., Fu, S., Li, X., Zhe, W., Li, X. G., et al. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.06.024 · Cited by 32
Assessment of intramuscular triglycerides: contribution to metabolic abnormalities
Dubé, J., & Goodpaster, B. H. (2006) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000241664.38385.12 · Cited by 31
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Joseph, A.-M., & Hood, D. A. (2014) · Medicine and sport science/Medicine and sport · doi:10.1159/000357335 · Cited by 32
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Gordon, J. W., Dolinsky, V. W., Mughal, W., Gordon, G. R., & McGavock, J. (2015) · Biochemistry and Cell Biology · doi:10.1139/bcb-2015-0012 · Cited by 30
Larsen, R. G., Befroy, D. E., & Kent‐Braun, J. A. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00409.2012 · Cited by 31
Valkovič, L., Ukropcová, B., Chmelík, M., Baláž, M., Bogner, W., Schmid, A. I., Frollo, I., Zemková, E., Klimeś, I., Ukropec, J., et al. (2013) · NMR in Biomedicine · doi:10.1002/nbm.3008 · Cited by 30
Self-citationHaigh, J., New, L. E., & Filippi, B. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.580879 · Cited by 30
Mehan, S., Bhalla, S., Siddiqui, E. M., Sharma, N., Shandilya, A., & Khan, A. (2022) · Degenerative Neurological and Neuromuscular Disease · doi:10.2147/dnnd.s247153 · Cited by 29
Makimura, H., Stanley, T. L., Suresh, C., Sousa‐Coelho, A. L. D., Frontera, W. R., Syu, S., Braun, L. R., Looby, S. E. D., Feldpausch, M. N., Torriani, M., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3696 · Cited by 29
for the GDS group, Apostolopoulou, M., Straßburger, K., Herder, C., Knebel, B., Kotzka, J., Szendroedi, J., & Roden, M. (2016) · Diabetologia · doi:10.1007/s00125-016-4038-9 · Cited by 29
Self-citationSzendroedi, J., Frossard, M., Klein, N., Bieglmayer, C., Wagner, O. F., Pacini, G., Decker, J., Nowotny, P., Müller, M., & Roden, M. (2012) · Diabetes · doi:10.2337/db12-0108 · Cited by 30
Self-citationSrikanthan, P., Singhal, A., Lee, C. C., Nagarajan, R., Wilson, N. E., Roberts, C. K., Hahn, T. J., & Thomas, M. A. (2012) · Magnetic Resonance Insights · doi:10.4137/mri.s10489 · Cited by 28
Lim, E. L., Hollingsworth, K. G., Smith, F. E., Thelwall, P. E., & Taylor, R. (2011) · Clinical Science · doi:10.1042/cs20100611 · Cited by 28
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Szendroedi, J., Kaul, K., Kloock, L., Straßburger, K., Schmid, A. I., Chmelík, M., Kacerovsky, M., Kacerovsky-Bielesz, G., Prikoszovich, T., Brehm, A., et al. (2013) · Diabetes Care · doi:10.2337/dc13-1359 · Cited by 27
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Self-citationCalorie restriction and reversal of type 2 diabetes
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Lim, E. L., Hollingsworth, K. G., Thelwall, P. E., & Taylor, R. (2010) · NMR in Biomedicine · doi:10.1002/nbm.1519 · Cited by 24
Murea, M., Lenchik, L., Register, T. C., Russell, G. B., Xu, J., Smith, S. C., Bowden, D. W., Divers, J., & Freedman, B. I. (2018) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2018.03.004 · Cited by 22
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Rocha, M., Rovira‐Llopis, S., Bañuls, C., Bellod, L., Falcón, R., Castelló, R., Morillas, C., Herance, J. R., Hernández‐Mijares, A., & Víctor, V. M. (2013) · Current Pharmaceutical Design · doi:10.2174/13816128113199990373 · Cited by 23
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Nistala, R., & Stump, C. S. (2006) · Journal of the CardioMetabolic Syndrome · doi:10.1111/j.0197-3118.2006.05455.x · Cited by 22
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Smilowitz, J. T., Wiest, M. M., Watkins, S. M., Teegarden, D., Zemel, M. B., German, J. B., & Loan, M. D. V. (2008) · Journal of Nutrition · doi:10.3945/jn.108.095364 · Cited by 22
Brunetta, H. S., de Paula, G. C., de Oliveira, J., Martins, E. L., dos Santos, G. J., Galina, A., Rafacho, A., Bem, A. F. D., & Nunes, E. A. (2018) · Experimental Physiology · doi:10.1113/ep087317 · Cited by 20
Omary, L., Canfora, E. E., Puhlmann, M.-L., Gavriilidou, A., Rijnaarts, I., Holst, J. J., Bruls, Y. M. H., de Vos, W. M., & Blaak, E. E. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102237 · Cited by 22
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Self-citationBrands, M., Hoeks, J., Sauerwein, H. P., Ackermans, M. T., Ouwens, M., Lammers, N. M., van der Plas, M. N., Schrauwen, P., Groen, A. K., & Serlie, M. J. (2011) · Metabolism · doi:10.1016/j.metabol.2011.02.006 · Cited by 19
Calderón-DuPont, D., Torre-Villalvazo, I., & Díaz‐Villaseñor, A. (2022) · Biochimie · doi:10.1016/j.biochi.2022.08.021 · Cited by 23
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ZHANG, Y., Zhao, Y., GAO, Y.-F., Fan, Z., LIU, M.-Y., CAI, X.-Y., Xia, Z., & Gao, C. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.3124 · Cited by 20
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Yerby, B., Deacon, R. W., Beaulieu, V., Liang, J., Gao, J., & Laurent, D. (2008) · Metabolism · doi:10.1016/j.metabol.2008.06.015 · Cited by 18
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Moriyama, K. (2025) · World Journal of Clinical Cases · doi:10.12998/wjcc.v13.i29.108380 · Cited by 26
Lim, E. L., Hollingsworth, K. G., Smith, F. E., Thelwall, P. E., & Taylor, R. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00278.2011 · Cited by 16
Li, Y., Solomon, T. P. J., Haus, J. M., Saidel, G. M., Cabrera, M. E., & Kirwan, J. P. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00713.2009 · Cited by 15
Jelenc, M. T., Chmelík, M., Bogner, W., Krššák, M., Trattnig, S., & Valkovič, L. (2015) · NMR in Biomedicine · doi:10.1002/nbm.3445 · Cited by 15
Brunetta, H. S., Petrick, H. L., Vachon, B., Nunes, E. A., & Holloway, G. P. (2021) · Biochemical Journal · doi:10.1042/bcj20210264 · Cited by 15
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Cusi, K. J. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-260-1_1 · Cited by 15
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Nagarajan, R., Carpenter, C. L., Lee, C. C., Michael, N., Sarma, M. K., Souza, R., Xu, E., Velan, S. S., Hahn, T. J., Go, V., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-17529-1 · Cited by 15
Insulin resistance: central and peripheral mechanisms. The 2007 Stock Conference Report
Ye, J., & Kraegen, T. (2007) · Obesity Reviews · doi:10.1111/j.1467-789x.2007.00402.x · Cited by 13
Phielix, E., Begovatz, P., Gancheva, S., Bierwagen, A., Moonen‐Kornips, E., Schaart, G., Hesselink, M. K. C., Schrauwen, P., & Roden, M. (2019) · JCI Insight · doi:10.1172/jci.insight.127928 · Cited by 14
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Gaggini, M., Carli, F., & Gastaldelli, A. (2017) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2017-0060 · Cited by 11
Cuthbertson, D. J., Irwin, A., Sprung, V. S., Jones, H., Pugh, C. J. A., Daousi, C., Adams, V. L., Bimson, W. E., Shojaee‐Moradie, F., Richardson, P., et al. (2014) · Clinical Science · doi:10.1042/cs20130404 · Cited by 10
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Lu, X., Yue, J., Liu, Q., He, S., Dong, Y., Zhang, M., Qi, Y., Yang, M., Zhang, W., Xu, H., et al. (2023) · Endocrine Connections · doi:10.1530/ec-23-0248 · Cited by 9
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Vázquez-Jiménez, J. G., Roura-Guiberna, A., Jiménez-Mena, L. R., & Olivares-Reyes, J. A. (2017) · Gaceta Médica de México · doi:10.24875/gmm.17002714 · Cited by 11
(2012) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/978160805361211201010039 · Cited by 7
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Turner, N. A. (2013) · InTech eBooks · doi:10.5772/56449 · Cited by 8
Relationship between Testosterone Level, Serum Omentin-1 and Insulin Resistance in Obese Men
El-Kaream, S. A. A., Abdel-Monem, S. M., Khalil, M., & Mohassab, G. I. (2015) · American Journal of Biomedical Sciences · doi:10.5099/aj150300134 · Cited by 7
Zhyzhneuskaya, S. V., & Taylor, R. (2017) · Endocrinology · doi:10.1007/978-3-319-47685-8_21-1 · Cited by 8
Pathogenesis of insulin resistance in metabolic obesity
Litvinova, L. S., Кириенкова, Е. В., Mazunin, I., Василенко, М. А., & Fattakhov, N. S. (2014) · Biochemistry (Moscow) Supplement Series B Biomedical Chemistry · doi:10.1134/s1990750814030093 · Cited by 8
Insulin resistance pathogenesis in metabolic obesity
Litvinova, L. S., Кириенкова, Е. В., Mazunin, I., Василенко, М. А., & Fattakhov, N. S. (2015) · Biomeditsinskaya Khimiya · doi:10.18097/pbmc20156101070 · Cited by 7
Turco, A., Guescini, M., Valtucci, V., Colosimo, C., Feo, P. D., Mantuano, M., Stocchi, V., Riccardi, G., & Capaldo, B. (2013) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2013.07.001 · Cited by 7
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Demerdash, H. M. (2017) · Obesity Research - Open Journal · doi:10.17140/oroj-4-131 · Cited by 5
Yang, M., Zhou, F., Wang, C., sun, T., zhao, W., Liu, L., Meng, Y., & tian, L. (2026) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00473.2025 · Cited by 5
Donnell, R. A., Carré, J. E., & Affourtit, C. (2022) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2022.101274 · Cited by 5
Brunetta, H. S., & Holloway, G. P. (2022) · Current Opinion in Physiology · doi:10.1016/j.cophys.2022.100491 · Cited by 5
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Duez, H., & Lewis, G. F. (2008) · Humana Press eBooks · doi:10.1007/978-1-60327-043-4_4 · Cited by 4
Barquissau, V., & Morio, B. (2011) · Nutrition Clinique et Métabolisme · doi:10.1016/j.nupar.2011.07.003 · Cited by 5
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Zhang, L., & Thurber, G. M. (2017) · Springer eBooks · doi:10.1007/978-3-319-61401-4_8 · Cited by 2
Metadata
- Authors
- Brehm, A., Krssak, M., Schmid, A. I., Nowotny, P., Waldhäusl, W., & Roden, M.
- Affiliations
- Medical University of Vienna (AT)
- Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
- Hanusch Hospital (AT)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2006-01-01
- Volume
- 55
- Issue
- 1
- Pages
- 136-140
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2148020672
- Semantic Scholar
- b3a41abeca324733de403ba64f78380ee994679e
- Cited by
- 239
- References
- 47
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 2 · 2022: 6 · 2021: 7 · 2020: 7 · 2019: 7 · 2018: 14 · 2017: 13 · 2016: 16 · 2015: 16 · 2014: 19 · 2013: 20 · 2012: 15
- FWCI
- 7.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- UCLA - Biblioteca de Ciencias de la Salud (submittedVersion)
- Funders
- European Foundation for the Study of Diabetes
- Austrian Science Fund (P 15656)
- Universität Wien
- Novo Nordisk
- Medizinische Universität Wien
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- insulin resistance, intramyocellular lipid, plasma free fatty acids, skeletal muscle, mitochondrial dysfunction, glucose transport, glucose-6-phosphate, hyperinsulinemic-euglycemic clamp, lipid infusion, glucose metabolism
- MeSH terms
- Adenosine Triphosphate, Adult, Biological Transport, Glucose, Humans, Insulin, Male, Glucose Clamp Technique, Muscle, Skeletal, Glucose-6-Phosphate, Lipid Metabolism
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